Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | DNA gyrase subunit B | Starlite/ChEMBL | References |
Streptococcus pneumoniae | ParE | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0306 | 0.3712 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0071 | 0.0146 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0071 | 0.0146 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0071 | 0.0146 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1745 | 0.1623 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0071 | 0.0146 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0177 | 0.1748 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0071 | 0.0146 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0071 | 0.0146 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0306 | 0.3712 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0071 | 0.0146 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0306 | 0.3712 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1745 | 0.1623 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0306 | 0.3712 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0306 | 0.3712 | 0.5 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0177 | 0.1748 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0177 | 0.1748 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0177 | 0.1748 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0177 | 0.1748 | 0.5 |
Echinococcus multilocularis | geminin | 0.0177 | 0.1745 | 0.1623 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0071 | 0.0146 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0071 | 0.0146 | 0.5 |
Echinococcus granulosus | geminin | 0.0177 | 0.1745 | 0.1623 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0306 | 0.3712 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0306 | 0.3712 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0105 | 0.0661 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.