Detailed information for compound 1177232

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 785.144 | Formula: C48H80O8
  • H donors: 2 H acceptors: 5 LogP: 12.45 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@@]1(O)C[C@@H]2[C@H]([C@H]([C@H]1O)OC(=O)C)CC[C@@]1(C2=CC[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)CC[C@H](C1(C)C)OC(=O)C)C
  • InChi: 1S/C48H80O8/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-22-41(51)54-32-48(53)31-36-35(42(43(48)52)56-34(3)50)25-29-46(7)37(36)23-24-39-45(6)28-27-40(55-33(2)49)44(4,5)38(45)26-30-47(39,46)8/h23,35-36,38-40,42-43,52-53H,9-22,24-32H2,1-8H3/t35-,36-,38+,39-,40-,42-,43-,45+,46-,47-,48+/m1/s1
  • InChiKey: ZPIQMIXTIQYVQX-UWUFFKRHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Smad1 0.0017 0.0084 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.1795 0.2032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0382 0.0433
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0748 0.0847
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0482 0.0545
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.191 0.8208
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0207 0.0186
Echinococcus granulosus microtubule associated protein 2 0.0716 0.8562 0.9695
Schistosoma mansoni hypothetical protein 0.002 0.0122 0.0143
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0382 0.0446
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0207 0.0186
Schistosoma mansoni rab6-interacting 0.002 0.0122 0.0143
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.014 0.0245
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0122 0.0122
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0122 0.0138
Echinococcus granulosus smad 0.0017 0.0084 0.0095
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0347 0.0406
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0207 0.0241
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0181 0.2065 0.8902
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.014 0.0602
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0748 0.0847
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.8562 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.1416 0.1416
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0776
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.017 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0108
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0207 0.0615
Loa Loa (eye worm) hypothetical protein 0.0129 0.1442 0.1633
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0122 0.0122
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0084 0.0098
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0256 0.029
Toxoplasma gondii thioredoxin reductase 0.0079 0.0834 0.5445
Schistosoma mansoni hypothetical protein 0.0176 0.2007 0.2344
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.2959 0.335
Loa Loa (eye worm) Smad1 0.0017 0.0084 0.0095
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0665 0.0753
Brugia malayi Pre-SET motif family protein 0.0032 0.0256 0.029
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.1416 0.1603
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.017 0.0412
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1704 0.4344
Echinococcus multilocularis Smad4 0.0017 0.0084 0.0084
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.014 0.0254
Plasmodium falciparum thioredoxin reductase 0.0079 0.0834 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0347 0.0393
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0207 0.151
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.5696 0.5696
Schistosoma mansoni lipoxygenase 0.0086 0.0912 0.1065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0201 0.2309 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0032 0.0256 0.029
Mycobacterium tuberculosis Probable reductase 0.0181 0.2065 0.8902
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0347 0.0577
Echinococcus multilocularis GPCR, family 2 0.005 0.0482 0.0482
Schistosoma mansoni loxhd1 0.002 0.0122 0.0143
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0151 0.1701 0.1926
Brugia malayi Doublecortin family protein 0.002 0.0122 0.0138
Onchocerca volvulus 0.0024 0.017 0.0584
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.374 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0382 0.0382
Brugia malayi AMP-binding enzyme family protein 0.0024 0.017 0.0192
Mycobacterium tuberculosis Probable dehydrogenase 0.0181 0.2065 0.8902
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0347 1
Plasmodium falciparum glutathione reductase 0.0079 0.0834 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.1359 0.1359
Brugia malayi hypothetical protein 0.002 0.0122 0.0138
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0084 0.0095
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0748 0.1691
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0027 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0108
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0665 0.0665
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0122 0.0366
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.1416 0.3544
Treponema pallidum NADH oxidase 0.0027 0.0207 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0776
Mycobacterium ulcerans hypothetical protein 0.0168 0.191 1
Brugia malayi MH1 domain containing protein 0.0017 0.0084 0.0095
Echinococcus granulosus Smad4 0.0017 0.0084 0.0095
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0207 0.0186
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.017 0.0412
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0256 0.0913
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0079 0.0834 0.3375
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0207 0.0526
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0417 0.0772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.014 0.014
Schistosoma mansoni Smad4 0.0017 0.0084 0.0098
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0347 0.3412
Onchocerca volvulus 0.025 0.2906 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0138
Schistosoma mansoni hypothetical protein 0.005 0.0482 0.0563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.017 0.039
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0122 0.0138
Brugia malayi hypothetical protein 0.0738 0.8831 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.017 0.0412
