Detailed information for compound 1076633

Basic information

Technical information
  • TDR Targets ID: 1076633
  • Name: 2-[4-[4-[(4-fluorophenyl)amino]-1-methylpyraz olo[5,4-d]pyrimidin-6-yl]piperazin-1-yl]ethan ol
  • MW: 371.412 | Formula: C18H22FN7O
  • H donors: 2 H acceptors: 4 LogP: 1.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)c1nc(Nc2ccc(cc2)F)c2c(n1)n(C)nc2
  • InChi: 1S/C18H22FN7O/c1-24-17-15(12-20-24)16(21-14-4-2-13(19)3-5-14)22-18(23-17)26-8-6-25(7-9-26)10-11-27/h2-5,12,27H,6-11H2,1H3,(H,21,22,23)
  • InChiKey: OTEUKYNSKQIOSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-[4-[(4-fluorophenyl)amino]-1-methyl-pyrazolo[5,4-d]pyrimidin-6-yl]piperazin-1-yl]ethanol
  • 2-[4-[4-[(4-fluorophenyl)amino]-1-methyl-6-pyrazolo[5,4-d]pyrimidinyl]-1-piperazinyl]ethanol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0056 0.0555 0.0792
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0009 0.013
Toxoplasma gondii HEAT repeat-containing protein 0.0067 0.0698 0.8426
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0009 0.013
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0045 0.0409 0.5603
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0026 0.0061
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Mycobacterium tuberculosis Conserved protein 0.0077 0.0828 0.1343
Entamoeba histolytica hypothetical protein 0.0084 0.0918 0.2214
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0828 0.2574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.0258 0.314 0.7577
Plasmodium vivax 6-phosphofructokinase, putative 0.007 0.073 0.8813
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0308
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0463 0.108
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0023
Leishmania major DNA polymerase eta, putative 0.002 0.0099 0.0231
Onchocerca volvulus 0.0056 0.0555 0.147
Onchocerca volvulus 0.0263 0.3212 0.8636
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0318 0.436
Echinococcus multilocularis Smad4 0.0018 0.0066 0.0066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0066 0.0066
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0056 0.0555 0.0615
Echinococcus multilocularis muscleblind protein 1 0.0354 0.4376 0.4376
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0045 0.0409 0.0409
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0983 0.0983
Schistosoma mansoni smad 0.0018 0.0066 0.0066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0308 0.0308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.027 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0114 0.0163
Toxoplasma gondii hypothetical protein 0.0056 0.0555 0.67
Trypanosoma cruzi major cysteine proteinase, putative 0.0167 0.1985 0.46
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0807 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Entamoeba histolytica cysteine protease, putative 0.0056 0.0555 0.1338
Echinococcus multilocularis chromobox protein 1 0.0082 0.0889 0.0889
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0555 0.0555
Trichomonas vaginalis importin beta-1, putative 0.0054 0.0535 0.1291
Trichomonas vaginalis phosphofructokinase, putative 0.007 0.073 0.1761
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0255 0.0615
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0481 0.146
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0049 0.047 0.5682
Echinococcus multilocularis chromobox protein 2 0.0013 0.0009 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.0918 0.0918
Loa Loa (eye worm) hypothetical protein 0.0077 0.0828 0.0918
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0555 0.0555
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0045 0.0409 0.0898
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0009 0.0023
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0222
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0056 0.0555 0.7601
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0009 0.0009
Onchocerca volvulus 0.0036 0.03 0.0782
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0205 0.2469 0.2737
Brugia malayi MH2 domain containing protein 0.0018 0.0066 0.0094
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.5315 0.5315
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0533
Echinococcus granulosus cathepsin L 0.0029 0.0207 0.0207
Echinococcus multilocularis chromobox protein 1 0.0082 0.0889 0.0889
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.0889 0.0986
Leishmania major importin beta-1 subunit, putative 0.0054 0.0535 0.1248
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0074 0.0106
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0258 0.314 0.7328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0634 0.7657
Trichomonas vaginalis phosphofructokinase, putative 0.007 0.073 0.1761
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0205 0.2469 0.2469
Trypanosoma cruzi cysteine peptidase, putative 0.0213 0.257 0.5973
Trichomonas vaginalis phosphofructokinase, putative 0.0258 0.314 0.7577
Plasmodium vivax 6-phosphofructokinase, putative 0.007 0.073 0.8813
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0049 0.047 0.0919
Schistosoma mansoni 6-phosphofructokinase 0.0258 0.314 0.314
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0392 0.0392
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.027 0.027
Brugia malayi CXXC zinc finger family protein 0.003 0.0222 0.0317
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0056 0.0136
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0392 0.0392
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0481 0.146
Brugia malayi hypothetical protein 0.002 0.0092 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0084 0.0918 0.0918
