Detailed information for compound 1177200

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 597.744 | Formula: C36H43N3O5
  • H donors: 3 H acceptors: 4 LogP: 6.53 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCC[C@@H]([C@@H]1CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)O1)Cc1ccccc1)C)C(c1ccccc1)c1ccccc1)C
  • InChi: 1S/C36H43N3O5/c1-4-5-15-24(2)30-23-31(40)39-33(32(27-18-11-7-12-19-27)28-20-13-8-14-21-28)35(42)37-25(3)34(41)38-29(36(43)44-30)22-26-16-9-6-10-17-26/h6-14,16-21,24-25,29-30,32-33H,4-5,15,22-23H2,1-3H3,(H,37,42)(H,38,41)(H,39,40)/t24-,25-,29+,30-,33-/m0/s1
  • InChiKey: BQVLECMLFYHZDZ-DFIXXEOTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.006 0.0092 0.0412
Brugia malayi hypothetical protein 0.0028 0.0006 0.0023
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.1206 0.1206
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0146 0.0464
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0058 0.0089 0.0089
Schistosoma mansoni coup transcription factor 0.006 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0092 0.0412
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0092 0.0412
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0259 0.0641 0.243
Toxoplasma gondii heat shock protein 75, putative 0.0055 0.0081 0.1679
Leishmania major cytochrome p450-like protein 0.0087 0.0168 0.3724
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0072 0.0067
Loa Loa (eye worm) heterochromatin protein 1 0.0141 0.0316 0.1418
Trypanosoma cruzi protein kinase A regulatory subunit 0.0037 0.0029 0.0421
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0057 0.1164
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0031 0.0015 0.0065
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0037 0.0029 0.0421
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0037 0.0036
Loa Loa (eye worm) beta-lactamase 0.0148 0.0336 0.1504
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0147 0.15
Mycobacterium leprae putative cytochrome p450 0.003 0.0011 0.0026
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0091 0.0377
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0058 0.0089 0.0399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Onchocerca volvulus 0.0148 0.0336 0.1299
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0147 0.0146
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0154 0.0687
Brugia malayi Endoplasmin precursor 0.0107 0.0224 0.1004
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0037 0.0029 0.0553
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.0336 0.0362
Echinococcus granulosus hyperpolarization activated cyclic 0.0058 0.0089 0.0089
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0058 0.0089 0.0089
Schistosoma mansoni zinc finger protein 0.0028 0.0006 0.0005
Brugia malayi nuclear receptor NHR-67 0.0028 0.0006 0.0023
Echinococcus multilocularis voltage gated potassium channel 0.0084 0.0159 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0037 0.0029 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.0641 0.2873
Trypanosoma brucei cAMP binding protein, putative 0.0037 0.0029 0.0669
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0154 0.0153
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0055 0.0079 0.0351
Brugia malayi Bromodomain containing protein 0.0077 0.014 0.0626
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0037 0.0029 0.002
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Mycobacterium ulcerans hypothetical protein 0.0037 0.0029 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0031 0.003
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.0835 0.2228 1
Schistosoma mansoni ets-related 0.0239 0.0586 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0119 0.0359
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0091 0.009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Mycobacterium leprae Conserved hypothetical protein 0.1103 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0146 0.0652
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.0399
Plasmodium falciparum cGMP-dependent protein kinase 0.0037 0.0031 0.0589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0056 0.0056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0221 0.022
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0037 0.0031 0.003
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0281 0.0701 0.07
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.006 0.0092 0.0412
Onchocerca volvulus 0.0037 0.0029 0.0092
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0374 0.0959 0.3224
Brugia malayi chromobox protein homolog 3 0.0079 0.0146 0.0652
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0037 0.0029 0.0028
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0058 0.0089 0.0089
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0002 0.0008
Mycobacterium ulcerans hypothetical protein 0.0037 0.0029 0.0084
Onchocerca volvulus 0.0047 0.0058 0.0204
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0336 0.0335
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.006 0.0092 0.0092
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0053 0.0052
Trypanosoma brucei protein kinase A regulatory subunit 0.0037 0.0029 0.0669
Mycobacterium ulcerans lipase LipD 0.0148 0.0336 0.1532
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.0336 0.7745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.006 0.0092 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0092 0.0412
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0037 0.0029 0.0028
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0037 0.0029 0.0028
Mycobacterium ulcerans transcriptional regulatory protein 0.0037 0.0029 0.0084
Schistosoma mansoni gabp alpha 0.0079 0.0145 0.0144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0092 0.0092
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.0336 0.0362
Trypanosoma cruzi Heat shock protein 83, putative 0.0107 0.0224 0.5047
Onchocerca volvulus Alhambra homolog 0.0029 0.0009 0.0013
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.036 0.0919 0.1014
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0336 0.1218
Echinococcus multilocularis heat shock protein 0.0107 0.0224 0.0224
Loa Loa (eye worm) transcription factor SMAD2 0.0353 0.0901 0.4042
Onchocerca volvulus 0.0081 0.0151 0.0572
Toxoplasma gondii heat shock protein 90, putative 0.0107 0.0224 0.4808
Echinococcus granulosus cGMP dependent protein kinase 1 0.0037 0.0031 0.003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0006 0.0005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0113 0.2416
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0119 0.0359
Mycobacterium ulcerans regulatory protein 0.0037 0.0029 0.0084
Echinococcus multilocularis ecdysone induced protein 78C 0.006 0.0092 0.0092
