Detailed information for compound 1076732

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.441 | Formula: C22H22FN5O
  • H donors: 2 H acceptors: 3 LogP: 2.99 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H](Cc1ccc(cc1C)F)COc1cncc(c1)c1ncc2c(c1)c(C)n[nH]2
  • InChi: 1S/C22H22FN5O/c1-13-5-17(23)4-3-15(13)6-18(24)12-29-19-7-16(9-25-10-19)21-8-20-14(2)27-28-22(20)11-26-21/h3-5,7-11,18H,6,12,24H2,1-2H3,(H,27,28)/t18-/m0/s1
  • InChiKey: XOBAXUSIWXJTRE-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0004 0.0023 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.3962 0.4516
Onchocerca volvulus 0.0004 0.0023 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0133 0.0133
Brugia malayi MH1 domain containing protein 0.0004 0.0039 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.115 0.1466
Entamoeba histolytica protein kinase 2, putative 0.0025 0.0937 0.5813
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Onchocerca volvulus 0.0004 0.0023 0.0021
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0133 0.0133
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0925 0.1178
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0207 0.0262
Schistosoma mansoni hypothetical protein 0.0183 0.7835 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0013 0.0397 0.0397
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0013 0.0409 0.0519
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.1076 0.1371
Echinococcus multilocularis serine:threonine protein kinase N2 0.0013 0.0409 0.0519
Loa Loa (eye worm) hypothetical protein 0.0004 0.0023 0.0024
Brugia malayi p70 ribosomal S6 kinase beta 0.0038 0.1487 0.1694
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.3962 0.5055
Schistosoma mansoni hypothetical protein 0.0183 0.7835 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.3962 0.5055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.115 0.1466
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0004 0.0023 0.0027
Toxoplasma gondii AGC kinase 0.0038 0.1487 0.2966
Loa Loa (eye worm) histone methyltransferase 0.001 0.0284 0.0322
Trichomonas vaginalis helicase, putative 0.0007 0.0133 0.0133
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0004 0.0023 0.0024
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0464
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0004 0.0023 0.0023
Trichomonas vaginalis AGC family protein kinase 0.004 0.1595 0.1595
Brugia malayi MH1 domain containing protein 0.0008 0.0194 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0519
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0194 0.0219
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0207 0.0262
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0284 0.036
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.1045 0.1332
Entamoeba histolytica protein kinase, putative 0.0013 0.0409 0.2452
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.1045 0.1332
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0013 0.0409 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0013 0.0409 0.0519
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0013 0.0409 0.0464
Schistosoma mansoni serine/threonine kinase 0.0013 0.0409 0.0519
Trichomonas vaginalis AGC family protein kinase 0.004 0.1595 0.1595
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0194 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0133 0.0133
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0004 0.0023 0.0024
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0004 0.0023 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0133 0.0133
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0013 0.0409 0.0464
Echinococcus granulosus nervana 2 0.0025 0.0925 0.1178
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0004 0.0023 0.0027
Entamoeba histolytica protein kinase, putative 0.004 0.1595 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.3962 0.5055
Trichomonas vaginalis AGC family protein kinase 0.004 0.1595 0.1595
Loa Loa (eye worm) G protein alpha subunit 3 0.0004 0.0023 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Trichomonas vaginalis AGC family protein kinase 0.004 0.1595 0.1595
Loa Loa (eye worm) hypothetical protein 0.0004 0.0023 0.0024
Echinococcus multilocularis protein kinase c epsilon type 0.0013 0.0409 0.0519
Echinococcus granulosus serine threonine protein kinase nrc 0.0025 0.0937 0.1194
Echinococcus granulosus geminin 0.0183 0.7835 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0023 0.0024
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0004 0.0023 0.0024
Echinococcus multilocularis Smad4 0.0008 0.0194 0.0246
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.115 0.1466
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0004 0.0023 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.111 0.1263
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0004 0.0023 0.0023
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0207 0.0262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.3962 0.5055
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0004 0.0023 0.0027
