Detailed information for compound 1178694

Basic information

Technical information
  • TDR Targets ID: 1178694
  • Name: (3S,5S)-5-(aminomethyl)-3-(4-methoxyphenyl)ox olan-2-one
  • MW: 221.252 | Formula: C12H15NO3
  • H donors: 1 H acceptors: 1 LogP: 0.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@@H]1C[C@H](C(=O)O1)c1ccc(cc1)OC
  • InChi: 1S/C12H15NO3/c1-15-9-4-2-8(3-5-9)11-6-10(7-13)16-12(11)14/h2-5,10-11H,6-7,13H2,1H3/t10-,11-/m0/s1
  • InChiKey: ZQPKBRYJALEZGX-QWRGUYRKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S,5S)-5-(aminomethyl)-3-(4-methoxyphenyl)tetrahydrofuran-2-one
  • (3S,5S)-5-(aminomethyl)-3-(4-methoxyphenyl)-2-tetrahydrofuranone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0063 0.0334 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0177 0.1332 0.1332
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Schistosoma mansoni calpain-7 (C02 family) 0.0076 0.0452 0.0648
Echinococcus granulosus ubiquitin specific protease 41 0.0116 0.0799 0.0837
Schistosoma mansoni hypothetical protein 0.0057 0.0286 0.041
Echinococcus granulosus calpain A 0.0171 0.128 0.1341
Loa Loa (eye worm) hypothetical protein 0.0596 0.5005 0.5005
Brugia malayi CXXC zinc finger family protein 0.0028 0.0031 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0038 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0134 0.096 0.7206
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0172 0.0172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0382 0.04
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.2507 0.2507
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0134 0.096 0.096
Brugia malayi Papain family cysteine protease containing protein 0.0134 0.096 0.096
Mycobacterium tuberculosis Conserved protein 0.0074 0.043 0.0794
Echinococcus multilocularis calpain family protein 1, d 0.012 0.0837 0.0877
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0004 0.0004
Onchocerca volvulus 0.0769 0.6518 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0323 0.0323
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0465 0.0666
Echinococcus granulosus importin subunit beta 1 0.0029 0.0038 0.004
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0134 0.096 0.1472
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Trichomonas vaginalis rotamase, putative 0.0039 0.0123 0.0188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1385 0.1451
Brugia malayi Trypsin family protein 0.0037 0.0107 0.0107
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0356 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0799 0.1226
Onchocerca volvulus 0.0037 0.0107 0.0164
Onchocerca volvulus Cathepsin L homolog 0.0134 0.096 0.1472
Plasmodium falciparum cysteine repeat modular protein 1 0.0177 0.1332 1
Plasmodium falciparum importin beta, putative 0.0029 0.0038 0.0286
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Loa Loa (eye worm) hypothetical protein 0.009 0.0571 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1015 0.1454
Schistosoma mansoni hypothetical protein 0.0311 0.2507 0.3592
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0116 0.0799 0.1226
Schistosoma mansoni survival motor neuron protein 0.0057 0.0286 0.041
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0116 0.0799 0.1144
Echinococcus multilocularis glycoprotein Antigen 5 0.0037 0.0107 0.0112
Leishmania major cathepsin L-like protease 0.0512 0.4266 0.4266
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0004 0.0006
Plasmodium vivax vivapain-3 0.0069 0.0389 0.2921
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0129 0.1345
Echinococcus multilocularis calpain 7 (C02 family) 0.0062 0.0323 0.0339
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0107 0.0153
Brugia malayi Cathepsin L-like precursor 0.009 0.0571 0.0571
Echinococcus multilocularis peregrin 0.0063 0.0335 0.0351
Mycobacterium ulcerans beta-lactamase 0.0074 0.043 0.1234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0389 0.0389
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0037 0.0107 0.0107
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0065
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0141 0.1015 0.1015
Loa Loa (eye worm) hypothetical protein 0.0116 0.0799 0.0799
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0636 0.0912
Brugia malayi hypothetical protein 0.0034 0.0077 0.0077
Brugia malayi Protein kinase domain containing protein 0.0177 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0074 0.043 0.043
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0335 0.2515
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0335 0.0351
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0171 0.128 0.1833
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.0551 0.0577
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0382 0.0382
