Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0251 | 0.0754 | 0.0796 |
Onchocerca volvulus | 0.0359 | 0.1132 | 0.1132 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0049 | 0.5 |
Brugia malayi | hypothetical protein | 0.005 | 0.0049 | 0.0056 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0261 | 0.0789 | 0.0899 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0105 | 0.0105 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0037 | 0.0003 | 0.0058 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0049 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0365 | 0.1151 | 0.1216 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0251 | 0.0754 | 0.0859 |
Echinococcus multilocularis | GPCR, family 2 | 0.0261 | 0.0789 | 0.0833 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.0754 | 0.0796 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0365 | 0.1151 | 0.1216 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0071 | 0.0122 | 0.2011 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.007 | 0.0119 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.1849 | 0.2108 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0089 | 0.0185 | 0.3056 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0066 | 0.0105 | 0.0915 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0042 | 0.0021 | 0.0353 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.006 | 0.006 |
Echinococcus granulosus | smad | 0.007 | 0.0119 | 0.0126 |
Loa Loa (eye worm) | RNA binding protein | 0.0251 | 0.0754 | 0.0859 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0058 | 0.0058 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0089 | 0.0185 | 0.0185 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.006 | 0.006 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.015 | 0.0401 | 0.0423 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0365 | 0.1151 | 0.1216 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0071 | 0.0122 | 0.2011 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0261 | 0.0789 | 0.0833 |
Echinococcus granulosus | GPCR family 2 | 0.0261 | 0.0789 | 0.0833 |
Schistosoma mansoni | smad1 5 8 and | 0.007 | 0.0119 | 0.0126 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0089 | 0.0185 | 0.0185 |
Brugia malayi | hypothetical protein | 0.015 | 0.0401 | 0.0457 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.007 | 0.0119 | 0.0136 |
Echinococcus granulosus | microtubule associated protein 2 | 0.2741 | 0.9465 | 1 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0071 | 0.0122 | 0.2011 |
Brugia malayi | MH2 domain containing protein | 0.007 | 0.0119 | 0.0136 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0105 | 0.0105 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0261 | 0.0789 | 0.0833 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.0675 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0049 | 0.0809 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.007 | 0.0119 | 0.0136 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0042 | 0.0042 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0121 | 0.0121 |
Schistosoma mansoni | Smad4 | 0.007 | 0.0119 | 0.0126 |
Echinococcus multilocularis | smad | 0.007 | 0.0119 | 0.0126 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0089 | 0.0185 | 0.3056 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.007 | 0.0119 | 0.0126 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0076 | 0.0139 | 0.0139 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0121 | 0.0121 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 0.0605 | 1 |
Onchocerca volvulus | 0.0365 | 0.1151 | 0.1151 | |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0401 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0564 | 0.1849 | 0.1954 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0105 | 0.0105 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.015 | 0.0401 | 0.0423 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0089 | 0.0185 | 0.0211 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2741 | 0.9465 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0261 | 0.0789 | 0.0899 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0059 | 0.0083 | 0.0083 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0049 | 0.0425 |
Schistosoma mansoni | hypothetical protein | 0.0261 | 0.0789 | 0.0833 |
Loa Loa (eye worm) | Smad1 | 0.007 | 0.0119 | 0.0136 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0058 | 0.0058 |
Echinococcus multilocularis | Smad4 | 0.007 | 0.0119 | 0.0126 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0049 | 0.0809 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0089 | 0.0185 | 0.3056 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1132 | 0.1291 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0089 | 0.0185 | 0.3056 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0121 | 0.0121 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0261 | 0.0789 | 0.0899 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0049 | 0.0809 |
Brugia malayi | RNA binding protein | 0.0251 | 0.0754 | 0.0859 |
Schistosoma mansoni | hypothetical protein | 0.0261 | 0.0789 | 0.0833 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0042 | 0.0042 |
Schistosoma mansoni | smad1 5 8 and | 0.007 | 0.0119 | 0.0126 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1026 | 0.3465 | 0.395 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0105 | 0.0105 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0251 | 0.0754 | 0.0859 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0401 | 0.0457 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0089 | 0.0185 | 0.0195 |
Brugia malayi | MH1 domain containing protein | 0.0039 | 0.001 | 0.0011 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0261 | 0.0789 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0049 | 0.0056 |
Loa Loa (eye worm) | nuclear factor I | 0.0039 | 0.001 | 0.0011 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0826 | 0.2763 | 0.315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.0754 | 0.0796 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0365 | 0.1151 | 0.1216 |
Brugia malayi | Pre-SET motif family protein | 0.0365 | 0.1151 | 0.1312 |
Loa Loa (eye worm) | TAR-binding protein | 0.0251 | 0.0754 | 0.0859 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0089 | 0.0185 | 0.0185 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.007 | 0.0119 | 0.0126 |
Echinococcus granulosus | tar DNA binding protein | 0.0251 | 0.0754 | 0.0796 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0401 | 0.0423 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.015 | 0.0401 | 0.0423 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0089 | 0.0185 | 0.0195 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0042 | 0.0042 |