Schistosoma mansoni smad1 5 8 and 0.0008 0.0194 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0519
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.115 0.1466
Echinococcus granulosus Protein kinase C brain isozyme 0.0013 0.0409 0.0519
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0004 0.0023 0.0027
Brugia malayi MH1 domain containing protein 0.0004 0.0039 0.0042
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0194 0.0246
Echinococcus granulosus protein kinase C gamma type 0.0013 0.0409 0.0519
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0004 0.0023 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.2573 0.3282
Echinococcus granulosus cpg binding protein 0.0031 0.1182 0.1506
Brugia malayi Hr1 repeat family protein 0.0013 0.0409 0.0464
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0519
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0004 0.0023 0.0023
Brugia malayi Pre-SET motif family protein 0.0205 0.8771 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.2286 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0004 0.0023 0.0024
Echinococcus granulosus serine:threonine protein kinase N2 0.0013 0.0409 0.0519
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0004 0.0023 0.0024
Echinococcus granulosus protein kinase c epsilon type 0.0013 0.0409 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Brugia malayi Protein kinase domain containing protein 0.004 0.1595 0.1817
Schistosoma mansoni smad1 5 8 and 0.0008 0.0194 0.0246
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0004 0.0023 0.0024
Schistosoma mansoni cpg binding protein 0.0031 0.1182 0.1506
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0004 0.0023 0.0027
Echinococcus multilocularis expressed protein 0.0004 0.0023 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0133 0.0133
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0519
Brugia malayi Smad1 0.0008 0.0194 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0519
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0004 0.0023 0.0027
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0004 0.0023 0.0027
Trypanosoma cruzi Protein kinase B 0.0028 0.1045 1
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.1045 0.1332
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0925 0.1178
Schistosoma mansoni smad1 5 8 and 0.0008 0.0194 0.0246
Echinococcus multilocularis smad 0.0008 0.0194 0.0246
Loa Loa (eye worm) Smad1 0.0008 0.0194 0.0219
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0004 0.0023 0.0024
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0004 0.0023 0.0024
Brugia malayi G-protein alpha subunit 0.0004 0.0023 0.0024
Entamoeba histolytica protein kinase, putative 0.004 0.1595 1
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0925 0.1178
Loa Loa (eye worm) hypothetical protein 0.0004 0.0023 0.0024
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0013 0.0409 0.0519
Entamoeba histolytica protein kinase, putative 0.0038 0.1487 0.9313
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0004 0.0023 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0519
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0004 0.0023 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.3962 0.5055
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0207 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Loa Loa (eye worm) AGC/AKT protein kinase 0.004 0.1595 0.1817
Loa Loa (eye worm) AGC/NDR protein kinase 0.0013 0.0409 0.0464
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0519
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0013 0.0409 0.0519
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0004 0.0023 0.0027
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0025 0.0937 0.1194
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.495 0.5643
Schistosoma mansoni cpg binding protein 0.0031 0.1182 0.1506
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.1045 0.1332
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0025 0.0937 0.5
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0004 0.0023 0.0027
Trypanosoma brucei rac serine-threonine kinase, putative 0.004 0.1595 0.5
Schistosoma mansoni GTP-binding protein alpha subunit 0.0004 0.0023 0.0027
Trichomonas vaginalis AGC family protein kinase 0.004 0.1595 0.1595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0133 0.0133
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0004 0.0023 0.0027
Schistosoma mansoni atypical protein kinase C 0.0013 0.0409 0.0519
Loa Loa (eye worm) hypothetical protein 0.003 0.115 0.1309
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0004 0.0023 0.0023
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0194 0.0246
Schistosoma mansoni cpg binding protein 0.0029 0.111 0.1414
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0004 0.0023 0.0027
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0004 0.0023 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.3962 0.4516
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0013 0.0409 0.0519
Onchocerca volvulus 0.0004 0.0023 0.0021
Brugia malayi MH2 domain containing protein 0.0008 0.0194 0.0219
Plasmodium vivax SET domain protein, putative 0.003 0.115 1