Entamoeba histolytica hypothetical protein 0.0042 0.0382 0.3985
Schistosoma mansoni smad1 5 8 and 0.0017 0.0084 0.0098
Loa Loa (eye worm) hypothetical protein 0.0129 0.1442 0.1633
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.1416 0.1653
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0207 0.0186
Schistosoma mansoni ap endonuclease 0.0022 0.014 0.0163
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0347 0.0347
Leishmania major trypanothione reductase 0.0079 0.0834 0.193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0108
Brugia malayi Pre-SET motif family protein 0.022 0.2538 0.2874
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0776
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0207 0.0615
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.017 0.039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0256 0.0256
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.017 0.0412
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.1416 0.7275
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0256 0.0299
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0347 0.0393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.1795 0.2032
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0207 0.151
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Echinococcus granulosus tar DNA binding protein 0.0065 0.0665 0.0753
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0181 0.2065 0.8902
Schistosoma mansoni smad 0.0017 0.0084 0.0098
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0748 0.1691
Schistosoma mansoni hypothetical protein 0.0108 0.1187 0.1386
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0181 0.2065 0.8902
Schistosoma mansoni lipoxygenase 0.0122 0.1359 0.1587
Schistosoma mansoni survival motor neuron protein 0.0151 0.1701 0.1986
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0118 0.0134
Onchocerca volvulus 0.002 0.0122 0.042
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0084 0.0084
Echinococcus granulosus transcription factor Dp 1 0.0042 0.038 0.043
Loa Loa (eye worm) thioredoxin reductase 0.0079 0.0834 0.0945
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.2959 0.335
Plasmodium falciparum glutathione reductase 0.0027 0.0207 0.151
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0207 0.0526
Brugia malayi MH2 domain containing protein 0.0017 0.0084 0.0095
Trypanosoma brucei trypanothione reductase 0.0079 0.0834 0.193
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0118 0.0134
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.0834 0.193
Echinococcus multilocularis smad 0.0017 0.0084 0.0084
Entamoeba histolytica hypothetical protein 0.0042 0.0382 0.3985
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0256 0.0299
Brugia malayi glutathione reductase 0.0079 0.0834 0.0945
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0084 0.0095
Schistosoma mansoni hypothetical protein 0.0176 0.2007 0.2344
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.1416 1
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0207 0.0243
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0084 0.0095
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.0192
Schistosoma mansoni smad1 5 8 and 0.0017 0.0084 0.0098
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.014 0.0158
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0122 0.0122
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.017 0.0084
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.374 1
Onchocerca volvulus Huntingtin homolog 0.0129 0.1442 0.4962
Echinococcus granulosus GPCR family 2 0.005 0.0482 0.0545
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.017 0.0499
Schistosoma mansoni hypothetical protein 0.005 0.0482 0.0563
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0536 0.1102
Brugia malayi TAR-binding protein 0.0065 0.0665 0.0753
Entamoeba histolytica hypothetical protein 0.0042 0.0382 0.3985
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.014 0.0158
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0256 0.0256
Onchocerca volvulus 0.0151 0.1701 0.5852
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0207 0.0615
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.017 0.0499
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.017 0.0412
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0748 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.0192
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.017 0.0084
Plasmodium vivax thioredoxin reductase, putative 0.0079 0.0834 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0482 0.0545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0256 0.0299
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1187 0.1344
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0181 0.2065 0.8857
Onchocerca volvulus Huntingtin homolog 0.0129 0.1442 0.4962
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0417 0.0772
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.1795 0.2032
Echinococcus multilocularis RUN 0.002 0.0122 0.0122
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0201 0.2309 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0122 0.0366
Brugia malayi RNA binding protein 0.0065 0.0665 0.0753
Trichomonas vaginalis set domain proteins, putative 0.025 0.2906 1
Brugia malayi Thioredoxin reductase 0.0079 0.0834 0.0945
Entamoeba histolytica hypothetical protein 0.0042 0.0382 0.3985
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0207 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0256 0.0299
Brugia malayi hypothetical protein 0.002 0.0122 0.0138
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0347 0.0393
Schistosoma mansoni hypothetical protein 0.005 0.0482 0.0563
Echinococcus granulosus geminin 0.0176 0.2007 0.2273
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0207 0.0186
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0347 0.0751
Echinococcus multilocularis neuropeptide s receptor 0.048 0.5696 0.5696
Brugia malayi hypothetical protein 0.0042 0.0382 0.0433
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.1416 0.5986
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0347 0.0406
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1704 0.4344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.1359 0.1539
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0108
Onchocerca volvulus 0.0032 0.0256 0.0881
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.0847 0.0959
