Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0149 | 0.5152 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0077 | 0.0976 | 0.1895 |
Loa Loa (eye worm) | cysteine protease | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.01 | 0.2305 | 0.2305 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0149 | 0.5152 | 0.5152 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0077 | 0.0976 | 0.1895 |
Plasmodium vivax | vivapain-1 | 0.0077 | 0.0976 | 0.1895 |
Plasmodium vivax | vivapain-3 | 0.0077 | 0.0976 | 0.1895 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | vivapain-2 | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin L | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0105 | 0.261 | 0.5066 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0149 | 0.5152 | 1 |
Leishmania major | trypanothione reductase | 0.0105 | 0.261 | 0.5066 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Brugia malayi | cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.2305 | 0.4474 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0077 | 0.0976 | 0.1895 |
Echinococcus granulosus | cysteine protease | 0.0077 | 0.0976 | 0.1895 |
Echinococcus granulosus | cathepsin l1 | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0077 | 0.0976 | 0.1895 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0105 | 0.261 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0077 | 0.0976 | 0.1895 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0.2305 | 0.3182 |
Plasmodium falciparum | glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.01 | 0.2305 | 0.4474 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0976 | 0.1895 |
Plasmodium vivax | vivapain-2 | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.2305 | 0.4474 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0149 | 0.5152 | 0.5152 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.01 | 0.2305 | 0.4474 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0077 | 0.0976 | 0.1895 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | unspecified product | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0105 | 0.261 | 0.5066 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0105 | 0.261 | 0.107 |
Echinococcus multilocularis | cysteine protease | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0149 | 0.5152 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0105 | 0.261 | 0.107 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0976 | 0.1895 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0105 | 0.261 | 0.5066 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.01 | 0.2305 | 0.4474 |
Toxoplasma gondii | thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cleavage (functional) | = 5 ug ml-1 | In vitro concentration inhibiting DNA gyrase induced cleavage in E. coli H560. | ChEMBL. | 1366133 |
MIC (functional) | = 0.8 ug ml-1 | In vitro antibacterial activity against gram negative E. coli Vogel. | ChEMBL. | 1366133 |
PD50 (functional) | = 0.4 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by E. coli vogel on subcutaneous injection. | ChEMBL. | 1366133 |
PD50 (functional) | = 1.3 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by E. coli Vogel on oral administration by gavage. | ChEMBL. | 1366133 |
PD50 (functional) | = 2 mg kg-1 | In vivo potency of the compound against acute systemic infection in mouse caused by P. aeruginosa. UI-18. on subcutaneous injection. | ChEMBL. | 1366133 |
PD50 (functional) | = 3 mg kg-1 | In vivo potency of the compound against acute systemic infection in mouse caused by P. aeruginosa UI-18 on oral administration by gavage. | ChEMBL. | 1366133 |
PD50 (functional) | = 10 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by S. pyogenes C-203 on subcutaneous injection | ChEMBL. | 1366133 |
PD50 (functional) | = 22 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by S. pyogenes C-203 on oral administration by gavage | ChEMBL. | 1366133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.