Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0237 | 0.3158 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0347 | 0.1098 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0325 | 0.1029 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0658 | 0.0658 |
Echinococcus multilocularis | lamin dm0 | 0.0084 | 0.0966 | 0.0966 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0658 | 0.0658 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0034 | 0.5 |
Onchocerca volvulus | 0.0084 | 0.0966 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0124 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0034 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0034 | 0.0109 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0658 | 0.0658 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0658 | 0.0658 |
Echinococcus granulosus | lamin | 0.0084 | 0.0966 | 0.0966 |
Echinococcus granulosus | lamin dm0 | 0.0084 | 0.0966 | 0.0966 |
Schistosoma mansoni | intermediate filament proteins | 0.0084 | 0.0966 | 0.0966 |
Echinococcus granulosus | intermediate filament protein | 0.0084 | 0.0966 | 0.0966 |
Onchocerca volvulus | 0.0084 | 0.0966 | 1 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0124 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0034 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0944 | 0.299 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.004 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0034 | 0.0109 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0124 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0124 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0084 | 0.0966 | 0.3059 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0124 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0658 | 0.2084 |
Echinococcus multilocularis | musashi | 0.0084 | 0.0966 | 0.0966 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0124 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0124 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0325 | 0.1029 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0124 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0124 | 0.0393 |
Loa Loa (eye worm) | intermediate filament protein | 0.0084 | 0.0966 | 0.3059 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0045 | 0.041 | 0.1299 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0124 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0658 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0034 | 0.0109 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0034 | 0.0109 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0124 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0658 | 0.2084 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0124 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.3059 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0045 | 0.041 | 0.1299 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0658 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0124 | 0.0393 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.004 | 0.0347 | 0.0347 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0124 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0124 | 0.0393 |
Brugia malayi | MH2 domain containing protein | 0.0237 | 0.3158 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0034 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0084 | 0.0966 | 0.3059 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0124 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0124 | 0.0393 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0237 | 0.3158 | 1 |
Schistosoma mansoni | lamin | 0.0084 | 0.0966 | 0.0966 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0124 | 0.0393 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0124 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0658 | 0.2084 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0124 | 1 |
Echinococcus multilocularis | lamin | 0.0084 | 0.0966 | 0.0966 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0034 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0084 | 0.0966 | 0.3059 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0658 | 0.2084 |
Schistosoma mansoni | lamin | 0.0084 | 0.0966 | 0.0966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.