TDR Targets

Basic information

Technical information

TDR Targets ID: 1178485
Name: (3R,4S,6S)-6-(hydroxymethyl)piperidine-3,4-di ol
MW: 147.172 | Formula: C6H13NO3
H donors: 4 H acceptors: 3 LogP: -1.93 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1NC[C@H]([C@H](C1)O)O
InChi: 1S/C6H13NO3/c8-3-4-1-5(9)6(10)2-7-4/h4-10H,1-3H2/t4-,5-,6+/m0/s1
InChiKey: SRFZPWAZZISKCU-HCWXCVPCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3R,4S,6S)-6-methylolpiperidine-3,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0035	0.0074	0.0345
Loa Loa (eye worm)	cathepsin B	0.0035	0.0074	0.0377
Plasmodium falciparum	serine repeat antigen 4	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0074	0.0268
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0074	0.0268
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0298	0.0291
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Giardia lamblia	Cysteine protease	0.0035	0.0074	0.1884
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Onchocerca volvulus	Cathepsin L homolog	0.019	0.196	1
Toxoplasma gondii	cathepsin CPL	0.019	0.196	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.1035	0.227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1195	0.6086
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.1035	0.528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0298	0.149
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0098	0.0839	0.4259
Leishmania major	cathepsin L-like protease	0.019	0.196	0.4456
Plasmodium falciparum	serine repeat antigen 7	0.0035	0.0074	0.0268
Brugia malayi	Cathepsin L-like precursor	0.019	0.196	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0412	0.0798
Leishmania major	cathepsin L-like protease	0.0382	0.4307	1
Entamoeba histolytica	cysteine proteinase, putative	0.0098	0.0839	0.4213
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0114	0.1035	1
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Giardia lamblia	Cysteine protease	0.0035	0.0074	0.1884
Onchocerca volvulus		0.019	0.196	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0839	0.4213
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0035	0.0074	0.0268
Brugia malayi	6-phosphofructokinase	0.0114	0.1035	0.5264
Leishmania major	cathepsin L-like protease	0.019	0.196	0.4456
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0839	0.1807
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.0119	0.0499
Brugia malayi	cathepsin F-like cysteine proteinase	0.0063	0.0412	0.2074
Entamoeba histolytica	hypothetical protein	0.0076	0.0568	0.282
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0035	0.0074	0.0268
Plasmodium vivax	unspecified product	0.0098	0.0839	0.4213
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.1035	0.528
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Brugia malayi	6-phosphofructokinase	0.0114	0.1035	0.5264
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0063	0.0412	0.2101
Trypanosoma cruzi	cysteine protease, putative	0.0098	0.0839	0.1807
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0035	0.0074	0.0377
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0022	0.5
Brugia malayi	phosphofructokinase	0.0114	0.1035	0.5264
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1195	0.6055
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0319	0.3542	0.8193
Echinococcus multilocularis	cysteine protease	0.019	0.196	0.1955
Entamoeba histolytica	cysteine proteinase 2	0.0098	0.0839	0.4213
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.0839	0.1807
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0377
Brugia malayi	Cathepsin L-like precursor	0.019	0.196	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0412	0.2101
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0119	0.0106
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0119	0.0112
Onchocerca volvulus		0.019	0.196	1
Echinococcus granulosus	6 phosphofructokinase	0.0114	0.1035	0.5264
Giardia lamblia	Cathepsin L-like protease	0.0035	0.0074	0.1884
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.1035	0.5264
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.1035	0.227
Loa Loa (eye worm)	fibroinase	0.019	0.196	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.0119	0.0499
Giardia lamblia	Hypothetical protein	0.0035	0.0074	0.1884
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0119	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1195	0.6099
Trypanosoma cruzi	cysteine peptidase, putative	0.019	0.196	0.4456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0839	0.4213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0035	0.0074	0.0268
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0298	0.149
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0074	0.0268
Echinococcus granulosus	cathepsin L	0.0035	0.0074	0.0345
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0076	0.0568	0.2876
Plasmodium vivax	serine-repeat antigen (SERA)	0.0035	0.0074	0.0268
Entamoeba histolytica	cysteine proteinase, putative	0.0098	0.0839	0.4213
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0035	0.0074	0.0345
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Onchocerca volvulus		0.019	0.196	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0074	0.0268