Echinococcus multilocularis thioredoxin glutathione reductase 0.0159 0.0367 0.0366
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0087 0.0168 0.0742
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0269 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0056 0.0056
Plasmodium falciparum thioredoxin reductase 0.0055 0.0079 0.1638
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0374 0.0959 0.4473
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0119 0.2524
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0037 0.0029 0.0128
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0112 0.0238 0.0237
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0147 0.0641
Leishmania major hypothetical protein, conserved 0.0037 0.0029 0.0421
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0336 0.1218
Echinococcus multilocularis potassium voltage gated channel protein 0.0117 0.025 0.0249
Schistosoma mansoni hypothetical protein 0.003 0.0011 0.0011
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0269 0.0268
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0037 0.0029 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0178 0.0593
Trichomonas vaginalis glutathione reductase, putative 0.0055 0.0079 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0146 0.0464
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Mycobacterium ulcerans heat shock protein 90 0.0092 0.0181 0.0803
Schistosoma mansoni nuclear hormone receptor 0.006 0.0092 0.0092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0056 0.0251
Brugia malayi hypothetical protein 0.0106 0.0221 0.0989
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0113 0.0922
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0158 0.0363 0.0392
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.0433 0.1606
Giardia lamblia Heat shock protein HSP 90-alpha 0.0088 0.0171 0.3823
Echinococcus granulosus patatin phospholipase domain containing protein 0.0037 0.0029 0.0028
Brugia malayi hypothetical protein 0.0031 0.0015 0.0065
Entamoeba histolytica heat shock protein 90, putative 0.0107 0.0224 0.4071
Mycobacterium leprae conserved hypothetical protein 0.0148 0.0336 0.1121
Echinococcus granulosus cGMP dependent protein kinase 0.0037 0.0031 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.0433 0.1606
Loa Loa (eye worm) CYP4Cod1 0.0087 0.0168 0.0754
Echinococcus granulosus voltage gated potassium channel 0.0084 0.0159 0.0159
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0154 0.0352 0.0352
Mycobacterium tuberculosis Probable reductase 0.036 0.0919 0.1014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.036 0.0919 0.1014
Schistosoma mansoni heat shock protein 0.0107 0.0224 0.0224
Brugia malayi Thioredoxin reductase 0.0158 0.0363 0.1625
Brugia malayi jmjC domain containing protein 0.0096 0.0193 0.0862
Trypanosoma cruzi cAMP response protein 1 0.0037 0.0029 0.0421
Treponema pallidum replicative DNA helicase (dnaB) 0.0374 0.0959 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0084 0.0159 0.0159
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0037 0.0036
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0362 0.0361
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Brugia malayi Bromodomain containing protein 0.0151 0.0343 0.1537
Loa Loa (eye worm) heat shock protein 90 0.0107 0.0224 0.1004
Onchocerca volvulus 0.0148 0.0336 0.1299
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0336 0.7685
Brugia malayi Heterochromatin protein 1 0.0141 0.0316 0.1418
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0151 0.0151
Leishmania major cyclic nucleotide-binding protein-like protein 0.0037 0.0029 0.0421
Plasmodium vivax heat shock protein, putative 0.0194 0.0463 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0336 0.1504
Toxoplasma gondii ABC1 family protein 0.0148 0.0336 0.7234
Mycobacterium tuberculosis Conserved protein 0.0037 0.0029 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0095 0.0423
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0092 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.006 0.0092 0.0412
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0316 0.1142
Schistosoma mansoni Tr4/Tr2 (homologue) 0.006 0.0092 0.0092
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0092 0.0181 0.4031
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0037 0.0029 0.0128
Brugia malayi hypothetical protein 0.0031 0.0015 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.006 0.0092 0.0412
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0193 0.0192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0091 0.1891
Onchocerca volvulus 0.0148 0.0336 0.1299
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0031 0.003
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Brugia malayi steroid hormone receptor 0.006 0.0092 0.0412
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0009 0.0117
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0562 0.0562
Mycobacterium ulcerans recombinase A 0.0104 0.0216 0.0967
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0037 0.0031 0.0589
Treponema pallidum catabolite gene activator 0.0037 0.0029 0.0266
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0037 0.0029 0.002
Echinococcus multilocularis hyperpolarization activated cyclic 0.0058 0.0089 0.0089
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0006 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.006 0.0092 0.0092
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0147 0.3122
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0119 0.2524
Loa Loa (eye worm) heat shock protein 75 0.0055 0.0081 0.036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.006 0.0092 0.0412
Brugia malayi nuclear hormone receptor 0.006 0.0092 0.0412
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.1206 0.1206
Echinococcus multilocularis tar DNA binding protein 0.0124 0.0269 0.0269
Leishmania major protein kinase, putative 0.0037 0.0031 0.046
Schistosoma mansoni hypothetical protein 0.0047 0.0058 0.0057
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.006 0.0092 0.0092
Onchocerca volvulus 0.0037 0.0029 0.0092
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0037 0.0029 0.0028
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0058 0.0089 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0336 0.7234
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0055 0.0079 0.1638
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0065
Schistosoma mansoni hypothetical protein 0.0106 0.0221 0.022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Trypanosoma brucei Flagellar Member 6 0.0037 0.0029 0.0669
Plasmodium vivax SET domain protein, putative 0.012 0.0258 0.5547
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.006 0.0092 0.0412
Brugia malayi Steroid receptor seven-up type 2 0.006 0.0092 0.0412
