Detailed information for compound 1078727

Basic information

Technical information
  • TDR Targets ID: 1078727
  • Name: 4-[bis(2,4,6-trimethylphenyl)boranyl-ethylami no]phenol
  • MW: 385.349 | Formula: C26H32BNO
  • H donors: 1 H acceptors: 1 LogP: 7.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(B(c1c(C)cc(cc1C)C)c1c(C)cc(cc1C)C)c1ccc(cc1)O
  • InChi: 1S/C26H32BNO/c1-8-28(23-9-11-24(29)12-10-23)27(25-19(4)13-17(2)14-20(25)5)26-21(6)15-18(3)16-22(26)7/h9-16,29H,8H2,1-7H3
  • InChiKey: BTNVMJSDQGZRPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[bis(2,4,6-trimethylphenyl)boranyl-ethyl-amino]phenol
  • 4-((dimesitylboryl)(2,2,2-trifluoroethyl)amino)phenol
  • nchembio.76-comp19

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0615 0.0677
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0804 0.0928
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0413 0.1291
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0584 0.7188
Loa Loa (eye worm) RNA binding protein 0.0065 0.1406 0.1548
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0746 0.0746
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0413 0.1291
Mycobacterium ulcerans lipase LipD 0.0035 0.0615 0.08
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0452 0.1419
Mycobacterium ulcerans glutaminase 0.0289 0.7429 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0804 0.2273
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0548 0.2412
Brugia malayi Importin beta-1 subunit 0.0033 0.0552 0.0638
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0584 0.2575
Loa Loa (eye worm) hypothetical protein 0.0035 0.0615 0.0677
Loa Loa (eye worm) hypothetical protein 0.0035 0.0615 0.0677
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0413 0.0124
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0584 1
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5064 0.6267
Brugia malayi Pre-SET motif family protein 0.0241 0.6126 0.7077
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0294 0.0294
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.1665 0.1777
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0386 0.0087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0804 0.0804
Brugia malayi Glycosyl hydrolases family 31 protein 0.0335 0.8657 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.3051 1
Onchocerca volvulus 0.0035 0.0612 0.0473
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.2203 0.7201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0306 0.789 0.8689
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0294 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0294 0.0324
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.3051 0.3359
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0804 0.1772
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.9081 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0804 0.0885
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0208 0.5258 0.6074
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.032 0.032
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.032 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0452 0.1419
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0548 0.071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0294 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.1737
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0294 0.034
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0141 0.346 0.5252
Loa Loa (eye worm) hypothetical protein 0.0033 0.0552 0.0608
Loa Loa (eye worm) hypothetical protein 0.0035 0.0615 0.0677
Trichomonas vaginalis glucosylceramidase, putative 0.0306 0.789 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0548 0.1737
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0804 0.046
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0294 0.0324
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0804 0.0885
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1665 0.5424
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.1146 0.1146
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5064 0.6267
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0552 0.0552
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0413 0.0344
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0215 0.5447 0.8837
Schistosoma mansoni importin beta-1 0.0033 0.0552 0.0608
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.3051 0.4514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.032 0.1363
Mycobacterium ulcerans hypothetical protein 0.0035 0.0615 0.08
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.032 0.3804
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0746 0.0563
Loa Loa (eye worm) hypothetical protein 0.012 0.2883 0.3175
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.3051 0.3607
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0584 0.0349
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.1665 0.4926
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.1737
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.3051 0.3051
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0804 0.258
Plasmodium falciparum glutathione reductase 0.0094 0.2203 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.032 0.0981
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.1351 0.156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0208 0.5258 0.579
Trichomonas vaginalis glucosylceramidase, putative 0.0212 0.5354 0.665
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0294 0.0324
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0294 0.034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0141 0.346 0.464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0612 0.0674
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.032 0.0981
Plasmodium falciparum thioredoxin reductase 0.0094 0.2203 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0225 0.5702 0.5702
Echinococcus multilocularis lysosomal alpha glucosidase 0.0335 0.8657 0.8657
Mycobacterium tuberculosis Conserved protein 0.0035 0.0615 0.012
Brugia malayi beta-lactamase family protein 0.0035 0.0615 0.071
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0413 0.0124
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0548 0.153
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0746 0.0563
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0548 0.1737
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0552 0.1542
