Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0228 | 0.0843 |
Echinococcus granulosus | smad | 0.0042 | 0.0209 | 0.0164 |
Brugia malayi | beta-lactamase family protein | 0.0113 | 0.0895 | 0.1492 |
Echinococcus multilocularis | lamin dm0 | 0.0053 | 0.0314 | 0.0269 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1496 | 0.5898 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.0256 | 0.1545 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0113 | 0.0895 | 0.3666 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0174 | 0.1496 | 0.2522 |
Trypanosoma cruzi | ISWI complex protein | 0.0047 | 0.0256 | 0.1545 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.0959 | 0.6615 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0044 | 0.0228 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1289 | 0.2167 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0139 | 0.0469 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0117 | 0.0374 |
Mycobacterium leprae | conserved hypothetical protein | 0.0113 | 0.0895 | 0.5 |
Echinococcus multilocularis | musashi | 0.0053 | 0.0314 | 0.0269 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0042 | 0.0209 | 0.0164 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0029 | 0.0002 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.0583 | 0.0957 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0051 | 0.0096 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0044 | 0.0228 | 0.1167 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0044 | 0.0228 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0185 | 0.1594 | 0.1556 |
Echinococcus multilocularis | lamin | 0.0053 | 0.0314 | 0.0269 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0055 | 0.0328 | 0.052 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0053 | 0.0309 | 0.0265 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0583 | 0.054 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0622 | 0.5861 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 0.2391 | 0.4056 |
Schistosoma mansoni | glutaminase | 0.0266 | 0.2391 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 0.2391 | 0.4056 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0035 | 0.014 | 0.1562 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0028 | 0.0073 | 0.0084 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0583 | 0.054 |
Echinococcus granulosus | zinc finger protein | 0.0061 | 0.0385 | 0.0341 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 0.2391 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0113 | 0.0895 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0036 | 0.0021 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0042 | 0.0209 | 0.0164 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0053 | 0.0314 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0583 | 0.0957 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0583 | 0.054 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.0583 | 0.054 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0113 | 0.0895 | 0.3666 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0583 | 0.1713 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0051 | 0.0096 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0111 | 0.0878 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0952 | 0.1589 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0053 | 0.0309 | 0.0265 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0185 | 0.1594 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0046 | 0.0037 |
Leishmania major | hypothetical protein, conserved | 0.0113 | 0.0895 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0583 | 0.054 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0113 | 0.0895 | 0.3666 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1081 | 0.181 |
Onchocerca volvulus | 0.0113 | 0.0895 | 0.5958 | |
Echinococcus granulosus | Smad4 | 0.0042 | 0.0209 | 0.0164 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0086 | 0.0241 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0042 | 0.0209 | 0.0316 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0255 | 0.2283 | 0.387 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0583 | 0.1713 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0228 | 0.1167 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0042 | 0.0209 | 0.0316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0165 | 0.0576 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0113 | 0.0895 | 0.3143 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0139 | 0.0469 |
Echinococcus multilocularis | zinc finger protein | 0.0061 | 0.0385 | 0.0341 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0117 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0895 | 0.1492 |
Trypanosoma cruzi | ISWI complex protein | 0.0047 | 0.0256 | 0.1545 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0113 | 0.0895 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0113 | 0.0895 | 0.3666 |
Brugia malayi | MH2 domain containing protein | 0.0622 | 0.5861 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0139 | 0.0469 |
Brugia malayi | beta-lactamase | 0.0113 | 0.0895 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0895 | 0.1492 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 0.0895 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0255 | 0.2283 | 0.387 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0255 | 0.2283 | 0.387 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0256 | 0.0219 |
Loa Loa (eye worm) | intermediate filament protein | 0.0053 | 0.0314 | 0.0496 |
Schistosoma mansoni | zinc finger protein | 0.0047 | 0.0256 | 0.0219 |
Mycobacterium leprae | Probable lipase LipE | 0.0113 | 0.0895 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0232 | 0.2055 | 0.348 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0209 | 0.0316 |
Brugia malayi | PHD-finger family protein | 0.0077 | 0.0546 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0959 | 0.1602 |
Onchocerca volvulus | 0.0113 | 0.0895 | 0.5958 | |
Mycobacterium ulcerans | glutaminase | 0.0266 | 0.2391 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0042 | 0.0209 | 0.0164 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0622 | 0.5861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1023 | 0.1711 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.007 | 0.0475 | 0.0431 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0111 | 0.0878 | 0.0836 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0139 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.1926 | 0.3259 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0054 | 0.0107 |