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0102
Brugia malayi Protein cec-1. 0.0013 0.0009 0.0014
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0555 0.0555
Mycobacterium ulcerans hypothetical protein 0.0183 0.218 0.6917
Brugia malayi plexin A 0.0023 0.0127 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0465 0.5622
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Mycobacterium ulcerans beta-lactamase 0.0077 0.0828 0.2574
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0097 0.0233
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0009 0.0009
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0828 0.1343
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0318 0.0516
Loa Loa (eye worm) hypothetical protein 0.0077 0.0828 0.0918
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0481 0.078
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0481 0.116
Toxoplasma gondii phosphofructokinase domain-containing protein 0.007 0.073 0.8813
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0026 0.0175 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.005 0.012
Loa Loa (eye worm) 6-phosphofructokinase 0.0258 0.314 0.3481
Echinococcus granulosus chromobox protein 1 0.0082 0.0889 0.0889
Echinococcus granulosus Smad4 0.0018 0.0066 0.0066
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.1973 0.1973
Mycobacterium ulcerans hypothetical protein 0.005 0.0481 0.146
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Mycobacterium ulcerans hypothetical protein 0.0077 0.0828 0.2574
Loa Loa (eye worm) hypothetical protein 0.0037 0.0317 0.0352
Leishmania major cathepsin L-like protease 0.0056 0.0555 0.1294
Brugia malayi Plexin repeat family protein 0.0019 0.0082 0.0117
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0009 0.0114
Onchocerca volvulus 0.0015 0.0026 0.0045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0029
Loa Loa (eye worm) phosphofructokinase 0.0258 0.314 0.3481
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0049 0.047 0.1043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0559 0.0559
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Plasmodium falciparum cysteine proteinase falcipain 1 0.0029 0.0207 0.2834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0099 0.0141
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.002 0.0092 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0026 0.0038
Echinococcus multilocularis dna polymerase eta 0.002 0.0099 0.0099
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0277 0.3351
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.1325 0.1468
Entamoeba histolytica phosphofructokinase, putative 0.0258 0.314 0.7577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0026 0.0043
Leishmania major cathepsin L-like protease 0.0056 0.0555 0.1294
Echinococcus multilocularis cathepsin L 0.0029 0.0207 0.0207
Schistosoma mansoni ran 0.0049 0.047 0.047
Toxoplasma gondii 6-phosphofructokinase 0.007 0.073 0.8813
Brugia malayi Serotonin receptor 0.0558 0.6999 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0828 0.1932
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.3192 0.3539
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0828 0.1998
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0099 0.0099
Echinococcus granulosus roundabout 2 0.0031 0.024 0.024
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.0918 0.0918
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.1279 0.1279
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0066 0.0066
Echinococcus granulosus Chromobox protein 3 0.0013 0.0009 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.017
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0555 0.147
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0481 0.146
Echinococcus granulosus GTP binding nuclear protein Ran 0.0049 0.047 0.047
Schistosoma mansoni importin beta-1 0.0067 0.0698 0.0698
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0481 0.146
Brugia malayi RNA, U transporter 1 0.0191 0.2284 0.3263
Echinococcus granulosus importin subunit beta 1 0.0067 0.0698 0.0698
Onchocerca volvulus 0.0056 0.0555 0.147
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0026 0.0043
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0099 0.011
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0056 0.0555 0.7601
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.007 0.073 0.1559
Brugia malayi hypothetical protein 0.0013 0.0009 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0023
Brugia malayi RNA binding protein 0.0137 0.1599 0.2285
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0045 0.0409 0.0409
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0164 0.1942 0.4533
Trichomonas vaginalis phosphofructokinase, putative 0.0258 0.314 0.7577
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.007 0.073 0.1761
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0555 0.1338
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0207 0.0499
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0026 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0099 0.0231
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0099 0.0099
Onchocerca volvulus 0.0056 0.0555 0.147
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.011
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0854 0.122
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0026 0.0063
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0207 0.0424
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0099 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0442 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0828 1
Onchocerca volvulus 0.0077 0.0828 0.2207
Entamoeba histolytica hypothetical protein 0.0013 0.0009 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0009 0.0009
