Detailed information for compound 1176865

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 220.698 | Formula: C12H13ClN2
  • H donors: 0 H acceptors: 1 LogP: 3.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)ncn2C1CCCC1
  • InChi: 1S/C12H13ClN2/c13-9-5-6-12-11(7-9)14-8-15(12)10-3-1-2-4-10/h5-8,10H,1-4H2
  • InChiKey: MALJBBGZYFOXJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0323 0.364
Schistosoma mansoni kinase 0.0047 0.0192 0.0497
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0323 0.1259
Echinococcus granulosus importin subunit beta 1 0.0063 0.0283 0.0732
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0167 0.1653
Brugia malayi MH2 domain containing protein 0.0032 0.0104 0.0389
Loa Loa (eye worm) inositol-1 0.0043 0.0167 0.0436
Loa Loa (eye worm) MH2 domain-containing protein 0.0472 0.2666 0.6952
Trypanosoma brucei unspecified product 0.0019 0.0027 0.0232
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0019
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1279 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0167 0.1653
Leishmania major importin beta-1 subunit, putative 0.0051 0.0214 0.2386
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.046 0.3455
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0061 0.0625
Echinococcus granulosus chromobox protein 1 0.0069 0.0317 0.0819
Leishmania major DNA polymerase eta, putative 0.0019 0.0027 0.0232
Brugia malayi TAR-binding protein 0.0124 0.0637 0.239
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0283 0.3187
Onchocerca volvulus 0.0041 0.0154 0.1201
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.007 0.0323 0.0841
Mycobacterium tuberculosis Conserved protein 0.007 0.0323 0.1259
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0104 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0235 0.0608
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0317 0.2316
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0141 0.1102
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0164 0.0874 1
Brugia malayi Importin beta-1 subunit 0.0063 0.0283 0.1063
Schistosoma mansoni hypothetical protein 0.0081 0.0386 0.0997
Schistosoma mansoni Smad4 0.0032 0.0104 0.0268
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0186 0.2069
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0061 0.0625
Schistosoma mansoni hypothetical protein 0.0673 0.3834 0.9904
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0235 0.0235
Leishmania major GTP-binding protein, putative 0.0046 0.0186 0.2069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0323 0.0833
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.006 0.0268 0.3007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Entamoeba histolytica hypothetical protein 0.0042 0.0161 0.1576
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0386 0.1448
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0027 0.0071
Entamoeba histolytica hypothetical protein 0.0042 0.0161 0.1576
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.023
Chlamydia trachomatis phosphoglycerate kinase 0.0164 0.0874 0.5
Echinococcus granulosus GPCR family 2 0.0081 0.0386 0.0997
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.14 0.5254
Loa Loa (eye worm) transcription factor SMAD2 0.0472 0.2666 0.6952
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0104 0.0268
Brugia malayi MH1 domain containing protein 0.0018 0.002 0.0075
Mycobacterium ulcerans beta-lactamase 0.007 0.0323 0.3488
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.0637 0.1662
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0637 0.1646
Onchocerca volvulus 0.007 0.0323 0.2521
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0323 0.0323
Trypanosoma brucei phosphoglycerate kinase 0.006 0.0268 0.3007
Mycobacterium ulcerans lipase LipD 0.007 0.0323 0.3488
Trichomonas vaginalis esterase, putative 0.007 0.0323 0.2359
Echinococcus multilocularis geminin 0.0679 0.3871 0.3871
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0186 0.0481
Schistosoma mansoni hypothetical protein 0.0081 0.0386 0.0997
Schistosoma mansoni hypothetical protein 0.0679 0.3871 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0323 0.0841
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0386 0.0997
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0088 0.0227
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0931 0.3492
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0235 0.0608
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0167 0.1847
Brugia malayi beta-lactamase 0.007 0.0323 0.121
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0167 0.1118
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0323 0.2359
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0158 0.1045
Mycobacterium tuberculosis Conserved protein 0.007 0.0323 0.1259
Echinococcus multilocularis chromobox protein 1 0.0069 0.0317 0.0317
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0167 0.0167
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0186 0.0486
Entamoeba histolytica Ran family GTPase 0.0046 0.0186 0.188
