TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.59 | Formula: C26H27N5OS
H donors: 3 H acceptors: 3 LogP: 5.34 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H](Nc1ccnc(n1)NCCc1ccccc1)Cc1ccccc1)NCc1cccs1
InChi: 1S/C26H27N5OS/c32-25(29-19-22-12-7-17-33-22)23(18-21-10-5-2-6-11-21)30-24-14-16-28-26(31-24)27-15-13-20-8-3-1-4-9-20/h1-12,14,16-17,23H,13,15,18-19H2,(H,29,32)(H2,27,28,30,31)/t23-/m0/s1
InChiKey: YMCNDMGXNRTWMD-QHCPKHFHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0465	0.1006
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0484	0.0484
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0479	0.1037
Mycobacterium leprae	Probable lipase LipE	0.0071	0.0988	1
Onchocerca volvulus		0.0095	0.1509	0.6432
Echinococcus granulosus	cathepsin b	0.0141	0.2523	0.2523
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0465	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.0988	1
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0053	0.0532
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.0988	0.1524
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0308	0.619	1
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0988	0.0906
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0812	0.1312
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0119	0.0119
Giardia lamblia	Cathepsin B precursor	0.0052	0.0561	0.5
Echinococcus granulosus	cathepsin b	0.0141	0.2523	0.2523
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0051	0.055	0.4802
Trypanosoma cruzi	hypothetical protein, conserved	0.0213	0.4098	1
Plasmodium vivax	vivapain-2	0.0048	0.0465	0.4704
Brugia malayi	beta-lactamase family protein	0.0071	0.0988	0.2139
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.2045	0.3246
Brugia malayi	Importin beta-1 subunit	0.0029	0.0053	0.0114
Schistosoma mansoni	importin beta-1	0.0029	0.0053	0.0085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.2523	0.4076
Schistosoma mansoni	cathepsin F (C01 family)	0.0048	0.0465	0.0751
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0148	0.032
Brugia malayi	Inositol-1	0.0037	0.0231	0.05
Onchocerca volvulus		0.0048	0.0465	0.1497
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Loa Loa (eye worm)	fibroinase	0.0048	0.0465	0.0672
Brugia malayi	hypothetical protein	0.0236	0.462	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.0988	0.0906
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0484	0.1047
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0119	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.0465	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0148	0.0155
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0988	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1509	0.2374
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0988	1
Onchocerca volvulus		0.0071	0.0988	0.397
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0479	0.0774
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0465	1
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0148	0.3182
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1509	0.2374
Leishmania major	hypothetical protein, conserved	0.0213	0.4098	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0119	0.0108
Brugia malayi	beta-lactamase	0.0071	0.0988	0.2139
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0051	0.055	0.1343
Onchocerca volvulus	Cathepsin L homolog	0.0048	0.0465	0.1497
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0988	0.1597
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0988	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0812	0.1312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0052	0.0561	0.137
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0933	0.1434
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0051	0.055	0.0435
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0231	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0812	0.1312
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0988	0.0906
Brugia malayi	cathepsin L-like precursor	0.0033	0.0148	0.032
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0231	0.0231
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.021	0.0339
Entamoeba histolytica	hypothetical protein	0.0036	0.021	0.4512
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0048	0.0465	0.0672
Trypanosoma cruzi	cruzipain precursor, putative	0.0048	0.0465	0.1134
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.0465	0.1134
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0129	0.2265	0.3659
Trypanosoma cruzi	prolyl endopeptidase	0.0129	0.2265	0.5526
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0465	0.1006
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0812	0.1312
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0484	0.0484
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0053	0.0128
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Loa Loa (eye worm)	beta-lactamase	0.0071	0.0988	0.1524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0231	0.4965
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0988	0.2411
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.1633	0.3535
Onchocerca volvulus		0.0048	0.0465	0.1497
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0033	0.0148	0.032
Echinococcus multilocularis	cathepsin b	0.0141	0.2523	0.2523
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0148	0.0155
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0988	0.1597
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0812	0.1312
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0988	1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0119	0.0258
Schistosoma mansoni	hypothetical protein	0.0048	0.0479	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0465	0.1006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0484	0.0781
