TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 312.32 | Formula: C17H16N2O4
H donors: 1 H acceptors: 2 LogP: 3.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1OC)OC)C(=O)c1nc2c([nH]1)cccc2
InChi: 1S/C17H16N2O4/c1-21-13-8-10(9-14(22-2)16(13)23-3)15(20)17-18-11-6-4-5-7-12(11)19-17/h4-9H,1-3H3,(H,18,19)
InChiKey: IQMUTEQFNTWYDF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0161	0.053
Schistosoma mansoni	alpha-glucosidase	0.0294	0.3901	0.3888
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Plasmodium falciparum	importin beta, putative	0.006	0.0606	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0076	0.0834	0.2187
Echinococcus multilocularis	lamin	0.0031	0.0201	0.0041
Leishmania major	cathepsin L-like protease	0.0054	0.0531	0.1609
Brugia malayi	cathepsin L-like precursor	0.0036	0.0279	0.0433
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0205	0.0185
Leishmania major	alpha glucosidase II subunit, putative	0.0076	0.0834	0.2797
Echinococcus multilocularis	snurportin 1	0.0638	0.8714	0.8693
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0531	0.0511
Onchocerca volvulus		0.0031	0.0201	0.0261
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Toxoplasma gondii	HEAT repeat-containing protein	0.006	0.0606	0.6782
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.012	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.012	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.0531	0.1318
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.012	1
Leishmania major	cathepsin L-like protease	0.0207	0.2672	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Onchocerca volvulus		0.0054	0.0531	0.1318
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0342	0.4569	0.7107
Echinococcus multilocularis	lamin dm0	0.0031	0.0201	0.0041
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0161	0.0141
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0048	0.0448	0.0933
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0028	0.0165	0.0634
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0201	0.0313
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0031	0.139
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0028	0.0165	0.0145
Leishmania major	cathepsin L-like protease	0.0207	0.2672	1
Onchocerca volvulus		0.0036	0.0279	0.0509
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0031	0.0182
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.012	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0127	0.0403
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.0279	0.0433
Loa Loa (eye worm)	fibroinase	0.0054	0.0531	0.0609
Echinococcus granulosus	muscleblind protein	0.0475	0.643	0.6371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0438	0.0502
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0048	0.0448	0.0933
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0205	0.0045
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.002	0.0032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0161	0.0133
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0076	0.0834	0.2187
Echinococcus multilocularis	muscleblind protein 1	0.0475	0.643	0.6371
Echinococcus granulosus	cathepsin l1	0.0054	0.0531	0.0376
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Loa Loa (eye worm)	hypothetical protein	0.006	0.0606	0.0696
Schistosoma mansoni	alpha glucosidase	0.0076	0.0834	0.0815
Entamoeba histolytica	cysteine proteinase 1, putative	0.0028	0.0161	0.0576
Plasmodium vivax	vivapain-1	0.0028	0.0161	0.24
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0161	0.0141
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0076	0.0834	0.1297
Schistosoma mansoni	ran	0.0044	0.0385	0.0365
Trichomonas vaginalis	alpha-glucosidase, putative	0.0076	0.0834	0.2187
Leishmania major	cathepsin L-like protease	0.0054	0.0531	0.1609
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.012	1
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0531	0.1318
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Brugia malayi	hypothetical protein	0.0026	0.0127	0.0198
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0531	0.0825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0205	0.1108
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.0531	0.8683
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0531	0.0609
Echinococcus granulosus	lamin dm0	0.0031	0.0201	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0319
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0279	0.2223
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0161	0.0576
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0044	0.0385	0.1375
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0028	0.0165	0.0013
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Trichomonas vaginalis	importin beta-1, putative	0.0048	0.0448	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0165	0.0013
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0834	0.3067
Plasmodium vivax	SET domain protein, putative	0.0031	0.0205	0.3158
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0201	0.0231
Trypanosoma cruzi	cruzipain precursor, putative	0.0207	0.2672	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.0531	0.0609
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0161	0.053
Trypanosoma brucei	glucosidase, putative	0.0076	0.0834	0.2776
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0028	0.0165	0.0257
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.012	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0438	0.0419
Plasmodium vivax	importin-beta 2, putative	0.006	0.0606	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0189	0.242	0.905
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0127	0.0403
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0044	0.0385	0.1375
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0127	0.1823
Schistosoma mansoni	alpha-glucosidase	0.0294	0.3901	0.3888
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0834	0.3067
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.0531	0.1609
Toxoplasma gondii	cathepsin CPL	0.0054	0.0531	0.571
Brugia malayi	RNA, U transporter 1	0.017	0.2151	0.3346
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0205	0.0045
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0342	0.4569	0.448
