Detailed information for compound 1178838

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 605.734 | Formula: C30H43N11O3
  • H donors: 9 H acceptors: 3 LogP: 0.09 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)NCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)[C@H](CCCNC(=N)N)N
  • InChi: 1S/C30H43N11O3/c31-22(11-6-14-36-29(32)33)26(42)40-24(13-7-15-37-30(34)35)28(44)41-25(27(43)39-17-19-8-2-1-3-9-19)16-20-18-38-23-12-5-4-10-21(20)23/h1-5,8-10,12,18,22,24-25,38H,6-7,11,13-17,31H2,(H,39,43)(H,40,42)(H,41,44)(H4,32,33,36)(H4,34,35,37)/t22-,24-,25-/m0/s1
  • InChiKey: FVKULCSGIXKHIC-HVCNVCAESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0007 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0037 0.0353
Echinococcus multilocularis fmrfamide receptor 0.0087 0.0154 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0346 0.3566
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0541 0.5577
Mycobacterium leprae conserved hypothetical protein 0.0114 0.021 0.0546
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.0154 0.0154
Brugia malayi hypothetical protein 0.0016 0.0007 0.0067
Schistosoma mansoni amine GPCR 0.0087 0.0154 0.0537
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.085 0.8126
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0061 0.01 0.0951
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0103 0.0359
Schistosoma mansoni coup transcription factor 0.0031 0.0037 0.0128
Schistosoma mansoni growth hormone secretagogue receptor 0.0087 0.0154 0.0537
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0032 0.0302
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0037 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.0093 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0052 0.0052
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0087 0.0154 0.1469
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.1999
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1666 0.3423 0.9388
Echinococcus granulosus neuropeptide receptor A26 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0108 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Loa Loa (eye worm) transcription factor SMAD2 0.0383 0.0767 0.7339
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0003 0.0003
Echinococcus multilocularis neuropeptide s receptor 0.0087 0.0154 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0111 0.0387
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0346 0.3566
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0037 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0003 0.0012
Schistosoma mansoni opsin-like receptor 0.0087 0.0154 0.0537
Brugia malayi steroid hormone receptor 0.0031 0.0037 0.0353
Schistosoma mansoni hypothetical protein 0.0014 0.0002 0.0008
Echinococcus multilocularis fmrfamide receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0037 0.0344
Brugia malayi G-protein coupled receptor 0.0087 0.0154 0.1477
Brugia malayi intermediate filament protein 0.0029 0.0033 0.0312
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0087 0.0154 0.0537
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0037 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.0154 0.0154
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0148 0.0405
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0093 0.0093
Echinococcus granulosus hypothetical protein 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0058
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) DR-78 0.0014 0.0003 0.0024
Onchocerca volvulus 0.0087 0.0154 0.157
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0099 0.0346
Brugia malayi tailless protein 0.0014 0.0003 0.0033
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0003 0.0012
Schistosoma mansoni amine GPCR 0.0087 0.0154 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0346 0.3566
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0037 0.0037
Echinococcus granulosus survival motor neuron protein 1 0.0518 0.1045 0.1045
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0037 0.0356
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0148 0.0405
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0099 0.0346
Mycobacterium leprae Probable lipase LipE 0.0114 0.021 0.0546
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0037 0.0037
Echinococcus multilocularis G protein coupled receptor 139 0.0087 0.0154 0.0154
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0037 0.0128
Schistosoma mansoni survival motor neuron protein 0.0106 0.0192 0.0669
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.0154 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0541 0.5577
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0058
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis musashi 0.0029 0.0033 0.0033
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0037 0.0037
Onchocerca volvulus 0.0114 0.021 0.2142
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Brugia malayi MH2 domain containing protein 0.0026 0.0028 0.0264
Chlamydia trachomatis recombinase RecA 0.0108 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.021 0.073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.01 0.01
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0003 0.0003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.021 0.0575
Brugia malayi ecdysteroid receptor 0.0031 0.0037 0.0353
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0014
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.0154 0.1469
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0037 0.0037
Schistosoma mansoni neuropeptide f receptor 76f 0.0087 0.0154 0.0537
