Detailed information for compound 1177463

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 994.794 | Formula: C31H53N10O19P3S
  • H donors: 12 H acceptors: 17 LogP: -6.71 Rotable bonds: 32
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(NCCSCC(=O)NCCCC[C@@H](C(=O)N)NC(=O)C)CCNC(=O)[C@@H](C(COP(=O)(OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(O)O)O)n1cnc2c1ncnc2N)O)O)(C)C)O
  • InChi: 1S/C31H53N10O19P3S/c1-17(42)40-18(27(33)47)6-4-5-8-34-21(44)13-64-11-10-35-20(43)7-9-36-29(48)25(46)31(2,3)14-57-63(54,55)60-62(52,53)56-12-19-24(59-61(49,50)51)23(45)30(58-19)41-16-39-22-26(32)37-15-38-28(22)41/h15-16,18-19,23-25,30,45-46H,4-14H2,1-3H3,(H2,33,47)(H,34,44)(H,35,43)(H,36,48)(H,40,42)(H,52,53)(H,54,55)(H2,32,37,38)(H2,49,50,51)/t18-,19+,23+,24+,25-,30+/m0/s1
  • InChiKey: YGZKIOPJGFQDSR-QGSWMBNESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens E1A binding protein p300 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Loa Loa (eye worm) CBP-B Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma japonicum IPR011071,Polysaccharide lyase family 8-like, C-terminal,domain-containing Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma japonicum Protein cbp-1, putative Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma japonicum CREB-binding protein, putative Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma japonicum ko:K04498 E1A/CREB-binding protein, putative Get druggable targets OG5_129174 All targets in OG5_129174
Brugia malayi TAZ zinc finger family protein Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma mansoni CREB-binding protein 2 Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0162 0.0931 0.0917
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0092 0.0101
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0102 0.0472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0018 0.0003
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0019 0.0003
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0142 0.379
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0786 0.4371
Plasmodium vivax hypothetical protein, conserved 0.0024 0.005 0.0621
Loa Loa (eye worm) transcription factor SMAD2 0.0425 0.2603 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.019 0.0205
Brugia malayi intermediate filament protein 0.0026 0.0062 0.024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0018 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0102 0.0897
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0018 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0019 0.0072
Loa Loa (eye worm) hypothetical protein 0.0146 0.0829 0.3185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0018 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Echinococcus granulosus mothers against decapentaplegic 5 0.0029 0.0082 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Schistosoma mansoni lamin 0.0026 0.0062 0.0067
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0018 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0212 0.0814
Brugia malayi MH1 domain containing protein 0.0029 0.0082 0.0316
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0293 0.297
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0018 0.0003
Echinococcus granulosus Smad4 0.0029 0.0082 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Brugia malayi Cathepsin L-like precursor 0.0042 0.0162 0.0624
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0062 0.0293 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0018 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0018 0.0003
Echinococcus granulosus cathepsin l cysteine peptidase 0.0062 0.0293 0.0326
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0333 0.128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Onchocerca volvulus Alhambra homolog 0.0024 0.005 0.0285
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0373 0.2487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0018 0.007
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Brugia malayi cathepsin L-like precursor 0.0042 0.0162 0.0624
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.011
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0018 0.007
Onchocerca volvulus 0.0075 0.0373 0.3184
Trichomonas vaginalis set domain proteins, putative 0.0194 0.1133 0.7819
Loa Loa (eye worm) hypothetical protein 0.0042 0.0162 0.0624
Loa Loa (eye worm) MH1 domain-containing protein 0.0029 0.0082 0.0316
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0232 0.1372 0.5271
Echinococcus multilocularis tumor protein p63 0.0917 0.5736 0.573
Echinococcus multilocularis lysine specific demethylase 5A 0.0029 0.0082 0.0067
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0006 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0018 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0019 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Schistosoma mansoni lamin 0.0026 0.0062 0.0067
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0123 0.2265
Echinococcus granulosus geminin 0.0162 0.0931 0.1077
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0018 0.0003
Brugia malayi Bromodomain containing protein 0.0037 0.0134 0.0513
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0102 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Onchocerca volvulus 0.0075 0.0373 0.3184
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0373 0.1216
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0373 0.2019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0232 0.1372 0.5271