Echinococcus multilocularis nervana 2 0.0025 0.0925 0.1178
Echinococcus granulosus Smad4 0.0008 0.0194 0.0246
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0004 0.0023 0.0027
Schistosoma mansoni GTP-binding protein alpha subunit 0.0004 0.0023 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0194 0.0219
Echinococcus granulosus protein kinase c iota type 0.0013 0.0409 0.0519
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0517 0.0517
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0004 0.0023 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.3962 0.5055
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Trichomonas vaginalis AGC family protein kinase 0.004 0.1595 0.1595
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.495 0.5643
Brugia malayi CXXC zinc finger family protein 0.0029 0.111 0.1263
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0004 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0464
Onchocerca volvulus 0.003 0.115 0.1148
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0194 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0133 0.0133
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.8771 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.1045 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0039 0.0042
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0004 0.0023 0.0023
Echinococcus multilocularis protein kinase c iota type 0.0013 0.0409 0.0519
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0038 0.1487 0.1694
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0004 0.0023 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0284 0.036
Brugia malayi MH2 domain containing protein 0.0008 0.0194 0.0219
Echinococcus multilocularis cpg binding protein 0.0031 0.1182 0.1506
Giardia lamblia Kinase, AGC PKA 0.0025 0.0937 0.5
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0004 0.0023 0.0023
Onchocerca volvulus 0.0029 0.111 0.1108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.1045 0.65
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0075 0.0093
Echinococcus granulosus smad 0.0008 0.0194 0.0246
Brugia malayi protein kinase C II. 0.0013 0.0409 0.0464
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0013 0.0409 0.0464
Brugia malayi MH1 domain containing protein 0.0008 0.0194 0.0219
Schistosoma mansoni smad 0.0008 0.0194 0.0246
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0925 0.1178
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0004 0.0023 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0409 0.0409
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0004 0.0023 0.0024
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0013 0.0409 0.0519
Echinococcus granulosus expressed protein 0.0004 0.0023 0.0027
Loa Loa (eye worm) AGC/PKN protein kinase 0.0013 0.0409 0.0464
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.1045 0.65
Echinococcus multilocularis serine:threonine protein kinase N2 0.0013 0.0409 0.0519
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0133 0.0133
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0464
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0133 0.0133
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0004 0.0023 0.0023
Brugia malayi Pre-SET motif family protein 0.003 0.115 0.1309
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0409 0.0409
Brugia malayi MH2 domain containing protein 0.0117 0.495 0.5643
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0279 0.0316
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0194 0.0246
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0207 0.0262
Trichomonas vaginalis AGC family protein kinase 0.004 0.1595 0.1595
Schistosoma mansoni Smad4 0.0008 0.0194 0.0246
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0004 0.0023 0.0024
Brugia malayi hypothetical protein 0.0004 0.0023 0.0024
Echinococcus multilocularis serine threonine protein kinase 0.0013 0.0409 0.0519
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.115 0.1466
Loa Loa (eye worm) nuclear factor I 0.0004 0.0039 0.0042
Echinococcus multilocularis nervana 2 0.0025 0.0925 0.1178
Echinococcus multilocularis serine:threonine protein kinase 38 0.0013 0.0409 0.0519
Echinococcus granulosus nervana 2 0.0025 0.0925 0.1178
Echinococcus granulosus NDR protein kinase 0.0013 0.0409 0.0519
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0004 0.0023 0.0027
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0025 0.0937 0.1194
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.115 0.1466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.3962 0.5055
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0004 0.0023 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.115 0.1466
Echinococcus multilocularis geminin 0.0183 0.7835 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0004 0.0023 0.0027
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0013 0.0409 0.0519

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6 nM Inhibition of Akt ChEMBL. 19497644

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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