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0037 0.0037
Onchocerca volvulus 0.0014 0.0003 0.0011
Brugia malayi follicle stimulating hormone receptor 0.0087 0.0154 0.1477
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis GPCR, family 2 0.0017 0.0008 0.0008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0148 0.0405
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.1999
Echinococcus granulosus neuropeptide receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Brugia malayi ORL1-like opioid receptor 0.0087 0.0154 0.1477
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0003 0.0003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.0154 0.0537
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.0154 0.1469
Brugia malayi nuclear receptor RXR 0.0014 0.0003 0.0033
Onchocerca volvulus 0.0476 0.0959 0.9881
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0545 0.1898
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Echinococcus multilocularis dro:myosuppressin receptor 0.0087 0.0154 0.0154
Schistosoma mansoni lipoxygenase 0.018 0.0346 0.1205
Echinococcus multilocularis Smad4 0.0026 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus granulosus g protein coupled receptor 0.0087 0.0154 0.0154
Brugia malayi CXXC zinc finger family protein 0.0028 0.0032 0.0311
Brugia malayi TAR-binding protein 0.0066 0.0111 0.1063
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.1999
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0003 0.0003
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0042 0.2013
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0099 0.0273
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Trichomonas vaginalis set domain proteins, putative 0.0482 0.0971 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0037 0.0353
Brugia malayi Pre-SET motif family protein 0.0423 0.085 0.8128
Brugia malayi Protein kinase domain containing protein 0.0089 0.0158 0.1512
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0099 0.474
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0003 0.0033
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0087 0.0154 0.1469
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.021 0.0575
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0037 0.0037
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0037 0.0353
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0366 0.3772
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0037 0.0353
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Schistosoma mansoni hypothetical protein 0.0058 0.0093 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0037 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.021 1
Leishmania major hypothetical protein, conserved 0.0114 0.021 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Brugia malayi neuropeptide F receptor 0.0087 0.0154 0.1477
Brugia malayi hypothetical protein 0.0058 0.0093 0.0889
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Brugia malayi G protein-coupled receptor 0.0087 0.0154 0.1477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Onchocerca volvulus 0.0087 0.0154 0.157
Trichomonas vaginalis esterase, putative 0.0114 0.021 0.2161
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0037 0.0344
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0003 0.0003
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0284 0.0561 0.0561
Schistosoma mansoni amine GPCR 0.0087 0.0154 0.0537
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.005 0.0137
Echinococcus multilocularis serotonin receptor 0.0087 0.0154 0.0154
Onchocerca volvulus 0.0087 0.0154 0.157
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0087 0.0154 0.1469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.0545 0.0545
Echinococcus multilocularis lamin dm0 0.0029 0.0033 0.0033
Echinococcus granulosus orexin receptor type 2 0.0087 0.0154 0.0154
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.005 0.238
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0028 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0082 0.0783
Onchocerca volvulus 0.0087 0.0154 0.157
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.0158 0.7537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0008 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0028 0.0255
Loa Loa (eye worm) hypothetical protein 0.0476 0.0959 0.9175
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.1999
Schistosoma mansoni biogenic amine receptor 0.0087 0.0154 0.0537
Brugia malayi Thioredoxin reductase 0.0037 0.005 0.0478
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Brugia malayi Pre-SET motif family protein 0.0061 0.01 0.0959
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0121 0.0121
Onchocerca volvulus 0.0114 0.021 0.2142
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.01 0.01
Mycobacterium leprae Conserved hypothetical protein 0.0632 0.1283 1
Brugia malayi MH1 domain containing protein 0.0026 0.0028 0.0264
Brugia malayi Smad1 0.0026 0.0028 0.0264
Echinococcus multilocularis sex peptide receptor 0.0087 0.0154 0.0154
Brugia malayi putative neuropeptide receptor NPR1 0.0087 0.0154 0.1477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Loa Loa (eye worm) TYRA-2 protein 0.0087 0.0154 0.1469
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0541 0.5577
Brugia malayi nuclear receptor RXR 0.0016 0.0007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0037 0.0353
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.021 0.021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0037 0.0353
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.021 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0037 0.0344