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.022 0.1145
Loa Loa (eye worm) hypothetical protein 0.0075 0.0373 0.1433
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0535 0.2053
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0102 0.0897
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0142 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0018 0.0003
Echinococcus granulosus CREB binding protein 0.002 0.0026 0.0012
Schistosoma mansoni smad1 5 8 and 0.0029 0.0082 0.009
Brugia malayi TAZ zinc finger family protein 0.0128 0.0712 0.2735
Onchocerca volvulus 0.0062 0.0293 0.2465
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0373 0.1216
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0062 0.0293 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0062 0.0293 0.1925
Brugia malayi Cathepsin L-like precursor 0.0062 0.0293 0.1126
Schistosoma mansoni hypothetical protein 0.0032 0.0099 0.011
Echinococcus multilocularis musashi 0.0026 0.0062 0.0047
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0102 0.0113
Brugia malayi beta-lactamase 0.0075 0.0373 0.1433
Loa Loa (eye worm) hypothetical protein 0.0057 0.0264 0.1014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Plasmodium vivax SET domain protein, putative 0.0024 0.0054 0.0727
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0055 0.0245 0.023
Brugia malayi PHD-finger family protein 0.0026 0.0064 0.0245
Leishmania major cathepsin L-like protease 0.0062 0.0293 0.1563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0162 0.0816
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Brugia malayi jmjC domain containing protein 0.0078 0.0396 0.1521
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0373 0.1433
Echinococcus multilocularis GPCR, family 2 0.0032 0.0099 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0123 0.0596
Echinococcus multilocularis cysteine protease 0.0062 0.0293 0.0278
Loa Loa (eye worm) inositol-1 0.0035 0.0123 0.0473
Schistosoma mansoni DNA polymerase eta 0.0019 0.0019 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0373 0.0432
Schistosoma mansoni intermediate filament proteins 0.0026 0.0062 0.0067
Giardia lamblia PHD finger protein 15 0.0024 0.005 0.2544
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0018 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0018 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0236 0.1403 0.7885
Leishmania major cathepsin L-like protease 0.0062 0.0293 0.1563
Echinococcus granulosus cathepsin l1 0.0042 0.0162 0.0173
Brugia malayi MH2 domain containing protein 0.0029 0.0082 0.0316
Leishmania major cathepsin L-like protease 0.0236 0.1403 0.7885
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0373 0.4086
Trichomonas vaginalis esterase, putative 0.0075 0.0373 0.2487
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0018 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0018 0.007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0019 0.0003
Brugia malayi steroid hormone receptor 0.0019 0.0018 0.007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0099 0.0382
Schistosoma mansoni coup transcription factor 0.0019 0.0018 0.0015
Entamoeba histolytica cysteine protease, putative 0.0062 0.0293 0.297
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0018 0.0015
Onchocerca volvulus 0.0134 0.0753 0.6589
Brugia malayi Inositol-1 0.0035 0.0123 0.0473
Echinococcus granulosus CREB binding protein 0.002 0.0026 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0162 0.1009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0019 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0062 0.0293 0.1925
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Onchocerca volvulus 0.0062 0.0293 0.2465
Onchocerca volvulus 0.0042 0.0162 0.1294
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0143 0.0161
Loa Loa (eye worm) fibroinase 0.0062 0.0293 0.1126
Echinococcus multilocularis smad 0.0029 0.0082 0.0067
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0102 0.2119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0223 0.0255
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0018 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0236 0.1403 0.7885
Brugia malayi Beta-glucuronidase precursor 0.0225 0.133 0.511
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0018 0.0003
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.01 0.0278
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0123 0.0596
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0018 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0018 0.0015
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0373 0.4086
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0373 0.0358
Echinococcus multilocularis PHD finger protein rhinoceros 0.0024 0.005 0.0035
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1774 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0829 0.3186
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0018 0.0003
Brugia malayi MH2 domain containing protein 0.0029 0.0082 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0223 0.0255
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0099 0.0382
Brugia malayi PHD-finger family protein 0.0024 0.005 0.0192
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0019 0.0072
Loa Loa (eye worm) hypothetical protein 0.0068 0.0333 0.128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Plasmodium falciparum cysteine proteinase falcipain 3 0.0062 0.0293 1
Schistosoma mansoni zinc finger protein 0.0022 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0162 0.1009
