TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 257.331 | Formula: C15H19N3O
H donors: 1 H acceptors: 3 LogP: 3.36 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1nnc[nH]1)CCCCCCc1ccccc1
InChi: 1S/C15H19N3O/c19-14(15-16-12-17-18-15)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H,16,17,18)
InChiKey: QGFMPQSHPGJYBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References
Homo sapiens	diacylglycerol lipase, alpha	Starlite/ChEMBL	References
Homo sapiens	fatty acid amide hydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	lipase containing protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma brucei	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	Get druggable targets OG5_129115	All targets in OG5_129115
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma brucei	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Onchocerca volvulus		Get druggable targets OG5_129115	All targets in OG5_129115
Brugia malayi	Lipase family protein	Get druggable targets OG5_129115	All targets in OG5_129115
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	lipase	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma congolense	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Leishmania donovani	Lipase (class 3), putative	Get druggable targets OG5_129115	All targets in OG5_129115
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma brucei gambiense	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	lipase containing protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %
Leishmania major	hypothetical protein, conserved	fatty acid amide hydrolase	579 aa	471 aa	26.5 %
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	glutathione reductase	0.0089	0.034	1
Onchocerca volvulus		0.0071	0.0237	0.1999
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0237	0.0766
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.0173	0.0809	0.0803
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0237	0.0866
Loa Loa (eye worm)	twinkle helicase	0.011	0.0458	0.1538
Schistosoma mansoni	intermediate filament proteins	0.0057	0.016	0.0369
Mycobacterium leprae	Probable lipase LipE	0.0071	0.0237	0.0866
Trichomonas vaginalis	lipase containing protein, putative	0.0173	0.0809	0.2714
Toxoplasma gondii	ABC1 family protein	0.0071	0.0237	0.693
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0237	0.0787
Treponema pallidum	replicative DNA helicase (dnaB)	0.0386	0.2005	1
Plasmodium vivax	glutathione reductase, putative	0.0089	0.034	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0031	0.0013	0.0202
Plasmodium vivax	SET domain protein, putative	0.003	0.0006	0.0004
Onchocerca volvulus		0.0071	0.0237	0.1999
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0203	0.0981	0.1028
Echinococcus granulosus	lamin	0.0057	0.016	0.0383
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0089	0.034	0.0352
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0031	0.0013	0.0084
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.1163	0.3921
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0203	0.0981	0.1028
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0237	0.0554
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0031	0.0013	0.0023
Echinococcus multilocularis	lamin dm0	0.0057	0.016	0.0154
Entamoeba histolytica	hypothetical protein	0.004	0.0066	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0057	0.016	0.0524
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0031	0.0013	0.0198
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0066	0.006
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0031	0.0013	0.0023
Leishmania major	trypanothione reductase	0.0089	0.034	0.4157
Brugia malayi	Lipase family protein	0.0173	0.0809	0.2731
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0066	0.0143
Loa Loa (eye worm)	glutaminase 2	0.0554	0.2946	1
Brugia malayi	hypothetical protein	0.004	0.0066	0.0203
Mycobacterium tuberculosis	Probable oxidoreductase	0.0226	0.1108	0.1163
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.0237	0.0244
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0153	0.05
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1221	0.4132
Echinococcus granulosus	lamin dm0	0.0057	0.016	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0237	0.0787
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0006	0.0015
Schistosoma mansoni	hypothetical protein	0.017	0.0793	0.1887
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0153	0.05
Schistosoma mansoni	hypothetical protein	0.017	0.0793	0.1887
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0237	0.2881
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.0237	0.0244
Loa Loa (eye worm)	beta-lactamase	0.0071	0.0237	0.0787
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0203	0.0981	0.3648
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0066	0.0157
Plasmodium falciparum	glutathione reductase	0.0031	0.0013	0.0202
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0031	0.0013	0.0084