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0438	0.0282
Brugia malayi	Muscleblind-like protein	0.0475	0.643	1
Onchocerca volvulus		0.0247	0.3236	1
Onchocerca volvulus		0.0031	0.0205	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0035
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0201	0.0181
Leishmania major	cathepsin L-like protease	0.0054	0.0531	0.1609
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0028	0.0165	0.0546
Loa Loa (eye worm)	ctsf protein	0.0054	0.0531	0.0609
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0205	0.0185
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0076	0.0834	0.2187
Loa Loa (eye worm)	hypothetical protein	0.0018	0.002	0.0023
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0028	0.0165	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0235
Plasmodium vivax	vivapain-2	0.0054	0.0531	0.8707
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0531	0.0825
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.012	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0531	0.0511
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.002	0.0032
Echinococcus granulosus	importin subunit beta 1	0.006	0.0606	0.0453
Leishmania major	glycosyl hydrolase-like protein	0.0028	0.0165	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.012	0.0186
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0531	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0035
Plasmodium vivax	vivapain-3	0.0028	0.0161	0.24
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0161	0.0141
Trichomonas vaginalis	alpha-glucosidase, putative	0.0076	0.0834	0.2187
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0531	0.0376
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0531	0.5753
Loa Loa (eye worm)	hypothetical protein	0.0018	0.002	0.0023
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Plasmodium vivax	unspecified product	0.0028	0.0161	0.24
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0044	0.0385	0.0599
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0438	0.0282
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0044	0.0385	0.1013
Schistosoma mansoni	lamin	0.0031	0.0201	0.0181
Entamoeba histolytica	cysteine proteinase 2	0.0028	0.0161	0.0576
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0531	0.5753
Onchocerca volvulus		0.0054	0.0531	0.1318
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0028	0.0165	0.0546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0279	0.0382
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0342	0.4569	0.5244
Onchocerca volvulus		0.0054	0.0531	0.1318
Echinococcus granulosus	intermediate filament protein	0.0031	0.0201	0.0041
Onchocerca volvulus		0.0054	0.0531	0.1318
Echinococcus granulosus	neutral alpha glucosidase AB	0.0076	0.0834	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0025	0.012	0.0137
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0048	0.0448	0.1612
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0028	0.0165	0.0013
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0076	0.0834	0.2187
Loa Loa (eye worm)	hypothetical protein	0.0475	0.643	0.7379
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.2815	0.3231
Trichomonas vaginalis	alpha-glucosidase, putative	0.0076	0.0834	0.2187
Brugia malayi	Pre-SET motif family protein	0.0031	0.0205	0.0319
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0279	0.0433
Echinococcus multilocularis	muscleblind protein	0.0475	0.643	0.6371
Schistosoma mansoni	importin beta-1	0.006	0.0606	0.0587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0165	0.0013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0438	0.0419
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0205	0.0185
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0076	0.0834	0.0956
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0076	0.0834	1
Echinococcus multilocularis	cysteine protease	0.0054	0.0531	0.0376
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0165	0.0013
Brugia malayi	intermediate filament protein	0.0031	0.0201	0.0313
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0044	0.0385	0.0228
Trypanosoma cruzi	cysteine peptidase, putative	0.0207	0.2672	1
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0028	0.0165	0.0013
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0531	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0127	0.0146
Trichomonas vaginalis	alpha-glucosidase, putative	0.0076	0.0834	0.2187
Echinococcus granulosus	snurportin 1	0.0638	0.8714	0.8693
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0205	0.0185
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0031	0.5
Echinococcus multilocularis	cysteine protease	0.0054	0.0531	0.0376
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0161	0.053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0165	0.0013
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0161	0.0576
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Echinococcus multilocularis	importin subunit beta 1	0.006	0.0606	0.0453
Trypanosoma cruzi	major cysteine proteinase, putative	0.0163	0.2051	0.7656
Leishmania major	importin beta-1 subunit, putative	0.0048	0.0448	0.1285
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Onchocerca volvulus		0.0031	0.0201	0.0261
Plasmodium vivax	vivapain-2	0.0054	0.0531	0.8707
Onchocerca volvulus		0.0198	0.2545	0.7782
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.012	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0205	0.0045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0127	0.1671
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0438	0.0282
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0161	0.0576
Trichomonas vaginalis	alpha-glucosidase, putative	0.0076	0.0834	0.2187
Entamoeba histolytica	Ran family GTPase	0.0044	0.0385	0.3715
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0044	0.0385	0.6154
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0531	0.1924
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0165	0.0013
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0438	0.0681
Leishmania major	cathepsin L-like protease	0.0054	0.0531	0.1609
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0531	0.1202
Onchocerca volvulus		0.0054	0.0531	0.1318