Schistosoma mansoni histamine h1 receptor 0.0087 0.0154 0.0537
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0033 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0005 0.0049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.034 0.0678 0.236
Schistosoma mansoni nuclear receptor 0.0014 0.0003 0.0012
Onchocerca volvulus 0.0087 0.0154 0.157
Schistosoma mansoni rab6-interacting 0.0058 0.0093 0.0323
Loa Loa (eye worm) melatonin receptor type 1A 0.0087 0.0154 0.1469
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.021 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0545 0.1898
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0037 0.0353
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0148 0.0405
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0096
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0028 0.0028
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0192 0.1838
Schistosoma mansoni hypothetical protein 0.0087 0.0154 0.0537
Brugia malayi G protein-coupled receptor F59B2.13 0.0087 0.0154 0.1477
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.0154 0.0154
Schistosoma mansoni cpg binding protein 0.003 0.0036 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.01 0.4781
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0346 0.3566
Schistosoma mansoni neuropeptide receptor 0.0087 0.0154 0.0537
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0276 0.0545 0.5217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.021 0.0575
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.1999
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.0154 0.0154
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.021 1
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0087 0.0154 0.0154
Schistosoma mansoni Smad4 0.0026 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0111 0.0387
Echinococcus granulosus tar DNA binding protein 0.0066 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) RNA binding protein 0.0066 0.0111 0.1055
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0037 0.0128
Trypanosoma brucei trypanothione reductase 0.0037 0.005 0.238
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0087 0.0154 0.0154
Brugia malayi beta-lactamase 0.0114 0.021 0.2007
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0028 0.0255
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.021 0.1999
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Toxoplasma gondii ABC1 family protein 0.0114 0.021 1
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0003 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.0154 0.0154
Brugia malayi nuclear receptor NHR-88 0.0031 0.0037 0.0353
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0042 0.2013
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0346 0.3566
Brugia malayi RE15519p 0.0087 0.0154 0.1477
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0099 0.474
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0027
Mycobacterium tuberculosis Conserved protein 0.0114 0.021 0.0575
Brugia malayi Uncoordinated protein 44 0.0014 0.0002 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0008 0.0008
Echinococcus granulosus neuropeptide s receptor 0.0087 0.0154 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.01 0.0349
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Loa Loa (eye worm) doublecortin family protein 0.0058 0.0093 0.0881
Echinococcus multilocularis survival motor neuron protein 1 0.0518 0.1045 0.1045
Mycobacterium ulcerans lipase LipD 0.0114 0.021 1
Brugia malayi nuclear hormone receptor 0.0014 0.0003 0.0033
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0087 0.0154 0.0537
Brugia malayi hypothetical protein 0.0038 0.0052 0.0501
Leishmania major trypanothione reductase 0.0037 0.005 0.238
Brugia malayi MH2 domain containing protein 0.0383 0.0767 0.7342
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0541 0.5577
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0729 0.1483 0.4067
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.021 0.0575
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0003 0.0003
Brugia malayi hypothetical protein 0.0476 0.0959 0.9176
Schistosoma mansoni neuropeptide receptor 0.0087 0.0154 0.0537
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0037 0.0128
Echinococcus granulosus sex peptide receptor 0.0087 0.0154 0.0154
Brugia malayi Serotonin receptor 0.0087 0.0154 0.1477
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.0154 0.0537
Echinococcus multilocularis microtubule associated protein 2 0.1401 0.2874 0.2874
Brugia malayi sulfakinin receptor protein 0.0087 0.0154 0.1477
Plasmodium vivax glutathione reductase, putative 0.0037 0.005 0.238
Brugia malayi glutathione reductase 0.0037 0.005 0.0478
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.005 0.0469
Mycobacterium ulcerans beta-lactamase 0.0114 0.021 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Echinococcus granulosus Smad4 0.0026 0.0028 0.0028
Echinococcus granulosus intermediate filament protein 0.0029 0.0033 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0111 0.0387
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0037 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.021 0.073
Brugia malayi Dopamine receptor protein 2 0.0087 0.0154 0.1477
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0346 0.3566
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.021 0.2007
Onchocerca volvulus 0.0106 0.0192 0.196
Schistosoma mansoni nuclear receptor 0.0014 0.0003 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.01 0.0349
Onchocerca volvulus 0.0029 0.0033 0.0312