Leishmania major | hypothetical protein, conserved | 0.0209 | 0.0605 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0365 | 0.1151 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0261 | 0.0789 | 0.0833 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0401 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0105 | 0.0105 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0564 | 0.1849 | 0.2108 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0049 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.2763 | 0.315 |
Schistosoma mansoni | smad1 5 8 and | 0.007 | 0.0119 | 0.0126 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.007 | 0.0119 | 0.0126 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0826 | 0.2763 | 0.315 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1026 | 0.3465 | 0.395 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0089 | 0.0185 | 0.3056 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0365 | 0.1151 | 0.1216 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2741 | 0.9465 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0042 | 0.0042 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0089 | 0.0185 | 0.0211 |
Brugia malayi | TAR-binding protein | 0.0251 | 0.0754 | 0.0859 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0351 | 0.1104 | 0.1166 |
Brugia malayi | Pre-SET motif family protein | 0.2543 | 0.8771 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.0754 | 0.0796 |
Schistosoma mansoni | smad | 0.007 | 0.0119 | 0.0126 |
Schistosoma mansoni | hypothetical protein | 0.0261 | 0.0789 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0789 | 0.0899 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.0754 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.001 | 0.0011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.0754 | 0.0796 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0401 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0359 | 0.1132 | 0.1196 |
Plasmodium vivax | SET domain protein, putative | 0.0365 | 0.1151 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.006 | 0.006 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0089 | 0.0185 | 0.0195 |
Brugia malayi | Smad1 | 0.007 | 0.0119 | 0.0136 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0042 | 0.0042 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0365 | 0.1151 | 0.1216 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0042 | 0.0042 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0049 | 0.0809 |
Brugia malayi | MH1 domain containing protein | 0.007 | 0.0119 | 0.0136 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0209 | 0.0605 | 1 |
Echinococcus granulosus | Smad4 | 0.007 | 0.0119 | 0.0126 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0261 | 0.0789 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1151 | 0.1312 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.007 | 0.0119 | 0.0126 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0089 | 0.0185 | 0.3056 |
Giardia lamblia | GTOR | 0.0089 | 0.0185 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0039 | 0.001 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0121 | 0.0121 |
Onchocerca volvulus | 0.015 | 0.0401 | 0.0401 | |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0401 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0826 | 0.2763 | 0.315 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0042 | 0.0042 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 0.0605 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0121 | 0.0121 |
Brugia malayi | hypothetical protein | 0.015 | 0.0401 | 0.0457 |
Brugia malayi | MH2 domain containing protein | 0.007 | 0.0119 | 0.0136 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0365 | 0.1151 | 0.1216 |
Brugia malayi | MH1 domain containing protein | 0.007 | 0.0119 | 0.0136 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0105 | 0.0105 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0058 | 0.0076 | 0.0076 |
Echinococcus granulosus | tumor protein p63 | 0.2456 | 0.8466 | 0.8945 |
Echinococcus multilocularis | tumor protein p63 | 0.2456 | 0.8466 | 0.8945 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.2543 | 0.8771 | 1 |
Brugia malayi | MH2 domain containing protein | 0.1026 | 0.3465 | 0.395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 0.5 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against 6 Hz electric shock-induced seizures at 100 mg/kg, ip after 0.25 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against subcutaneous metrazole-induced seizures at 300 mg/kg, ip after 0.5 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 4 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 0.5 hrs | ChEMBL. | 19286282 | |
Activity (ADMET) | Neurotoxicity in CF1 mouse at 100 mg/kg, ip after 4 hrs by rotarod test | ChEMBL. | 19286282 | |
Activity (ADMET) | Neurotoxicity in CF1 mouse at 300 mg/kg, ip after 0.5 hrs by rotarod test | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against 6 Hz electric shock-induced seizures at 100 mg/kg, ip after 4 hrs | ChEMBL. | 19286282 | |
Activity (ADMET) | Neurotoxicity in CF1 mouse at 30 mg/kg, ip after 4 hrs by rotarod test | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against subcutaneous metrazole-induced seizures at 100 mg/kg, ip after 4 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 0.5 hrs | ChEMBL. | 19286282 | |
Activity (ADMET) | Neurotoxicity in CF1 mouse at 100 mg/kg, ip after 0.5 hrs by rotarod test | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against subcutaneous metrazole-induced seizures at 30 mg/kg, ip after 4 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against subcutaneous metrazole-induced seizures at 300 mg/kg, ip after 4 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 4 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 4 hrs | ChEMBL. | 19286282 | |
Activity (ADMET) | Neurotoxicity in CF1 mouse at 30 mg/kg, ip after 0.5 hrs by rotarod test | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against subcutaneous metrazole-induced seizures at 30 mg/kg, ip after 0.5 hrs | ChEMBL. | 19286282 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against 6 Hz electric shock-induced seizures at 100 mg/kg, ip after 0.5 hrs | ChEMBL. | 19286282 | |
Activity (ADMET) | Neurotoxicity in CF1 mouse at 300 mg/kg, ip after 4 hrs by rotarod test | ChEMBL. | 19286282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.