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0092 0.0353
Echinococcus granulosus TGF beta signal transducer SmadC 0.0029 0.0082 0.0079
Brugia malayi beta-lactamase family protein 0.0075 0.0373 0.1433
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0373 1
Plasmodium vivax unspecified product 0.0032 0.0102 0.2116
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0018 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0018 0.0003
Echinococcus multilocularis zinc finger protein 0.0022 0.0036 0.002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0829 0.0968
Schistosoma mansoni hypothetical protein 0.0024 0.005 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0562
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0142 0.1337
Brugia malayi Pre-SET motif family protein 0.017 0.0983 0.3776
Entamoeba histolytica hypothetical protein 0.0101 0.0541 0.5651
Mycobacterium leprae Probable lipase LipE 0.0075 0.0373 1
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0092 0.009
Schistosoma mansoni bromodomain containing protein 0.0057 0.0264 0.0303
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.017 0.0983 0.3776
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.019 0.1205
Brugia malayi Cytochrome P450 family protein 0.0054 0.0244 0.0938
Echinococcus granulosus PHD finger protein rhinoceros 0.0024 0.005 0.0041
Echinococcus multilocularis cathepsin L cysteine protease 0.0062 0.0293 0.0278
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0099 0.0382
Schistosoma mansoni hypothetical protein 0.0068 0.0333 0.0385
Schistosoma mansoni hypothetical protein 0.0032 0.0099 0.011
Loa Loa (eye worm) MH2 domain-containing protein 0.0425 0.2603 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0078 0.0396 0.0381
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0062 0.0293 0.1126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0018 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0099 0.0382
Loa Loa (eye worm) hypothetical protein 0.0041 0.0156 0.06
Loa Loa (eye worm) acetyltransferase 0.0146 0.0829 0.3186
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0018 0.007
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0373 0.1216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Onchocerca volvulus 0.0062 0.0293 0.2465
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.1081 0.605
Echinococcus granulosus tumor protein p63 0.0917 0.5736 0.6728
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0019 0.0015
Echinococcus granulosus cysteine protease 0.0032 0.0102 0.0101
Echinococcus multilocularis cathepsin L cysteine protease 0.0062 0.0293 0.0278
Echinococcus granulosus smad 0.0029 0.0082 0.0079
Brugia malayi jmjC domain containing protein 0.003 0.0092 0.0353
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0829 0.0815
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0102 0.039
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0035 0.0123 0.1132
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0123 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0377
Mycobacterium ulcerans hypothetical protein 0.0155 0.0886 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0062 0.0293 0.0278
Schistosoma mansoni cathepsin s 0.0021 0.0029 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Onchocerca volvulus Cathepsin L homolog 0.0062 0.0293 0.2465
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0373 0.2487
Echinococcus multilocularis peregrin 0.0031 0.0098 0.0083
Leishmania major cathepsin L-like protease 0.0062 0.0293 0.1563
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0293 0.297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0102 0.0897
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Echinococcus granulosus dna polymerase eta 0.0019 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0159 0.0609
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0143 0.0149
Schistosoma mansoni hypothetical protein 0.0032 0.0099 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Leishmania major hypothetical protein, conserved 0.0075 0.0373 0.2019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0223 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0223 0.0244
Entamoeba histolytica beta-galactosidase, putative 0.0164 0.0942 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0048 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0373 0.2487
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0102 0.0897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0102 0.0472
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0223 0.0856
Loa Loa (eye worm) hypothetical protein 0.0075 0.0373 0.1433
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0123 0.0127
Trypanosoma cruzi cruzipain precursor, putative 0.0021 0.0029 0.0057
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0373 0.1216
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0373 0.1216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0102 0.0582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0223 0.0207
Brugia malayi Smad1 0.0029 0.0082 0.0316
Echinococcus granulosus peregrin 0.0031 0.0098 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Loa Loa (eye worm) hypothetical protein 0.017 0.0979 0.3762
Mycobacterium tuberculosis Conserved protein 0.0075 0.0373 0.1216
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0162 0.1557
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0293 0.1126
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Onchocerca volvulus 0.0026 0.0062 0.0397