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.021 0.0575
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.021 0.0575
Echinococcus multilocularis g protein coupled receptor 0.0087 0.0154 0.0154
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0087 0.0154 0.0537
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.0158 0.1505
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.0154 0.0154
Echinococcus multilocularis geminin 0.034 0.0678 0.0678
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0052 0.0082 0.0775
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0052 0.0052
Schistosoma mansoni adenoreceptor 0.0087 0.0154 0.0537
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0087 0.0154 0.0154
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.0154 0.1469
Echinococcus multilocularis muscleblind protein 0.0299 0.0592 0.0592
Echinococcus granulosus RUN 0.0058 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0003 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.021 0.2161
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0005 0.004
Brugia malayi nuclear hormone receptor 0.0031 0.0037 0.0353
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0087 0.0154 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0002 0.0023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0087 0.0154 0.0154
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.0158 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0003 0.0003
Brugia malayi Serotonin receptor 0.0087 0.0154 0.1477
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Brugia malayi G-protein coupled receptor 0.0087 0.0154 0.1477
Onchocerca volvulus 0.0087 0.0154 0.157
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0148 0.0405
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.021 0.0575
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0087 0.0154 0.1469
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1774 0.3646 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0087 0.0154 0.1477
Echinococcus granulosus dro:myosuppressin receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0066
Brugia malayi GnHR receptor homolog 0.0087 0.0154 0.1477
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.0093 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.01 0.0349
Echinococcus multilocularis muscleblind protein 1 0.0299 0.0592 0.0592
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0008 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.021 0.2161
Treponema pallidum recombinase A 0.0108 0.0197 1
Onchocerca volvulus 0.0087 0.0154 0.157
Echinococcus granulosus g protein coupled receptor 0.0087 0.0154 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0008 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.0154 0.1469
Plasmodium falciparum glutathione reductase 0.0037 0.005 0.5369
Loa Loa (eye worm) hypothetical protein 0.0089 0.0157 0.1495
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Echinococcus granulosus Ankyrin 0.0014 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Mycobacterium tuberculosis Probable reductase 0.0084 0.0148 0.0405
Onchocerca volvulus 0.0087 0.0154 0.157
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Schistosoma mansoni opsin-like receptor 0.0087 0.0154 0.0537
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0037 0.0353
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Onchocerca volvulus Huntingtin homolog 0.0246 0.0484 0.497
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0003 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0111 0.1063
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0158 0.7537
Onchocerca volvulus 0.0482 0.0971 1
Brugia malayi beta-lactamase family protein 0.0114 0.021 0.2007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0037 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0087 0.0154 0.0154
Brugia malayi MH1 domain containing protein 0.0026 0.0028 0.0264
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0052 0.0182
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0093 0.0093
Echinococcus multilocularis neuropeptide FF receptor 2 0.0087 0.0154 0.0154
Schistosoma mansoni lamin 0.0029 0.0033 0.0113
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0016
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.0093 0.4432
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0276 0.0545 0.5213
Onchocerca volvulus 0.0014 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0036 0.0048 0.0166
Loa Loa (eye worm) MH2 domain-containing protein 0.0383 0.0767 0.7339
Echinococcus granulosus serotonin receptor 0.0087 0.0154 0.0154
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0087 0.0154 0.0537
Brugia malayi putative neuropeptide receptor 0.0087 0.0154 0.1477
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Onchocerca volvulus 0.0087 0.0154 0.157
Echinococcus granulosus allatostatin A receptor 0.0087 0.0154 0.0154
Schistosoma mansoni amine GPCR 0.0087 0.0154 0.0537
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Schistosoma mansoni loxhd1 0.0058 0.0093 0.0323
Onchocerca volvulus Neuropeptide F receptor homolog 0.0087 0.0154 0.157
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0037 0.0128
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0087 0.0154 0.0154
Schistosoma mansoni opsin-like receptor 0.0087 0.0154 0.0537
Echinococcus granulosus 7TM GPCR rhodopsin 0.0087 0.0154 0.0154
Brugia malayi hypothetical protein 0.0518 0.1045 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0344
Schistosoma mansoni biogenic amine receptor 0.0087 0.0154 0.0537
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0114 0.021 1
