Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0285 | 0.0285 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0457 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1878 | 0.1878 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.4765 | 0.4765 |
Echinococcus granulosus | lamin | 0.003 | 0.0964 | 0.0964 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0355 | 0.0355 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0285 | 0.0285 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0457 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.4765 | 0.4765 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0457 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.1762 | 1 | |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.1762 | 0.1762 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0457 | 0.0457 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0457 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0457 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0964 | 0.0964 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0457 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0964 | 0.0964 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0457 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0964 | 0.0964 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0964 | 0.0964 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0964 | 0.5134 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.094 | 0.094 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0457 | 0.5 |
Echinococcus multilocularis | lamin | 0.003 | 0.0964 | 0.0964 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0457 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1878 | 0.1878 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0457 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0457 | 0.0457 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1878 | 0.1878 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0457 | 0.5 |
Echinococcus multilocularis | musashi | 0.003 | 0.0964 | 0.0964 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0457 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1762 | 0.9386 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0964 | 0.0964 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0457 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1878 | 0.1878 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0457 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0457 | 0.2434 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0355 | 0.0355 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0457 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1878 | 0.1878 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1878 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1878 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0457 | 0.2434 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.1762 | 0.9386 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0261 | 0.0261 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.4765 | 0.4765 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0457 | 0.5 |
Schistosoma mansoni | lamin | 0.003 | 0.0964 | 0.5134 |
Schistosoma mansoni | lamin | 0.003 | 0.0964 | 0.5134 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1878 | 0.1878 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0964 | 0.0964 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1878 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0261 | 0.0261 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0457 | 0.0457 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0964 | 0.0964 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of p38 phosphorylation in PMA-stimulated human U937 cells at 50 uM after 3 hrs by Western blotting | ChEMBL. | 19796943 | |
Inhibition (binding) | Inhibition of ERK1/2 phosphorylation in PMA-stimulated human U937 cells at 50 uM after 3 hrs by Western blotting | ChEMBL. | 19796943 | |
Inhibition (binding) | Inhibition of MEK1/2 phosphorylation in PMA-stimulated human U937 cells at 50 uM after 3 hrs by Western blotting | ChEMBL. | 19796943 | |
Inhibition (binding) | Inhibition of Elk1 phosphorylation in PMA-stimulated human U937 cells at 50 uM after 3 hrs by Western blotting | ChEMBL. | 19796943 | |
Inhibition (binding) | Inhibition of Rsk1 phosphorylation in PMA-stimulated human U937 cells at 50 uM after 3 hrs by Western blotting | ChEMBL. | 19796943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.