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0446 0.2512 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0186 0.0186
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0164 0.0874 0.346
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0164 0.0874 1
Brugia malayi MH2 domain containing protein 0.0472 0.2666 1
Schistosoma mansoni chromobox protein 0.0069 0.0317 0.0819
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0186 0.0699
Mycobacterium ulcerans hypothetical protein 0.007 0.0323 0.3488
Echinococcus granulosus dna polymerase eta 0.0019 0.0027 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.046 0.3455
Echinococcus granulosus chromobox protein 1 0.0069 0.0317 0.0819
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0052
Entamoeba histolytica phosphoglycerate kinase, putative 0.0164 0.0874 1
Trichomonas vaginalis ran, putative 0.0046 0.0186 0.1271
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0088 0.0227
Plasmodium vivax importin-beta 2, putative 0.0063 0.0283 0.3187
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.046 0.5223
Trypanosoma brucei polo-like protein kinase 0.0093 0.046 0.5223
Plasmodium falciparum importin beta, putative 0.0063 0.0283 0.3187
Echinococcus granulosus geminin 0.0679 0.3871 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0283 0.0739
Entamoeba histolytica hypothetical protein 0.0042 0.0161 0.1576
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0186 0.2069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0235 0.0608
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0164 0.0874 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0323 0.3488
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0061 0.0625
Brugia malayi beta-lactamase family protein 0.007 0.0323 0.121
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0186 0.2069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0088 0.0227
Schistosoma mansoni smad 0.0032 0.0104 0.0268
Loa Loa (eye worm) Smad1 0.0032 0.0104 0.027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0088 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.007 0.0323 0.0841
Echinococcus granulosus phosphoglycerate kinase 1 0.0164 0.0874 0.2257
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0386 0.0386
Leishmania major phosphoglycerate kinase C, glycosomal 0.0164 0.0874 1
Leishmania major hypothetical protein, conserved 0.007 0.0323 0.364
Onchocerca volvulus 0.007 0.0323 0.2521
Loa Loa (eye worm) hypothetical protein 0.0174 0.0931 0.2428
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0102
Brugia malayi RNA binding protein 0.0124 0.0637 0.239
Mycobacterium tuberculosis Conserved protein 0.007 0.0323 0.1259
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Loa Loa (eye worm) beta-lactamase 0.007 0.0323 0.0841
Onchocerca volvulus 0.007 0.0323 0.2521
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.006 0.0268 0.3007
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.0909
Echinococcus multilocularis phosphoglycerate kinase 1 0.0164 0.0874 0.0874
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0214 0.1491
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0167 0.1847
Schistosoma mansoni inositol monophosphatase 0.0043 0.0167 0.0432
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0386 0.0997
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0167 0.1847
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0167 0.1847
Echinococcus multilocularis GPCR, family 2 0.0081 0.0386 0.0386
Brugia malayi Phosphoglycerate kinase 0.006 0.0268 0.1004
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0323 0.2359
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.046 0.3455
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0164 0.0874 1
Loa Loa (eye worm) TAR-binding protein 0.0124 0.0637 0.1662
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0164 0.0874 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0323 0.364
Brugia malayi MH2 domain containing protein 0.0032 0.0104 0.0389
Brugia malayi MH1 domain containing protein 0.0032 0.0104 0.0389
Leishmania major phosphoglycerate kinase B, cytosolic 0.0164 0.0874 1
Brugia malayi Pre-SET motif family protein 0.0206 0.1114 0.4178
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0323 0.364
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.046 0.5223
Mycobacterium leprae Probable lipase LipE 0.007 0.0323 0.2479
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0185 0.1263
Schistosoma mansoni importin beta-1 0.0063 0.0283 0.0732
Brugia malayi MH1 domain containing protein 0.0032 0.0104 0.0389
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0317 0.0827
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0323 0.1259
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0386 0.0386
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.046 0.5223
Schistosoma mansoni phosphoglycerate kinase 0.0164 0.0874 0.2257
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.046 0.3455
Loa Loa (eye worm) hypothetical protein 0.0164 0.0874 0.2279
Schistosoma mansoni DNA polymerase eta 0.0019 0.0027 0.007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0088 0.0088
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0104 0.0104