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0074 0.0083
Brugia malayi Smad1 0.0018 0.0066 0.0094
Echinococcus multilocularis basement membrane specific heparan sulfate 0.002 0.0092 0.0092
Schistosoma mansoni chromobox protein 0.0082 0.0889 0.0889
Echinococcus multilocularis importin subunit beta 1 0.0067 0.0698 0.0698
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0049 0.047 0.1098
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0054 0.0535 0.1291
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0347 0.4285 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0277 0.0277
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0049 0.047 0.0672
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Schistosoma mansoni cell adhesion molecule 0.0026 0.0175 0.0175
Brugia malayi 6-phosphofructokinase 0.0258 0.314 0.4487
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.027 0.3261
Echinococcus multilocularis roundabout 2 0.0031 0.024 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0292 0.0473
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0026 0.0043
Echinococcus granulosus dnaJ subfamily B 0.0427 0.5315 0.5315
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0258 0.314 0.5093
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0413 0.5661
Trichomonas vaginalis ap endonuclease, putative 0.0045 0.0409 0.0986
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0277 0.0308
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0026 0.0038
Schistosoma mansoni tyrosine kinase 0.0014 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0059 0.0592 0.0656
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0099 0.016
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0481 0.078
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0026 0.0063
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0258 0.314 0.7312
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0481 0.146
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0026 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0555 0.1338
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0481 0.116
Echinococcus granulosus smad 0.0018 0.0066 0.0066
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0207 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0207 0.0483
Loa Loa (eye worm) hypothetical protein 0.0077 0.0828 0.0918
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0207 0.0295
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0074 0.0113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0097 0.0233
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0031 0.0031
Brugia malayi Cathepsin L-like precursor 0.0056 0.0555 0.0792
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0308
Onchocerca volvulus 0.0015 0.0026 0.0045
Leishmania major ATP-dependent phosphofructokinase 0.0258 0.314 0.7328
Echinococcus granulosus jumonji domain containing protein 0.0048 0.045 0.045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0023
Giardia lamblia Fructose-bisphosphate aldolase 0.0336 0.4144 1
Echinococcus granulosus snurportin 1 0.0716 0.9021 0.9021
Trypanosoma cruzi cysteine protease, putative 0.0029 0.0207 0.0424
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0465 0.5622
Echinococcus granulosus dna polymerase eta 0.002 0.0099 0.0099
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0031 0.0031
Onchocerca volvulus 0.003 0.0222 0.0573
Echinococcus multilocularis Immunoglobulin 0.002 0.0092 0.0092
Brugia malayi Bromodomain containing protein 0.0038 0.033 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0023
Schistosoma mansoni hypothetical protein 0.0034 0.0277 0.0277
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0045 0.0409 0.5
Trypanosoma cruzi importin beta-1 subunit, putative 0.0054 0.0535 0.1194
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.218 0.3536
Schistosoma mansoni cathepsin s 0.0018 0.0074 0.0074
Echinococcus granulosus cpg binding protein 0.0032 0.0244 0.0244
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0324 0.3991 0.4424
Entamoeba histolytica hypothetical protein 0.0084 0.0918 0.2214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Brugia malayi MH2 domain containing protein 0.0262 0.3192 0.4561
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0049 0.047 0.047
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0026 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0036 0.03 0.0332
Brugia malayi beta-lactamase family protein 0.0077 0.0828 0.1183
Trichomonas vaginalis esterase, putative 0.0077 0.0828 0.1998
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0292 0.0473
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0066 0.0066
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0049 0.047 0.0521
Schistosoma mansoni smad1 5 8 and 0.0018 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Entamoeba histolytica hypothetical protein 0.0084 0.0918 0.2214
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0026 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0255 0.0615
Brugia malayi Cathepsin L-like precursor 0.0018 0.0074 0.0106
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0828 0.1183
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Schistosoma mansoni chromobox protein 0.0082 0.0889 0.0889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0009 0.0114
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0318 0.3843
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0353
Brugia malayi Cathepsin L-like precursor 0.0056 0.0555 0.0792
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0205 0.2469 0.2469
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0164 0.1941 0.615
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0005 0.0056