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Loa Loa (eye worm) thioredoxin reductase 0.0158 0.0363 0.1625
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Loa Loa (eye worm) hypothetical protein 0.0148 0.0336 0.1504
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0037 0.0029 0.0553
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.1206 0.1206
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0056 0.0251
Echinococcus granulosus heat shock protein 90 0.0107 0.0224 0.0224
Trypanosoma cruzi DNA repair protein, putative 0.0032 0.0017 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Brugia malayi Egg laying defective protein 4 0.0037 0.0031 0.0135
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0151 0.0676
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.006 0.0092 0.0341
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0151 0.0151
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0011 0.0026
Plasmodium vivax heat shock protein 90, putative 0.0055 0.0081 0.1679
Echinococcus granulosus potassium voltage gated channel protein 0.0117 0.025 0.0249
Loa Loa (eye worm) hypothetical protein 0.0244 0.06 0.2692
Schistosoma mansoni nuclear receptor 0.0028 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0038
Trichomonas vaginalis heat shock protein, putative 0.0071 0.0124 0.0376
Schistosoma mansoni hypothetical protein 0.0124 0.0269 0.0268
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0336 0.1218
Brugia malayi nuclear receptor NHR-88 0.006 0.0092 0.0412
Echinococcus granulosus cGMP dependent protein kinase 1 0.0037 0.0031 0.003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0079 0.1601
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0316 0.1142
Echinococcus multilocularis endoplasmin 0.0092 0.0181 0.0181
Schistosoma mansoni endoplasmin 0.0107 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0128
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0037 0.0029 0.0028
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0006 0.0023
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Echinococcus granulosus FTZ F1 alpha 0.006 0.0092 0.0092
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.04 0.103 0.3463
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0147 0.1268
Loa Loa (eye worm) hypothetical protein 0.0086 0.0164 0.0734
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0015 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0258 0.0258
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0006 0.0023
Brugia malayi Cytochrome P450 family protein 0.0087 0.0168 0.0754
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.0336 0.0362
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Loa Loa (eye worm) hypothetical protein 0.0148 0.0336 0.1504
Entamoeba histolytica hypothetical protein 0.0069 0.0119 0.11
Trichomonas vaginalis glutaminase, putative 0.0799 0.2129 0.8345
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0037 0.0161
Chlamydia trachomatis recombinase RecA 0.0104 0.0216 0.2012
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0055 0.0079 0.0536
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0071 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.006 0.0092 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-49 0.006 0.0092 0.0412
Loa Loa (eye worm) glutathione reductase 0.0158 0.0363 0.1625
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0006 0.0005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0193 0.0192
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0055 0.0079 0.1638
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0037 0.0029 0.0421
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.006 0.0092 0.0412
Leishmania major protein kinase A regulatory subunit, putative 0.0037 0.0029 0.0421
Mycobacterium tuberculosis Putative ferredoxin reductase 0.036 0.0919 0.1014
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0088 0.0171 0.0171
Brugia malayi jmjC domain containing protein 0.0039 0.0037 0.0161
Toxoplasma gondii heat shock protein HSP90 0.0107 0.0224 0.4808
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0006 0.0005
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Giardia lamblia Kinase, PLK 0.0183 0.0433 1
Schistosoma mansoni hypothetical protein 0.0165 0.0382 0.0382
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0153
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0011 0.0166
Schistosoma mansoni voltage-gated potassium channel 0.0306 0.0771 0.077
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0294 0.0738 0.3312
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0035 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0006 0.0023
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Loa Loa (eye worm) twinkle helicase 0.0107 0.0223 0.0997
Brugia malayi nuclear receptor RXR 0.0028 0.0006 0.0023
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0091 0.0089
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.006 0.0092 0.0092
Trichomonas vaginalis heat shock protein, putative 0.0092 0.0181 0.0605
Echinococcus granulosus adam 0.0033 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0084 0.0159 0.0159
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0835 0.2228 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0058 0.0089 0.0089
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0053 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.0433 0.0433
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0168 0.0754
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.0336 0.1532
Mycobacterium tuberculosis Conserved protein 0.0148 0.0336 0.0362
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0031 0.0015 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0336 0.1218
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0119 0.2564
Trichomonas vaginalis heat shock protein, putative 0.0092 0.0181 0.0605
Echinococcus multilocularis chromobox protein 1 0.0141 0.0316 0.0316
Treponema pallidum cyclic nucleotide binding protein 0.0037 0.0029 0.0266
Brugia malayi nuclear receptor RXR 0.0031 0.0015 0.0065
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0057 0.1316
Mycobacterium leprae Probable lipase LipE 0.0148 0.0336 0.1121
Echinococcus granulosus thioredoxin glutathione reductase 0.0159 0.0367 0.0366
Trypanosoma cruzi heat shock protein 90, putative 0.0088 0.0171 0.379
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0145 0.0144
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0033 0.0018 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0055 0.0079 0.1819
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0006 0.0005
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0006 0.0005
Echinococcus multilocularis GPCR, family 2 0.0082 0.0154 0.0153
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0055 0.0079 0.1601
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0113 0.0506
