Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0251 | 0.0251 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0251 | 0.0251 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0251 | 0.0251 |
Schistosoma mansoni | smad | 0.0009 | 0.0251 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0251 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.793 | 0.793 |
Brugia malayi | Smad1 | 0.0009 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.793 | 0.793 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0251 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0251 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0251 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0251 | 0.0251 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0251 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.793 | 0.793 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0251 | 0.0251 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 4.8 % | Cytotoxicity against human MCF7 cells at 0.64 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 11.3 % | Cytotoxicity against human HT-29 cells at 0.64 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 11.8 % | Cytotoxicity against human MCF7 cells at 1.6 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 16.4 % | Cytotoxicity against human HT-29 cells at 1.6 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 33.4 % | Cytotoxicity against human MCF7 cells at 6.4 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 41.5 % | Cytotoxicity against human HT-29 cells at 6.4 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 46.2 % | Cytotoxicity against human MCF7 cells at 16 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 52.8 % | Cytotoxicity against human MCF7 cells at 32 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 52.9 % | Cytotoxicity against human MCF7 cells at 80 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 52.9 % | Cytotoxicity against human HT-29 cells at 16 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 55.6 % | Cytotoxicity against human HT-29 cells at 32 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Activity (functional) | = 60.7 % | Cytotoxicity against human HT-29 cells at 80 ug/ml after 24 hrs by MTT assay | ChEMBL. | 20451307 |
IC50 (functional) | = 12 ug ml-1 | Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay | ChEMBL. | 20451307 |
IC50 (functional) | = 21 ug ml-1 | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | ChEMBL. | 20451307 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20451307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.