Plasmodium vivax vivapain-2 0.0056 0.0555 0.6699
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.007 0.073 1
Brugia malayi hypothetical protein 0.0084 0.0918 0.1311
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Mycobacterium ulcerans lipase LipD 0.0077 0.0828 0.2574
Onchocerca volvulus 0.0056 0.0555 0.147
Leishmania major DNA polymerase kappa, putative 0.002 0.0099 0.0231
Loa Loa (eye worm) hypothetical protein 0.0046 0.0427 0.0473
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0555 0.0615
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0828 0.1343
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0099 0.0238
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.017
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.007 0.073 1
Brugia malayi jmjC domain containing protein 0.0043 0.0392 0.056
Onchocerca volvulus 0.0013 0.0009 0.000000047916
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0026 0.0029
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0427 0.1126
Brugia malayi CHD4 protein 0.0015 0.0031 0.0045
Brugia malayi Pre-SET motif family protein 0.0231 0.2803 0.4006
Onchocerca volvulus 0.0077 0.0828 0.2207
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0472 0.1246
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.1325 0.1892
Echinococcus granulosus cathepsin l1 0.0037 0.0317 0.0317
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0026 0.0043
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0318 0.0937
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0828 0.2574
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0828 0.1343
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0828 0.1998
Brugia malayi AMP-binding enzyme family protein 0.005 0.0481 0.0687
Loa Loa (eye worm) fibroinase 0.0056 0.0555 0.0615
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Entamoeba histolytica hypothetical protein 0.0013 0.0009 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.1325 0.1892
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1599 0.1599
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0066 0.0066
Schistosoma mansoni Neurotrimin precursor (hNT) 0.002 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Brugia malayi AMP-binding enzyme family protein 0.005 0.0481 0.0687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Onchocerca volvulus 0.005 0.0481 0.1271
Onchocerca volvulus Tyrosine kinase homolog 0.0303 0.3718 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1599 0.1599
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0336 0.4144 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.1942 0.4499
Loa Loa (eye worm) hypothetical protein 0.0067 0.0698 0.0773
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0555 0.0792
Entamoeba histolytica phosphofructokinase, putative 0.0258 0.314 0.7577
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0005 0.0063
Brugia malayi MH1 domain containing protein 0.0018 0.0066 0.0094
Loa Loa (eye worm) hypothetical protein 0.0031 0.024 0.0266
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0026 0.0043
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0828 0.0828
Plasmodium vivax unspecified product 0.0029 0.0207 0.2498
Brugia malayi Cathepsin L-like precursor 0.0056 0.0555 0.0792
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0018 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0555 0.0555
Echinococcus multilocularis GPCR, family 2 0.0037 0.0308 0.0308
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0009 0.0023
Echinococcus granulosus GPCR family 2 0.0037 0.0308 0.0308
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0828 0.1343
Echinococcus multilocularis cpg binding protein 0.0032 0.0244 0.0244
Echinococcus multilocularis cysteine protease 0.0056 0.0555 0.0555
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0347 0.4285 1
Onchocerca volvulus 0.0015 0.0026 0.0045
Trypanosoma brucei unspecified product 0.002 0.0099 0.0231
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0009 0.0023
Schistosoma mansoni nephrin 0.0025 0.0157 0.0157
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0049 0.047 0.1043
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0277 0.3351
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0308
Loa Loa (eye worm) acetyltransferase 0.0167 0.1973 0.2187
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0308 0.044
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.1279 0.1279
Loa Loa (eye worm) hypothetical protein 0.0056 0.0559 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0029
Trichomonas vaginalis 6-phosphofructokinase, putative 0.007 0.073 0.1761
Echinococcus multilocularis Immunoglobulin 0.002 0.0092 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0292 0.0473
Onchocerca volvulus 0.0047 0.0442 0.1167
Onchocerca volvulus 0.0037 0.0317 0.0831
Toxoplasma gondii exonuclease III APE 0.0045 0.0409 0.4938
Schistosoma mansoni smad1 5 8 and 0.0018 0.0066 0.0066
Echinococcus granulosus Immunoglobulin 0.002 0.0092 0.0092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0828 0.0828
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0347 0.4285 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0031 0.0031
Echinococcus granulosus cathepsin L cysteine protease 0.0029 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0034 0.027 0.0299
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0026 0.0061
Echinococcus granulosus neuroglian 0.0025 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0116 0.1325 0.1468
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0066 0.0073
Brugia malayi AMP-binding enzyme family protein 0.005 0.0481 0.0687
Trypanosoma cruzi cruzipain precursor, putative 0.0213 0.257 0.5973
Loa Loa (eye worm) hypothetical protein 0.0354 0.4376 0.4852
