Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Smad4 | 0.0008 | 0.016 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.016 | 0.016 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.016 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.016 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.016 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.016 | 0.016 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.016 | 0.016 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.016 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.016 | 0.016 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.5059 | 0.5059 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.016 | 0.5 |
Schistosoma mansoni | smad | 0.0008 | 0.016 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.5059 | 0.5059 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.5059 | 0.5059 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.016 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.016 | 0.016 |
Echinococcus multilocularis | smad | 0.0008 | 0.016 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.016 | 0.5 |
Echinococcus granulosus | smad | 0.0008 | 0.016 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.016 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.016 | 0.016 |
Brugia malayi | Smad1 | 0.0008 | 0.016 | 0.016 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.016 | 0.016 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.016 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.016 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 at <=10 ug/ml after 48 hrs as LDH activity by Makler assay | ChEMBL. | 8984156 | |
Activity (functional) | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 at <=10 ug/ml after 48 hrs as LDH activity by Makler assay | ChEMBL. | 8984156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.