Echinococcus multilocularis geminin 0.034 0.2758 0.289
Brugia malayi Trypsin family protein 0.0214 0.1656 0.1656
Trypanosoma brucei DNA polymerase beta thumb, putative 0.009 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.0177 0.1332 0.1908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Echinococcus granulosus cathepsin l cysteine peptidase 0.0134 0.096 0.1006
Trypanosoma cruzi hypothetical protein, conserved 0.0177 0.1332 0.1332
Echinococcus multilocularis dna polymerase kappa 0.004 0.0129 0.0135
Leishmania major hypothetical protein, conserved 0.0074 0.043 0.043
Leishmania major hypothetical protein, conserved 0.0177 0.1332 0.1332
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0129 0.0135
Echinococcus multilocularis ubiquitin specific protease 41 0.0116 0.0799 0.0837
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0335 0.0335
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0056 0.008
Plasmodium vivax hypothetical protein, conserved 0.0074 0.043 0.3226
Loa Loa (eye worm) hypothetical protein 0.0214 0.1656 0.1656
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0074 0.043 0.043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0382 0.04
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0037 0.0108 0.0113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.1385 0.1385
Onchocerca volvulus Cathepsin L homolog 0.0134 0.096 0.1472
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0323 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0171 0.128 0.1341
Schistosoma mansoni cpg binding protein 0.0028 0.0031 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1385 0.1984
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.6668 0.6988
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0134 0.096 0.1006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.2423 0.2423
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0637 0.5362 0.5362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Loa Loa (eye worm) cysteine protease 0.0134 0.096 0.096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1385 0.1451
Schistosoma mansoni Mername-AA248 (C02 family) 0.0062 0.0323 0.0463
Leishmania major mitochondrial DNA polymerase beta 0.0637 0.5362 0.5362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0129 0.0129
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0134 0.096 0.7206
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0172 0.0172
Plasmodium vivax unspecified product 0.0044 0.0172 0.1291
Brugia malayi Cathepsin L-like precursor 0.0134 0.096 0.096
Entamoeba histolytica protein kinase, putative 0.0043 0.0161 0.1674
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0389 0.4054
Loa Loa (eye worm) calpain 5 0.0043 0.0161 0.0161
Schistosoma mansoni cathepsin F (C01 family) 0.0134 0.096 0.1375
Schistosoma mansoni microtubule-associated protein tau 0.0822 0.698 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0107 0.0803
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.034 0.0487
Loa Loa (eye worm) hypothetical protein 0.0177 0.1332 0.1332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.043 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0123 0.0188
Schistosoma mansoni DNA polymerase eta 0.0064 0.0346 0.0495
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1015 0.1454
Brugia malayi jmjC domain containing protein 0.0078 0.0465 0.0465
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0214 0.1656 0.2373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1385 0.1451
Toxoplasma gondii kringle domain-containing protein 0.0177 0.1332 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0107
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0107 0.0153
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0116 0.0799 0.0799
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0335 0.2515
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0382 0.0382
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0356 0.0952
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0206 0.1591 0.1667
Schistosoma mansoni smad1 5 8 and 0.0025 0.0004 0.0006
Plasmodium falciparum cysteine proteinase falcipain 3 0.0134 0.096 0.7206
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0062 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0163 0.1211 0.1211
Brugia malayi Trypsin family protein 0.0037 0.0107 0.0107
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.3915 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0238 0.0238
Schistosoma mansoni cathepsin F (C01 family) 0.0134 0.096 0.1375
Schistosoma mansoni hypothetical protein 0.0037 0.0107 0.0153
Loa Loa (eye worm) hypothetical protein 0.0145 0.1052 0.1052
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Schistosoma mansoni cathepsin s 0.0044 0.0172 0.0246
