Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Brugia malayi | glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Plasmodium vivax | vivapain-2 | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Leishmania major | trypanothione reductase | 0.0105 | 0.261 | 0.5066 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Echinococcus granulosus | cathepsin l1 | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0105 | 0.261 | 0.5066 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0149 | 0.5152 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0105 | 0.261 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0976 | 0.1895 |
Toxoplasma gondii | thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.2305 | 0.4474 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0149 | 0.5152 | 0.5152 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin L | 0.0077 | 0.0976 | 0.1895 |
Loa Loa (eye worm) | ctsf protein | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0105 | 0.261 | 0.5066 |
Plasmodium vivax | vivapain-1 | 0.0077 | 0.0976 | 0.1895 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0.2305 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.0976 | 0.1895 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0105 | 0.261 | 0.5066 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0149 | 0.5152 | 0.5152 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.01 | 0.2305 | 0.4474 |
Brugia malayi | Thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.01 | 0.2305 | 0.4474 |
Leishmania major | cysteine peptidase A (CPA) | 0.0149 | 0.5152 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0077 | 0.0976 | 0.1895 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0105 | 0.261 | 0.5066 |
Plasmodium falciparum | thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.01 | 0.2305 | 0.2305 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0105 | 0.261 | 0.107 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0077 | 0.0976 | 0.1895 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0976 | 0.1895 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0105 | 0.261 | 0.107 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cysteine protease | 0.0077 | 0.0976 | 0.1895 |
Onchocerca volvulus | Cathepsin F homolog | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | vivapain-3 | 0.0077 | 0.0976 | 0.1895 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.2305 | 0.4474 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Plasmodium vivax | unspecified product | 0.0077 | 0.0976 | 0.1895 |
Echinococcus granulosus | cathepsin l1 | 0.01 | 0.2305 | 0.4474 |
Plasmodium vivax | vivapain-2 | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0077 | 0.0976 | 0.1895 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0149 | 0.5152 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cleavage (functional) | = 5 ug ml-1 | In vitro concentration inhibiting DNA gyrase induced cleavage in E. coli H560. | ChEMBL. | 1366133 |
MIC (functional) | = 0.8 ug ml-1 | In vitro antibacterial activity against gram negative E. coli Vogel. | ChEMBL. | 1366133 |
PD50 (functional) | = 0.4 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by E. coli vogel on subcutaneous injection. | ChEMBL. | 1366133 |
PD50 (functional) | = 1.3 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by E. coli Vogel on oral administration by gavage. | ChEMBL. | 1366133 |
PD50 (functional) | = 2 mg kg-1 | In vivo potency of the compound against acute systemic infection in mouse caused by P. aeruginosa. UI-18. on subcutaneous injection. | ChEMBL. | 1366133 |
PD50 (functional) | = 3 mg kg-1 | In vivo potency of the compound against acute systemic infection in mouse caused by P. aeruginosa UI-18 on oral administration by gavage. | ChEMBL. | 1366133 |
PD50 (functional) | = 10 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by S. pyogenes C-203 on subcutaneous injection | ChEMBL. | 1366133 |
PD50 (functional) | = 22 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by S. pyogenes C-203 on oral administration by gavage | ChEMBL. | 1366133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.