Detailed information for compound 1076590

Basic information

Technical information
  • TDR Targets ID: 1076590
  • Name: 4-chloro-N-methyl-N-(4-pyridin-4-yl-1,3-thiaz ol-2-yl)benzamide
  • MW: 329.804 | Formula: C16H12ClN3OS
  • H donors: 0 H acceptors: 3 LogP: 3.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)N(c1scc(n1)c1ccncc1)C
  • InChi: 1S/C16H12ClN3OS/c1-20(15(21)12-2-4-13(17)5-3-12)16-19-14(10-22-16)11-6-8-18-9-7-11/h2-10H,1H3
  • InChiKey: QOIYGLHUBGCRFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-methyl-N-[4-(4-pyridyl)thiazol-2-yl]benzamide
  • 4-chloro-N-methyl-N-[4-(4-pyridyl)-2-thiazolyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, metabotropic 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0054 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0062 0.0581
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0054 0.0051
Schistosoma mansoni hypothetical protein 0.0065 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0549
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0254 0.1136 0.3153
Trichomonas vaginalis esterase, putative 0.0114 0.0446 0.4358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Echinococcus multilocularis cysteine protease 0.0036 0.0062 0.0044
Brugia malayi hypothetical protein 0.0025 0.0003 0.0012
Mycobacterium tuberculosis Probable oxidoreductase 0.0254 0.1136 0.3153
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0229 0.101 0.4062
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0062 0.0203
Loa Loa (eye worm) hypothetical protein 0.0114 0.0446 0.1525
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0114 0.0446 0.1525
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0054 0.0897
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0026 0.0008
Brugia malayi Cathepsin L-like precursor 0.0024 0.0002 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0026 0.0026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0054 0.0897
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.0565 1
Schistosoma mansoni hypothetical protein 0.0123 0.0488 0.0488
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.0446 0.1144
Loa Loa (eye worm) cysteine protease 0.0036 0.0062 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Plasmodium falciparum thioredoxin reductase 0.01 0.0377 0.204
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0062 0.0062
Mycobacterium ulcerans lipase LipD 0.0114 0.0446 0.2206
Schistosoma mansoni smad 0.0042 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.0565 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0054 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0062 0.0044
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0089 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0446 0.0446
Plasmodium vivax glutathione reductase, putative 0.01 0.0377 0.204
Brugia malayi Cathepsin L-like precursor 0.0036 0.0062 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0377 0.036
Onchocerca volvulus 0.0114 0.0446 0.4358
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0396 0.1834 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0396 0.1834 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0396 0.1834 0.1834
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0089 0.0298
Schistosoma mansoni hypothetical protein 0.0065 0.0205 0.0205
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1021 1
Echinococcus granulosus Smad4 0.0042 0.0089 0.0087
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0054 0.0897
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0008 0.0028
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0085 0.0082
Mycobacterium ulcerans beta-lactamase 0.0114 0.0446 0.2206
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.058 0.1989
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0205 0.0203
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0054 0.0275
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0062 0.1036
Leishmania major cathepsin L-like protease 0.0138 0.0565 1
Onchocerca volvulus 0.0231 0.1021 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0396 0.1834 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Echinococcus granulosus intermediate filament protein 0.0057 0.0162 0.016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0003 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0377 0.6649
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0488 0.0471
Leishmania major cathepsin L-like protease 0.0036 0.0062 0.1036
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0085 0.0085
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0883 0.3024
Brugia malayi MH2 domain containing protein 0.0042 0.0089 0.0305
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0259 0.1161 0.1146
Loa Loa (eye worm) hypothetical protein 0.0114 0.0446 0.1525
Loa Loa (eye worm) fibroinase 0.0036 0.0062 0.0203
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0054 0.0275
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0002 0.0002
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0101 0.0346
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.012 0.012
Schistosoma mansoni transcription factor LCR-F1 0.0259 0.1161 0.1161
