Detailed information for compound 1077015

Basic information

Technical information
  • TDR Targets ID: 1077015
  • Name: 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]p yridin-3-yl]-3-methyl-1,3-dihydroindol-2-one
  • MW: 412.484 | Formula: C25H24N4O2
  • H donors: 3 H acceptors: 2 LogP: 3.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H](Cc1c[nH]c2c1cccc2)COc1cncc(c1)c1ccc2c(c1)C(C)C(=O)N2
  • InChi: 1S/C25H24N4O2/c1-15-22-10-16(6-7-24(22)29-25(15)30)17-9-20(13-27-11-17)31-14-19(26)8-18-12-28-23-5-3-2-4-21(18)23/h2-7,9-13,15,19,28H,8,14,26H2,1H3,(H,29,30)/t15?,19-/m0/s1
  • InChiKey: KMCCWLYZWXETDV-FUBQLUNQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-3-pyridyl]-3-methyl-indolin-2-one
  • 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-3-pyridyl]-3-methyl-2-indolinone
  • 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-3-pyridyl]-3-methyl-oxindole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma cruzi Protein kinase B 0.0028 0.0056 0.0192
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0056 0.0192
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.0481 0.4054
Loa Loa (eye worm) AGC/AKT protein kinase 0.004 0.0206 0.1733
Brugia malayi Protein kinase domain containing protein 0.004 0.0206 0.1733
Plasmodium falciparum cysteine proteinase falcipain 1 0.0063 0.0481 0.4054
Brugia malayi Cathepsin L-like precursor 0.0123 0.1187 1
Brugia malayi Cathepsin L-like precursor 0.0082 0.0706 0.5946
Onchocerca volvulus 0.0123 0.1187 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0025 0.0027 0.0027
Onchocerca volvulus 0.0123 0.1187 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0056 0.0476
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0063 0.0481 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0272 0.2941 1
Toxoplasma gondii cathepsin CPL 0.0123 0.1187 1
Loa Loa (eye worm) fibroinase 0.0123 0.1187 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0056 0.0476
Leishmania major cathepsin L-like protease 0.0272 0.2941 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0041 0.0213 0.1791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Schistosoma mansoni cathepsin F (C01 family) 0.0123 0.1187 1
Echinococcus granulosus nervana 2 0.0025 0.0024 0.0201
Brugia malayi Cathepsin L-like precursor 0.0041 0.0213 0.1791
Loa Loa (eye worm) hypothetical protein 0.0082 0.0706 0.5946
Schistosoma mansoni cathepsin F (C01 family) 0.0123 0.1187 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0024 0.0201
Echinococcus granulosus cathepsin l1 0.0123 0.1187 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0041 0.0213 0.1791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Trichomonas vaginalis AGC family protein kinase 0.004 0.0206 0.1733
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0123 0.1187 0.1187
Trichomonas vaginalis AGC family protein kinase 0.004 0.0206 0.1733
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0123 0.1187 1
Plasmodium vivax unspecified product 0.0041 0.0213 0.1791
Entamoeba histolytica hypothetical protein 0.0038 0.0186 0.1568
Onchocerca volvulus Cathepsin L homolog 0.0123 0.1187 1
Brugia malayi Cathepsin L-like precursor 0.0123 0.1187 1
Schistosoma mansoni cathepsin F (C01 family) 0.0082 0.0706 0.5946
Trichomonas vaginalis AGC family protein kinase 0.004 0.0206 0.1733
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0038 0.0176 0.1486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Trichomonas vaginalis AGC family protein kinase 0.004 0.0206 0.1733
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0186 0.1568
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.0056 0.0056
Echinococcus granulosus cysteine protease 0.0063 0.0481 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0481 0.1637
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Echinococcus granulosus cathepsin L 0.0063 0.0481 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma cruzi cysteine peptidase, putative 0.0123 0.1187 0.4037
Echinococcus multilocularis cathepsin L cysteine protease 0.0123 0.1187 0.1187
Brugia malayi Cathepsin L-like precursor 0.0123 0.1187 1
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Onchocerca volvulus 0.0123 0.1187 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0123 0.1187 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0025 0.0027 0.0229
Echinococcus multilocularis cathepsin L 0.0063 0.0481 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma cruzi cruzipain precursor, putative 0.0041 0.0213 0.0723
Echinococcus granulosus serine threonine protein kinase nrc 0.0025 0.0027 0.0229
Echinococcus granulosus cathepsin L cysteine proteinase 0.0123 0.1187 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.1187 1
Echinococcus multilocularis cysteine protease 0.0123 0.1187 0.1187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0025 0.0027 0.0229
Echinococcus granulosus cathepsin L cysteine protease 0.0063 0.0481 0.4054
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.0481 0.4054
Entamoeba histolytica protein kinase, putative 0.004 0.0206 0.1733
Brugia malayi Papain family cysteine protease containing protein 0.0063 0.0481 0.4054
Giardia lamblia Kinase, AGC PKA 0.0025 0.0027 1
Trypanosoma cruzi cysteine proteinase, putative 0.0063 0.0481 0.1637
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0063 0.0481 0.1637
Entamoeba histolytica protein kinase, putative 0.0038 0.0176 0.1486
Entamoeba histolytica cysteine proteinase, putative 0.0123 0.1187 1
Toxoplasma gondii AGC kinase 0.0038 0.0176 0.1486
Brugia malayi cathepsin L-like precursor 0.0082 0.0706 0.5946
Leishmania major cathepsin L-like protease 0.0123 0.1187 0.4037
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0123 0.1187 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0231 0.2459 0.8363
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.0481 0.4054
Echinococcus granulosus nervana 2 0.0025 0.0024 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.0272 0.2941 1
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.0481 0.4054