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0347 0.0577
Loa Loa (eye worm) hypothetical protein 0.0738 0.8831 1
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0347 0.0393
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Brugia malayi AMP-binding enzyme family protein 0.0024 0.017 0.0192
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0207 0.0243
Echinococcus multilocularis geminin 0.0176 0.2007 0.2007
Schistosoma mansoni smad1 5 8 and 0.0017 0.0084 0.0098
Brugia malayi Latrophilin receptor protein 2 0.005 0.0482 0.0545
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0084 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Schistosoma mansoni hypothetical protein 0.0042 0.0382 0.0446
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0108
Schistosoma mansoni polycystin 1-related 0.002 0.0122 0.0143
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0095 0.0054
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.014 0.0158
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0482 0.0482
Schistosoma mansoni hypothetical protein 0.0151 0.1701 0.1986
Plasmodium vivax glutathione reductase, putative 0.0079 0.0834 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1795 0.2032
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0482 0.0545
Loa Loa (eye worm) RNA binding protein 0.0065 0.0665 0.0753
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0201 0.2309 1
Brugia malayi hypothetical protein 0.0129 0.1442 0.1633
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0748 0.1691
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.374 1
Echinococcus granulosus neuropeptide s receptor 0.048 0.5696 0.645
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0122 0.0138
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0417 0.0772
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.1416 0.7275
Brugia malayi MH1 domain containing protein 0.0017 0.0084 0.0095
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.1416 0.1653
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0665 0.0753
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0748 0.1691
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0242 0.0274
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0417 0.0772
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0482 0.0545
Echinococcus multilocularis survival motor neuron protein 1 0.0738 0.8831 0.8831
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0748 0.0748
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0207 0.0186
Echinococcus granulosus survival motor neuron protein 1 0.0738 0.8831 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0748 0.0874
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0776
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2538 0.2874
Echinococcus granulosus RUN 0.002 0.0122 0.0138
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.0207 0.3233
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.038 0.038
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0207 0.151
Mycobacterium ulcerans hypothetical protein 0.0024 0.017 0.0412
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0347 0.0751
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0207 0.151
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0665 0.0753
Loa Loa (eye worm) hypothetical protein 0.0039 0.0347 0.0393
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0207 0.0207
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0207 0.0186
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0207 0.0556
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.374 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0207 0.0186
Mycobacterium tuberculosis Probable oxidoreductase 0.0201 0.2309 1
Toxoplasma gondii hypothetical protein 0.0051 0.0497 0.2805
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0482 0.0545
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0347 0.0577
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.017 0.0412
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.017 0.0412
Echinococcus granulosus neuropeptide receptor A26 0.048 0.5696 0.645
Brugia malayi MH2 domain containing protein 0.0254 0.2959 0.335
Loa Loa (eye worm) hypothetical protein 0.0108 0.1187 0.1344
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0207 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0207 0.0186
Brugia malayi MH2 domain containing protein 0.0017 0.0084 0.0095
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0347 0.0577
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.1416 0.7275
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0347 0.0347
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.014 0.0602
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0776
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0482 0.0482
Plasmodium falciparum thioredoxin reductase 0.0027 0.0207 0.151
Schistosoma mansoni rab6-interacting 0.002 0.0122 0.0143
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0347 0.0347
Schistosoma mansoni ap endonuclease 0.0022 0.014 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0347 0.0751
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0748 0.0847
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0181 0.2065 0.8902
Onchocerca volvulus 0.002 0.0122 0.042
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0207 0.0234
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0084 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.8562 0.8562
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0207 0.0234
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0207 1
Schistosoma mansoni hypothetical protein 0.005 0.0482 0.0563
Plasmodium vivax SET domain protein, putative 0.0032 0.0256 0.2177
Loa Loa (eye worm) glutathione reductase 0.0079 0.0834 0.0945
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.017 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0024 0.017 0.0192
Loa Loa (eye worm) doublecortin family protein 0.002 0.0122 0.0138
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.1704 0.4344

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 50 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 ChEMBL. 18419156
MIC (functional) > 50 ug ml-1 Antimicrobial activity against Candida albicans ChEMBL. 18419156

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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