Brugia malayi Cathepsin L-like precursor 0.0044 0.0172 0.0172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0356 0.0952
Onchocerca volvulus 0.009 0.0571 0.0875
Trypanosoma cruzi cysteine peptidase, putative 0.0512 0.4266 0.4266
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0116 0.0799 0.0799
Echinococcus multilocularis nmda type glutamate receptor 0.0087 0.0549 0.0575
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0037 0.0108 0.0113
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.06 0.0629
Brugia malayi beta-lactamase 0.0074 0.043 0.043
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0107 0.0153
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0636 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0134 0.096 0.1472
Brugia malayi TAR-binding protein 0.0141 0.1015 0.1015
Echinococcus granulosus tumor protein p63 0.1114 0.9542 1
Echinococcus granulosus peregrin 0.0063 0.0335 0.0351
Onchocerca volvulus 0.0134 0.096 0.1472
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.043 0.0659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0571 0.0875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.043 0.0615
Echinococcus multilocularis cathepsin L cysteine protease 0.0134 0.096 0.1006
Mycobacterium tuberculosis Conserved protein 0.0074 0.043 0.0794
Plasmodium vivax vivapain-1 0.0069 0.0389 0.2921
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0038 0.004
Plasmodium vivax SET domain protein, putative 0.0097 0.0636 0.4779
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.043 0.0659
Onchocerca volvulus 0.0028 0.0031 0.0047
Brugia malayi RNA binding protein 0.0141 0.1015 0.1015
Brugia malayi calpain family protein 1 0.0163 0.1215 0.1215
Schistosoma mansoni importin beta-1 0.0029 0.0038 0.0055
Leishmania major cathepsin L-like protease 0.0512 0.4266 0.4266
Schistosoma mansoni calpain C (C02 family) 0.0062 0.0323 0.0463
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0238 0.0238
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0389 0.0389
Echinococcus granulosus Smad4 0.0025 0.0004 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1385 0.1451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0069 0.0389 0.0557
Echinococcus granulosus glycoprotein Antigen 5 0.0037 0.0107 0.0112
Brugia malayi Smad1 0.0025 0.0004 0.0004
Echinococcus multilocularis snurportin 1 0.0311 0.2507 0.2628
Schistosoma mansoni hypothetical protein 0.0068 0.0382 0.0547
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0214 0.1656 0.2373
Loa Loa (eye worm) hypothetical protein 0.012 0.0837 0.0837
Echinococcus granulosus tissue type plasminogen activator 0.0177 0.1332 0.1395
Loa Loa (eye worm) hypothetical protein 0.0044 0.0172 0.0172
Echinococcus multilocularis tumor protein p63 0.1114 0.9542 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0323 0.0323
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0284 0.2133
Trypanosoma cruzi cysteine protease, putative 0.0069 0.0389 0.0389
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0129 0.0198
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0346 0.0346
Schistosoma mansoni rotamase 0.0039 0.0123 0.0176
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.043 0.043
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0063 0.0334 0.5
Brugia malayi jmjC domain containing protein 0.0206 0.1591 0.1591
Leishmania major cathepsin L-like protease 0.0134 0.096 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Echinococcus granulosus tar DNA binding protein 0.0141 0.1015 0.1063
Giardia lamblia DINP protein human, muc B family 0.004 0.0129 0.1616
Brugia malayi hypothetical protein 0.0037 0.0109 0.0109
Brugia malayi beta-lactamase family protein 0.0074 0.043 0.043
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0063 0.0334 0.0868
Loa Loa (eye worm) hypothetical protein 0.0108 0.0729 0.0729
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Giardia lamblia PHD finger protein 15 0.0063 0.0335 0.4192
Trypanosoma cruzi cysteine proteinase, putative 0.0069 0.0389 0.0389
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0346 0.0346
Echinococcus granulosus enteropeptidase 0.0037 0.0107 0.0112
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0129 0.0198
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Leishmania major cathepsin L-like protease 0.0134 0.096 0.096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.043 0.0794
Schistosoma mansoni Smad4 0.0025 0.0004 0.0006
Trypanosoma brucei antigen, putative 0.0062 0.0323 0.0323
Onchocerca volvulus 0.0074 0.043 0.0659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Echinococcus granulosus calpain A 0.0062 0.0323 0.0339
Trypanosoma brucei unspecified product 0.0027 0.0022 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0676 0.5701 0.5701
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0037 0.0108 0.0113