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.012	0.0186
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.002	0.0023
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0342	0.4569	0.448
Loa Loa (eye worm)	hypothetical protein	0.0018	0.002	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0319
Onchocerca volvulus		0.0054	0.0531	0.1318
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0279	0.0259
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0189	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0475	0.643	0.7379
Brugia malayi	Importin beta-1 subunit	0.006	0.0606	0.0943
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0201	0.0231
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0076	0.0834	0.0684
Trypanosoma cruzi	cysteine peptidase, putative	0.0207	0.2672	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0438	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0165	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0231
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.0531	0.0376
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0438	0.0282
Echinococcus granulosus	lysosomal alpha glucosidase	0.0342	0.4569	0.448
Leishmania major	cathepsin L-like protease	0.0207	0.2672	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0531	0.1202
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0044	0.0385	0.5
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0044	0.0385	0.6224
Trypanosoma brucei	importin beta-1 subunit, putative	0.006	0.0606	0.1883
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0531	0.1318
Schistosoma mansoni	hypothetical protein	0.0638	0.8714	0.8711
Trichomonas vaginalis	ran, putative	0.0044	0.0385	0.0729
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0279	0.0433
Entamoeba histolytica	hypothetical protein	0.0048	0.0448	0.4594
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0044	0.0385	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0025	0.012	0.0137
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0044	0.0385	0.0442
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0531	0.0825
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0127	0.1671
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0076	0.0834	1
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0161	0.0576
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.012	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0531	0.0376
Onchocerca volvulus		0.0054	0.0531	0.1318
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0531	0.0376
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0028	0.0161	0.053
Echinococcus granulosus	lamin	0.0031	0.0201	0.0041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0531	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0531	0.0609
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0161	0.0133
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.0531	0.8683
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0076	0.0834	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.012	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.006	0.0606	0.1883
Loa Loa (eye worm)	cysteine protease	0.0054	0.0531	0.0609
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0025	0.012	0.0137
Leishmania major	GTP-binding protein, putative	0.0044	0.0385	0.1039
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0531	0.0825
Schistosoma mansoni	ran	0.0044	0.0385	0.0365
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0035
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Loa Loa (eye worm)	hypothetical protein	0.003	0.0193	0.0222
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0044	0.0385	0.3651
Echinococcus granulosus	cathepsin l1	0.0036	0.0279	0.012
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Trypanosoma cruzi	cysteine peptidase, putative	0.0207	0.2672	1
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0161	0.0576
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0531	0.0825
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0638	0.8714	1
Echinococcus multilocularis	musashi	0.0031	0.0201	0.0041
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0161	0.025
Trichomonas vaginalis	set domain proteins, putative	0.0247	0.3236	1
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0161	0.025
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0319
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.0531	0.0376
Brugia malayi	Cathepsin L-like precursor	0.0018	0.002	0.0032
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0531	0.0376
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.012	0.0186
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.0531	0.8683
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0028	0.0161	0.2259
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.012	1
Schistosoma mansoni	lamin	0.0031	0.0201	0.0181
Trypanosoma cruzi	cysteine protease, putative	0.0028	0.0161	0.053
Leishmania major	hypothetical protein, conserved	0.0026	0.0127	0.0028
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0531	0.1202
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0531	0.5753
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0207	0.2672	1
Leishmania major	cathepsin L-like protease	0.0054	0.0531	0.1609
Mycobacterium ulcerans	hypothetical protein	0.0025	0.012	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0279	0.0382
Brugia malayi	Pre-SET motif family protein	0.0217	0.2815	0.4379

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 10 uM	Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay	ChEMBL.	21775150
IC50 (functional)	> 10 uM	Antiproliferative activity against human LNCAP cells after 96 hrs by sulforhodamine B assay	ChEMBL.	21775150
IC50 (functional)	> 10 uM	Antiproliferative activity against human PC3 cells after 96 hrs by sulforhodamine B assay	ChEMBL.	21775150
IC50 (functional)	> 10 uM	Antiproliferative activity against human DU145 cells after 96 hrs by sulforhodamine B assay	ChEMBL.	21775150
IC50 (functional)	> 10 uM	Antiproliferative activity against human PPC1 cells after 96 hrs by sulforhodamine B assay	ChEMBL.	21775150

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	21775150

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1813170

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1077830