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0027 0.0232
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0323 0.2359
Giardia lamblia Kinase, PLK 0.0093 0.046 0.511
Onchocerca volvulus 0.0234 0.1279 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0235 0.0608
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0186 0.188
Leishmania major hypothetical protein, conserved 0.0025 0.0061 0.0625
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0241
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.046 0.3455
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.046 0.1199
Echinococcus granulosus dna polymerase kappa 0.0019 0.0027 0.007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0323 0.121
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.046 0.046
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.006 0.0268 0.3007
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0164 0.0874 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0637 0.1646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0235 0.0608
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0158 0.1236
Leishmania major DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0027 0.008
Brugia malayi hypothetical protein 0.0016 0.001 0.0037
Brugia malayi chromobox protein homolog 3 0.0039 0.0141 0.0529
Echinococcus multilocularis smad 0.0032 0.0104 0.0104
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0161 0.0415
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.14 0.5254
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0637 0.1646
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.007 0.0323 0.0841
Schistosoma mansoni inositol monophosphatase 0.0043 0.0167 0.0432
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0323 0.0833
Plasmodium vivax phosphoglycerate kinase, putative 0.0164 0.0874 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0061 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0075 0.0385
Schistosoma mansoni ran 0.0046 0.0186 0.0481
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0158 0.1045
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0283 0.3187
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0386 0.1448
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0027 0.007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0323 0.3488
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0186 0.2069
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0186 0.2069
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0323 0.2359
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0027 0.0232
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0141 0.0534
Echinococcus multilocularis dna polymerase eta 0.0019 0.0027 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1114 0.2905
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0232
Echinococcus multilocularis Smad4 0.0032 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.007 0.0323 0.0841
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0161 0.0415
Brugia malayi Pre-SET motif family protein 0.0029 0.0088 0.033
Schistosoma mansoni hypothetical protein 0.0679 0.3871 1
Schistosoma mansoni hypothetical protein 0.0042 0.0161 0.0415
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0323 0.1259
Loa Loa (eye worm) nuclear factor I 0.0018 0.002 0.0052
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0027 0.008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0637 0.1646
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Echinococcus granulosus tar DNA binding protein 0.0124 0.0637 0.1646
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0186 0.2069
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0104 0.027
Loa Loa (eye worm) hypothetical protein 0.0081 0.0386 0.1006
Toxoplasma gondii ABC1 family protein 0.007 0.0323 0.364
Plasmodium vivax SET domain protein, putative 0.0029 0.0088 0.0934
Brugia malayi RNA, U transporter 1 0.0179 0.096 0.3601
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0102
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0323 0.2359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0235 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0154 0.0397
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0042 0.0161 0.1576
Trypanosoma cruzi phosphoglycerate kinase, putative 0.006 0.0268 0.3007
Loa Loa (eye worm) RNA binding protein 0.0124 0.0637 0.1662
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0167 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Trypanosoma brucei phosphoglycerate kinase 0.0164 0.0874 1
Brugia malayi Heterochromatin protein 1 0.0069 0.0317 0.119
Entamoeba histolytica hypothetical protein 0.0051 0.0214 0.2205
Schistosoma mansoni ran 0.0046 0.0186 0.0481
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0323 0.1259
Brugia malayi MH1 domain containing protein 0.0018 0.002 0.0075
Plasmodium falciparum phosphoglycerate kinase 0.0164 0.0874 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0061 0.0625
Brugia malayi hypothetical protein 0.0025 0.0061 0.023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0323 0.0833
Trypanosoma brucei phosphoglycerate kinase, putative 0.006 0.0268 0.3007
