Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2501 | 0.2505 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0.3079 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0085 | 0.3079 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1348 | 0.1348 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2501 | 0.2505 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2501 | 0.2501 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0.3079 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0.3079 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2501 | 0.2501 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0.3079 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0085 | 0.3079 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1348 | 0.1348 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0085 | 0.3079 | 0.0773 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.9982 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2501 | 0.2501 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2501 | 0.2501 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0085 | 0.3079 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2501 | 0.2505 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2501 | 0.2501 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0.3079 | 1 |
Echinococcus multilocularis | geminin | 0.0182 | 0.9982 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0085 | 0.3079 | 0.3079 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0085 | 0.3079 | 0.0773 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0085 | 0.3079 | 0.3079 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.9982 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2501 | 0.2501 |
Echinococcus granulosus | geminin | 0.0182 | 0.9982 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2501 | 0.2505 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1348 | 0.1348 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1348 | 0.1348 |
Schistosoma mansoni | kinase | 0.0043 | 0.0133 | 0.0133 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0.3079 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0.3079 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0085 | 0.3079 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2501 | 0.2505 |
Trypanosoma brucei | polo-like protein kinase | 0.0085 | 0.3079 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0085 | 0.3079 | 0.3085 |
Giardia lamblia | Kinase, PLK | 0.0085 | 0.3079 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.