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0017 0.0015
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0062 0.0062
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0179 0.0162
Plasmodium vivax vivapain-2 0.0036 0.0062 0.0318
Leishmania major cathepsin L-like protease 0.0036 0.0062 0.1036
Leishmania major hypothetical protein, conserved 0.0114 0.0446 0.789
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0062 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0062 0.0581
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0488 0.0486
Brugia malayi beta-lactamase family protein 0.0114 0.0446 0.1532
Echinococcus multilocularis smad 0.0042 0.0089 0.0072
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.0446 0.0444
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0377 0.0941
Plasmodium falciparum thioredoxin reductase 0.0035 0.0054 0.0275
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0062 0.0581
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0446 0.242
Loa Loa (eye worm) hypothetical protein 0.0207 0.0903 0.3091
Loa Loa (eye worm) hypothetical protein 0.0141 0.058 0.1983
Echinococcus multilocularis musashi 0.0057 0.0162 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0446 0.789
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0136 0.0555 0.3012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0396 0.1834 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0229 0.101 0.2787
Mycobacterium tuberculosis Conserved protein 0.0114 0.0446 0.1144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Echinococcus multilocularis cysteine protease 0.0036 0.0062 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0229 0.101 0.2787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0203
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0162 0.0549
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0054 0.0897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Brugia malayi glutathione reductase 0.01 0.0377 0.1293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Onchocerca volvulus 0.0048 0.012 0.1152
Mycobacterium tuberculosis Conserved protein 0.0114 0.0446 0.1144
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0034
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0396 0.1834 0.182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0205 0.0203
Loa Loa (eye worm) hypothetical protein 0.0065 0.0205 0.0697
Brugia malayi Pre-SET motif family protein 0.0029 0.0026 0.0089
Schistosoma mansoni smad1 5 8 and 0.0042 0.0089 0.0089
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0054 0.0275
Brugia malayi Cathepsin L-like precursor 0.0036 0.0062 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Echinococcus granulosus GPCR family 2 0.0065 0.0205 0.0203
Onchocerca volvulus 0.0029 0.0026 0.0232
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0062 0.0044
Echinococcus multilocularis Smad4 0.0042 0.0089 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0026
Brugia malayi Cathepsin L-like precursor 0.0024 0.0002 0.0008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0062 0.0044
Echinococcus multilocularis peptidase Clp (S14 family) 0.0259 0.1162 0.1146
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0254 0.1136 0.3153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Plasmodium falciparum glutathione reductase 0.0035 0.0054 0.0275
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0054 0.0897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Echinococcus multilocularis tumor protein p63 0.0329 0.1504 0.1489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0446 0.4358
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.0446 0.2206
Loa Loa (eye worm) hypothetical protein 0.0396 0.1834 0.629
Brugia malayi MH1 domain containing protein 0.0042 0.0089 0.0305
Trypanosoma cruzi major cysteine proteinase, putative 0.0109 0.0419 0.7399
Onchocerca volvulus 0.0036 0.0062 0.0581
Brugia malayi MH2 domain containing protein 0.0615 0.2915 1
Schistosoma mansoni hypothetical protein 0.0141 0.058 0.058
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.0446 0.1525
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0089 0.0087
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0062 0.0203
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0396 0.1834 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0054 0.0897
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0002 0.0008
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0136 0.0555 0.2815
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0229 0.101 0.2787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Loa Loa (eye worm) glutamate receptor 0.0049 0.0124 0.0417
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0089 0.0089
Trypanosoma brucei trypanothione reductase 0.01 0.0377 0.6649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Schistosoma mansoni smad1 5 8 and 0.0042 0.0089 0.0089
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0062 0.0318
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0026 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0446 0.4358