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0031	0.0013	0.0023
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0011	0.0018
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.0237	0.0787
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0153	0.05
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0226	0.1108	0.4125
Leishmania major	hypothetical protein, conserved	0.0071	0.0237	0.2881
Echinococcus multilocularis	lamin	0.0057	0.016	0.0154
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.0237	0.2881
Mycobacterium ulcerans	glutaminase	0.0554	0.2946	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0237	0.0787
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0246	0.1221	0.2922
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0031	0.0013	0.0202
Brugia malayi	glutathione reductase	0.0089	0.034	0.1135
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0011	0.0018
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0203	0.0981	0.1028
Mycobacterium leprae	Conserved hypothetical protein	0.0506	0.2677	1
Mycobacterium tuberculosis	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].	0.1333	0.7318	0.7715
Onchocerca volvulus		0.0236	0.1163	1
Plasmodium falciparum	thioredoxin reductase	0.0089	0.034	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.1002	0.3388
Schistosoma mansoni	lamin	0.0057	0.016	0.0369
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0237	0.0244
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0237	0.0244
Entamoeba histolytica	hypothetical protein	0.004	0.0066	0.5
Brugia malayi	beta-lactamase family protein	0.0071	0.0237	0.0787
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.0237	0.0787
Trichomonas vaginalis	esterase, putative	0.0071	0.0237	0.0766
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.0237	0.0244
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0031	0.0013	0.0016
Trypanosoma brucei	lipase domain protein, putative	0.0173	0.0809	1
Brugia malayi	intermediate filament protein	0.0057	0.016	0.0524
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.0237	0.0244
Mycobacterium ulcerans	beta-lactamase	0.0071	0.0237	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0054	0.0162
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0031	0.0013	0.0202
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0246	0.1221	0.2922
Onchocerca volvulus		0.0057	0.016	0.1331
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0203	0.0981	0.1028
Schistosoma mansoni	hypothetical protein	0.0038	0.0054	0.0114
Loa Loa (eye worm)	lipase	0.0173	0.0809	0.2731
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.0237	0.0244
Schistosoma mansoni	glutaminase	0.0554	0.2946	0.7045
Mycobacterium tuberculosis	Probable replicative DNA helicase DnaB	0.1719	0.9483	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0031	0.0013	0.0084
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0031	0.0013	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.0237	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0154	0.0504
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0031	0.0013	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0237	0.0787
Toxoplasma gondii	thioredoxin reductase	0.0089	0.034	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0153	0.05
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0031	0.0013	0.0084
Echinococcus granulosus	intermediate filament protein	0.0057	0.016	0.0383
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.0173	0.0809	0.1935
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0031	0.0013	0.0202
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.0237	0.0231
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0453	0.2381	0.2506
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0031	0.0013	0.0034
Brugia malayi	Pre-SET motif family protein	0.0207	0.1002	0.3388
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0031	0.0013	0.0034
Trypanosoma cruzi	hypothetical protein, conserved	0.0173	0.0809	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.009	0.0343	0.0337
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0237	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0057	0.016	0.0524
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0237	0.0766
Echinococcus granulosus	thioredoxin glutathione reductase	0.009	0.0343	0.082
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0057	0.016	0.0524
Leishmania major	hypothetical protein, conserved	0.0173	0.0809	1
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0237	0.6931
Brugia malayi	glutaminase DH11.1	0.0554	0.2946	1
Mycobacterium leprae	PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase	0.0386	0.2005	0.7484
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0246	0.1221	0.1215
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Schistosoma mansoni	microtubule-associated protein tau	0.0773	0.4178	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0031	0.0013	0.0023