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0463 0.1025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0099 0.016
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0074 0.0113
Brugia malayi phosphofructokinase 0.0258 0.314 0.4487
Mycobacterium ulcerans 6-phosphofructokinase 0.0258 0.314 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0465 0.0465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.2469 0.2469
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0828 0.1998
Brugia malayi Pre-SET motif family protein 0.0034 0.027 0.0386
Schistosoma mansoni hypothetical protein 0.0716 0.9021 0.9021
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0392 0.0435
Echinococcus multilocularis peregrin 0.0038 0.033 0.033
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0026 0.0317
Trichomonas vaginalis ran, putative 0.0049 0.047 0.1135
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0308 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0427 0.103
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Schistosoma mansoni ap endonuclease 0.0045 0.0409 0.0409
Loa Loa (eye worm) ctsf protein 0.0056 0.0555 0.0615
Loa Loa (eye worm) fli-1 protein 0.023 0.2782 0.3084
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0828 0.1343
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0009 0.0014
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0074 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Loa Loa (eye worm) RNA binding protein 0.0137 0.1599 0.1773
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0207 0.0483
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0099 0.017
Echinococcus multilocularis cysteine protease 0.0056 0.0555 0.0555
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0009 0.0009
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0413 0.0777
Trichomonas vaginalis phosphofructokinase, putative 0.007 0.073 0.1761
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0207 0.0207
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0026 0.0061
Plasmodium vivax unspecified product 0.0018 0.0074 0.0899
Brugia malayi exodeoxyribonuclease III family protein 0.0045 0.0409 0.0584
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0533
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0026 0.0038
Brugia malayi chromobox protein homolog 3 0.0046 0.0427 0.061
Echinococcus multilocularis neuroglian 0.0025 0.0157 0.0157
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0023
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0207 0.0207
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0009 0.013
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0207 0.0424
Loa Loa (eye worm) oxidoreductase 0.0015 0.0026 0.0029
Leishmania major cathepsin L-like protease 0.0056 0.0555 0.1294
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0828 0.2574
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0026 0.0043
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0074 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0308 0.0341
Leishmania major cathepsin L-like protease 0.0056 0.0555 0.1294
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0828 0.1882
Brugia malayi Cathepsin L-like precursor 0.0037 0.0317 0.0454
Schistosoma mansoni plexin 0.0019 0.0082 0.0082
Echinococcus granulosus cysteine protease 0.0029 0.0207 0.0207
Echinococcus multilocularis tumor protein p63 0.0385 0.477 0.477
Schistosoma mansoni ap endonuclease 0.0045 0.0409 0.0409
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0009 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0472 0.1138
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0009 0.0114
Loa Loa (eye worm) helicase 0.0013 0.0009 0.001
Echinococcus multilocularis plexin a4 0.0023 0.0127 0.0126
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.2803 0.3108
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0465 0.1123
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0066 0.0073
Brugia malayi 6-phosphofructokinase 0.0258 0.314 0.4487
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0828 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.1599 0.1773
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0029 0.0207 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0222 0.0246
Onchocerca volvulus 0.0056 0.0555 0.147
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0341
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0066 0.0066
Echinococcus granulosus cathepsin l cysteine peptidase 0.0056 0.0555 0.0555
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.037 0.037
Leishmania major cathepsin L-like protease 0.0213 0.257 0.5998
Trypanosoma brucei unspecified product 0.0014 0.0018 0.0041
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0026 0.0043
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0164 0.1941 0.615
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0092 0.0132
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.007 0.073 1
Brugia malayi TAR-binding protein 0.0137 0.1599 0.2285
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0099 0.0233
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0746 0.0827
Loa Loa (eye worm) plexin A 0.0023 0.0127 0.014
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.1973 0.1973
Echinococcus granulosus plexin a4 0.0023 0.0127 0.0126
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0481 0.1122
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0207 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0207 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0026 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Brugia malayi MH2 domain containing protein 0.0018 0.0066 0.0094
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0045 0.0409 0.0954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0097 0.0233