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Mycobacterium ulcerans hypothetical protein 0.0037 0.0029 0.0084
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0006 0.0005
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0119 0.11
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0113 0.2416
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.0641 0.2873
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.006 0.0092 0.0412
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0091 0.009
Brugia malayi Cytochrome P450 family protein 0.003 0.0011 0.0048
Trypanosoma brucei trypanothione reductase 0.0158 0.0363 0.8367
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0055 0.0081 0.008
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0153
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0006 0.0005
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0113 0.2613
Mycobacterium tuberculosis Probable oxidoreductase 0.04 0.103 0.1137
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0269 0.0269
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0154 0.0153
Mycobacterium ulcerans hypothetical protein 0.0037 0.0029 0.0084
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0259 0.0641 0.243
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0058 0.0089 0.0089
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0118 0.0253 0.0252
Trichomonas vaginalis mercuric reductase, putative 0.0055 0.0079 0.0198
Brugia malayi beta-lactamase family protein 0.0148 0.0336 0.1504
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0041 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0092 0.0412
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.0336 0.0335
Giardia lamblia Heat shock protein HSP 90-alpha 0.0107 0.0224 0.5073
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.0162 0.0617
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0009 0.0008
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0072 0.0229
Schistosoma mansoni Replicative DNA helicase 0.0374 0.0959 0.0958
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0011 0.0011
Schistosoma mansoni bromodomain containing protein 0.0127 0.0278 0.0278
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0057 0.0254
Schistosoma mansoni chromobox protein 0.0141 0.0316 0.0316
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0015 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0009 0.0117
Trypanosoma cruzi heat shock protein, putative 0.0055 0.0081 0.1646
Schistosoma mansoni kinase 0.0093 0.0185 0.0184
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0118 0.0253 0.0252
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0147 0.3122
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0006 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.0336 0.1504
Brugia malayi MH2 domain containing protein 0.0353 0.0901 0.4042
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.0269 0.1207
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0058 0.0256
Onchocerca volvulus 0.095 0.2546 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0092 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.006 0.0092 0.0092
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0055 0.0079 0.0319
Echinococcus granulosus histone lysine methyltransferase setb 0.0154 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0065
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0006 0.0023
Loa Loa (eye worm) fli-1 protein 0.0239 0.0586 0.2627
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0029 0.002
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0006 0.0023
Trypanosoma cruzi heat shock protein 85, putative 0.0107 0.0224 0.5047
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0058 0.0089 0.0399
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0055 0.0079 0.0319
Loa Loa (eye worm) hypothetical protein 0.005 0.0067 0.0297
Echinococcus granulosus heat shock protein 0.0107 0.0224 0.0224
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0079 0.1819
Toxoplasma gondii NADPH-glutathione reductase 0.0055 0.0079 0.1638
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0037 0.0029 0.0553
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0211 0.021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0056 0.0056
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0037 0.0029 0.0028
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0037 0.0029 0.0669
Loa Loa (eye worm) hypothetical protein 0.0259 0.0641 0.2873
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0154 0.0687
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Echinococcus multilocularis geminin 0.0165 0.0382 0.0382
Schistosoma mansoni 60S ribosomal protein L21 0.0047 0.0059 0.0058
Entamoeba histolytica hypothetical protein 0.0106 0.0221 0.3974
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0037 0.0029 0.0092
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0092 0.0181 0.1166
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0006 0.0023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0006 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0168 0.3724
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0006 0.0005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.004 0.0039 0.0172
Echinococcus multilocularis adam 0.0033 0.0018 0.0018
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0089 0.0172 0.0772
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0055 0.0079 0.1819
Schistosoma mansoni nuclear receptor 0.0028 0.0006 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0147 0.0484
Schistosoma mansoni heat shock protein 0.0107 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0082 0.0154 0.0687
Loa Loa (eye worm) hypothetical protein 0.0062 0.0099 0.0441
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.0336 0.0335
Brugia malayi beta-lactamase 0.0148 0.0336 0.1504
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0057 0.0051
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0055 0.0079 0.0078
Schistosoma mansoni heat shock protein 0.0055 0.0081 0.008
Schistosoma mansoni hypothetical protein 0.0037 0.0029 0.0028
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0089 0.0172 0.0172
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0037 0.0029 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0029 0.002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0072 0.0067
Mycobacterium tuberculosis Conserved protein 0.0148 0.0336 0.0362
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Trypanosoma cruzi heat shock protein 85, putative 0.0107 0.0224 0.5047
Echinococcus multilocularis hyperpolarization activated cyclic 0.0058 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0119 0.0359
Leishmania major trypanothione reductase 0.0158 0.0363 0.8324
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0281 0.0701 0.07