Chlamydia trachomatis glutamine binding protein 0.0063 0.0334 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0356 0.2672
Entamoeba histolytica hypothetical protein 0.0037 0.0109 0.1141
Schistosoma mansoni glutamate receptor NMDA 0.0207 0.1596 0.2286
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0389 0.0389
Loa Loa (eye worm) Smad1 0.0025 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0282 0.2249 0.2249
Brugia malayi Cathepsin L-like precursor 0.0134 0.096 0.096
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0129 0.0129
Loa Loa (eye worm) RNA binding protein 0.0141 0.1015 0.1015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1385 0.1984
Mycobacterium tuberculosis Conserved protein 0.0074 0.043 0.0794
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0129 0.0129
Schistosoma mansoni calpain (C02 family) 0.0062 0.0323 0.0463
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0323 0.0323
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.043 0.0794
Onchocerca volvulus 0.0177 0.1332 0.2043
Brugia malayi latrophilin 2 splice variant baaae 0.0148 0.1076 0.1076
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0037 0.0107 0.0112
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0116 0.0799 0.0799
Loa Loa (eye worm) TAR-binding protein 0.0141 0.1015 0.1015
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0107 0.0107
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0116 0.0799 0.8325
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0037 0.0108 0.0113
Brugia malayi calpain family protein 1 0.0163 0.1215 0.1215
Onchocerca volvulus 0.0037 0.0107 0.0164
Trypanosoma cruzi cysteine proteinase, putative 0.0069 0.0389 0.0389
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0129 0.0185
Echinococcus granulosus jumonji domain containing protein 0.0088 0.0551 0.0577
Entamoeba histolytica hypothetical protein 0.0037 0.0109 0.1141
Schistosoma mansoni cathepsin F (C01 family) 0.009 0.0571 0.0817
Brugia malayi Bromodomain containing protein 0.0063 0.0335 0.0335
Echinococcus granulosus smad 0.0025 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.009 0.0571 0.0571
Onchocerca volvulus 0.0177 0.1332 0.2044
Plasmodium vivax importin-beta 2, putative 0.0029 0.0038 0.0286
Echinococcus granulosus cathepsin L 0.0069 0.0389 0.0408
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.043 0.0615
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0636 0.0912
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Brugia malayi Cathepsin L-like precursor 0.0134 0.096 0.096
Brugia malayi Trypsin family protein 0.0037 0.0107 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0636 0.0912
Echinococcus granulosus glutamate NMDA receptor subunit 0.0207 0.1596 0.1672
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Brugia malayi MH2 domain containing protein 0.0025 0.0004 0.0004
Loa Loa (eye worm) calpain family protein 1 0.0163 0.1215 0.1215
Loa Loa (eye worm) hypothetical protein 0.0063 0.0335 0.0335
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0031 0.0031
Trypanosoma cruzi cruzipain precursor, putative 0.0512 0.4266 0.4266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Onchocerca volvulus Alhambra homolog 0.0063 0.0335 0.0514
Entamoeba histolytica hypothetical protein 0.0037 0.0109 0.1141
Schistosoma mansoni hypothetical protein 0.034 0.2758 0.3951
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0323 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0022 0.0022
Onchocerca volvulus 0.0134 0.096 0.1472
Entamoeba histolytica cysteine proteinase 1, putative 0.0069 0.0389 0.4054
Echinococcus multilocularis hypothetical protein 0.0062 0.0323 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0115 0.1194
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0637 0.5362 0.5362
Loa Loa (eye worm) calpain family protein 1 0.012 0.0837 0.0837
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0037 0.0108 0.0113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0116 0.0799 0.1226
Brugia malayi MH2 domain containing protein 0.0025 0.0004 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0109 0.0157
Onchocerca volvulus 0.0214 0.1656 0.2541
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0636 0.0667
Schistosoma mansoni hypothetical protein 0.0068 0.0382 0.0547
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0286 0.0286
Loa Loa (eye worm) ctsf protein 0.0134 0.096 0.096
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1015 0.1454
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.096 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0129 0.0085
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.043 0.0659
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0238 0.1787
Echinococcus granulosus cysteine protease 0.0069 0.0389 0.0408