Plasmodium vivax | hypothetical protein, conserved | 0.0113 | 0.0895 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0196 | 0.1702 | 0.6843 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0228 | 0.0843 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0895 | 0.1492 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0113 | 0.0895 | 0.3666 |
Echinococcus multilocularis | smad | 0.0042 | 0.0209 | 0.0164 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.0583 | 0.0957 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0583 | 0.1713 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0044 | 0.0228 | 0.0088 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.079 | 0.7496 | 0.7484 |
Echinococcus granulosus | lamin | 0.0053 | 0.0314 | 0.0269 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0042 | 0.0209 | 0.0164 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0209 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0314 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0309 | 0.0489 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.007 | 0.0475 | 0.0431 |
Schistosoma mansoni | zinc finger protein | 0.0061 | 0.0385 | 0.0809 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0053 | 0.0309 | 0.0265 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0054 | 0.0107 |
Schistosoma mansoni | lamin | 0.0053 | 0.0314 | 0.048 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0053 | 0.0309 | 0.0265 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0113 | 0.0895 | 0.0853 |
Loa Loa (eye worm) | Smad1 | 0.0042 | 0.0209 | 0.0316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0117 | 0.0374 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0029 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0117 | 0.0374 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0113 | 0.0895 | 0.0853 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0228 | 0.0843 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0117 | 0.0374 |
Echinococcus granulosus | lamin dm0 | 0.0053 | 0.0314 | 0.0269 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 0.2391 | 0.4056 |
Giardia lamblia | GTOR | 0.0044 | 0.0228 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0053 | 0.0314 | 0.0496 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0117 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0959 | 0.1602 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0417 | 0.0955 |
Brugia malayi | intermediate filament protein | 0.0053 | 0.0314 | 0.0496 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0228 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0895 | 0.1492 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 0.0895 | 1 |
Brugia malayi | Smad1 | 0.0042 | 0.0209 | 0.0316 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0309 | 0.0461 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.007 | 0.0475 | 0.1219 |
Schistosoma mansoni | lamin | 0.0053 | 0.0314 | 0.048 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0153 | 0.1289 | 0.495 |
Trypanosoma brucei | ISWI complex protein | 0.0047 | 0.0256 | 0.2866 |
Onchocerca volvulus | 0.0113 | 0.0895 | 0.5958 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0895 | 0.1492 |
Brugia malayi | Bromodomain containing protein | 0.0118 | 0.095 | 0.1586 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0228 | 0.2547 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0304 | 0.048 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0209 | 0.0316 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0228 | 0.0183 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0064 | 0.0417 | 0.0674 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0044 | 0.0228 | 0.0349 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0113 | 0.0895 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.2283 | 0.387 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0044 | 0.0228 | 0.1167 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.0959 | 0.6615 |
Brugia malayi | hypothetical protein | 0.0119 | 0.0959 | 0.1602 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0209 | 0.0316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0117 | 0.0374 |
Trichomonas vaginalis | esterase, putative | 0.0113 | 0.0895 | 0.3666 |
Echinococcus multilocularis | Smad4 | 0.0042 | 0.0209 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1496 | 0.2522 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0139 | 0.0469 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0044 | 0.0228 | 0.2547 |
Schistosoma mansoni | intermediate filament proteins | 0.0053 | 0.0314 | 0.048 |
Toxoplasma gondii | ABC1 family protein | 0.0113 | 0.0895 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.0583 | 0.054 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0029 | 0.0002 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0053 | 0.0309 | 0.0461 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0721 | 0.6819 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0029 | 0.0002 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0113 | 0.0895 | 0.3143 |
Brugia malayi | beta-lactamase family protein | 0.0113 | 0.0895 | 0.1492 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0044 | 0.0228 | 0.0349 |
Echinococcus granulosus | intermediate filament protein | 0.0053 | 0.0314 | 0.0269 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0076 | 0.0201 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0054 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0036 | 0.0021 |
Onchocerca volvulus | 0.0153 | 0.1289 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0583 | 0.1713 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0044 | 0.0228 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.0583 | 0.0957 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0028 | 0.0073 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0895 | 0.1492 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0309 | 0.0461 |
Loa Loa (eye worm) | beta-lactamase | 0.0113 | 0.0895 | 0.1492 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0053 | 0.0309 | 0.0461 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli 26 after 18 to 24 hrs by twofold serial dilution method | ChEMBL. | 19481308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.