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0035	0.0074	0.0268
Giardia lamblia	Cysteine protease	0.0035	0.0074	0.1884
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0119	0.0574
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0035	0.0074	0.1884
Plasmodium falciparum	serine repeat antigen 3	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.019	0.196	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Schistosoma mansoni	hypothetical protein	0.0076	0.0568	0.2876
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0298	0.0529
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.1035	0.5226
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0098	0.0839	0.4213
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0074	0.0345
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0298	0.149
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0119	0.0106
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0035	0.0074	0.0268
Leishmania major	cathepsin L-like protease	0.0382	0.4307	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0007	0.0034
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0035	0.0074	0.1884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0298	0.0529
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0063	0.0412	0.2074
Leishmania major	cathepsin L-like protease	0.019	0.196	0.4456
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0114	0.1035	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0412	0.2101
Echinococcus multilocularis	6 phosphofructokinase	0.0114	0.1035	0.1029
Entamoeba histolytica	cysteine proteinase, putative	0.0098	0.0839	0.4213
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.1035	0.5264
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.1035	0.5226
Giardia lamblia	Hypothetical protein	0.0035	0.0074	0.1884
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0074	0.0345
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Echinococcus granulosus	cysteine protease	0.0098	0.0839	0.4259
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0035	0.0074	0.0268
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0298	0.0529
Entamoeba histolytica	cysteine proteinase, putative	0.0098	0.0839	0.4213
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Loa Loa (eye worm)	inositol-1	0.0039	0.0119	0.0605
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0298	0.0529
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1195	0.6086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.019	0.196	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0127	0.1195	0.6086
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Plasmodium falciparum	serine repeat antigen 1	0.0035	0.0074	0.0268
Entamoeba histolytica	hypothetical protein	0.0076	0.0568	0.282
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0074	0.0345
Leishmania major	cathepsin L-like protease	0.0382	0.4307	1
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0298	0.1422
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0298	0.0529
Giardia lamblia	Kinase, CMGC MAPK	0.0053	0.0298	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0298	0.0291
Plasmodium vivax	vivapain-2	0.019	0.196	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0035	0.0074	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1195	0.6099
Giardia lamblia	Cathepsin L precursor	0.0035	0.0074	0.1884
Loa Loa (eye worm)	ctsf protein	0.019	0.196	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0382	0.4307	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0035	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0377
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0114	0.1035	1
Echinococcus granulosus	cathepsin l1	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0035	0.0074	0.0268
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1035	0.5226
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Leishmania major	ATP-dependent phosphofructokinase	0.0114	0.1035	0.227
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0298	0.1422
Onchocerca volvulus	Cathepsin L homolog	0.019	0.196	1
Echinococcus granulosus	cathepsin l1	0.0127	0.1195	0.6086
Plasmodium vivax	vivapain-3	0.0098	0.0839	0.4213
Toxoplasma gondii	cathepsin CPC1	0.0035	0.0074	0.0268
Trypanosoma cruzi	cruzipain precursor, putative	0.0382	0.4307	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0098	0.0839	0.4213
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0035	0.0074	0.0268
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.1035	0.5226
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0119	0.0499
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0074	0.0268
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0412	0.2074
Echinococcus granulosus	cathepsin b	0.0035	0.0074	0.0345
Onchocerca volvulus		0.0127	0.1195	0.6086
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0035	0.0074	0.0377
Onchocerca volvulus		0.019	0.196	1
Entamoeba histolytica	hypothetical protein	0.0076	0.0568	0.282
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0127	0.1195	0.6086
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Toxoplasma gondii	cathepsin B	0.0035	0.0074	0.0268