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0026 0.0043
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0481 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0018 0.0041
Toxoplasma gondii cathepsin CPL 0.0056 0.0555 0.6699
Trypanosoma brucei unspecified product 0.0014 0.0018 0.0041
Plasmodium vivax importin-beta 2, putative 0.0067 0.0698 0.8426
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0555 0.147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0079 0.0854 0.0947
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0669 0.0669
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0097 0.0233
Schistosoma mansoni ets-related 0.023 0.2782 0.2782
Schistosoma mansoni cpg binding protein 0.0032 0.0244 0.0244
Schistosoma mansoni smad1 5 8 and 0.0018 0.0066 0.0066
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.1973 0.2819
Brugia malayi Fibronectin type III domain containing protein 0.002 0.0092 0.0132
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0045 0.0409 0.0954
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0097 0.0233
Brugia malayi Muscleblind-like protein 0.0354 0.4376 0.6253
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0828 0.0918
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0026 0.0317
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0045 0.0409 0.0986
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0102
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.3192 0.3539
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0308 0.0308
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0099 0.0099
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0889 0.2145
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0026 0.0317
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0481 0.146
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0353
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Leishmania major mitochondrial DNA polymerase beta 0.0347 0.4285 1
Loa Loa (eye worm) hypothetical protein 0.0354 0.4376 0.4852
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0828 0.1882
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0099 0.0099
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0807 0.0895
Loa Loa (eye worm) Smad1 0.0018 0.0066 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0207 0.0499
Trichomonas vaginalis phosphofructokinase, putative 0.0258 0.314 0.7577
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0049 0.047 0.5682
Brugia malayi Importin beta-1 subunit 0.0067 0.0698 0.0997
Brugia malayi cathepsin L-like precursor 0.0037 0.0317 0.0454
Schistosoma mansoni hypothetical protein 0.0013 0.0009 0.0009
Brugia malayi beta-lactamase 0.0077 0.0828 0.1183
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.1599 0.2285
Entamoeba histolytica hypothetical protein 0.0013 0.0009 0.0023
Brugia malayi Heterochromatin protein 1 0.0082 0.0889 0.127
Plasmodium vivax vivapain-3 0.0029 0.0207 0.2498
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0533
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0026 0.036
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.024 0.0266
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0481 0.146
Brugia malayi Fli-1 protein 0.023 0.2782 0.3974
Plasmodium vivax vivapain-1 0.0029 0.0207 0.2498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0481 0.146
Brugia malayi PHD-finger family protein 0.0034 0.0277 0.0396
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0463 0.1025
Onchocerca volvulus 0.0295 0.3618 0.973
Onchocerca volvulus Cathepsin F homolog 0.0056 0.0555 0.147
Entamoeba histolytica hypothetical protein 0.0054 0.0535 0.1291
Schistosoma mansoni ran 0.0049 0.047 0.047
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0023
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0026 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1599 0.1599
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0277 0.0277
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0099 0.0233
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0277 0.3351
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0009 0.0014
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0009 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0555 0.1241
Toxoplasma gondii phosphofructokinase PFKII 0.007 0.073 0.8813
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0099 0.0231
Loa Loa (eye worm) hypothetical protein 0.0077 0.0828 0.0918
Trichomonas vaginalis set domain proteins, putative 0.0263 0.3212 0.7751
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0045 0.0409 0.4938
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.2469 0.2469
Loa Loa (eye worm) hypothetical protein 0.0037 0.0317 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Brugia malayi Ets-domain containing protein 0.0076 0.0807 0.1153
Brugia malayi Cathepsin L-like precursor 0.0037 0.0317 0.0454
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0195 0.2333 0.5417
Echinococcus granulosus muscleblind protein 0.0354 0.4376 0.4376
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0097 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.0918 0.0918
Entamoeba histolytica Ran family GTPase 0.0049 0.047 0.1135
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.027 0.027
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0258 0.314 0.7312
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0889 0.2145
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0828 0.1343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Schistosoma mansoni gabp alpha 0.0076 0.0807 0.0807
Onchocerca volvulus 0.0019 0.0082 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0317 0.0766