Entamoeba histolytica protein kinase, putative 0.0089 0.0158 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0111 0.0111
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0087 0.0154 0.1477
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.0154 0.0154
Echinococcus granulosus peptide allatostatin:somatostatin 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Schistosoma mansoni hypothetical protein 0.0087 0.0154 0.0537
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.0154 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0545 0.1898
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.1999
Onchocerca volvulus 0.0114 0.021 0.2142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0058
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.0154 0.0154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0111 0.0387
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0099 0.0099
Brugia malayi hypothetical protein 0.0246 0.0484 0.4627
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0082 0.0783
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0037 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0037 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.021 1
Onchocerca volvulus 0.0087 0.0154 0.157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0008 0.0066
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0158 0.7537
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0087 0.0154 0.0537
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0037 0.0037
Echinococcus granulosus lamin dm0 0.0029 0.0033 0.0033
Echinococcus multilocularis somatostatin receptor 0.0087 0.0154 0.0154
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.01 0.01
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0087 0.0154 0.1469
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.0154 0.0154
Brugia malayi hypothetical protein 0.0058 0.0093 0.0889
Schistosoma mansoni hypothetical protein 0.0087 0.0154 0.0537
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0087 0.0154 0.0154
Echinococcus granulosus muscleblind protein 0.0299 0.0592 0.0592
Schistosoma mansoni cpg binding protein 0.0028 0.0032 0.0113
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus granulosus GPCR family 2 0.0017 0.0008 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0037 0.0356
Schistosoma mansoni myosin xvIII 0.0087 0.0154 0.0537
Loa Loa (eye worm) beta-lactamase 0.0114 0.021 0.1999
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0099 0.474
Echinococcus granulosus geminin 0.034 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.0541 0.5173
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0037 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0037 0.0353
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.0154 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0007 0.0067
Echinococcus multilocularis allatostatin A receptor 0.0087 0.0154 0.0154
Schistosoma mansoni smad 0.0026 0.0028 0.0096
Brugia malayi neuropeptide F receptor 0.0087 0.0154 0.1477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0037 0.0344
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0037 0.0356
Echinococcus multilocularis serotonin receptor 0.0087 0.0154 0.0154
Schistosoma mansoni cpg binding protein 0.003 0.0036 0.0125
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0003 0.0033
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0037 0.0037
Brugia malayi hypothetical protein 0.0016 0.0007 0.0067
Brugia malayi Dopamine receptor protein 1 0.0087 0.0154 0.1477
Schistosoma mansoni hypothetical protein 0.0087 0.0154 0.0537
Loa Loa (eye worm) hypothetical protein 0.0246 0.0484 0.4622
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0002 0.0008
Brugia malayi hypothetical protein 0.0014 0.0003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.0154 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0037 0.0344
Onchocerca volvulus 0.0087 0.0154 0.157
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0037 0.0128
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.0545 0.0545
Schistosoma mansoni microtubule-associated protein tau 0.1401 0.2874 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0167 0.0171
Schistosoma mansoni intermediate filament proteins 0.0029 0.0033 0.0113
Plasmodium falciparum thioredoxin reductase 0.0037 0.005 0.5369
Schistosoma mansoni zinc finger protein 0.0014 0.0003 0.0012
Echinococcus multilocularis g-protein coupled receptor 0.0087 0.0154 0.0154
Onchocerca volvulus Huntingtin homolog 0.0246 0.0484 0.497
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.0154 0.0154
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.0154 0.0154
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0087 0.0154 0.0154
Onchocerca volvulus 0.0087 0.0154 0.157
Echinococcus granulosus cpg binding protein 0.003 0.0036 0.0036
Brugia malayi MH2 domain containing protein 0.0026 0.0028 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.01 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0158 0.055
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.0158 0.7537
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Echinococcus granulosus tachykinin peptides receptor 99D 0.0087 0.0154 0.0154
Mycobacterium ulcerans hypothetical protein 0.0114 0.021 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0087 0.0154 0.1477
Onchocerca volvulus 0.0087 0.0154 0.157
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.021 0.2161
Brugia malayi RNA binding protein 0.0066 0.0111 0.1063
Onchocerca volvulus 0.0028 0.0032 0.0311
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0087 0.0154 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0541 0.5577
