Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0056 | 0.807 | 0.807 |
Onchocerca volvulus | 0.0056 | 0.807 | 1 | |
Onchocerca volvulus | 0.0056 | 0.807 | 1 | |
Schistosoma mansoni | lamin | 0.0056 | 0.807 | 0.807 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2861 | 0.3546 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.807 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.807 | 0.807 |
Schistosoma mansoni | lamin | 0.0056 | 0.807 | 0.807 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.2861 | 0.2861 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.2861 | 0.2861 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.7886 | 0.9772 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.3396 | 0.4208 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.3396 | 0.4208 |
Echinococcus multilocularis | lamin | 0.0056 | 0.807 | 0.807 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.807 | 0.807 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.807 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.807 | 1 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.807 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.807 | 0.807 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.807 | 0.807 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2677 | 0.3318 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.807 | 1 |
Echinococcus multilocularis | musashi | 0.0056 | 0.807 | 0.807 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2677 | 0.3318 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 10 ug ml-1 | Antiproliferative activity against human SKHEP1 cells by SRB assay | ChEMBL. | 18023932 |
GI50 (functional) | > 10 ug ml-1 | Antiproliferative activity against human MDA-MB-231 cells by SRB assay | ChEMBL. | 18023932 |
GI50 (functional) | > 10 ug ml-1 | Antiproliferative activity against human NUGC3 cells by SRB assay | ChEMBL. | 18023932 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.