Schistosoma mansoni hypothetical protein 0.0427 0.5315 0.5315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Echinococcus granulosus defective proboscis extension response 0.002 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0099 0.0231
Mycobacterium tuberculosis Conserved protein 0.0077 0.0828 0.1343
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Trypanosoma cruzi cysteine peptidase, putative 0.0213 0.257 0.5973
Entamoeba histolytica cysteine proteinase 2 0.0029 0.0207 0.0499
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.017
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0472 0.1138
Brugia malayi Ets-domain containing protein 0.0076 0.0807 0.1153
Echinococcus granulosus twitchin 0.0025 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0079 0.0854 0.0854
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0099 0.0238
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0481 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Echinococcus granulosus tar DNA binding protein 0.0137 0.1599 0.1599
Loa Loa (eye worm) 6-phosphofructokinase 0.0258 0.314 0.3481
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0009 0.0009
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0807 0.0807
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0317 0.0766
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0092 0.0092
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.007 0.073 0.0859
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Echinococcus granulosus chromobox protein 2 0.0013 0.0009 0.0009
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0026 0.0043
Schistosoma mansoni Smad4 0.0018 0.0066 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0481 0.146
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0026 0.0043
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.0499
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0555 0.1338
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0102
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0045 0.0409 0.0766
Loa Loa (eye worm) hypothetical protein 0.0056 0.0555 0.0615
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0049 0.047 0.6447
Brugia malayi Cathepsin L-like precursor 0.0056 0.0555 0.0792
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0102
Echinococcus multilocularis tar DNA binding protein 0.0137 0.1599 0.1599
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0099 0.0231
Trichomonas vaginalis phosphofructokinase, putative 0.007 0.073 0.1761
Echinococcus granulosus Chromo domain 0.0013 0.0009 0.0009
Plasmodium falciparum importin beta, putative 0.0067 0.0698 0.956
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0097 0.0233
Loa Loa (eye worm) cysteine protease 0.0056 0.0555 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Trichomonas vaginalis ap endonuclease, putative 0.0045 0.0409 0.0986
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0045 0.0409 0.0898
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0205 0.2469 0.2469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0463 0.1025
Echinococcus multilocularis 6 phosphofructokinase 0.0258 0.314 0.314
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0258 0.314 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0555 0.1338
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0009 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Brugia malayi SET domain containing protein 0.0015 0.0033 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0828 0.1998
Echinococcus granulosus chromobox protein 1 0.0082 0.0889 0.0889
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Giardia lamblia PHD finger protein 15 0.0034 0.0277 0.0442
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0205 0.2469 0.3527
Leishmania major cysteine peptidase A (CPA) 0.0056 0.0555 0.1294
Schistosoma mansoni cpg binding protein 0.0032 0.0244 0.0244
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0009 0.0114
Trichomonas vaginalis phosphofructokinase, putative 0.007 0.073 0.1761
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0413 0.0997
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0097 0.0233
Brugia malayi Cathepsin L-like precursor 0.0056 0.0555 0.0792
Schistosoma mansoni 6-phosphofructokinase 0.0258 0.314 0.314
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0246 0.0246
Echinococcus granulosus cathepsin L cysteine proteinase 0.0056 0.0555 0.0555
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0465 0.5622
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0074 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0317 0.0352
Loa Loa (eye worm) beta-lactamase 0.0077 0.0828 0.0918
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0091
Echinococcus granulosus peregrin 0.0038 0.033 0.033
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0026 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0205 0.2469 0.2469
Schistosoma mansoni DNA polymerase eta 0.002 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.6166 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0213 0.257 0.5998
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Echinococcus multilocularis Chromo domain 0.0013 0.0009 0.0009
Brugia malayi beta-lactamase family protein 0.0077 0.0828 0.1183
Echinococcus granulosus 6 phosphofructokinase 0.0258 0.314 0.314
Echinococcus multilocularis muscleblind protein 0.0354 0.4376 0.4376
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0031 0.0035
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0828 0.0828
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0026 0.0038
Loa Loa (eye worm) hypothetical protein 0.0077 0.0828 0.0918
Leishmania major cathepsin L-like protease 0.0213 0.257 0.5998
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0056 0.0136