Toxoplasma gondii ABC1 family protein 0.0114 0.0446 0.242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0259 0.1161 0.1159
Loa Loa (eye worm) hypothetical protein 0.0114 0.0446 0.1525
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0396 0.1834 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0089 0.0298
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0032 0.0111
Brugia malayi Cathepsin L-like precursor 0.0036 0.0062 0.0211
Mycobacterium tuberculosis Possible penicillin-binding protein 0.073 0.3486 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.0446 0.043
Entamoeba histolytica cysteine protease, putative 0.0036 0.0062 0.0511
Schistosoma mansoni Smad4 0.0042 0.0089 0.0089
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0396 0.1834 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0054 0.0054
Echinococcus granulosus cathepsin l1 0.0036 0.0062 0.0059
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0054 0.0504
Mycobacterium tuberculosis Conserved protein 0.0114 0.0446 0.1144
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Loa Loa (eye worm) beta-lactamase 0.0114 0.0446 0.1525
Loa Loa (eye worm) glutathione reductase 0.01 0.0377 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0062 0.0059
Onchocerca volvulus 0.0114 0.0446 0.4358
Schistosoma mansoni hypothetical protein 0.0259 0.1161 0.1161
Echinococcus multilocularis lamin 0.0057 0.0162 0.0145
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0054 0.0897
Onchocerca volvulus 0.0036 0.0062 0.0581
Plasmodium vivax vivapain-2 0.0036 0.0062 0.0318
Onchocerca volvulus 0.0057 0.0162 0.157
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0062 0.0211
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0532
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0259 0.1162 0.3228
Brugia malayi beta-lactamase 0.0114 0.0446 0.1532
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.0565 1
Mycobacterium ulcerans hypothetical protein 0.0114 0.0446 0.2206
Leishmania major cathepsin L-like protease 0.0036 0.0062 0.1036
Brugia malayi intermediate filament protein 0.0057 0.0162 0.0557
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0054 0.0897
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0446 0.4358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0062 0.0581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0136 0.0555 0.0781
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0052
Entamoeba histolytica hypothetical protein 0.0259 0.1161 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0054 0.0897
Onchocerca volvulus 0.0114 0.0446 0.4358
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0446 0.4358
Echinococcus granulosus peptidase Clp S14 family 0.0259 0.1162 0.116
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0446 0.789
Entamoeba histolytica hypothetical protein 0.0259 0.1161 1
Onchocerca volvulus 0.0036 0.0062 0.0581
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.0446 0.1144
Loa Loa (eye worm) ctsf protein 0.0036 0.0062 0.0203
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0136 0.0555 0.3012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0008 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.0446 0.789
Leishmania major cathepsin L-like protease 0.0138 0.0565 1
Echinococcus granulosus lamin dm0 0.0057 0.0162 0.016
Schistosoma mansoni intermediate filament proteins 0.0057 0.0162 0.0162
Plasmodium vivax SET domain protein, putative 0.0029 0.0026 0.0123
Loa Loa (eye worm) hypothetical protein 0.0114 0.0446 0.1525
Echinococcus multilocularis lamin dm0 0.0057 0.0162 0.0145
Loa Loa (eye worm) MH2 domain-containing protein 0.0615 0.2915 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0124 0.0424
Schistosoma mansoni hypothetical protein 0.0065 0.0205 0.0205
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0062 0.0318
Schistosoma mansoni lamin 0.0057 0.0162 0.0162
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0162 0.0549
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0054 0.0036
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0396 0.1834 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0403
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0054 0.0275
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0396 0.1834 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Onchocerca volvulus 0.0036 0.0062 0.0581
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0377 0.1286
Brugia malayi MH2 domain containing protein 0.0042 0.0089 0.0305
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.0903 0.3097
Brugia malayi MH1 domain containing protein 0.0042 0.0089 0.0305
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0205 0.0704
Brugia malayi hypothetical protein 0.0259 0.1161 0.3984
Onchocerca volvulus 0.0036 0.0062 0.0581
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0205 0.0188
Loa Loa (eye worm) Smad1 0.0042 0.0089 0.0298
Trypanosoma cruzi cruzipain precursor, putative 0.0138 0.0565 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0259 0.1162 0.3228
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0396 0.1834 0.1832
Schistosoma mansoni hypothetical protein 0.0065 0.0205 0.0205
Leishmania major trypanothione reductase 0.01 0.0377 0.6649