Leishmania major DNA polymerase kappa, putative 0.004 0.0129 0.0129
Echinococcus granulosus cathepsin L cysteine protease 0.0069 0.0389 0.0408
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0206 0.1591 0.1667
Echinococcus granulosus dna polymerase kappa 0.004 0.0129 0.0135
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0177 0.1332 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0069 0.0389 0.0557
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0129 0.0129
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Loa Loa (eye worm) MH2 domain-containing protein 0.0371 0.3035 0.3035
Loa Loa (eye worm) hypothetical protein 0.0074 0.043 0.043
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0356 0.051
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0037 0.0107 0.0112
Echinococcus multilocularis tar DNA binding protein 0.0141 0.1015 0.1063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0129 0.0129
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0037 0.0108 0.0113
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0044 0.0172 0.0172
Mycobacterium leprae Probable lipase LipE 0.0074 0.043 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0109 0.0739 0.0739
Onchocerca volvulus 0.0037 0.0107 0.0164
Echinococcus multilocularis cysteine protease 0.0134 0.096 0.1006
Brugia malayi MH2 domain containing protein 0.0371 0.3035 0.3035
Trichomonas vaginalis rotamase, putative 0.0038 0.0115 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Onchocerca volvulus 0.0037 0.0107 0.0164
Loa Loa (eye worm) hypothetical protein 0.0064 0.0346 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.096 0.096
Brugia malayi hypothetical protein 0.0037 0.0107 0.0107
Schistosoma mansoni smad1 5 8 and 0.0025 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0107
Entamoeba histolytica cysteine protease, putative 0.0134 0.096 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0097 0.0636 0.0912
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0382 0.04
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0389 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0172 0.0172
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0123 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0356 0.051
Brugia malayi hypothetical protein 0.0282 0.2249 0.2249
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0107 0.0153
Trypanosoma cruzi kinesin, putative 0.0043 0.0161 0.0161
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0129 0.0085
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0238 0.0238
Brugia malayi Pre-SET motif family protein 0.0676 0.5701 0.5701
Brugia malayi Calcitonin receptor-like protein seb-1 0.0216 0.1675 0.1675
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0335 0.2515
Leishmania major DNA polymerase eta, putative 0.0064 0.0346 0.0346
Brugia malayi calpain 5 0.0043 0.0161 0.0161
Brugia malayi cathepsin L-like precursor 0.009 0.0571 0.0571
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0109 0.0115
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.2423 0.2423
Echinococcus multilocularis cathepsin L 0.0069 0.0389 0.0408
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0465 0.0666
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0069 0.0389 0.0389
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0129 0.0185
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0129 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0129 0.0129
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0038 0.0286
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.043 0.0794
Onchocerca volvulus 0.0057 0.0286 0.0439
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0301 0.2423 0.2423
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0356 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Echinococcus multilocularis microtubule associated protein 2 0.0822 0.698 0.7315
Echinococcus granulosus expressed protein 0.0039 0.0123 0.0128
Echinococcus granulosus GPCR family 2 0.0068 0.0382 0.04
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0567 0.0567
Trypanosoma brucei kinesin, putative 0.0043 0.0161 0.0161
Plasmodium falciparum phd finger protein, putative 0.0063 0.0335 0.2515
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Echinococcus multilocularis smad 0.0025 0.0004 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0164 0.1219 0.1747
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0467 0.3877 0.3877
Schistosoma mansoni hypothetical protein 0.034 0.2758 0.3951
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0567 0.0567
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0134 0.096 0.096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0382 0.04
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0238 0.1787
Brugia malayi Cathepsin L-like precursor 0.0134 0.096 0.096