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Echinococcus granulosus tumor protein p63 0.0385 0.477 0.477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0317 0.0766
Mycobacterium tuberculosis Conserved protein 0.0077 0.0828 0.1343
Plasmodium vivax SET domain protein, putative 0.0034 0.027 0.3261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0336 0.4144 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0308
Brugia malayi PHD-finger family protein 0.0013 0.0003 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.027 0.027
Toxoplasma gondii ABC1 family protein 0.0077 0.0828 1
Onchocerca volvulus Alhambra homolog 0.0034 0.0277 0.0723
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0054 0.0535 0.1291
Mycobacterium leprae Probable lipase LipE 0.0077 0.0828 0.2574
Echinococcus multilocularis snurportin 1 0.0716 0.9021 0.9021
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0099 0.0141
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0045 0.0409 0.0453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.2469 0.2469
Onchocerca volvulus 0.0056 0.0555 0.147
Loa Loa (eye worm) hypothetical protein 0.0077 0.0828 0.0918
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0207 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0427 0.103
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1599 0.1599
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0026 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0555 0.1338
Entamoeba histolytica phosphofructokinase, putative 0.0258 0.314 0.7577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.257 0.5998
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0231
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0207 0.0499
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.007 0.073 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0045 0.0409 0.1228
Leishmania major GTP-binding protein, putative 0.0049 0.047 0.1098
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.045 0.045
Trypanosoma cruzi cysteine peptidase, putative 0.0213 0.257 0.5973
Echinococcus multilocularis smad 0.0018 0.0066 0.0066
Brugia malayi jmjC domain containing protein 0.0112 0.1279 0.1827
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0317 0.0454
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.1942 0.4533
Echinococcus multilocularis dna polymerase kappa 0.002 0.0099 0.0099
Brugia malayi Immunoglobulin I-set domain containing protein 0.0324 0.3991 0.5702
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0317 0.0317
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0828 0.1343
Brugia malayi MH1 domain containing protein 0.0018 0.0066 0.0094
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.0499
Echinococcus granulosus histone acetyltransferase KAT2B 0.0162 0.1913 0.1913
Trichomonas vaginalis hypothetical protein 0.0013 0.0009 0.0023
Onchocerca volvulus 0.0077 0.0828 0.2207
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0277 0.0277
Plasmodium falciparum phd finger protein, putative 0.0034 0.0277 0.3803
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0465 0.1123
Treponema pallidum fructose-bisphosphate aldolase 0.0336 0.4144 1
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0555 0.1338
Trichomonas vaginalis phosphofructokinase, putative 0.007 0.073 0.1761
Echinococcus granulosus cathepsin l1 0.0056 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0102
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Plasmodium vivax vivapain-2 0.0056 0.0555 0.6699
Loa Loa (eye worm) hypothetical protein 0.0065 0.0666 0.0739
Entamoeba histolytica cysteine proteinase 1, putative 0.0029 0.0207 0.0499
Trypanosoma brucei importin beta-1 subunit, putative 0.0067 0.0698 0.1628
Onchocerca volvulus 0.0056 0.0559 0.1483
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0828 0.1998
Loa Loa (eye worm) TAR-binding protein 0.0137 0.1599 0.1773
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0716 0.9021 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0045 0.0409 0.0663
Entamoeba histolytica hypothetical protein 0.0084 0.0918 0.2214
Onchocerca volvulus 0.0056 0.0555 0.147
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.06 0.1346
Onchocerca volvulus 0.0015 0.0026 0.0045
Plasmodium falciparum cysteine proteinase falcipain 3 0.0056 0.0555 0.7601
Leishmania major hypothetical protein, conserved 0.0077 0.0828 0.1932
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0009 0.0114
Leishmania major cathepsin L-like protease 0.0056 0.0555 0.1294
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0026 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0481 0.1122
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.0009
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0099 0.0238
Trypanosoma brucei importin beta-1 subunit, putative 0.0067 0.0698 0.1628
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0555 0.0555
Schistosoma mansoni vesicular amine transporter 0.002 0.0092 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1599 0.1599
Echinococcus granulosus dna polymerase kappa 0.002 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0023
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0164 0.1941 0.3148
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0336 0.4144 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0292 0.0473
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0353

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 494 nM Displacement of [3H]Mesulergine from human recombinant serotonin 5-HT2C expressed in CHO-K1 cells ChEMBL. 19464901
Inhibition (binding) = 97 % Displacement of [3H]Mesulergine from human recombinant serotonin 5-HT2C expressed in CHO-K1 cells at 10 um ChEMBL. 19464901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.