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Mycobacterium ulcerans recombinase A 0.0108 0.0197 0.9377
Echinococcus multilocularis lamin 0.0029 0.0033 0.0033
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0003 0.0003
Schistosoma mansoni lamin 0.0029 0.0033 0.0113
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0003 0.0024
Brugia malayi hypothetical protein 0.0014 0.0003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0293
Onchocerca volvulus 0.0087 0.0154 0.157
Brugia malayi Tachykinin-like peptides receptor 99D 0.0087 0.0154 0.1477
Onchocerca volvulus 0.0031 0.0037 0.0356
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0028 0.0096
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0003 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0007 0.0067
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.0154 0.0537
Echinococcus granulosus smad 0.0026 0.0028 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Schistosoma mansoni neuropeptide receptor 0.0087 0.0154 0.0537
Entamoeba histolytica protein kinase, putative 0.0089 0.0158 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0037 0.0353
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0087 0.0154 0.0154
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0037 0.0037
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0037 0.0037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.0154 0.0537
Schistosoma mansoni hypothetical protein 0.0038 0.0052 0.0182
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.0813 0.0813
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.009 0.4284
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0037 0.0353
Loa Loa (eye worm) hypothetical protein 0.0246 0.0484 0.4622
Loa Loa (eye worm) glutathione reductase 0.0037 0.005 0.0469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0037 0.0344
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0087 0.0154 0.1477
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0051 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0003 0.0003
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0518 0.1045 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0111 0.0387
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0366 0.3772
Brugia malayi nuclear receptor NHR-88 0.0014 0.0003 0.0033
Schistosoma mansoni biogenic amine receptor 0.0087 0.0154 0.0537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Echinococcus granulosus 7tm_1 domain containing protein 0.0087 0.0154 0.0154
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0037 0.0128
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0037 0.0128
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0002 0.0014
Echinococcus multilocularis cpg binding protein 0.003 0.0036 0.0036
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0087 0.0154 0.157
Schistosoma mansoni alpha-1 adrenergic receptor 0.0087 0.0154 0.0537
Brugia malayi conserved hypotetical protein 0.0014 0.0003 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0033 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0541 0.5577
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.0541 0.5178
Schistosoma mansoni rab6-interacting 0.0058 0.0093 0.0323
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0003 0.0033
Brugia malayi Melatonin receptor type 1A 0.0087 0.0154 0.1477
Brugia malayi Protein kinase domain containing protein 0.0014 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0299 0.0592 0.5661
Echinococcus multilocularis neuropeptide receptor 0.0087 0.0154 0.0154
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0002 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0037 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0008 0.0075
Brugia malayi ecdysone receptor 0.0014 0.0003 0.0033
Echinococcus granulosus lamin 0.0029 0.0033 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0037 0.0353
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0087 0.0154 0.0537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0037 0.0344
Echinococcus granulosus microtubule associated protein 2 0.1401 0.2874 0.2874
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0028 0.0028
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0284 0.0561 0.0561
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.0154 0.0537
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.0545 0.0545
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.0154 0.0154
Entamoeba histolytica hypothetical protein 0.0089 0.0158 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.005 0.238
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0099 0.0099
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0003 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0048 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.021 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0087 0.0154 0.1477
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0111 0.1055
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0048 0.0446
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0007 0.0058
Echinococcus multilocularis dual specificity 0.0089 0.0158 0.0158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.0154 0.0537
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Schistosoma mansoni netrin receptor unc5 0.0014 0.0002 0.0008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0094 0.0094
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0003 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0082 0.0775
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0087 0.0154 0.0537
Brugia malayi nuclear receptor NHR-67 0.0014 0.0003 0.0033
