Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5898 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0164 | 0.4664 | 0.7883 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.372 | 0.3643 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.5898 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5898 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.005 | 0.007 | 0.0119 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.5898 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5898 | 0.5848 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5898 | 0.3468 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0169 | 0.4854 | 0.7455 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5898 | 0.3468 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.5898 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.5898 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.5898 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.5898 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.5898 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.4357 | 0.6242 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.005 | 0.007 | 0.0119 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.5898 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0093 | 0.1798 | 0.1698 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5898 | 1 |
Onchocerca volvulus | 0.0195 | 0.5898 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.1798 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of Enterococcus faecalis thymidylate synthase using N5,N10-methylene tetrahydrofolate at 50 uM by chromogenic assay | ChEMBL. | 21696158 | |
Inhibition (binding) | Inhibition of human thymidylate synthase using N5,N10-methylene tetrahydrofolate at 50 uM by chromogenic assay | ChEMBL. | 21696158 | |
Ki (binding) | = 3 uM | Inhibition of Lactobacillus casei thymidylate synthase using N5,N10-methylene tetrahydrofolate by chromogenic assay | ChEMBL. | 21696158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.