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0119	0.0106
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0035	0.0074	0.0345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Entamoeba histolytica	cysteine protease, putative	0.019	0.196	1
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Echinococcus granulosus	cathepsin L cysteine proteinase	0.019	0.196	1
Echinococcus multilocularis	cathepsin b	0.0035	0.0074	0.0067
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Onchocerca volvulus		0.019	0.196	1
Plasmodium vivax	vivapain-2	0.019	0.196	1
Plasmodium vivax	unspecified product	0.0035	0.0074	0.0268
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0074	0.0268
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0035	0.0074	0.0377
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.1195	0.6055
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0098	0.0839	0.1807
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.0119	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0035	0.0074	0.0345
Leishmania major	cysteine peptidase A (CPA)	0.019	0.196	0.4456
Plasmodium vivax	unspecified product	0.0063	0.0412	0.2011
Giardia lamblia	Cysteine protease	0.0035	0.0074	0.1884
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0074	0.0268
Brugia malayi	Cathepsin L-like precursor	0.019	0.196	1
Leishmania major	cathepsin L-like protease	0.019	0.196	0.4456
Plasmodium vivax	vivapain-1	0.0098	0.0839	0.4213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Echinococcus multilocularis	cysteine protease	0.019	0.196	0.1955
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0412	0.0798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0007	0.0034
Giardia lamblia	Cathepsin L-like protease	0.0035	0.0074	0.1884
Leishmania major	cathepsin L-like protease	0.019	0.196	0.4456
Brugia malayi	cathepsin L-like precursor	0.0127	0.1195	0.6086
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0298	0.0529
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.019	0.196	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0035	0.0074	0.1884
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0035	0.0074	0.0345
Entamoeba histolytica	cysteine proteinase, putative	0.019	0.196	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Brugia malayi	Cathepsin L-like precursor	0.019	0.196	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0074	0.0268
Plasmodium falciparum	serine repeat antigen 5	0.0035	0.0074	0.0268
Brugia malayi	hypothetical protein	0.0076	0.0568	0.2876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.019	0.196	1
Giardia lamblia	Cathepsin L precursor	0.0035	0.0074	0.1884
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0035	0.0074	0.0268
Brugia malayi	cathepsin F-like cysteine proteinase	0.0035	0.0074	0.0345
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.019	0.196	1
Brugia malayi	Papain family cysteine protease containing protein	0.0098	0.0839	0.4259
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Mycobacterium ulcerans	6-phosphofructokinase	0.0114	0.1035	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Trypanosoma brucei	protein kinase, putative	0.0053	0.0298	0.0529
Echinococcus multilocularis	cathepsin L	0.0035	0.0074	0.0067
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Plasmodium falciparum	cysteine proteinase falcipain 3	0.019	0.196	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0377
Brugia malayi	fibroinase precursor	0.0035	0.0074	0.0345
Echinococcus granulosus	cathepsin b	0.0035	0.0074	0.0345
Echinococcus multilocularis	cathepsin b	0.0035	0.0074	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0839	0.1807
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0074	0.0345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0035	0.0074	0.0345
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0298	0.0529
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0035	0.0074	0.0268
Echinococcus granulosus	cathepsin L	0.0098	0.0839	0.4259
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Entamoeba histolytica	hypothetical protein	0.0076	0.0568	0.282
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Brugia malayi	cathepsin L precursor	0.0035	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0377
Giardia lamblia	Cathepsin L precursor	0.0035	0.0074	0.1884
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0035	0.0074	0.0268
Echinococcus multilocularis	cathepsin L	0.0098	0.0839	0.0833
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0007	0.0034
Loa Loa (eye worm)	cysteine protease	0.019	0.196	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0098	0.0839	0.1807
Brugia malayi	Cathepsin L-like precursor	0.019	0.196	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0035	0.0074	0.0268
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.019	0.196	0.1955
Trypanosoma cruzi	cysteine peptidase, putative	0.0382	0.4307	1
Brugia malayi	Cathepsin L-like precursor	0.019	0.196	1
Giardia lamblia	Cathepsin L precursor	0.0035	0.0074	0.1884
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0035	0.0074	0.0268
Loa Loa (eye worm)	phosphofructokinase	0.0114	0.1035	0.528