Brugia malayi Cathepsin L-like precursor 0.0062 0.0293 0.1126
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0062 0.0293 0.0278
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0101 0.0541 0.0618
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0535 0.2053
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0102 0.0101
Loa Loa (eye worm) cysteine protease 0.0062 0.0293 0.1126
Plasmodium vivax vivapain-2 0.0062 0.0293 0.7675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Schistosoma mansoni hypothetical protein 0.0162 0.0931 0.1087
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0123 0.0596
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0293 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0143 0.0161
Brugia malayi cathepsin F-like cysteine proteinase 0.0021 0.0029 0.011
Brugia malayi MH2 domain containing protein 0.0425 0.2603 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0062 0.0293 0.1126
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0143 0.0127
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0026 0.01
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.005 0.0192
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0078 0.0396 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0018 0.007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0085 0.007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0018 0.007
Trichomonas vaginalis glycoside hydrolase, putative 0.0243 0.1444 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0373 0.0432
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0373 0.1216
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0123 0.0108
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0778 0.0897
Schistosoma mansoni hypothetical protein 0.0032 0.0099 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0018 0.007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0029 0.0082 0.0067
Schistosoma mansoni hypothetical protein 0.0101 0.0541 0.0628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Echinococcus multilocularis CREB binding protein 0.0089 0.0467 0.0452
Echinococcus multilocularis cysteine protease 0.0062 0.0293 0.0278
Echinococcus multilocularis jumonji domain containing protein 0.0033 0.011 0.0094
Toxoplasma gondii ABC1 family protein 0.0075 0.0373 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0192
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0293 0.1126
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0018 0.0015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0024 0.005 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0054 0.0056
Brugia malayi Cathepsin L-like precursor 0.0062 0.0293 0.1126
Schistosoma mansoni beta-mannosidase 0.0079 0.0399 0.0462
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0099 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0223 0.0255
Loa Loa (eye worm) CBP-B 0.009 0.0474 0.182
Loa Loa (eye worm) hypothetical protein 0.0042 0.0162 0.0624
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0162 0.0816
Mycobacterium ulcerans beta-lactamase 0.0075 0.0373 0.4086
Loa Loa (eye worm) hypothetical protein 0.0134 0.0753 0.2891
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.017 0.0979 0.3762
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0029 0.0082 0.0067
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0018 0.0015
Brugia malayi Cathepsin L-like precursor 0.0042 0.0162 0.0624
Echinococcus multilocularis CREB binding protein 0.002 0.0026 0.001
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Schistosoma mansoni Smad4 0.0029 0.0082 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0373 0.2487
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0062 0.024
Echinococcus multilocularis cathepsin L 0.0032 0.0102 0.0086
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0373 0.042
Loa Loa (eye worm) hypothetical protein 0.01 0.0535 0.2053
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0535 0.2053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0786 0.4371
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0548
Brugia malayi Pre-SET motif family protein 0.0024 0.0054 0.0206
Brugia malayi Cathepsin L-like precursor 0.0062 0.0293 0.1126
Echinococcus multilocularis lamin dm0 0.0026 0.0062 0.0047
Loa Loa (eye worm) hypothetical protein 0.0075 0.0373 0.1433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0018 0.007
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0018 0.0015
Schistosoma mansoni microtubule-associated protein tau 0.1354 0.8519 1
Onchocerca volvulus Cathepsin L homolog 0.0062 0.0293 0.2465
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0102 0.0897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0018 0.007
Brugia malayi Cathepsin L-like precursor 0.0062 0.0293 0.1126
Schistosoma mansoni inositol monophosphatase 0.0035 0.0123 0.0138
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0062 0.024
Trichomonas vaginalis beta-galactosidase, putative 0.0243 0.1444 1
Onchocerca volvulus Cathepsin F homolog 0.0062 0.0293 0.2465
Leishmania major cysteine peptidase A (CPA) 0.0062 0.0293 0.1563
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0477 0.2933 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0101 0.0541 0.0526
Schistosoma mansoni hypothetical protein 0.0162 0.0931 0.1087
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0019 0.0015
Schistosoma mansoni cathepsin F (C01 family) 0.0062 0.0293 0.0338
Trypanosoma cruzi cruzipain precursor, putative 0.0236 0.1403 0.7885