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0072 0.0071
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0006 0.0005
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0023 0.0022
Echinococcus granulosus peregrin 0.0034 0.0022 0.0022
Onchocerca volvulus 0.0157 0.0362 0.1401
Brugia malayi Cytochrome P450 family protein 0.003 0.0011 0.0048
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0113 0.0113
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0945 0.2531 0.2814
Trypanosoma cruzi heat shock protein 85, putative 0.0107 0.0224 0.5047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0056 0.0056
Trypanosoma cruzi ISWI complex protein 0.0031 0.0013 0.0039
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0057 0.0056
Brugia malayi beta-lactamase family protein 0.0148 0.0336 0.1504
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0281 0.0701 0.3144
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0221 0.022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.0336 0.0362
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0057 0.1164
Loa Loa (eye worm) TAR-binding protein 0.0124 0.0269 0.1207
Echinococcus multilocularis FTZ F1 alpha 0.006 0.0092 0.0092
Echinococcus granulosus geminin 0.0165 0.0382 0.0382
Brugia malayi glutaminase DH11.1 0.0799 0.2129 0.9556
Loa Loa (eye worm) hypothetical protein 0.0148 0.0336 0.1504
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0057 0.1085
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0057 0.0056
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0147 0.0641
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0092 0.0412
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0092 0.0092
Trypanosoma cruzi polo-like protein kinase, putative 0.0183 0.0433 1
Leishmania major basic transcription factor 3a, putative 0.0069 0.0119 0.2564
Brugia malayi hypothetical protein 0.0028 0.0006 0.0023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0394 0.1015 0.4553
Leishmania major hypothetical protein, unknown function 0.0037 0.0029 0.0421
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0037 0.0036
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0162 0.053
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0037 0.0029 0.0553
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0031 0.0015 0.0014
Onchocerca volvulus 0.0294 0.0738 0.2884
Brugia malayi Pip kinase protein 2 0.0157 0.0362 0.1621
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Onchocerca volvulus 0.006 0.0092 0.0341
Brugia malayi TAR-binding protein 0.0124 0.0269 0.1207
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0055 0.0079 0.1638
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0117 0.025 0.0249
Loa Loa (eye worm) hypothetical protein 0.0148 0.0336 0.1504
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0006 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0055 0.0079 0.1638
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0183 0.0433 0.0433
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0057 0.1085
Brugia malayi conserved hypotetical protein 0.0028 0.0006 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0168 0.3724
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0082 0.0212
Echinococcus granulosus chromobox protein 1 0.0141 0.0316 0.0316
Entamoeba histolytica serine/threonine protein kinase, putative 0.0183 0.0433 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0058 0.0089 0.0089
Plasmodium falciparum glutathione reductase 0.0055 0.0079 0.1638
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.0146 0.0552
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0011 0.0259
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0258 0.5547
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Schistosoma mansoni hypothetical protein 0.0177 0.0415 0.0415
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0006 0.0023
Brugia malayi hypothetical protein 0.023 0.0562 0.2521
Leishmania major hypothetical protein, conserved 0.0031 0.0013 0.0039
Brugia malayi Ets-domain containing protein 0.0079 0.0145 0.0648
Schistosoma mansoni voltage-gated potassium channel 0.0306 0.0771 0.077
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0183 0.0433 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0029 0.0421
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0006 0.0005
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0037 0.0029 0.0553
Echinococcus multilocularis peregrin 0.0034 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0258 0.0258
Echinococcus granulosus endoplasmin 0.0092 0.0181 0.0181
Trypanosoma cruzi polo-like protein kinase, putative 0.0183 0.0433 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0057 0.0056
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Schistosoma mansoni transcription factor btf3 0.0069 0.0119 0.0119
Brugia malayi beta-NAC-like protein 0.0069 0.0119 0.0534
Plasmodium falciparum endoplasmin, putative 0.0071 0.0124 0.2614
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0089 0.0172 0.0172
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0154 0.0153
Echinococcus granulosus heat shock protein 90 0.0088 0.0171 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0154 0.0352 0.0352
Brugia malayi PHD-finger family protein 0.005 0.0066 0.0294
Schistosoma mansoni survival motor neuron protein 0.0047 0.0058 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0015 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0091 0.0377
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0055 0.0079 0.1601
Trypanosoma cruzi heat shock protein 90, putative 0.0107 0.0224 0.5047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.006 0.0092 0.0092
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0037 0.0029 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0082 0.0212
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0147 0.0146
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0002 0.0002
Brugia malayi serine/threonine-protein kinase plk-2 0.0183 0.0433 0.1943
Loa Loa (eye worm) hypothetical protein 0.023 0.0562 0.2521
Echinococcus multilocularis heat shock protein 90 0.0088 0.0171 0.0171
Echinococcus granulosus ecdysone induced protein 78C 0.006 0.0092 0.0092
Brugia malayi CHD4 protein 0.0027 0.0002 0.0008
Plasmodium vivax endoplasmin, putative 0.0107 0.0224 0.4808
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0104 0.0216 0.156
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.0415 0.1861
Schistosoma mansoni voltage-gated potassium channel 0.0117 0.025 0.0249
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0119 0.2524
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0037 0.0029 0.0471
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0057 0.0056
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0006 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0269 0.0269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.0336 0.1532
