Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0032 | 0.0749 | 0.098 | |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0101 | 0.2858 | 0.2858 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.587 | 0.587 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0556 | 0.0728 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0295 | 0.0295 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2858 | 0.3739 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0101 | 0.2858 | 0.7572 |
Trichomonas vaginalis | set domain proteins, putative | 0.0259 | 0.7645 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.3775 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0771 | 0.0771 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0771 | 0.0771 |
Onchocerca volvulus | 0.0033 | 0.0771 | 0.1009 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1304 | 0.1706 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0057 | 0.1514 | 0.1828 |
Leishmania major | GTP-binding protein, putative | 0.0023 | 0.0485 | 0.1284 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0485 | 0.0485 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0333 | 0.0333 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0556 | 0.0728 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0485 | 0.0586 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0103 | 0.2901 | 0.3504 |
Giardia lamblia | Kinase, PLK | 0.0101 | 0.2858 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0248 | 0.0248 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0295 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.3775 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0248 | 0.0248 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0295 |
Schistosoma mansoni | survival motor neuron protein | 0.0057 | 0.1514 | 0.1514 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0738 | 0.0738 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0738 | 0.258 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0023 | 0.0485 | 0.0485 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0295 | 0.1032 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.028 | 0.8279 | 0.8279 |
Echinococcus granulosus | expressed protein | 0.0036 | 0.0869 | 0.0869 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0356 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.0869 | 0.0869 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0248 | 0.0248 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.2901 | 0.2901 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.0295 | 0.0782 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.2901 | 0.2901 |
Echinococcus multilocularis | geminin | 0.0201 | 0.587 | 0.587 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.2901 | 0.2901 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0843 | 0.2949 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0749 | 0.0749 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0295 | 0.1032 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0132 | 0.3775 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0333 | 0.0333 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.1526 | 0.1843 |
Brugia malayi | RNA, U transporter 1 | 0.009 | 0.2503 | 0.3023 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0485 | 0.4288 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0771 | 1 |
Onchocerca volvulus | 0.0259 | 0.7645 | 1 | |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0035 | 0.0843 | 0.2949 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0749 | 0.0749 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0749 | 0.0749 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0738 | 0.9291 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0333 | 0.0333 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0295 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2858 | 0.3739 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0101 | 0.2858 | 0.3739 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.023 | 0.023 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0485 | 0.1696 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.2901 | 0.2901 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.0295 | 0.1032 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0749 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0732 | 0.0732 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0132 | 0.3775 | 0.3775 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0485 | 0.1696 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0735 | 0.0735 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.0011 | 0.0111 | 0.0294 |
Trypanosoma brucei | polo-like protein kinase | 0.0101 | 0.2858 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0749 | 0.0749 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0738 | 0.0738 |
Trichomonas vaginalis | ran, putative | 0.0023 | 0.0485 | 0.0634 |
Schistosoma mansoni | lamin | 0.0032 | 0.0749 | 0.0749 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0556 | 0.1947 |
Brugia malayi | hypothetical protein | 0.028 | 0.8279 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2858 | 0.3739 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0132 | 0.3775 | 0.3775 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0771 | 0.0771 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0869 | 0.1136 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0011 | 0.0111 | 0.0389 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.2901 | 0.2901 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.023 | 0.023 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0738 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0738 | 0.0738 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0295 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2858 | 0.3739 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0749 | 0.0749 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0333 | 0.0333 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0782 |
Echinococcus granulosus | lamin | 0.0032 | 0.0749 | 0.0749 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0485 | 0.1696 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0023 | 0.0485 | 0.0485 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0485 | 0.1696 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.0869 | 0.1136 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1304 | 0.1706 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0974 | 0.0974 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0356 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.2901 | 0.2901 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.2901 | 0.2901 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.1526 | 0.1526 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0333 | 0.0333 |
Schistosoma mansoni | lamin | 0.0032 | 0.0749 | 0.0749 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2858 | 0.3739 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0738 | 0.0738 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0556 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0771 | 0.0771 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0132 | 0.3775 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0333 | 0.0333 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0023 | 0.0485 | 0.3984 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.3775 | 0.3775 |
Schistosoma mansoni | rotamase | 0.0036 | 0.0869 | 0.0869 |
Schistosoma mansoni | kinase | 0.0052 | 0.1345 | 0.1345 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.2858 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.587 | 0.587 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.0843 | 0.1103 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0011 | 0.0111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1526 | 0.1526 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0228 | 0.669 | 0.669 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.3775 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.8279 | 0.8279 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.1514 | 0.1514 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0295 | 0.0782 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0333 | 0.0333 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0771 | 0.0771 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0101 | 0.2858 | 0.2858 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0333 | 0.0402 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0011 | 0.0111 | 0.0294 |
Echinococcus multilocularis | expressed protein | 0.0036 | 0.0869 | 0.0869 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0333 | 0.0333 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.2858 | 0.2858 |
Schistosoma mansoni | ran | 0.0023 | 0.0485 | 0.0485 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0738 | 0.0891 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0132 | 0.3775 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0011 | 0.0111 | 0.0389 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0299 | 0.0299 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.3775 | 0.3775 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0035 | 0.0843 | 0.2233 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0771 | 0.0932 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0738 | 0.258 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0556 | 0.0728 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0295 |
Onchocerca volvulus | 0.0032 | 0.0749 | 0.098 | |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0843 | 0.2949 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0023 | 0.0485 | 0.1284 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0333 | 0.0333 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0299 | 0.0362 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0749 | 0.0749 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0295 | 0.0782 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0771 | 0.0771 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0974 | 0.1176 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0035 | 0.0843 | 0.2949 |
Schistosoma mansoni | ran | 0.0023 | 0.0485 | 0.0485 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0101 | 0.2858 | 1 |
Entamoeba histolytica | Ran family GTPase | 0.0023 | 0.0485 | 0.1696 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2858 | 0.3739 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0749 | 0.0905 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0749 | 0.0749 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0771 | 0.0771 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0333 | 0.0402 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0.0295 | 0.1032 |
Onchocerca volvulus | 0.0057 | 0.1514 | 0.198 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.1526 | 0.1843 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0036 | 0.0869 | 0.1049 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2858 | 0.3739 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0035 | 0.0843 | 0.2233 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0771 | 0.0771 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0749 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0974 | 0.0974 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.2858 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0738 | 0.1954 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0771 | 0.2043 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.028 | 0.8279 | 0.8279 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0101 | 0.2858 | 0.2858 |
Echinococcus granulosus | geminin | 0.0201 | 0.587 | 0.587 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0103 | 0.2901 | 0.2901 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0333 | 0.0333 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0556 | 0.1947 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0333 | 0.0333 |
Brugia malayi | Pre-SET motif family protein | 0.0228 | 0.669 | 0.8081 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0749 | 0.0905 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0101 | 0.2858 | 0.3452 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0011 | 0.0111 | 0.0389 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0333 | 0.0333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.