Loa Loa (eye worm) fibroinase 0.0134 0.096 0.096
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0044 0.0172 0.0172
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0356 0.0356
Echinococcus granulosus cathepsin l1 0.009 0.0571 0.0598
Brugia malayi Cathepsin L-like precursor 0.0134 0.096 0.096
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0004 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Onchocerca volvulus Cathepsin F homolog 0.0134 0.096 0.1472
Entamoeba histolytica cysteine proteinase, putative 0.009 0.0571 0.5946
Echinococcus multilocularis transmembrane protease serine 3 0.0037 0.0107 0.0112
Echinococcus multilocularis calpain 5 0.0062 0.0323 0.0339
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0062 0.0323 0.0323
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.043 0.0794
Echinococcus multilocularis tissue type plasminogen activator 0.0177 0.1332 0.1395
Schistosoma mansoni hypothetical protein 0.0148 0.1076 0.1542
Loa Loa (eye worm) hypothetical protein 0.0074 0.043 0.043
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0116 0.0799 0.0799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Loa Loa (eye worm) beta-lactamase 0.0074 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0074 0.043 0.043
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0346 0.0346
Leishmania major cysteine peptidase A (CPA) 0.0134 0.096 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0107 0.0153
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.007 0.007
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0116 0.0799 0.0837
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0063 0.0334 0.5
Echinococcus granulosus dna polymerase eta 0.0064 0.0346 0.0362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0207 0.1596 0.1672
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0382 0.0382
Onchocerca volvulus 0.0134 0.096 0.1472
Echinococcus granulosus calpain 0.0062 0.0323 0.0339
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0323 0.0323
Brugia malayi Cathepsin L-like precursor 0.0134 0.096 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Leishmania major cathepsin L-like protease 0.0512 0.4266 0.4266
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.043 0.043
Onchocerca volvulus 0.0134 0.096 0.1472
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1015 0.1454
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0107 0.0112
Brugia malayi MH1 domain containing protein 0.0025 0.0004 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.043 0.0794
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1385 0.1984
Plasmodium falciparum cysteine proteinase falcipain 1 0.0069 0.0389 0.2921
Schistosoma mansoni calpain-7 (C02 family) 0.0076 0.0452 0.0648
Entamoeba histolytica cysteine proteinase 2 0.0069 0.0389 0.4054
Trypanosoma cruzi major cysteine proteinase, putative 0.0402 0.3306 0.3306
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1015 0.1454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0163 0.1215 0.174
Onchocerca volvulus 0.0097 0.0636 0.0976
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.043 0.045
Loa Loa (eye worm) hypothetical protein 0.0214 0.1656 0.1656
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0123 0.0123
Brugia malayi calpain 7 0.0062 0.0323 0.0323
Trypanosoma brucei unspecified product 0.004 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.043 0.1234
Brugia malayi Cathepsin L-like cysteine proteinase 0.009 0.0571 0.0571
Echinococcus granulosus calpain 5 0.0062 0.0323 0.0339
Loa Loa (eye worm) calpain 0.0062 0.0323 0.0323
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0134 0.096 0.1006
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Mycobacterium ulcerans lipase LipD 0.0074 0.043 0.1234
Trypanosoma cruzi cysteine peptidase, putative 0.0512 0.4266 0.4266
Echinococcus granulosus cpg binding protein 0.003 0.0045 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0571 0.0875
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0037 0.0108 0.0113
Schistosoma mansoni hypothetical protein 0.0068 0.0382 0.0547
Leishmania major kinesin, putative 0.0043 0.0161 0.0161
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0323 0.0323
Onchocerca volvulus 0.0163 0.1211 0.1858
Plasmodium vivax calpain, putative 0.0062 0.0323 0.2426
Plasmodium vivax vivapain-2 0.0134 0.096 0.7206
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.043 0.0794
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0116 0.0799 0.1144
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0238 0.1787
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Schistosoma mansoni hypothetical protein 0.0063 0.0335 0.048
Echinococcus multilocularis dna polymerase eta 0.0064 0.0346 0.0362
Echinococcus granulosus calpain 7 C02 family 0.0062 0.0323 0.0339
