Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0033 | 0.0648 | 0.1408 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.135 | 0.3632 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0054 | 0.1366 | 0.3676 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0033 | 0.0648 | 0.1089 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0119 | 0.3717 | 0.4241 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0033 | 0.0648 | 0.1408 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0033 | 0.0648 | 0.1408 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0033 | 0.0648 | 0.1408 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.135 | 0.3632 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0033 | 0.0648 | 0.1089 |
Brugia malayi | polk-prov protein | 0.0033 | 0.0631 | 0.072 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0033 | 0.0648 | 0.1408 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.8765 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0033 | 0.0648 | 0.1089 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0033 | 0.0648 | 0.1089 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.3717 | 0.3612 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0165 | 0.0443 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0033 | 0.0648 | 0.1744 |
Trypanosoma cruzi | cytochrome P450, putative | 0.008 | 0.2299 | 0.6186 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0165 | 0.0188 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0251 | 0.0674 |
Brugia malayi | Cytochrome P450 family protein | 0.008 | 0.2299 | 0.2623 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0044 | 0.101 | 0.086 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0251 | 0.0545 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0631 | 0.1698 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.0648 | 0.1744 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0165 | 0.0165 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0631 | 0.1698 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0033 | 0.0648 | 0.1089 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0119 | 0.3717 | 0.4241 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0033 | 0.0648 | 0.1408 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.0648 | 0.1744 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0119 | 0.3717 | 0.4241 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0044 | 0.101 | 0.086 |
Leishmania major | cytochrome p450-like protein | 0.008 | 0.2299 | 0.6186 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0044 | 0.101 | 0.1905 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0165 | 0.0358 |
Onchocerca volvulus | 0.0053 | 0.135 | 1 | |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0033 | 0.0648 | 0.1089 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0033 | 0.0648 | 0.1408 |
Brugia malayi | Cytochrome P450 family protein | 0.008 | 0.2299 | 0.2623 |
Echinococcus multilocularis | 0.0033 | 0.0648 | 0.0739 | |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0033 | 0.0648 | 0.1089 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.0251 | 0.0087 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.0251 | 0.0674 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0033 | 0.0648 | 0.1089 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0033 | 0.0648 | 0.1744 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0166 | 0.5381 | 0.6139 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0033 | 0.0648 | 0.1744 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0165 | 0.0443 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.008 | 0.2299 | 0.4809 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0033 | 0.0648 | 0.1089 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0033 | 0.0648 | 0.1408 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0033 | 0.0648 | 0.1089 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0033 | 0.0648 | 0.1089 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.0648 | 0.0739 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0033 | 0.0648 | 0.1089 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0033 | 0.0648 | 0.1089 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0033 | 0.0648 | 0.1089 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0165 | 0.0443 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0165 | 0.0188 |
Loa Loa (eye worm) | CYP4Cod1 | 0.008 | 0.2299 | 0.2623 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0165 | 0.0443 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0033 | 0.0648 | 0.1408 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.135 | 0.154 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.026 | 0.8765 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0033 | 0.0648 | 0.1408 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.076 | 0.2044 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0033 | 0.0648 | 0.0739 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0119 | 0.3717 | 0.4241 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0119 | 0.3717 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Trypanosoma cruzi | cytochrome P450, putative | 0.008 | 0.2299 | 0.6186 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0033 | 0.0648 | 0.1408 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.026 | 0.8765 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0165 | 0.0443 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0119 | 0.3717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0631 | 0.072 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.4604 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0119 | 0.3717 | 0.3612 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0033 | 0.0648 | 0.1408 |
Schistosoma mansoni | cytochrome P450 | 0.0033 | 0.0648 | 0.1744 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0119 | 0.3717 | 0.4241 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0165 | 0.0188 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0119 | 0.3717 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0648 | 0.0739 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0044 | 0.101 | 0.2718 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0044 | 0.101 | 0.1905 |
Echinococcus granulosus | dna polymerase kappa | 0.0044 | 0.101 | 0.1153 |
Trypanosoma brucei | cytochrome P450, putative | 0.008 | 0.2299 | 0.6186 |
Brugia malayi | PAS domain containing protein | 0.0054 | 0.1366 | 0.1559 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0648 | 0.1744 |
Echinococcus multilocularis | dna polymerase kappa | 0.0044 | 0.101 | 0.1153 |
Brugia malayi | hypothetical protein | 0.018 | 0.5879 | 0.6707 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0119 | 0.3717 | 0.3612 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.008 | 0.0215 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.008 | 0.0215 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0165 | 0.5 |
Schistosoma mansoni | single-minded | 0.0054 | 0.1366 | 0.3676 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0033 | 0.0648 | 0.1089 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.076 | 0.2044 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0033 | 0.0648 | 0.1408 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.008 | 0.2299 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3717 | 0.4241 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0165 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0033 | 0.0648 | 0.1089 |
Echinococcus granulosus | single minded 2 | 0.004 | 0.0868 | 0.0991 |
Mycobacterium ulcerans | putative regulatory protein | 0.004 | 0.0868 | 0.1585 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1101 | 0.1256 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0033 | 0.0648 | 0.1408 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0648 | 0.0739 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0119 | 0.3717 | 0.4241 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0119 | 0.3717 | 0.3612 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0165 | 0.0188 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.4604 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.004 | 0.0868 | 0.0991 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0033 | 0.0648 | 0.1089 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0033 | 0.0648 | 0.1089 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.008 | 0.0215 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0033 | 0.0648 | 0.1408 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0033 | 0.0648 | 0.1089 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.4604 | 1 |
Brugia malayi | hypothetical protein | 0.026 | 0.8765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5879 | 0.6707 |
Brugia malayi | hypoxia-induced factor 1 | 0.0166 | 0.5381 | 0.6139 |
Brugia malayi | cytochrome P450 | 0.0033 | 0.0648 | 0.0739 |
Loa Loa (eye worm) | cytochrome P450 | 0.0033 | 0.0648 | 0.0739 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0033 | 0.0648 | 0.1089 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0119 | 0.3717 | 0.4241 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0033 | 0.0648 | 0.1408 |
Echinococcus multilocularis | transfer RNA-Lys | 0.004 | 0.0868 | 0.0991 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0033 | 0.0648 | 0.1408 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0165 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0033 | 0.0648 | 0.1408 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0033 | 0.0648 | 0.1408 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0033 | 0.0648 | 0.1744 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0119 | 0.3717 | 0.3717 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0119 | 0.3717 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0044 | 0.101 | 0.2718 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0033 | 0.0648 | 0.1744 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0033 | 0.0648 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0119 | 0.3717 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.008 | 0.2299 | 0.2623 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.101 | 0.2718 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0033 | 0.0648 | 0.1408 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.0251 | 0.0674 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0165 | 0.0443 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0119 | 0.3717 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 44 uM | Cytotoxicity against human THP1 cells after 72 hrs by flow cytometry | ChEMBL. | 20833057 |
IC50 (functional) | > 50 uM | Antileishmanial activity against promastigotes of Leishmania donovani HOM/IN/01/2001 after 72 hrs by flow cytometry | ChEMBL. | 20833057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.