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.0637 0.239
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0161 0.0161
Treponema pallidum phosphoglycerate kinase 0.0164 0.0874 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0082 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.0909
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.046 0.3455
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0317 0.2316
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0214 0.2386
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0027 0.007
Echinococcus multilocularis snurportin 1 0.0673 0.3834 0.3834
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.046 0.1188
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0214 0.1491
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0232
Schistosoma mansoni hypothetical protein 0.0174 0.0931 0.2405
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.046 0.1188
Trypanosoma cruzi phosphoglycerate kinase, putative 0.006 0.0268 0.3007
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0164 0.0874 0.6762
Schistosoma mansoni chromobox protein 0.0069 0.0317 0.0819
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0323 0.1259
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0104 0.0268
Trypanosoma brucei phosphoglycerate kinase 0.0164 0.0874 1
Onchocerca volvulus 0.003 0.0092 0.0723
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0167 0.1847
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0027 0.0232
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.14 0.3653
Brugia malayi beta-lactamase family protein 0.007 0.0323 0.121
Brugia malayi Inositol-1 0.0043 0.0167 0.0627
Giardia lamblia Phosphoglycerate kinase 0.0164 0.0874 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0317 0.0317
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.046 0.1725
Echinococcus granulosus Smad4 0.0032 0.0104 0.0268
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.046 0.511
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0061 0.0625
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0386 0.1006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0214 0.1491
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0088 0.0227
Plasmodium vivax hypothetical protein, conserved 0.007 0.0323 0.364
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0104 0.0268
Echinococcus multilocularis tar DNA binding protein 0.0124 0.0637 0.0637
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0235 0.0614
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0323 0.1259
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0061 0.0625
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0164 0.0874 0.6762
Schistosoma mansoni hypothetical protein 0.0081 0.0386 0.0997
Mycobacterium leprae conserved hypothetical protein 0.007 0.0323 0.2479
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Schistosoma mansoni phosphoglycerate kinase 0.0164 0.0874 0.2257
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0323 0.0841
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0185 0.1263
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0673 0.3834 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0104 0.0104
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0167 0.1118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0323 0.1259
Schistosoma mansoni smad1 5 8 and 0.0032 0.0104 0.0268
Schistosoma mansoni smad1 5 8 and 0.0032 0.0104 0.0268
Brugia malayi Smad1 0.0032 0.0104 0.0389
Echinococcus granulosus smad 0.0032 0.0104 0.0268
Loa Loa (eye worm) hypothetical protein 0.0025 0.0061 0.016
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0283 0.3187
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0167 0.1118
Mycobacterium ulcerans phosphoglycerate kinase 0.0164 0.0874 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0368
Schistosoma mansoni hypothetical protein 0.0081 0.0386 0.0997
Echinococcus granulosus snurportin 1 0.0673 0.3834 0.9904
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.046 0.3594
Loa Loa (eye worm) hypothetical protein 0.007 0.0323 0.0841
Brugia malayi hypothetical protein 0.0042 0.0161 0.0603
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0088 0.0934
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0637 0.1646
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0235 0.0883
Schistosoma mansoni smad1 5 8 and 0.0032 0.0104 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0075 0.0385
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.046 0.3455
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.006 0.0268 0.3007
Brugia malayi Phosphoglycerate kinase 0.0164 0.0874 0.3278
Loa Loa (eye worm) hypothetical protein 0.0255 0.14 0.3653

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) >= 50 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 by tube dilution method ChEMBL. 18718694
MIC (functional) = 50 ug ml-1 Antimicrobial activity against Candida albicans ATCC 10145 by tube dilution method ChEMBL. 18718694

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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