TDR Targets

Basic information

Technical information

TDR Targets ID: 1178405
Name: 1-[6-(6,7-dimethoxyquinolin-4-yl)oxy-1-methyl indazol-3-yl]-3-(4-methylphenyl)urea
MW: 483.519 | Formula: C27H25N5O4
H donors: 2 H acceptors: 3 LogP: 4.57 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(ccnc2cc1OC)Oc1ccc2c(c1)n(C)nc2NC(=O)Nc1ccc(cc1)C
InChi: 1S/C27H25N5O4/c1-16-5-7-17(8-6-16)29-27(33)30-26-19-10-9-18(13-22(19)32(2)31-26)36-23-11-12-28-21-15-25(35-4)24(34-3)14-20(21)23/h5-15H,1-4H3,(H2,29,30,31,33)
InChiKey: ILJAQTWNHCZSRL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[6-[(6,7-dimethoxy-4-quinolyl)oxy]-1-methyl-indazol-3-yl]-3-(4-methylphenyl)urea
1-[6-[(6,7-dimethoxy-4-quinolyl)oxy]-1-methyl-3-indazolyl]-3-(4-methylphenyl)urea
1-[6-(6,7-dimethoxyquinolin-4-yl)oxy-1-methyl-indazol-3-yl]-3-(4-methylphenyl)urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0014	0.009	0.0107
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0217	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0079	0.2742	0.3431
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0995	0.2653
Echinococcus multilocularis	peregrin	0.0032	0.0846	0.2257
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0297	0.0546
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.1352	1
Echinococcus multilocularis	lamin dm0	0.003	0.0748	0.1996
Brugia malayi	PHD-finger family protein	0.0028	0.0655	0.0814
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.151	0.4029
Brugia malayi	Bromodomain containing protein	0.0083	0.2937	0.3675
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.1352	0.1688
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0134	0.0134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0882	0.0953
Onchocerca volvulus		0.0235	0.9151	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0748	0.0932
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0748	0.0932
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0882	0.0953
Echinococcus multilocularis	roundabout 2	0.0018	0.0247	0.0659
Giardia lamblia	GTOR	0.0045	0.1352	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0977	0.1056
Brugia malayi	Bromodomain containing protein	0.0032	0.0846	0.1054
Loa Loa (eye worm)	hypothetical protein	0.003	0.0738	0.0919
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.046	0.057
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.1352	0.3605
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0882	0.3487
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0325	0.0401
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.1084	0.1174
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0297	0.0546
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.151	0.4029
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.1157	0.3085
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.116	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.116	0.1257
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0134	0.0101
Plasmodium vivax	hypothetical protein, conserved	0.004	0.116	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.116	0.1448
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0733	0.1956
Brugia malayi	PHD-finger family protein	0.003	0.0738	0.0919
Schistosoma mansoni	hypothetical protein	0.003	0.0738	0.1756
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0178	0.0217
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0748	0.0807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0882	0.0953
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0509	0.0545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0882	0.0953
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.151	0.387
Echinococcus granulosus	lamin dm0	0.003	0.0748	0.1996
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0748	0.0932
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0738	0.0919
Echinococcus multilocularis	lamin	0.003	0.0748	0.1996
Loa Loa (eye worm)	beta-lactamase	0.004	0.116	0.1448
Onchocerca volvulus		0.003	0.0748	0.0018
Onchocerca volvulus		0.004	0.116	0.0507
Loa Loa (eye worm)	hypothetical protein	0.004	0.116	0.1448
Brugia malayi	beta-lactamase family protein	0.004	0.116	0.1448
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.116	0.8427
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0113	0.03
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0134	0.0134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.1352	0.1467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0614	0.066
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0748	0.0932
Echinococcus granulosus	neuropeptide receptor	0.0103	0.3749	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.1352	0.3435
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0183	0.6995	0.8763
Brugia malayi	jmjC domain containing protein	0.0097	0.3511	0.4395
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1376	0.1718
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0134	0.0162
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0978	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0507	0.0543
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.116	0.1257
Echinococcus multilocularis	zinc finger protein	0.0022	0.0412	0.1098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0709	0.0763
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0509	0.0545
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0738	0.1969
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.7982	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.1157	0.3085
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.116	0.1257
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0977	0.1056
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.116	0.2911
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0386	0.207
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0547	0.1458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0509	0.0545
Echinococcus granulosus	zinc finger protein	0.0022	0.0412	0.1098
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.3511	0.9365
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0247	0.0304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.1352	0.1467
Echinococcus granulosus	intermediate filament protein	0.003	0.0748	0.1996
Schistosoma mansoni	zinc finger protein	0.0017	0.0217	0.0327
Mycobacterium ulcerans	hypothetical protein	0.004	0.116	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0183	0.6995	0.8763
Toxoplasma gondii	ABC1 family protein	0.004	0.116	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0134	0.0162
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.1215	0.3242
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0113	0.03
Brugia malayi	Bromodomain containing protein	0.0043	0.1265	0.1579
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0733	0.1742
Echinococcus multilocularis	neuropeptide receptor	0.0103	0.3749	1
Echinococcus granulosus	roundabout 2	0.0018	0.0247	0.0659
Mycobacterium leprae	conserved hypothetical protein	0.004	0.116	0.5
Schistosoma mansoni	hypothetical protein	0.0017	0.0217	0.0327
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0614	0.066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0977	0.1056
Loa Loa (eye worm)	MH2 domain-containing protein	0.0133	0.4959	0.621
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.151	0.387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0614	0.066
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.224	0.5974
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0178	0.0217