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0119	0.0106
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1035	0.5226
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0074	0.0268
Schistosoma mansoni	cathepsin C	0.0035	0.0074	0.0345
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0035	0.0074	0.0268
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0074	0.0268
Giardia lamblia	Encystation-specific protease	0.0035	0.0074	0.1884
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0074	0.0268
Plasmodium falciparum	serine repeat antigen 9	0.0035	0.0074	0.0268
Giardia lamblia	Cathepsin L precursor	0.0035	0.0074	0.1884
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.019	0.196	0.1955
Toxoplasma gondii	cathepsin CPC2	0.0035	0.0074	0.0268
Echinococcus multilocularis	cathepsin L cysteine protease	0.019	0.196	0.1955
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0074	0.0268
Echinococcus granulosus	cathepsin l cysteine peptidase	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Giardia lamblia	Cathepsin L precursor	0.0035	0.0074	0.1884
Onchocerca volvulus		0.0035	0.0074	0.0345
Onchocerca volvulus		0.019	0.196	1
Schistosoma mansoni	cathepsin F (C01 family)	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0035	0.0074	0.0268
Echinococcus granulosus	cathepsin L cysteine protease	0.0098	0.0839	0.4259
Onchocerca volvulus	Cathepsin F homolog	0.019	0.196	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4307	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0076	0.0568	0.0562
Brugia malayi	MAP kinase sur-1	0.0053	0.0298	0.149
Schistosoma mansoni	cathepsin S (C01 family)	0.0035	0.0074	0.0345
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1195	0.6099
Schistosoma mansoni	transcription factor LCR-F1	0.0076	0.0568	0.2876
Trypanosoma cruzi	cysteine proteinase, putative	0.0098	0.0839	0.1807
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0377
Echinococcus multilocularis	cathepsin L cysteine protease	0.019	0.196	0.1955
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0298	0.1422
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0035	0.0074	0.0345
Onchocerca volvulus		0.019	0.196	1
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Plasmodium falciparum	serine repeat antigen 6	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.019	0.196	1
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0412	0.2101
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0298	0.1422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1195	0.6055
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0035	0.0074	0.0268
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0035	0.0074	0.0268
Entamoeba histolytica	cysteine proteinase, putative	0.019	0.196	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0035	0.0074	0.0345
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0119	0.0574
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.0119	0.0499
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0098	0.0839	0.4259
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0035	0.0074	0.1884
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0298	0.1422
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1035	0.5226
Plasmodium vivax	serine-repeat antigen (SERA)	0.0035	0.0074	0.0268
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0298	0.1519
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0035	0.0074	0.0345
Brugia malayi	Papain family cysteine protease containing protein	0.0098	0.0839	0.4259
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0377
Plasmodium falciparum	serine repeat antigen 8	0.0035	0.0074	0.0268
Trypanosoma cruzi	major cysteine proteinase, putative	0.0227	0.242	0.5544
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.019	0.196	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0035	0.0074	0.0345
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0035	0.0074	0.0345
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0022	0.5
Schistosoma mansoni	cathepsin s	0.0063	0.0412	0.2074
Brugia malayi	Inositol-1	0.0039	0.0119	0.0574
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0098	0.0839	0.4259
Schistosoma mansoni	cathepsin F (C01 family)	0.019	0.196	1
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0119	0.0574
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0839	0.4213
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0035	0.0074	0.0268
Giardia lamblia	Cathepsin B precursor	0.0035	0.0074	0.1884
Brugia malayi	Papain family cysteine protease containing protein	0.019	0.196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0074	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0074	0.0268
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0074	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0377
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1035	0.5226
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0074	0.0268
Plasmodium falciparum	serine repeat antigen 2	0.0035	0.0074	0.0268
Trypanosoma cruzi	cysteine peptidase, putative	0.0382	0.4307	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL446497

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1178485