Schistosoma mansoni	fatty-acid amide hydrolase	0.0246	0.1221	0.2911
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0031	0.0013	0.0007
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0237	0.0787
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0237	0.2881
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0237	0.0766
Mycobacterium tuberculosis	Probable reductase	0.0203	0.0981	0.1028
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0237	0.0244
Onchocerca volvulus		0.0173	0.0809	0.694
Schistosoma mansoni	Replicative DNA helicase	0.0386	0.2005	0.4791
Trypanosoma brucei	lipase domain protein, putative	0.0173	0.0809	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.0237	0.0787
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0237	0.0554
Brugia malayi	Thioredoxin reductase	0.0089	0.034	0.1135
Toxoplasma gondii	NADPH-glutathione reductase	0.0031	0.0013	0.0198
Onchocerca volvulus		0.0071	0.0237	0.1999
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0246	0.1221	0.1215
Onchocerca volvulus		0.0057	0.016	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0237	0.0787
Schistosoma mansoni	lamin	0.0057	0.016	0.0369
Brugia malayi	amidase	0.0246	0.1221	0.4132
Mycobacterium ulcerans	replicative DNA helicase DnaB	0.0386	0.2005	0.68
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0031	0.0013	0.0084
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Loa Loa (eye worm)	thioredoxin reductase	0.0089	0.034	0.1135
Trypanosoma brucei	trypanothione reductase	0.0089	0.034	0.4157
Trichomonas vaginalis	glutaminase, putative	0.0554	0.2946	1
Entamoeba histolytica	hypothetical protein	0.004	0.0066	0.5
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Brugia malayi	beta-lactamase family protein	0.0071	0.0237	0.0787
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0054	0.0162
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0226	0.1108	0.1163
Mycobacterium ulcerans	lipase LipD	0.0071	0.0237	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0237	0.0787
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Loa Loa (eye worm)	glutaminase	0.0554	0.2946	1
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0806	0.2705
Brugia malayi	beta-lactamase	0.0071	0.0237	0.0787
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0031	0.0013	0.003
Chlamydia trachomatis	replicative DNA helicase	0.0386	0.2005	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0031	0.0013	0.0007
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0031	0.0013	0.0084
Treponema pallidum	NADH oxidase	0.0031	0.0013	0.0034
Echinococcus granulosus	geminin	0.017	0.0793	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0833	0.2815
Trypanosoma cruzi	trypanothione reductase, putative	0.0089	0.034	0.4157
Echinococcus granulosus	fatty acid amide hydrolase 1	0.003	0.0006	0.0014
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.0237	0.0244
Plasmodium vivax	thioredoxin reductase, putative	0.0089	0.034	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0031	0.0013	0.0084
Loa Loa (eye worm)	intermediate filament protein	0.0057	0.016	0.0524
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0226	0.1108	0.1163
Echinococcus multilocularis	geminin	0.017	0.0793	0.0788
Echinococcus multilocularis	microtubule associated protein 2	0.0773	0.4178	0.4175
Schistosoma mansoni	hypothetical protein	0.004	0.0066	0.0143
Entamoeba histolytica	hypothetical protein	0.004	0.0066	0.5
Trichomonas vaginalis	lipase containing protein, putative	0.0173	0.0809	0.2714
Echinococcus multilocularis	musashi	0.0057	0.016	0.0154
Trypanosoma cruzi	trypanothione reductase, putative	0.0031	0.0013	0.0084
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.0237	0.0787
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.0237	0.0244
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.003	0.0006	0.0014
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0031	0.0013	0.0084
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0237	0.0766
Plasmodium falciparum	thioredoxin reductase	0.0031	0.0013	0.0202
Trypanosoma cruzi	hypothetical protein, conserved	0.0173	0.0809	1
Wolbachia endosymbiont of Brugia malayi	replicative DNA helicase	0.0386	0.2005	1
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0177	0.0833	0.2815
Mycobacterium tuberculosis	Probable dehydrogenase	0.0203	0.0981	0.1028
Echinococcus granulosus	microtubule associated protein 2	0.0773	0.4178	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0013	0.0084
Schistosoma mansoni	amidase	0.0246	0.1221	0.2911
Loa Loa (eye worm)	glutathione reductase	0.0089	0.034	0.1135

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 5	Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay	ChEMBL.	26584396
Ki (binding)	> 1000 nM	Inhibition of FAAH	ChEMBL.	18983142
Ki (binding)	> 1000 nM	Inhibition of rat FAAH expressed in Escherichia coli at pH 9.0	ChEMBL.	18630870

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL499698

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1176606