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Leishmania major cathepsin L-like protease 0.0134 0.096 0.096
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0115 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Onchocerca volvulus 0.0134 0.096 0.1472
Echinococcus multilocularis enteropeptidase 0.0037 0.0107 0.0112
Loa Loa (eye worm) hypothetical protein 0.0074 0.043 0.043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0097 0.0636 0.4779
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0335 0.0351
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Trypanosoma cruzi kinesin, putative 0.0043 0.0161 0.0161
Plasmodium vivax vivapain-2 0.0134 0.096 0.7206
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.0923 0.0923
Leishmania major DNA polymerase eta, putative 0.0037 0.0107 0.0107
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0116 0.0799 0.0799
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0216 0.1675 0.1675
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0238 0.1787
Schistosoma mansoni hypothetical protein 0.0068 0.0382 0.0547
Schistosoma mansoni hypothetical protein 0.0037 0.0107 0.0153
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.043 0.0659
Leishmania major hypothetical protein, conserved 0.0052 0.0238 0.0238
Loa Loa (eye worm) transcription factor SMAD2 0.0371 0.3035 0.3035
Schistosoma mansoni smad1 5 8 and 0.0025 0.0004 0.0006
Mycobacterium ulcerans hypothetical protein 0.0074 0.043 0.1234
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0637 0.5362 0.5362
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0335 0.048
Onchocerca volvulus 0.0134 0.096 0.1472
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0004 0.0005
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Brugia malayi cathepsin F-like cysteine proteinase 0.0044 0.0172 0.0172
Echinococcus granulosus glutamate receptor 2 0.0037 0.0108 0.0113
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.043 0.043
Onchocerca volvulus 0.0037 0.0107 0.0164
Schistosoma mansoni cellular tumor antigen P53 0.0163 0.1211 0.1735
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0116 0.0799 0.0837
Brugia malayi Cathepsin L-like precursor 0.009 0.0571 0.0571
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.0465 0.0487
Toxoplasma gondii cathepsin CPL 0.0134 0.096 0.7206
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0097 0.0636 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0129 0.0129
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0356 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Toxoplasma gondii ABC1 family protein 0.0074 0.043 0.3226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Brugia malayi PHD-finger family protein 0.0063 0.0335 0.0335
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0129 0.0129
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.043 0.043
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0238 0.0238
Brugia malayi Kringle domain containing protein 0.0177 0.1332 0.1332
Echinococcus multilocularis Smad4 0.0025 0.0004 0.0005
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0115 0.0115
Trichomonas vaginalis set domain proteins, putative 0.0769 0.6518 1
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.096 1
Onchocerca volvulus 0.0134 0.096 0.1472
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0389 0.4054
Schistosoma mansoni smad 0.0025 0.0004 0.0006
Mycobacterium ulcerans hypothetical protein 0.0335 0.2722 1
Brugia malayi RNA, U transporter 1 0.0083 0.0509 0.0509
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.0451 0.0473
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.009 0.0567 0.0567
Toxoplasma gondii hypothetical protein 0.0103 0.0683 0.5128
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0171 0.128 0.1833
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.1385 0.1385
Mycobacterium tuberculosis Conserved hypothetical protein 0.0335 0.2722 0.6849
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0116 0.0799 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0216 0.1675 0.1675
Echinococcus multilocularis calpain 0.0062 0.0323 0.0339
Echinococcus multilocularis expressed protein 0.0039 0.0123 0.0128
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0044 0.0172 0.0172
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Brugia malayi Trypsin-like protease protein 5 0.0037 0.0107 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.009 0.0571 0.0571
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0038
Leishmania major cathepsin L-like protease 0.0134 0.096 0.096
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.043 0.0659
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0171 0.128 0.1341
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0037 0.0108 0.0113