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.5702 0.9297
Echinococcus multilocularis dna polymerase eta 0.0042 0.0804 0.0804
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5064 0.6267
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0141 0.346 0.346
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.3051 0.3607
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.1146 0.1146
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0612 0.0674
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.1665 0.1777
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0615 0.012
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0386 0.1199
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0315 0.0364
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.1146 0.1262
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0615 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0294 0.0324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0294 0.0294
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0615 0.0615
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0804 0.258
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0584 0.0349
Brugia malayi TAR-binding protein 0.0065 0.1406 0.1624
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1434 0.1579
Echinococcus granulosus geminin 0.0348 0.9017 0.9017
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0552 0.175
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.3051 0.3051
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0074 0.1665 0.1833
Leishmania major trypanothione reductase 0.0094 0.2203 0.6344
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0294 0.0294
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0294 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0208 0.5258 0.579
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0615 0.012
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.032 0.1363
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0804 0.1055
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0548 0.071
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0552 0.175
Onchocerca volvulus 0.0035 0.0615 0.0477
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0025
Echinococcus granulosus dna polymerase kappa 0.0042 0.0804 0.0804
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0804 0.0928
Mycobacterium tuberculosis Probable oxidoreductase 0.0239 0.6092 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.1406 0.1406
Echinococcus granulosus lysosomal alpha glucosidase 0.0335 0.8657 0.8657
Echinococcus multilocularis geminin 0.0348 0.9017 0.9017
Trichomonas vaginalis glucosylceramidase, putative 0.0306 0.789 1
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5064 0.6267
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0746 0.0746
Loa Loa (eye worm) beta-lactamase 0.0035 0.0615 0.0677
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1406 0.1548
Entamoeba histolytica hypothetical protein 0.0027 0.0386 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0208 0.5258 0.5258
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0548 0.071
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.3051 0.881
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0294 0.0324
Loa Loa (eye worm) hypothetical protein 0.0063 0.1351 0.1487
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0615 0.039
Trichomonas vaginalis glucosylceramidase, putative 0.0306 0.789 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0615 0.039
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0239 0.6092 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0413 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0212 0.5354 0.665
Loa Loa (eye worm) hypothetical protein 0.0042 0.0804 0.0885
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.3051 0.3607
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0746 0.2389
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0413 0.1291
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0548 0.153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0615 0.0677
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.1737
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1665 0.5424
Echinococcus granulosus importin subunit beta 1 0.0033 0.0552 0.0552
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0584 1
Loa Loa (eye worm) phosphofructokinase 0.0126 0.3051 0.3359
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Schistosoma mansoni ran 0.0024 0.032 0.0352
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0804 0.258
Brugia malayi glutaminase DH11.1 0.0289 0.7429 0.8582
Brugia malayi hypothetical protein 0.0277 0.7108 0.8212
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.1146 0.1262
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.1146 0.1146
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0548 0.0633
Mycobacterium ulcerans beta-lactamase 0.0035 0.0615 0.08
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0615 0.08
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0294 0.034
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.1351 0.1351
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.056 0.056
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0746 0.9259
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0294 0.0324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0615 0.1956
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0615 0.2717
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.1183 0.1302
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0239 0.6092 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1406 0.1548
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0615 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.6126 0.6747
Plasmodium vivax importin-beta 2, putative 0.0033 0.0552 0.243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0294 0.0294
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0548 0.0548
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0804 0.046
Brugia malayi beta-lactamase family protein 0.0035 0.0615 0.071
Trypanosoma brucei trypanothione reductase 0.0094 0.2203 0.7201
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0548 0.0604
Onchocerca volvulus Huntingtin homolog 0.012 0.2883 0.3852
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0584 0.0968
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0413 0.1138
