Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0514 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0015 | 0.003 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0056 | 0.0518 | 0.1967 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 0.2894 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0514 | 0.1036 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0142 | 0.0142 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 0.2575 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.1528 | 0.3082 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0297 | 0.0683 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0095 | 0.0316 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0386 | 0.4958 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0297 | 0.06 |
Onchocerca volvulus | 0.004 | 0.0297 | 0.0982 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0116 | 0.0234 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0297 | 0.0982 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.1528 | 0.1528 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0095 | 0.0316 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.2514 | 0.5071 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0157 | 0.0157 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0116 | 0.076 |
Brugia malayi | hypothetical protein | 0.0148 | 0.176 | 0.355 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0086 | 0.0279 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0297 | 0.0683 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0015 | 0.0015 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.1528 | 0.3082 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1261 | 0.2543 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0157 | 0.1026 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0015 | 0.003 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.1528 | 0.3082 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0297 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0297 | 0.0982 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0297 | 0.06 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0297 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.0015 | 0.003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0116 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0297 | 0.06 |
Brugia malayi | beta-lactamase | 0.004 | 0.0297 | 0.06 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0015 | 0.0096 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0015 | 0.003 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0095 | 0.2858 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.0724 | 0.2771 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0015 | 0.5 |
Onchocerca volvulus | 0.0148 | 0.176 | 0.6062 | |
Onchocerca volvulus | 0.0233 | 0.2894 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0209 | 0.2575 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0254 | 0.3181 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0209 | 0.2575 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0297 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0297 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0157 | 0.1026 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1528 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0157 | 0.1026 |
Echinococcus multilocularis | smad | 0.0026 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.0015 | 0.003 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0026 | 0.0116 | 0.0116 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0297 | 0.1946 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0297 | 1 |
Onchocerca volvulus | 0.004 | 0.0297 | 0.0982 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.2514 | 0.5071 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0095 | 0.2858 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0015 | 0.0015 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0297 | 0.0982 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0297 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0297 | 0.06 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0015 | 0.003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1528 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0026 | 0.0116 | 0.0234 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0116 | 0.0234 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1528 | 1 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0086 | 0.0279 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0116 | 0.076 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0157 | 0.0316 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0297 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0297 | 0.06 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0157 | 0.5031 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0024 | 0.0086 | 0.0086 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.0015 | 0.003 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0297 | 0.0297 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0111 | 0.1261 | 0.8249 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.0015 | 0.003 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0026 | 0.0116 | 0.076 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0015 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0015 | 0.0015 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0386 | 0.4958 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0297 | 0.0683 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0026 | 0.0116 | 0.0116 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0276 | 0.1806 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0297 | 0.1946 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0297 | 0.06 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0297 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0276 | 0.0557 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0297 | 0.1104 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.0724 | 0.2771 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.0724 | 0.2771 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0297 | 0.0683 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0297 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0297 | 0.06 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0116 | 0.0234 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.1528 | 0.3082 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.176 | 0.355 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0026 | 0.0116 | 0.0116 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0297 | 0.1104 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0157 | 0.0157 |
Echinococcus granulosus | smad | 0.0026 | 0.0116 | 0.0116 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0086 | 0.0279 |
Onchocerca volvulus | 0.004 | 0.0297 | 0.0982 | |
Schistosoma mansoni | smad | 0.0026 | 0.0116 | 0.076 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0297 | 0.0982 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.0724 | 0.2771 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0514 | 0.1036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1528 | 1 |
Brugia malayi | Smad1 | 0.0026 | 0.0116 | 0.0234 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0297 | 0.06 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0026 | 0.0116 | 0.0234 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0095 | 0.0193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1528 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0015 | 0.003 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0065 | 0.0641 | 0.2445 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0116 | 0.076 |
Onchocerca volvulus | 0.0111 | 0.1261 | 0.4327 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0095 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0071 | 0.0724 | 0.2771 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.0015 | 0.003 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0157 | 0.1026 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 0.2575 | 1 |
Echinococcus multilocularis | Smad4 | 0.0026 | 0.0116 | 0.0116 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0015 | 0.0096 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0297 | 0.0683 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0015 | 0.003 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0024 | 0.0086 | 0.0086 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0297 | 0.0683 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0297 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0095 | 0.0316 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0514 | 0.1036 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0015 | 0.003 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0157 | 0.5031 |
Schistosoma mansoni | Smad4 | 0.0026 | 0.0116 | 0.076 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0297 | 0.1104 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0026 | 0.0116 | 0.0234 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.0724 | 0.2771 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0297 | 0.0683 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0026 | 0.0116 | 0.0116 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0297 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0386 | 0.4958 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.0724 | 0.2535 |
Echinococcus granulosus | Smad4 | 0.0026 | 0.0116 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0095 | 0.0193 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.0724 | 0.2771 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0297 | 0.0982 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.1528 | 0.3082 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0297 | 0.0982 |
Entamoeba histolytica | cysteine protease, putative | 0.0019 | 0.0015 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.0015 | 0.003 |
Brugia malayi | RNA binding protein | 0.0131 | 0.1528 | 0.3082 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0297 | 0.0683 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0297 | 0.0683 |
Onchocerca volvulus | 0.0029 | 0.0157 | 0.0494 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0297 | 0.0814 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0157 | 0.0316 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0297 | 0.06 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0095 | 1 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0024 | 0.0086 | 0.0248 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0276 | 0.0557 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.329 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.18 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.134 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Inhibition (binding) | = 26 % | Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate at 10 uM after 20 mins | ChEMBL. | 21788139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.