Onchocerca volvulus	Cathepsin F homolog	0.0048	0.0465	0.1497
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.1633	0.3535
Trypanosoma cruzi	hypothetical protein, conserved	0.0213	0.4098	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0141	0.2523	0.6156
Echinococcus granulosus	snurportin 1	0.0308	0.619	0.619
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0988	0.1524
Schistosoma mansoni	hypothetical protein	0.0036	0.021	0.0339
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Leishmania major	oligopeptidase b	0.0051	0.055	0.0826
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0484	0.0484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Brugia malayi	RNA binding protein	0.0063	0.0812	0.1757
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0465	0.1006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0051	0.055	0.1343
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0051	0.055	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0988	0.1524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.0988	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0988	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0108
Schistosoma mansoni	cathepsin F (C01 family)	0.0048	0.0465	0.0751
Schistosoma mansoni	hypothetical protein	0.0069	0.0933	0.1507
Plasmodium falciparum	importin beta, putative	0.0029	0.0053	0.1132
Giardia lamblia	Cathepsin B precursor	0.0052	0.0561	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0048	0.0465	0.0465
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0095	0.1509	0.2439
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0812	0.1237
Toxoplasma gondii	cathepsin B	0.0052	0.0561	0.23
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.2045	0.3246
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0048	0.0465	0.0465
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0048	0.0465	0.0465
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0116	0.1966	0.1957
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0048	0.0465	1
Entamoeba histolytica	hypothetical protein	0.0036	0.021	0.4512
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0465	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0048	0.0465	0.4704
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0051	0.055	0.4217
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.2523	0.4076
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.0988	0.2411
Echinococcus multilocularis	cathepsin L cysteine protease	0.0048	0.0465	0.0465
Loa Loa (eye worm)	cysteine protease	0.0048	0.0465	0.0672
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0148	0.032
Mycobacterium ulcerans	beta-lactamase	0.0071	0.0988	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.0988	0.2139
Brugia malayi	hypothetical protein	0.0036	0.021	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0236	0.462	0.7442
Loa Loa (eye worm)	hypothetical protein	0.0141	0.2523	0.4025
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0193
Onchocerca volvulus		0.0048	0.0465	0.1497
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Brugia malayi	Trypsin family protein	0.0095	0.1509	0.3267
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0231	0.0231
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0988	0.2411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0988	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.462	0.462
Toxoplasma gondii	ABC1 family protein	0.0071	0.0988	0.423
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0484	0.0702
Echinococcus multilocularis	cysteine protease	0.0048	0.0465	0.0465
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0033	0.0148	0.0361
Brugia malayi	prolyl oligopeptidase family protein	0.0129	0.2265	0.4902
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Trichomonas vaginalis	esterase, putative	0.0071	0.0988	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0095	0.1509	0.2439
Giardia lamblia	Cathepsin B precursor	0.0052	0.0561	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0231	0.0806
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0129	0.2265	0.3659
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.0561	0.0907
Onchocerca volvulus		0.0087	0.1323	0.5554
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0193
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0231	0.0373
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.0988	0.0906
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0231	0.0563
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0988	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.1633	0.2576
Entamoeba histolytica	hypothetical protein	0.0036	0.021	0.4512
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.0988	0.0988
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.0988	0.0906
Echinococcus granulosus	cathepsin l1	0.0048	0.0465	0.0465
Schistosoma mansoni	hypothetical protein	0.0308	0.619	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0048	0.0465	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1633	0.2576
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0231	0.2336
Onchocerca volvulus		0.0048	0.0465	0.1497
Leishmania major	cysteine peptidase A (CPA)	0.0048	0.0465	0.0605
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0129	0.2265	1
Onchocerca volvulus		0.0071	0.0988	0.397
Echinococcus granulosus	GPCR family 2	0.0032	0.0119	0.0119
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.0988	0.0906
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0933	0.2018
Loa Loa (eye worm)	ctsf protein	0.0048	0.0465	0.0672
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0231	0.0563
Plasmodium vivax	vivapain-2	0.0048	0.0465	0.4704
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Mycobacterium ulcerans	lipase LipD	0.0071	0.0988	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0231	0.0373