Loa Loa (eye worm) hypothetical protein 0.0068 0.0382 0.0382
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0512 0.4266 0.4266
Echinococcus granulosus cathepsin l1 0.0134 0.096 0.1006
Brugia malayi Importin beta-1 subunit 0.0029 0.0038 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0134 0.096 0.1006
Brugia malayi hypothetical protein 0.0052 0.0238 0.0238
Echinococcus multilocularis cysteine protease 0.0134 0.096 0.1006
Echinococcus granulosus nmda type glutamate receptor 0.0087 0.0549 0.0575
Entamoeba histolytica cysteine protease, putative 0.0069 0.0389 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0069 0.0389 0.0557
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0115 0.0115
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0116 0.0799 0.0837
Echinococcus multilocularis Mastin 0.0037 0.0107 0.0112
Echinococcus multilocularis survival motor neuron protein 1 0.0282 0.2249 0.2357
Echinococcus granulosus cathepsin L cysteine proteinase 0.0134 0.096 0.1006
Brugia malayi MH1 domain containing protein 0.0025 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0163 0.1215 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0389 0.0597
Schistosoma mansoni hypothetical protein 0.0037 0.0109 0.0157
Trypanosoma cruzi cysteine peptidase, putative 0.0512 0.4266 0.4266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0323 0.0323
Onchocerca volvulus 0.0074 0.043 0.0659
Trypanosoma brucei unspecified product 0.0027 0.0022 0.0022
Echinococcus granulosus survival motor neuron protein 1 0.0282 0.2249 0.2357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0389 0.0597
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0109 0.0115
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.043 0.043
Schistosoma mansoni glutamate receptor NMDA 0.0037 0.0108 0.0155
Loa Loa (eye worm) trypsin family protein 0.0037 0.0107 0.0107
Onchocerca volvulus 0.0074 0.043 0.0659
Entamoeba histolytica hypothetical protein 0.0037 0.0109 0.1141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0107 0.0153
Entamoeba histolytica calpain large subunit domain III containing protein 0.0043 0.0161 0.1674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0134 0.096 0.1472
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0087 0.0549 0.0575
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0216 0.1675 0.1675
Trichomonas vaginalis esterase, putative 0.0074 0.043 0.0659
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0356 0.0952
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0116 0.0799 1
Echinococcus granulosus microtubule associated protein 2 0.0822 0.698 0.7315
Leishmania major cathepsin L-like protease 0.0134 0.096 0.096
Echinococcus multilocularis cpg binding protein 0.003 0.0045 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Echinococcus granulosus geminin 0.034 0.2758 0.289
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.096 0.1472
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0323 0.0323
Echinococcus multilocularis glutamate receptor 2 0.0037 0.0108 0.0113
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0004 0.0005
Mycobacterium leprae conserved hypothetical protein 0.0074 0.043 0.5
Echinococcus granulosus transmembrane protease serine 3 0.0037 0.0107 0.0112
Plasmodium vivax unspecified product 0.0069 0.0389 0.2921
Echinococcus multilocularis GPCR, family 2 0.0068 0.0382 0.04
Loa Loa (eye worm) hypothetical protein 0.0097 0.0636 0.0636
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0389 0.4054
Echinococcus multilocularis calpain A 0.0171 0.128 0.1341
Brugia malayi Pre-SET motif family protein 0.0097 0.0636 0.0636
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.043 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0022 0.0022
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.043 0.1234
Loa Loa (eye worm) hypothetical protein 0.0102 0.0675 0.0675
Brugia malayi RNA recognition motif domain containing protein 0.0141 0.1015 0.1015
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0063 0.0334 0.0541
Loa Loa (eye worm) hypothetical protein 0.0148 0.1076 0.1076
Echinococcus granulosus snurportin 1 0.0311 0.2507 0.2628
Onchocerca volvulus 0.0102 0.0675 0.1035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0107
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0115 0.0115
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.0465 0.0465
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0037 0.0107 0.0112
Echinococcus granulosus Mastin 0.0037 0.0107 0.0112
Brugia malayi beta-lactamase family protein 0.0074 0.043 0.043
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0107 0.0153
Loa Loa (eye worm) hypothetical protein 0.0134 0.096 0.096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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