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.2203 0.2985
Leishmania major DNA polymerase eta, putative 0.0042 0.0804 0.2273
Mycobacterium tuberculosis Probable reductase 0.0215 0.5447 0.8837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.153
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0294 0.0294
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0584 0.1634
Onchocerca volvulus 0.0035 0.0615 0.0477
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0615 0.0615
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.3051 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0022 0.0025
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.3051 0.4447
Onchocerca volvulus Glucosylceramidase homolog 0.0201 0.5064 0.7096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0612 0.0674
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0584 0.2575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0208 0.5258 0.579
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0804 0.0639
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0294 0.0294
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.032 0.0352
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0746 0.3317
Echinococcus multilocularis neutral alpha glucosidase AB 0.0074 0.1665 0.1665
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0548 0.6733
Leishmania major alpha glucosidase II subunit, putative 0.0074 0.1665 0.4778
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.1665 0.1777
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.2219 0.2219
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0804 0.0885
Plasmodium falciparum glutathione reductase 0.0033 0.0548 0.2412
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0548 0.2412
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0612 0.0612
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0294 0.0294
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0804 0.0639
Loa Loa (eye worm) glutathione reductase 0.0094 0.2203 0.2426
Mycobacterium tuberculosis Probable dehydrogenase 0.0215 0.5447 0.8837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.153
Schistosoma mansoni ap endonuclease 0.004 0.0746 0.0821
Plasmodium falciparum importin beta, putative 0.0033 0.0552 0.243
Schistosoma mansoni DNA polymerase eta 0.0042 0.0804 0.0885
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0215 0.5447 0.8823
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0548 0.153
Loa Loa (eye worm) glutaminase 2 0.0289 0.7429 0.8182
Trichomonas vaginalis esterase, putative 0.0035 0.0615 0.039
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1406 0.1548
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0548 0.1737
Schistosoma mansoni hypothetical protein 0.0343 0.8858 0.9754
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.347 0.3822
Loa Loa (eye worm) hypothetical protein 0.0055 0.1146 0.1262
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Leishmania major importin beta-1 subunit, putative 0.0027 0.0386 0.1057
Schistosoma mansoni cpg binding protein 0.0032 0.0532 0.0586
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0208 0.5258 0.5258
Brugia malayi steroid hormone receptor 0.0023 0.0294 0.034
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1406 0.1548
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0413 0.0178
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0746 0.2104
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0584 0.2575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0141 0.346 0.464
Toxoplasma gondii ABC1 family protein 0.0035 0.0615 0.1724
Brugia malayi RNA binding protein 0.0065 0.1406 0.1624
Trypanosoma brucei glucosidase, putative 0.0074 0.1665 0.5424
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0215 0.5447 0.8837
Echinococcus granulosus dna polymerase eta 0.0042 0.0804 0.0804
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0584 0.0142
Echinococcus granulosus cpg binding protein 0.0032 0.0532 0.0532
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0294 0.034
Schistosoma mansoni ran 0.0024 0.032 0.0352
Schistosoma mansoni hypothetical protein 0.0348 0.9017 0.9929
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0306 0.789 0.9115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0294 0.0324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0294 0.0324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0208 0.5258 0.5258
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0615 0.012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0294 0.0294
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0615 0.1956
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0413 0.0455
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.1351 0.1487
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0804 0.258
Onchocerca volvulus 0.003 0.0486 0.0286
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.1665 0.1777
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0294 0.0294
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.3051 1
Onchocerca volvulus 0.0056 0.1183 0.1322
Trichomonas vaginalis glucosylceramidase, putative 0.0306 0.789 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.1737
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0746 0.0789
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0294 0.0324
Brugia malayi Glycosyl hydrolases family 31 protein 0.0074 0.1665 0.1923
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0548 0.0302
Loa Loa (eye worm) MBCTL1 0.0063 0.1351 0.1487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0294 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0294 0.034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0294 0.0294
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0208 0.5258 0.579
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0584 0.1634
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0746 0.3317
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0548 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0294 0.034
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1406 0.1548
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0612 0.1716
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0294 0.0324
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0141 0.346 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.1665 0.4926
Plasmodium falciparum thioredoxin reductase 0.0033 0.0548 0.2412