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Entamoeba histolytica hypothetical protein 0.0101 0.0541 0.5651
Schistosoma mansoni cathepsin F (C01 family) 0.0062 0.0293 0.0338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0018 0.0003
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1774 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0018 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0373 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0021 0.0029 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0223 0.0207
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0102 0.0897
Loa Loa (eye worm) beta-lactamase 0.0075 0.0373 0.1433
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0373 0.2019
Brugia malayi Cathepsin L-like precursor 0.0021 0.0029 0.011
Brugia malayi nuclear hormone receptor 0.0019 0.0018 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Echinococcus granulosus jumonji domain containing protein 0.0033 0.011 0.0111
Echinococcus granulosus microtubule associated protein 2 0.1354 0.8519 1
Mycobacterium ulcerans hypothetical protein 0.0075 0.0373 0.4086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Toxoplasma gondii hypothetical protein 0.0048 0.0201 0.4662
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Echinococcus granulosus lamin dm0 0.0026 0.0062 0.0055
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0102 0.0113
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.019 0.1205
Echinococcus granulosus cathepsin L cysteine proteinase 0.0062 0.0293 0.0326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0102 0.0472
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0123 0.0734
Mycobacterium tuberculosis Conserved protein 0.0075 0.0373 0.1216
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.019 0.4342
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0123 0.0596
Loa Loa (eye worm) hypothetical protein 0.0075 0.0373 0.1433
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0293 0.1563
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0018 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0162 0.0816
Loa Loa (eye worm) hypothetical protein 0.0058 0.0267 0.1025
Brugia malayi Cathepsin L-like precursor 0.0062 0.0293 0.1126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0236 0.1403 0.7885
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0162 0.0184
Schistosoma mansoni smad1 5 8 and 0.0029 0.0082 0.009
Brugia malayi ecdysteroid receptor 0.0019 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0072
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0373 0.1216
Schistosoma mansoni smad1 5 8 and 0.0029 0.0082 0.009
Brugia malayi hypothetical protein 0.0101 0.0541 0.2077
Onchocerca volvulus 0.0026 0.0062 0.0397
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0373 0.1433
Echinococcus multilocularis CREB binding protein 0.002 0.0026 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0244 0.0938
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0228
Echinococcus granulosus intermediate filament protein 0.0026 0.0062 0.0055
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0018 0.0016 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0102 0.0582
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0102 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0018 0.007
Echinococcus multilocularis lamin 0.0026 0.0062 0.0047
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0128 0.0712 0.083
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0054 0.0113
Plasmodium vivax vivapain-1 0.0032 0.0102 0.2116
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0373 0.2487
Trypanosoma cruzi cysteine peptidase, putative 0.0236 0.1403 0.7885
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0018 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Echinococcus multilocularis microtubule associated protein 2 0.1354 0.8519 0.8516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0018 0.007
Leishmania major cathepsin L-like protease 0.0062 0.0293 0.1563
Trichomonas vaginalis beta-mannosidase, putative 0.0079 0.0399 0.2672
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Loa Loa (eye worm) MH2 domain-containing protein 0.0029 0.0082 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.024
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0021 0.0029 0.011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0054 0.0038
Brugia malayi MH1 domain containing protein 0.0029 0.0082 0.0316
Leishmania major cathepsin L-like protease 0.0236 0.1403 0.7885
Entamoeba histolytica hypothetical protein 0.0101 0.0541 0.5651
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0099 0.0099
Schistosoma mansoni cellular tumor antigen P53 0.0134 0.0753 0.0877
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0085 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.095 0.6534
Loa Loa (eye worm) hypothetical protein 0.0075 0.0373 0.1433
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0123 0.0734
Echinococcus granulosus zinc finger protein 0.0022 0.0036 0.0024
Echinococcus granulosus CREB binding protein 0.0081 0.0413 0.0468
Onchocerca volvulus 0.0075 0.0373 0.3184
Mycobacterium ulcerans lipase LipD 0.0075 0.0373 0.4086
Loa Loa (eye worm) ctsf protein 0.0062 0.0293 0.1126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0293 0.1925
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0886 0.2977
Onchocerca volvulus 0.0062 0.0293 0.2465