Entamoeba histolytica cysteine proteinase 1, putative 0.0063 0.0481 0.4054
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Trypanosoma cruzi cysteine protease, putative 0.0063 0.0481 0.1637
Brugia malayi p70 ribosomal S6 kinase beta 0.0038 0.0176 0.1486
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0706 0.5946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.0056 0.0476
Trypanosoma cruzi major cysteine proteinase, putative 0.0171 0.1753 0.5963
Schistosoma mansoni hypothetical protein 0.0038 0.0186 0.1568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0213 0.1791
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Onchocerca volvulus 0.0082 0.0706 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0481 0.1637
Brugia malayi Cathepsin L-like precursor 0.0123 0.1187 1
Leishmania major cathepsin L-like protease 0.0123 0.1187 0.4037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0025 0.0027 0.0229
Entamoeba histolytica protein kinase, putative 0.004 0.0206 0.1733
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0082 0.0706 0.5946
Entamoeba histolytica hypothetical protein 0.0038 0.0186 0.1568
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0024 0.0024
Plasmodium vivax vivapain-1 0.0063 0.0481 0.4054
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0056 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.004 0.0206 0.07
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0063 0.0481 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0123 0.1187 0.1187
Echinococcus multilocularis nervana 2 0.0025 0.0024 0.0024
Leishmania major cysteine peptidase A (CPA) 0.0123 0.1187 0.4037
Echinococcus multilocularis nervana 2 0.0025 0.0024 0.0024
Onchocerca volvulus Cathepsin L homolog 0.0123 0.1187 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Leishmania major cathepsin L-like protease 0.0272 0.2941 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Onchocerca volvulus 0.0123 0.1187 1
Trypanosoma cruzi cysteine peptidase, putative 0.0272 0.2941 1
Onchocerca volvulus Cathepsin F homolog 0.0123 0.1187 1
Brugia malayi hypothetical protein 0.0038 0.0186 0.1568
Loa Loa (eye worm) cysteine protease 0.0123 0.1187 1
Echinococcus multilocularis cysteine protease 0.0123 0.1187 0.1187
Echinococcus granulosus cathepsin l cysteine peptidase 0.0123 0.1187 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0213 0.1791
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0063 0.0481 0.4054
Entamoeba histolytica protein kinase 2, putative 0.0025 0.0027 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0706 0.5946
Brugia malayi Cathepsin L-like precursor 0.0123 0.1187 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.0481 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0024 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0481 0.1637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Onchocerca volvulus 0.0123 0.1187 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0213 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0123 0.1187 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Trichomonas vaginalis AGC family protein kinase 0.004 0.0206 0.1733
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0056 0.0476
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Entamoeba histolytica hypothetical protein 0.0038 0.0186 0.1568
Echinococcus multilocularis cathepsin L cysteine protease 0.0123 0.1187 0.1187
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Schistosoma mansoni cathepsin s 0.0041 0.0213 0.1791
Entamoeba histolytica cysteine protease, putative 0.0063 0.0481 0.4054
Loa Loa (eye worm) hypothetical protein 0.0041 0.0213 0.1791
Leishmania major cathepsin L-like protease 0.0272 0.2941 1
Leishmania major cathepsin L-like protease 0.0123 0.1187 0.4037
Plasmodium vivax vivapain-2 0.0123 0.1187 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.2941 1
Trypanosoma cruzi cruzipain precursor, putative 0.0272 0.2941 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Loa Loa (eye worm) ctsf protein 0.0123 0.1187 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.0706 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.1187 1
Entamoeba histolytica cysteine proteinase, putative 0.0123 0.1187 1
Brugia malayi Cathepsin L-like precursor 0.0123 0.1187 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0123 0.1187 1
Brugia malayi Cathepsin L-like precursor 0.0082 0.0706 0.5946
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0186 0.1568
Onchocerca volvulus 0.0123 0.1187 1
Onchocerca volvulus 0.0123 0.1187 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.0027 0.0093
Echinococcus granulosus cathepsin l1 0.0082 0.0706 0.5946
Plasmodium vivax vivapain-2 0.0123 0.1187 1
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0213 0.0723
Entamoeba histolytica cysteine protease, putative 0.0123 0.1187 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0123 0.1187 1
Leishmania major cathepsin L-like protease 0.0123 0.1187 0.4037
Entamoeba histolytica cysteine proteinase 2 0.0063 0.0481 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.0481 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Trichomonas vaginalis AGC family protein kinase 0.004 0.0206 0.1733
Leishmania major cathepsin L-like protease 0.0123 0.1187 0.4037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0123 0.1187 1
Trypanosoma cruzi cysteine proteinase, putative 0.0063 0.0481 0.1637
Trichomonas vaginalis AGC family protein kinase 0.004 0.0206 0.1733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.0706 0.5946
Brugia malayi Papain family cysteine protease containing protein 0.0123 0.1187 1
Plasmodium vivax unspecified product 0.0063 0.0481 0.4054
Plasmodium vivax vivapain-3 0.0063 0.0481 0.4054
Loa Loa (eye worm) hypothetical protein 0.0082 0.0706 0.5946
Brugia malayi Papain family cysteine protease containing protein 0.0063 0.0481 0.4054
Entamoeba histolytica hypothetical protein 0.0038 0.0186 0.1568

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 nM Inhibition of Akt ChEMBL. 19497644

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.