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.1188 0.1372
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0746 0.2389
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0804 0.258
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.032 0.0865
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.3051 0.4088
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0294 0.0324
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0141 0.346 0.346
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0584 0.2575
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.1665 0.1777
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0386 0.0087
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0413 0.0478
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0804 0.0804
Onchocerca volvulus 0.0274 0.7016 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0294 0.0324
Brugia malayi phosphofructokinase 0.0126 0.3051 0.3524
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0294 0.0294
Leishmania major hypothetical protein, conserved 0.0035 0.0615 0.1724
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0548 0.1737
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0239 0.6092 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0746 0.0976
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.1665 0.1777
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.3051 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0612 0.0674
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.1737
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Schistosoma mansoni hypothetical protein 0.0351 0.9081 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0804 0.258
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0413 0.0124
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0386 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5064 0.6267
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0225 0.5702 0.5702
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0548 0.1737
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0615 0.012
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.3051 0.3607
Mycobacterium ulcerans aldehyde dehydrogenase 0.0141 0.346 0.464
Schistosoma mansoni ap endonuclease 0.004 0.0746 0.0821
Brugia malayi polk-prov protein 0.0013 0.0022 0.0026
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0746 0.0861
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0294 0.034
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0584 0.1634
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0215 0.5447 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0294 0.034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0615 0.0677
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0413 0.0124
Schistosoma mansoni alpha-glucosidase 0.0288 0.7405 0.8155
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0486 0.0535
Plasmodium vivax glutathione reductase, putative 0.0094 0.2203 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0584 0.0349
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0548 0.1737
Brugia malayi glutathione reductase 0.0094 0.2203 0.2545
Brugia malayi Thioredoxin reductase 0.0094 0.2203 0.2545
Loa Loa (eye worm) hypothetical protein 0.0035 0.0615 0.0677
Schistosoma mansoni alpha-glucosidase 0.0288 0.7405 0.8155
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0548 0.2412
Schistosoma mansoni aldehyde dehydrogenase 0.0141 0.346 0.381
Toxoplasma gondii aldehyde dehydrogenase 0.0141 0.346 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0612 0.0612
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0208 0.5258 0.5258
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0612 0.0612
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.2203 0.2426
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0548 0.2412
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0615 0.039
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0584 0.0349
Schistosoma mansoni aldehyde dehydrogenase 0.0141 0.346 0.381
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0804 0.258
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0413 0.0124
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0804 0.1055
Brugia malayi 6-phosphofructokinase 0.0126 0.3051 0.3524
Toxoplasma gondii thioredoxin reductase 0.0094 0.2203 0.6344
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.7108 0.7108
Trichomonas vaginalis set domain proteins, putative 0.0274 0.7016 0.8845
Echinococcus granulosus snurportin 1 0.0351 0.9081 0.9081
Brugia malayi RNA, U transporter 1 0.0093 0.2177 0.2515
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.1351 0.1351
Schistosoma mansoni coup transcription factor 0.0023 0.0294 0.0324
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0584 0.0349
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.1351 0.1351
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0548 0.1737
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0294 0.034
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0294 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5064 0.6267
Onchocerca volvulus 0.0057 0.1188 0.133
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.3051 0.3359
Brugia malayi nuclear hormone receptor 0.0023 0.0294 0.034
Trypanosoma brucei unspecified product 0.0029 0.0452 0.1419
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0294 0.034
Schistosoma mansoni hypothetical protein 0.0057 0.1188 0.1308
Trypanosoma brucei unspecified product 0.0029 0.0452 0.1419
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1406 0.1548
Schistosoma mansoni survival motor neuron protein 0.0057 0.1188 0.1308
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0615 0.039
Brugia malayi mbt repeat family protein 0.0055 0.1146 0.1324
Leishmania major DNA polymerase kappa, putative 0.0042 0.0804 0.2273
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0215 0.5447 0.8837
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.1146 0.1146
Trichomonas vaginalis sucrase-isomaltase, putative 0.0074 0.1665 0.1777
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0804 0.0804
Schistosoma mansoni hypothetical protein 0.0348 0.9017 0.9929
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.347 0.3822
Schistosoma mansoni cpg binding protein 0.003 0.0486 0.0535
Mycobacterium tuberculosis Conserved protein 0.0035 0.0615 0.012
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.1146 0.1268