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.0433 0.1606
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0183 0.0433 0.1943
Leishmania major hypothetical protein, conserved 0.0148 0.0336 0.7685
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0037 0.0031 0.003
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0037 0.0029 0.0028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.006 0.0092 0.0092
Schistosoma mansoni glutaminase 0.0799 0.2129 0.2129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0065
Plasmodium falciparum phd finger protein, putative 0.0029 0.0009 0.0117
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.0336 0.0362
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.006 0.0092 0.0092
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.04 0.103 0.1137
Schistosoma mansoni RAR-like nuclear receptor 0.006 0.0092 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0269 0.0269
Brugia malayi hypothetical protein 0.0033 0.0018 0.0079
Trypanosoma cruzi cAMP response protein 1, putative 0.0037 0.0029 0.0421
Trichomonas vaginalis set domain proteins, putative 0.095 0.2546 1
Trypanosoma cruzi ISWI complex protein 0.0031 0.0013 0.0039
Onchocerca volvulus Serine\/threonine kinase homolog 0.0183 0.0433 0.1683
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0281 0.0701 0.3144
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0037 0.0029 0.0669
Loa Loa (eye worm) glutaminase 0.0799 0.2129 0.9556
Echinococcus multilocularis chromobox protein 1 0.0141 0.0316 0.0316
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0113 0.0506
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0037 0.0029 0.0553
Schistosoma mansoni hypothetical protein 0.0165 0.0382 0.0382
Trypanosoma cruzi Flagellar Member 6 0.0037 0.0029 0.0421
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0023 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0056 0.0056
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0037 0.0029 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-41 0.006 0.0092 0.0412
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0336 0.7685
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0057 0.0056
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0006 0.0005
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0055 0.0079 0.0078
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0079 0.1819
Echinococcus multilocularis transcription factor btf3 0.0069 0.0119 0.0119
Schistosoma mansoni voltage-gated potassium channel 0.0117 0.025 0.0249
Brugia malayi PHD-finger family protein 0.0029 0.0009 0.0038
Brugia malayi ecdysone receptor 0.0028 0.0006 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0154 0.0352 0.0352
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0037 0.0029 0.0028
Brugia malayi nuclear hormone receptor 0.0028 0.0006 0.0023
Trypanosoma brucei polo-like protein kinase 0.0183 0.0433 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0183 0.0433 0.0432
Loa Loa (eye worm) endoplasmin 0.0107 0.0224 0.1004
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0562 0.0562
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0058 0.0089 0.0089
Onchocerca volvulus 0.0143 0.0322 0.1244
Entamoeba histolytica hypothetical protein 0.0106 0.0221 0.3974
Brugia malayi Probable ClpP-like protease 0.0079 0.0147 0.0657
Mycobacterium ulcerans beta-lactamase 0.0148 0.0336 0.1532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.006 0.0092 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0023 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.0336 0.0362
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.161 0.4362 0.4362
Brugia malayi Cytochrome P450 family protein 0.0087 0.0168 0.0754
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0092 0.0092
Brugia malayi Ets-domain containing protein 0.0079 0.0145 0.0648
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0057 0.1316
Loa Loa (eye worm) hypothetical protein 0.0177 0.0415 0.1861
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0143 0.0322 0.0321
Entamoeba histolytica heat shock protein 90, putative 0.0107 0.0224 0.4071
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0147 0.1268
Chlamydia trachomatis replicative DNA helicase 0.0374 0.0959 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.006 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0117 0.025 0.1119
Mycobacterium tuberculosis Conserved protein 0.0148 0.0336 0.0362
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.036 0.0919 0.1014
Onchocerca volvulus Protein ultraspiracle homolog 0.006 0.0092 0.0341
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0381
Brugia malayi glutathione reductase 0.0158 0.0363 0.1625
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0037 0.0029 0.0128
Brugia malayi ecdysteroid receptor 0.006 0.0092 0.0412
Plasmodium vivax glutathione reductase, putative 0.0158 0.0363 0.7822
Giardia lamblia NADH oxidase lateral transfer candidate 0.0055 0.0079 0.1645
Loa Loa (eye worm) hypothetical protein 0.0081 0.0151 0.0676
Schistosoma mansoni thyroid hormone receptor 0.0183 0.0433 0.0432
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0145 0.0648
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.004 0.0039 0.0172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0336 0.0335
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0104 0.0216 0.0717
Brugia malayi isocitrate dehydrogenase 0.0047 0.0057 0.0254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0056 0.0056
Brugia malayi Bromodomain containing protein 0.0034 0.0022 0.0097
Plasmodium vivax thioredoxin reductase, putative 0.0158 0.0363 0.7822
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0362 0.0361
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0113 0.0113
Onchocerca volvulus Bile acid receptor homolog 0.006 0.0092 0.0341
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0031 0.0015 0.0014
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0374 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0162 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0056 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0011 0.0048
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0006 0.0005
Schistosoma mansoni endoplasmin 0.0107 0.0224 0.0224
Trichomonas vaginalis esterase, putative 0.0148 0.0336 0.1218
Trypanosoma brucei cAMP response protein 1, putative 0.0037 0.0029 0.0669
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Treponema pallidum recombinase A 0.0104 0.0216 0.2224
Echinococcus granulosus chromobox protein 1 0.0141 0.0316 0.0316
Brugia malayi N-terminal motif family protein 0.0037 0.0029 0.0128
Giardia lamblia Grp94/Hsp90 0.0092 0.0181 0.4062
Entamoeba histolytica hypothetical protein 0.0106 0.0221 0.3974