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0148	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0465	0.0672
Onchocerca volvulus		0.0048	0.0479	0.1566
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.0988	1
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0988	1
Brugia malayi	TAR-binding protein	0.0063	0.0812	0.1757
Leishmania major	hypothetical protein, conserved	0.0071	0.0988	0.1959
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0193
Entamoeba histolytica	hypothetical protein	0.0036	0.021	0.4512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0484	0.0484
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.2523	0.4076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0048	0.0465	0.4704
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Trypanosoma brucei	hypothetical protein, conserved	0.0213	0.4098	1
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0129	0.2265	0.5259
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0988	0.1524
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0465	0.1006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.0465	0.1134
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0141	0.2523	0.4076
Toxoplasma gondii	cathepsin CPL	0.0048	0.0465	0.1864
Brugia malayi	RNA, U transporter 1	0.0082	0.1222	0.2645
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0048	0.0465	0.0465
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.0465	0.1134
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.0988	0.0988
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.462	0.462
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0465	0.1006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0193
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0048	0.0465	0.0672
Onchocerca volvulus		0.0071	0.0988	0.397
Echinococcus multilocularis	snurportin 1	0.0308	0.619	0.619
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0051	0.055	0.0826
Onchocerca volvulus	Cathepsin L homolog	0.0048	0.0465	0.1497
Onchocerca volvulus		0.0048	0.0465	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0988	0.1524
Echinococcus multilocularis	cysteine protease	0.0048	0.0465	0.0465
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0484	0.0781
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0812	0.1757
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0052	0.0561	0.137
Trypanosoma brucei	prolyl endopeptidase	0.0129	0.2265	0.5526
Brugia malayi	MH2 domain containing protein	0.0119	0.2045	0.4425
Echinococcus granulosus	cathepsin l1	0.0033	0.0148	0.0148
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.0988	0.0906
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.0988	0.0906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0148	0.1497
Brugia malayi	beta-lactamase family protein	0.0071	0.0988	0.2139
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0988	0.0906
Mycobacterium tuberculosis	Probable peptidase	0.0051	0.055	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0148	0.0155
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0052	0.0561	0.0855
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0051	0.055	0.1343
Echinococcus multilocularis	prolyl endopeptidase	0.0129	0.2265	0.2265
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0053	0.0128
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0231	0.2336
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0812	0.0812
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0053	0.0053
Onchocerca volvulus		0.0048	0.0465	0.1497
Trypanosoma cruzi	oligopeptidase b	0.0051	0.055	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0988	0.1524
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0988	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0119	0.0119
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.021	0.021
Leishmania major	cathepsin L-like protease	0.0048	0.0465	0.0605
Toxoplasma gondii	prolyl endopeptidase	0.0129	0.2265	1
Loa Loa (eye worm)	inositol-1	0.0037	0.0231	0.029
Onchocerca volvulus		0.0048	0.0465	0.1497
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0812	0.0812
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Echinococcus granulosus	prolyl endopeptidase	0.0129	0.2265	0.2265
Trypanosoma cruzi	oligopeptidase b	0.0051	0.055	0.1343
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0119	0.0119
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0484	0.0781
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0812	0.1237
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0231	0.0563
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0119	0.0119
Echinococcus multilocularis	cathepsin L cysteine protease	0.0048	0.0465	0.0465
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0456	0.9448	1
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0465	0.1006
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0052	0.0561	0.568
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0231	0.2336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0465	0.4704
Echinococcus multilocularis	cathepsin b	0.0141	0.2523	0.2523
Trypanosoma brucei	oligopeptidase b	0.0051	0.055	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2265	0.3604
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0812	0.1237
Loa Loa (eye worm)	cathepsin B	0.0052	0.0561	0.0829
Brugia malayi	cathepsin B-like cysteine proteinase	0.0141	0.2523	0.546
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0048	0.0465	1
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0119	0.0119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0465	0.1134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0465	0.4704
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0148	0.1497

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL582043

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1079655