Toxoplasma gondii cathepsin CPL 0.0036 0.0062 0.0318
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0446 0.4358
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.0446 0.1532
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.0446 0.1144
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0054 0.0275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0205 0.0704
Brugia malayi Cathepsin L-like precursor 0.0036 0.0062 0.0211
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0054 0.0504
Leishmania major cathepsin L-like protease 0.0138 0.0565 1
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0162 0.0557
Echinococcus granulosus lamin 0.0057 0.0162 0.016
Toxoplasma gondii thioredoxin reductase 0.01 0.0377 0.204
Toxoplasma gondii hypothetical protein 0.0136 0.0555 0.3012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0205 0.0697
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0026 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.0446 0.1144
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0126 0.0506 0.8945
Brugia malayi Smad1 0.0042 0.0089 0.0305
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0062 0.0511
Onchocerca volvulus 0.0036 0.0062 0.0581
Brugia malayi Thioredoxin reductase 0.01 0.0377 0.1293
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0254 0.1136 0.4969
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.0446 0.2206
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Entamoeba histolytica hypothetical protein 0.0259 0.1161 1
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0062 0.0581
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0085 0.0067
Loa Loa (eye worm) transcription factor SMAD2 0.0615 0.2915 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0062 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0054 0.0897
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.0446 0.1144
Brugia malayi Cathepsin L-like precursor 0.0036 0.0062 0.0211
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.0536 0.052
Brugia malayi beta-lactamase family protein 0.0114 0.0446 0.1532
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0062 0.1036
Mycobacterium tuberculosis Probable dehydrogenase 0.0229 0.101 0.2787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.0062 0.0211
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0032 0.0103
Loa Loa (eye worm) hypothetical protein 0.0114 0.0446 0.1525
Entamoeba histolytica hypothetical protein 0.0259 0.1161 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.0903 0.3097
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0054 0.0184
Onchocerca volvulus 0.0036 0.0062 0.0581
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.0903 0.3091
Leishmania major cathepsin L-like protease 0.0036 0.0062 0.1036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0034
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0229 0.101 0.2787
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.0446 0.1144
Schistosoma mansoni smad1 5 8 and 0.0042 0.0089 0.0089
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.006 0.0179 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0062 0.0581
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0259 0.1162 0.5154
Brugia malayi cathepsin L-like precursor 0.0024 0.0002 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0089 0.0072
Schistosoma mansoni lamin 0.0057 0.0162 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0565 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0396 0.1834 1
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0536 0.0536
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0026 0.0123
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0062 0.0059
Echinococcus multilocularis GPCR, family 2 0.0065 0.0205 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0026
Echinococcus granulosus smad 0.0042 0.0089 0.0087
Mycobacterium tuberculosis Probable reductase 0.0229 0.101 0.2787
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0377 0.204
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0205 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0062 0.0318
Brugia malayi Pre-SET motif family protein 0.0203 0.0883 0.303
Echinococcus granulosus tumor protein p63 0.0329 0.1504 0.1502
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0396 0.1834 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0089 0.0087
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0179 0.0177
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.0446 0.1144
Leishmania major cathepsin L-like protease 0.0036 0.0062 0.1036
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0377 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0062 0.0581
Onchocerca volvulus 0.0057 0.0162 0.157
Brugia malayi Probable ClpP-like protease 0.0396 0.1834 0.6292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0446 0.0446
Plasmodium falciparum glutathione reductase 0.01 0.0377 0.204

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 62 nM Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay ChEMBL. 19674894

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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