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0037 0.0029 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Loa Loa (eye worm) AGC/PKG protein kinase 0.0037 0.0031 0.0135
Plasmodium vivax heat shock protein 86, putative 0.0107 0.0224 0.4808
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0089 0.0172 0.0172
Echinococcus granulosus tar DNA binding protein 0.0124 0.0269 0.0269
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3281 0.8965 1
Loa Loa (eye worm) pip kinase 2 0.0157 0.0362 0.1621
Trypanosoma cruzi heat shock protein 85, putative 0.0088 0.0171 0.379
Trypanosoma brucei Heat shock protein 83, putative 0.0107 0.0224 0.5175
Leishmania major heat shock protein, putative 0.0055 0.0081 0.1646
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0127 0.0126
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0037 0.0029 0.0028
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0113 0.2416
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0119 0.0534
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0058 0.0089 0.024
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0154 0.0687
Echinococcus granulosus retinoic acid receptor rxr beta a 0.006 0.0092 0.0092
Echinococcus granulosus hyperpolarization activated cyclic 0.0058 0.0089 0.0089
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0072 0.0071
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0147 0.3122
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.006 0.0092 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.0433 0.1606
Brugia malayi RNA binding protein 0.0124 0.0269 0.1207
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3011 0.8222 0.9171
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0041 0.004
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0055 0.0079 0.0319
Echinococcus granulosus adam 17 protease 0.0206 0.0497 0.0496
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0145 0.0144
Brugia malayi hypothetical protein 0.0294 0.0738 0.3312
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0009 0.0008
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0009 0.0117
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0183 0.0433 1
Schistosoma mansoni hypothetical protein 0.0041 0.0042 0.0042
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0159 0.0159
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0009 0.0008
Echinococcus granulosus tumor protein p63 0.07 0.1856 0.1856
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0151 0.0151
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0037 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0082 0.0153 0.0686
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0058 0.0089 0.024
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0055 0.0079 0.1638
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0147 0.0774
Treponema pallidum catabolite gene activator (Crp) 0.0037 0.0029 0.0266
Brugia malayi tailless protein 0.0028 0.0006 0.0023
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0055 0.0081 0.0295
Trypanosoma cruzi cAMP binding protein, putative 0.0037 0.0029 0.0421
Trypanosoma brucei heat shock protein 84, putative 0.0055 0.0081 0.1862
Loa Loa (eye worm) cytochrome P450 0.003 0.0011 0.0048
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0009 0.0038
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0092 0.0181 0.06
Brugia malayi cytochrome P450 0.003 0.0011 0.0048
Trypanosoma brucei heat shock protein 90, putative 0.0107 0.0224 0.5175
Trichomonas vaginalis endoplasmin, putative 0.0071 0.0124 0.0376
Schistosoma mansoni zinc finger protein 0.0031 0.0013 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0138 0.0138
Leishmania major regulatory subunit of protein kinase a-like protein 0.0037 0.0029 0.0421
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0037 0.0029 0.0028
Brugia malayi Cyclic-nucleotide gated cation channel 0.0058 0.0089 0.0399
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0065
Loa Loa (eye worm) RNA binding protein 0.0124 0.0269 0.1207
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0065
Leishmania major protein kinase, putative 0.0037 0.0031 0.046
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0362 0.0361
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.04 0.103 0.1137
Leishmania major hypothetical protein, conserved 0.0037 0.0029 0.0421
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0058 0.0089 0.0089
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0119 0.2564
Onchocerca volvulus 0.0102 0.0211 0.0806
Echinococcus multilocularis adam 17 protease 0.0188 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0079 0.0147 0.0657
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0037 0.0029 0.0028
Trypanosoma brucei ISWI complex protein 0.0031 0.0013 0.0297
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0055 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.0029 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0153
Toxoplasma gondii Hsp90 domain-containing protein 0.0194 0.0463 1
Trypanosoma cruzi heat shock protein 90, putative 0.0056 0.0082 0.1678
Loa Loa (eye worm) glutaminase 2 0.0799 0.2129 0.9556
Echinococcus granulosus transcription factor btf3 0.0069 0.0119 0.0119
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0026 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0269 0.0269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.006 0.0092 0.0092
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0057 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Schistosoma mansoni chromobox protein 0.0141 0.0316 0.0316
Brugia malayi heat shock protein 90 0.0107 0.0224 0.1004
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0037 0.0029 0.0028
Onchocerca volvulus 0.0062 0.0099 0.0367
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0037 0.0029 0.0028
Echinococcus multilocularis zinc finger protein 0.0039 0.0037 0.0036
Entamoeba histolytica hypothetical protein 0.0106 0.0221 0.3974
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Loa Loa (eye worm) hypothetical protein 0.0117 0.025 0.1119
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0002 0.0002
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0057 0.1164
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0362 0.0361
Trypanosoma cruzi trypanothione reductase, putative 0.0158 0.0363 0.8324
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0079 0.1601
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0067 0.0113 0.0507
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Mycobacterium ulcerans transmembrane transport protein 0.0037 0.0029 0.0084
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0037 0.0029 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.0433 0.1606
Plasmodium falciparum thioredoxin reductase 0.0158 0.0363 0.7822
Mycobacterium leprae Conserved hypothetical protein 0.0037 0.0029 0.0086