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0373 0.2019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Echinococcus multilocularis CREB binding protein 0.002 0.0026 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0101 0.0541 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0018 0.007
Schistosoma mansoni inositol monophosphatase 0.0035 0.0123 0.0138
Onchocerca volvulus 0.0024 0.0054 0.0318
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1774 1
Loa Loa (eye worm) Smad1 0.0029 0.0082 0.0316
Schistosoma mansoni CREB-binding protein 2 0.0128 0.0712 0.083
Schistosoma mansoni smad 0.0029 0.0082 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.011
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0035 0.0123 0.5
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0123 0.0734
Onchocerca volvulus 0.0062 0.0293 0.2465
Toxoplasma gondii cathepsin CPL 0.0062 0.0293 0.7521
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0018 0.007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0018 0.0003
Brugia malayi Bromodomain containing protein 0.0067 0.0325 0.1248
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1774 1
Leishmania major cathepsin L-like protease 0.0236 0.1403 0.7885
Plasmodium vivax vivapain-2 0.0062 0.0293 0.7675
Echinococcus granulosus cathepsin L 0.0032 0.0102 0.0101
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0029 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0075 0.0373 0.1433
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.019 0.4693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Echinococcus granulosus CREB binding protein 0.0128 0.0712 0.0819
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0062 0.024
Onchocerca volvulus 0.0194 0.1133 1
Onchocerca volvulus 0.0062 0.0293 0.2465
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.1444 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0102 0.0472
Echinococcus granulosus GPCR family 2 0.0032 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0085 0.0441 0.0512
Echinococcus granulosus lamin 0.0026 0.0062 0.0055
Brugia malayi Cathepsin L-like cysteine proteinase 0.0042 0.0162 0.0624
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0102 0.0472
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0223 0.0856
Brugia malayi Bromodomain containing protein 0.0031 0.0098 0.0377
Echinococcus multilocularis dna polymerase eta 0.0019 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0162 0.0624
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0162 0.0816
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0102 0.039
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0018 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0055 0.0245 0.027
Onchocerca volvulus 0.0062 0.0293 0.2465
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0216 0.1272 0.7141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0099 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0092 0.0101
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0102 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0018 0.007
Loa Loa (eye worm) beta-glucuronidase 0.0225 0.133 0.511
Mycobacterium tuberculosis Conserved protein 0.0075 0.0373 0.1216
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Echinococcus multilocularis Smad4 0.0029 0.0082 0.0067
Plasmodium vivax vivapain-3 0.0032 0.0102 0.2116
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0018 0.007
Entamoeba histolytica cysteine protease, putative 0.0032 0.0102 0.0897
Brugia malayi manba-prov protein 0.0079 0.0399 0.1534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0018 0.007
Entamoeba histolytica hypothetical protein 0.0101 0.0541 0.5651
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0018 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.019 0.4342
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0029 0.0082 0.009
Echinococcus granulosus dna polymerase kappa 0.0019 0.0019 0.0004
Echinococcus granulosus cathepsin l1 0.0062 0.0293 0.0326
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0786 0.4371
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0018 0.007
Leishmania major cathepsin L-like protease 0.0062 0.0293 0.1563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0293 0.1925
Brugia malayi beta-lactamase family protein 0.0075 0.0373 0.1433

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0032 uM Inhibition of human recombinant C-terminal GST-tagged p300 (1195 to 1673 residues) expressed in competent Escherichia coli DH5alpha cells using histone substrate after 30 mins by scintillation counting method in presence of [3H]acetyl-CoA ChEMBL. 26701186
IC50 (binding) = 0.05 uM Inhibition of recombinant full length p300 (unknown origin) using N-terminal H4-20 peptide substrate incubated for 7 mins by radiometric gel assay in presence of [14C]acetyl-CoA ChEMBL. 26701186
IC50 (binding) = 0.5 uM Inhibition of full length recombinant human FLAG-tagged p300 expressed in baculovirus expression system using histone substrate incubated for 10 mins by radiometric gel assay ChEMBL. 26701186
IC50 (binding) = 0.98 uM Inhibition of recombinant p300 ChEMBL. 19114310
IC50 (binding) = 29.75 uM Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillation ChEMBL. 19114310
IC50 (binding) = 108.3 uM Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3) ChEMBL. 19114310
IC50 (binding) = 200 uM Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus expression system using histone substrate incubated for 10 mins by radiometric gel assay ChEMBL. 26701186
Ki (binding) = 19 nM Inhibition of p300 (unknown origin) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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