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.2036	0.2546
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1463	0.1827
Leishmania major	hypothetical protein, conserved	0.0017	0.0217	0.0679
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0603	0.0648
Schistosoma mansoni	lamin	0.003	0.0748	0.1783
Trypanosoma brucei	ISWI complex protein	0.0017	0.0217	0.0679
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0507	0.0543
Mycobacterium ulcerans	beta-lactamase	0.004	0.116	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0882	0.0953
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.1082	0.135
Loa Loa (eye worm)	hypothetical protein	0.004	0.116	0.1448
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0507	0.0543
Mycobacterium ulcerans	lipase LipD	0.004	0.116	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0882	0.0953
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0547	0.1231
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0738	0.0113
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0738	0.0113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0977	0.1056
Brugia malayi	F/Y-rich N-terminus family protein	0.0013	0.005	0.0056
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.116	0.1448
Schistosoma mansoni	zinc finger protein	0.0022	0.0412	0.0861
Onchocerca volvulus	Alhambra homolog	0.003	0.0738	0.0006
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.0978	0.6934
Echinococcus multilocularis	neuroglian	0.0014	0.0097	0.0259
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.1215	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0134	0.0134
Schistosoma mansoni	hypothetical protein	0.0023	0.046	0.0993
Trichomonas vaginalis	esterase, putative	0.004	0.116	0.1257
Echinococcus granulosus	lamin	0.003	0.0748	0.1996
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0978	0.6934
Onchocerca volvulus		0.004	0.116	0.0507
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.1082	0.2885
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.1352	0.3605
Onchocerca volvulus		0.003	0.0748	0.0018
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.1352	1
Schistosoma mansoni	intermediate filament proteins	0.003	0.0748	0.1783
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.116	0.8427
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.1352	1
Brugia malayi	Pre-SET motif family protein	0.0207	0.7982	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0133	0.4959	0.621
Echinococcus granulosus	twitchin	0.0014	0.0097	0.0259
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.116	0.8427
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.1082	0.2696
Loa Loa (eye worm)	hypothetical protein	0.004	0.116	0.1448
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.1352	1
Brugia malayi	beta-lactamase family protein	0.004	0.116	0.1448
Leishmania major	hypothetical protein, conserved	0.004	0.116	0.8427
Brugia malayi	jmjC domain containing protein	0.0038	0.1082	0.135
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.1352	0.1688
Loa Loa (eye worm)	hypothetical protein	0.004	0.116	0.1448
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0217	0.0679
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0738	0.1969
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.0281	0.1204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0134	0.0134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.1352	0.1467
Onchocerca volvulus		0.0167	0.6343	0.6664
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.116	0.2911
Loa Loa (eye worm)	hypothetical protein	0.0049	0.151	0.1887
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0689	0.1837
Echinococcus multilocularis	musashi	0.003	0.0748	0.1996
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0738	0.1756
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0882	0.0953
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.1352	0.5
Echinococcus granulosus	neuroglian	0.0014	0.0097	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0015	0.013	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0113	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1268	0.1583
Brugia malayi	intermediate filament protein	0.003	0.0748	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1609	0.2011
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.224	0.5974
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0547	0.1458
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0297	0.0791
Brugia malayi	MH2 domain containing protein	0.0133	0.4959	0.621
Mycobacterium leprae	Probable lipase LipE	0.004	0.116	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.116	0.1448
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.1352	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.009	0.0107
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.116	0.1448
Brugia malayi	Pre-SET motif family protein	0.003	0.0733	0.0913
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0134	0.0134
Echinococcus multilocularis	G protein coupled receptor 139	0.0103	0.3749	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0726	0.0904
Echinococcus granulosus	peregrin	0.0032	0.0846	0.2257
Onchocerca volvulus		0.004	0.116	0.0507
Schistosoma mansoni	bromodomain containing protein	0.007	0.2403	0.6314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0977	0.1056
Schistosoma mansoni	lamin	0.003	0.0748	0.1783
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.116	0.5
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.1352	1
Schistosoma mansoni	cell adhesion molecule	0.0015	0.013	0.0089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0603	0.0648
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.9151	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.116	0.3094
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0134	0.0357
Onchocerca volvulus	Tyrosine kinase homolog	0.0171	0.6502	0.6853
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.269	0.7101
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.116	0.1257
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.116	0.3094
Brugia malayi	beta-lactamase	0.004	0.116	0.1448
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0134	0.0357
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.3511	0.9365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0509	0.0545
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0297	0.0791
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.1082	0.2696
Schistosoma mansoni	neuropeptide receptor	0.0103	0.3749	1
Plasmodium falciparum	phd finger protein, putative	0.003	0.0738	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0733	0.1742
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.116	0.1257
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.1352	0.5
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.013	0.0346
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0738	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0247	0.0304

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.002 uM	Inhibition of recombinant KDR by HTRF assay	ChEMBL.	18682324
IC50 (functional)	= 0.003 uM	Inhibition of VEGF-stimulated HUVEC cell proliferation treated before 2 hrs of VEGF challenge assessed after 72 hrs	ChEMBL.	18682324
IC50 (functional)	> 1 uM	Inhibition of bFGF-stimulated HUVEC cell proliferation treated before 2 hrs of bFGF challenge assessed after 72 hrs	ChEMBL.	18682324

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	18682324

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL509707

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1178405