Trypanosoma cruzi DNA repair protein, putative 0.0032 0.0017 0.0134
Loa Loa (eye worm) hypothetical protein 0.0154 0.0352 0.158
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0091 0.1905
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0092 0.0412
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0221 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0091 0.0377
Schistosoma mansoni thyroid hormone receptor 0.0183 0.0433 0.0432
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.0641 0.2873
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0042 0.0188
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.0336 0.0362
Trichomonas vaginalis heat shock protein, putative 0.0088 0.0171 0.0565
Echinococcus multilocularis heat shock protein 90 0.0107 0.0224 0.0224
Leishmania major hypothetical protein, conserved 0.0037 0.0029 0.0421
Echinococcus multilocularis 0.003 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0006 0.0005
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0057 0.1164
Loa Loa (eye worm) DR-78 0.0028 0.0006 0.0023
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.0433 0.1606
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0053 0.0052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0127 0.0126
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0037 0.0029 0.0028
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0084 0.0159 0.0713
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0037 0.0029 0.002
Treponema pallidum cyclic nucleotide binding protein 0.0037 0.0029 0.0266
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0092 0.0181 0.019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0055 0.0079 0.0075
Trichomonas vaginalis heat shock protein, putative 0.0107 0.0224 0.0776
Leishmania major heat shock protein 83-1 0.0107 0.0224 0.5047
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0031 0.003
Echinococcus granulosus GPCR family 2 0.0082 0.0154 0.0153
Brugia malayi Hsp90 protein 0.0055 0.0081 0.036
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0058 0.0089 0.0089
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0113 0.0113
Mycobacterium ulcerans glutaminase 0.0799 0.2129 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0058 0.0089 0.0089
Echinococcus granulosus neuropeptide s receptor 0.0464 0.1206 0.1206
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0269 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-1 0.006 0.0092 0.0412
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0336 0.1218
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0057 0.1085
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0037 0.0029 0.0028
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0059 0.0058
Echinococcus multilocularis expressed conserved protein 0.0037 0.0031 0.003
Mycobacterium ulcerans hypothetical protein 0.0148 0.0336 0.1532
Echinococcus multilocularis tumor protein p63 0.07 0.1856 0.1856
Loa Loa (eye worm) hypothetical protein 0.0077 0.014 0.0628
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0079 0.1601
Loa Loa (eye worm) MH2 domain-containing protein 0.0353 0.0901 0.4042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0057 0.0056
Trypanosoma brucei heat shock protein 90, putative 0.0107 0.0224 0.5175
Loa Loa (eye worm) hypothetical protein 0.0148 0.0336 0.1504
Plasmodium falciparum heat shock protein 90, putative 0.0194 0.0463 1
Echinococcus granulosus zinc finger protein 0.0039 0.0037 0.0036
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.006 0.0092 0.0092
Schistosoma mansoni cytochrome P450 0.003 0.0011 0.0011
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0119 0.2757
Plasmodium falciparum heat shock protein 90, putative 0.0052 0.0071 0.1458
Toxoplasma gondii thioredoxin reductase 0.0158 0.0363 0.7822
Schistosoma mansoni retinoic acid receptor RXR 0.006 0.0092 0.0092
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0168 0.0754
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.0433 0.1606
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0188 0.0445 0.0445
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.0102 0.0211 0.0942
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0154 0.0153
Brugia malayi photoreceptor-specific nuclear receptor 0.006 0.0092 0.0412
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0037 0.0029 0.0028
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.0269 0.1207
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.0336 0.1504
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0037 0.0029 0.0028
Plasmodium falciparum glutathione reductase 0.0158 0.0363 0.7822
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0091 0.009
Brugia malayi nuclear receptor NHR-88 0.0028 0.0006 0.0023
Schistosoma mansoni zinc finger protein 0.0039 0.0037 0.0036
Brugia malayi Pre-SET motif family protein 0.012 0.0258 0.1157
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0079 0.1601
Brugia malayi Fli-1 protein 0.0239 0.0586 0.2627
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0058 0.0089 0.0089
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0147 0.0146
Plasmodium falciparum heat shock protein 90 0.0107 0.0224 0.4808
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0026 0.0025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.006 0.0092 0.0092
Treponema pallidum NADH oxidase 0.0055 0.0079 0.0787
Brugia malayi SET domain containing protein 0.0027 0.0004 0.0015
Trypanosoma brucei heat shock protein, putative 0.0107 0.0224 0.5175
Mycobacterium tuberculosis Probable dehydrogenase 0.036 0.0919 0.1014
Loa Loa (eye worm) hypothetical protein 0.0142 0.0319 0.143
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0057 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-31 0.006 0.0092 0.0412
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0032 0.0017 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0178 0.0593
Trypanosoma brucei cytochrome P450, putative 0.0087 0.0168 0.3887
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0037 0.0029 0.0421
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0147 0.3122
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0037 0.0029 0.0028
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0055 0.0081 0.008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0157 0.0362 0.1621
Loa Loa (eye worm) hypothetical protein 0.0084 0.0159 0.0713
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0153
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0412
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.036 0.0919 0.3089
Treponema pallidum heat shock protein 90 0.0092 0.0181 0.1861

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 71 % Inhibition of ACAT in mouse liver microsomes at 20 uM ChEMBL. 18620856

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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