Echinococcus multilocularis lysosomal alpha glucosidase 0.0335 0.8657 0.8657
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0615 0.08
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0294 0.0294
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0335 0.8657 0.9533
Schistosoma mansoni glutaminase 0.0289 0.7429 0.8182
Onchocerca volvulus 0.0055 0.1146 0.1268
Brugia malayi MH2 domain containing protein 0.0142 0.347 0.4009
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1406 0.1624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0294 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0452 0.1419
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0315 0.0364
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0804 0.258
Loa Loa (eye worm) glutaminase 0.0289 0.7429 0.8182
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1406 0.1548
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0294 0.0294
Mycobacterium tuberculosis Conserved protein 0.0035 0.0615 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.1665 0.1777
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0294 0.034
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1406 0.1406
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0615 0.1956
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.032 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0294 0.034
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.032 0.032
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0584 0.0349
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.3051 0.3359
Loa Loa (eye worm) hypothetical protein 0.012 0.2883 0.3175
Brugia malayi 6-phosphofructokinase 0.0126 0.3051 0.3524
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0548 0.0548
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0615 0.039
Trypanosoma brucei unspecified product 0.0042 0.0804 0.258
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0804 0.258
Trichomonas vaginalis glucosylceramidase, putative 0.0306 0.789 1
Brugia malayi mbt repeat family protein 0.0055 0.1146 0.1324
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0615 0.071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Brugia malayi CXXC zinc finger family protein 0.003 0.0486 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0294 0.0324
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0413 0.0124
Leishmania major GTP-binding protein, putative 0.0024 0.032 0.0865
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0294 0.0324
Schistosoma mansoni alpha glucosidase 0.0074 0.1665 0.1833
Loa Loa (eye worm) hypothetical protein 0.0277 0.7108 0.7828
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.3051 0.3359
Brugia malayi ecdysteroid receptor 0.0023 0.0294 0.034
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.2203 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0746 0.156
Brugia malayi Pre-SET motif family protein 0.0035 0.0612 0.0707
Trichomonas vaginalis glucosylceramidase, putative 0.0306 0.789 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0413 0.0124
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0548 0.153
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.2219 0.2219
Giardia lamblia DINP protein human, muc B family 0.0042 0.0804 1
Echinococcus multilocularis snurportin 1 0.0351 0.9081 0.9081
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0746 0.0356
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0584 0.0349
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0746 0.2389
Brugia malayi nuclear receptor NHR-88 0.0023 0.0294 0.034
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0746 0.0821
Plasmodium vivax SET domain protein, putative 0.0035 0.0612 0.2704
Trichomonas vaginalis maltase-glucoamylase, putative 0.0074 0.1665 0.1777
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0612 0.0674
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0074 0.1665 0.4778
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.1146 0.1262
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.3051 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0615 0.012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1249 0.3569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0294 0.0324
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.7108 0.7108
Onchocerca volvulus Huntingtin homolog 0.012 0.2883 0.3852
Trichomonas vaginalis glutaminase, putative 0.0289 0.7429 0.9391
Echinococcus multilocularis cpg binding protein 0.0032 0.0532 0.0532
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.1146 0.1262
Toxoplasma gondii exonuclease III APE 0.004 0.0746 0.2104
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0294 0.0324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0324
Loa Loa (eye worm) hypothetical protein 0.0056 0.1183 0.1302
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0294 0.034
Brugia malayi beta-lactamase 0.0035 0.0615 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0804 0.258
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0294 0.0324
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0615 0.0677
Onchocerca volvulus 0.0194 0.4868 0.6805
Schistosoma mansoni cpg binding protein 0.0032 0.0532 0.0586
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0548 0.1737
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5064 0.6267
Onchocerca volvulus 0.0035 0.0615 0.0477
Echinococcus granulosus neutral alpha glucosidase AB 0.0074 0.1665 0.1665
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0294 0.034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0615 0.0677
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.1351 0.1351
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0294 0.034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0294 0.0294
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0294 0.0294
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0746 1
Brugia malayi hypothetical protein 0.012 0.2883 0.333

Activities

Activity type Activity value Assay description Source Reference
Ratio IC50 (binding) = 1.1 Ratio of estradiol IC50 to compound IC50 for ERbeta receptor by relative binding affinity assay ChEMBL. 21707083
Ratio IC50 (binding) = 1.3 Ratio of estradiol IC50 to compound IC50 for ERalpha receptor by relative binding affinity assay ChEMBL. 21707083

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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