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0099 0.474
Echinococcus multilocularis smad 0.0026 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0058 0.0093 0.0881
Onchocerca volvulus 0.0087 0.0154 0.157
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.021 0.2161
Mycobacterium tuberculosis Conserved protein 0.0114 0.021 0.0575
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0003 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Echinococcus granulosus neuropeptide receptor 0.0087 0.0154 0.0154
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0303
Schistosoma mansoni hypothetical protein 0.034 0.0678 0.236
Echinococcus granulosus alpha 1A adrenergic receptor 0.0087 0.0154 0.0154
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.0154 0.0537
Loa Loa (eye worm) nuclear factor I 0.0014 0.0003 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0111 0.1055
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0087 0.0154 0.0154
Echinococcus granulosus dual specificity 0.0089 0.0158 0.0158
Echinococcus granulosus g protein coupled receptor 0.0087 0.0154 0.0154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Onchocerca volvulus 0.0029 0.0033 0.0312
Onchocerca volvulus 0.0087 0.0154 0.157
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0167 0.0459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.0154 0.0537
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.0346 0.3549
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Onchocerca volvulus 0.0061 0.01 0.1011
Onchocerca volvulus 0.0058 0.0093 0.0936
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0002 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.0154 0.0537
Brugia malayi larval opioid receptor 0.0087 0.0154 0.1477
Brugia malayi hypothetical protein 0.0087 0.0154 0.1477
Brugia malayi beta-lactamase family protein 0.0114 0.021 0.2007
Echinococcus granulosus fmrfamide receptor 0.0087 0.0154 0.0154
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.021 0.2161
Schistosoma mansoni hypothetical protein 0.0106 0.0192 0.0669
Loa Loa (eye worm) hypothetical protein 0.0299 0.0592 0.5661
Schistosoma mansoni lipoxygenase 0.0284 0.0561 0.1953
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0108 0.0197 0.0431
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0037 0.0037
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0167 0.0459
Echinococcus multilocularis neuropeptide receptor A26 0.0087 0.0154 0.0154
Brugia malayi Muscleblind-like protein 0.0299 0.0592 0.5665
Schistosoma mansoni neuropeptide receptor 0.0087 0.0154 0.0537
Echinococcus multilocularis orexin receptor type 2 0.0087 0.0154 0.0154
Echinococcus multilocularis neuropeptide receptor 0.0087 0.0154 0.0154
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0037 0.0128
Schistosoma mansoni amine GPCR 0.0087 0.0154 0.0537
Plasmodium vivax SET domain protein, putative 0.0061 0.01 0.4781
Echinococcus granulosus somatostatin receptor 0.0087 0.0154 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0099 0.474
Brugia malayi Death domain containing protein 0.0014 0.0002 0.0023
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0003 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0346 0.3566
Brugia malayi Dopamine receptor 0.0087 0.0154 0.1477
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0037 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0037 0.0353
Echinococcus granulosus g-protein coupled receptor 0.0087 0.0154 0.0154
Onchocerca volvulus 0.0058 0.0093 0.0936
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0042 0.2013
Onchocerca volvulus 0.0087 0.0154 0.157
Echinococcus multilocularis RUN 0.0058 0.0093 0.0093
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0089 0.0157 0.1495
Schistosoma mansoni polycystin 1-related 0.0058 0.0093 0.0323
Mycobacterium tuberculosis Conserved protein 0.0114 0.021 0.0575
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0096
Schistosoma mansoni hypothetical protein 0.0406 0.0813 0.283
Echinococcus granulosus death domain containing protein 0.0014 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0087 0.0154 0.0537
Echinococcus granulosus neuropeptide FF receptor 2 0.0087 0.0154 0.0154
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0037 0.0037
Echinococcus granulosus G protein coupled receptor 139 0.0087 0.0154 0.0154
Echinococcus granulosus dnaJ subfamily B 0.0406 0.0813 0.0813
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0003 0.0003
Loa Loa (eye worm) Smad1 0.0026 0.0028 0.0255
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0033 0.0303
Echinococcus multilocularis g protein coupled receptor 0.0087 0.0154 0.0154
Brugia malayi Doublecortin family protein 0.0058 0.0093 0.0889
Loa Loa (eye worm) hypothetical protein 0.0058 0.0093 0.0881
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0121 0.0121
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0167 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0037 0.0353
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.005 0.238
Echinococcus multilocularis Ankyrin 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0037 0.0353
Brugia malayi AKH receptor 0.0087 0.0154 0.1477
Loa Loa (eye worm) hypothetical protein 0.0087 0.0154 0.1469
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0033

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) > 200 uM Antibacterial activity against Escherichia coli ATCC 25922 ChEMBL. 20608742
MIC (functional) > 150 ug ml-1 Antibacterial activity against Escherichia coli by micro dilution method ChEMBL. 21401113

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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