Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Protein lozenge | 0.0058 | 0.054 | 0.054 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.1154 | 0.1828 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0218 | 0.2833 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0041 | 0.0298 | 0.0298 |
Onchocerca volvulus | 0.0101 | 0.1154 | 0.1423 | |
Brugia malayi | Cytochrome P450 family protein | 0.006 | 0.0573 | 0.0908 |
Schistosoma mansoni | lipoxygenase | 0.0171 | 0.2163 | 0.2163 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0298 | 0.0472 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0218 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.006 | 0.0573 | 1 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.006 | 0.0573 | 0.2118 |
Mycobacterium leprae | putative cytochrome p450 | 0.006 | 0.0573 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.006 | 0.0573 | 0.2023 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0218 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.006 | 0.0573 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.006 | 0.0573 | 0.2118 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.006 | 0.0573 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.006 | 0.0573 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0209 | 0.2707 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0218 | 0.2833 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0298 | 0.0472 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.006 | 0.0573 | 0.2118 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.006 | 0.0573 | 0.0908 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.006 | 0.0573 | 0.2118 |
Onchocerca volvulus | 0.0101 | 0.1154 | 0.1423 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.1154 | 0.1154 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.006 | 0.0573 | 1 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.006 | 0.0573 | 0.2118 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.006 | 0.0573 | 0.2118 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.6315 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0244 | 0.3219 | 0.3219 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.006 | 0.0573 | 0.2118 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0209 | 0.2707 | 0.9554 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0218 | 0.2833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0298 | 0.0472 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.006 | 0.0573 | 0.2118 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0209 | 0.2707 | 0.4286 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0041 | 0.0298 | 0.0298 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.006 | 0.0573 | 0.2118 |
Trypanosoma brucei | protein kinase, putative | 0.0218 | 0.2833 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0218 | 0.2833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1055 | 0.167 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0244 | 0.3219 | 0.3219 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0298 | 0.0472 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.006 | 0.0573 | 0.2023 |
Brugia malayi | Cytochrome P450 family protein | 0.0209 | 0.2707 | 0.4286 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0218 | 0.2833 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.006 | 0.0573 | 0.2118 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.006 | 0.0573 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.006 | 0.0573 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0218 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.006 | 0.0573 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.006 | 0.0573 | 0.0908 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.006 | 0.0573 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0209 | 0.2707 | 0.9554 |
Echinococcus multilocularis | RUN | 0.0041 | 0.0298 | 0.0298 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0218 | 0.2833 | 0.2833 |
Loa Loa (eye worm) | runx1 | 0.0058 | 0.054 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1154 | 0.1828 |
Leishmania major | cytochrome p450-like protein | 0.006 | 0.0573 | 0.2023 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.006 | 0.0573 | 1 |
Brugia malayi | Doublecortin family protein | 0.0041 | 0.0298 | 0.0472 |
Schistosoma mansoni | rab6-interacting | 0.0041 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0209 | 0.2707 | 0.4286 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.1154 | 0.1154 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.006 | 0.0573 | 0.2023 |
Brugia malayi | follicle stimulating hormone receptor | 0.0245 | 0.3221 | 0.5101 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.006 | 0.0573 | 1 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.006 | 0.0573 | 0.2118 |
Leishmania major | cytochrome p450-like protein | 0.0209 | 0.2707 | 0.9554 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.006 | 0.0573 | 0.2118 |
Brugia malayi | Cytochrome P450 family protein | 0.0209 | 0.2707 | 0.4286 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.006 | 0.0573 | 0.2023 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0245 | 0.3221 | 0.5101 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0041 | 0.0298 | 0.0298 |
Brugia malayi | MAP kinase sur-1 | 0.0218 | 0.2833 | 0.4487 |
Brugia malayi | cytochrome P450 | 0.006 | 0.0573 | 0.0908 |
Echinococcus multilocularis | 0.006 | 0.0573 | 0.0573 | |
Onchocerca volvulus | 0.0101 | 0.1154 | 0.1423 | |
Loa Loa (eye worm) | doublecortin family protein | 0.0041 | 0.0298 | 0.0472 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0041 | 0.0298 | 0.0298 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.006 | 0.0573 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.006 | 0.0573 | 0.2118 |
Schistosoma mansoni | lozenge | 0.0058 | 0.054 | 0.054 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0209 | 0.2707 | 0.4286 |
Schistosoma mansoni | rab6-interacting | 0.0041 | 0.0298 | 0.0298 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.006 | 0.0573 | 0.2118 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1154 | 0.1828 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0218 | 0.2833 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0218 | 0.2833 | 0.2833 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.006 | 0.0573 | 0.2118 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0041 | 0.0298 | 0.0298 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.006 | 0.0573 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.006 | 0.0573 | 0.2118 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0218 | 0.2833 | 1 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0573 | 0.0573 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.006 | 0.0573 | 0.2118 |
Mycobacterium leprae | Conserved hypothetical protein | 0.006 | 0.0573 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0041 | 0.0298 | 0.0298 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.006 | 0.0573 | 0.2118 |
Brugia malayi | hypothetical protein | 0.046 | 0.6315 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.006 | 0.0573 | 0.2023 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.006 | 0.0573 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.006 | 0.0573 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0218 | 0.2833 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0218 | 0.2833 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.006 | 0.0573 | 0.2023 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.006 | 0.0573 | 0.0573 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.006 | 0.0573 | 0.2118 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1845 | 0.2922 |
Schistosoma mansoni | cytochrome P450 | 0.006 | 0.0573 | 0.0573 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0218 | 0.2833 | 0.2833 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0218 | 0.2833 | 0.2833 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0218 | 0.2833 | 0.2833 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0209 | 0.2707 | 0.9554 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.006 | 0.0573 | 0.2023 |
Schistosoma mansoni | lipoxygenase | 0.0244 | 0.3219 | 0.3219 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0218 | 0.2833 | 0.4487 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0041 | 0.0298 | 1 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.006 | 0.0573 | 0.2118 |
Brugia malayi | Cytochrome P450 family protein | 0.006 | 0.0573 | 0.0908 |
Schistosoma mansoni | polycystin 1-related | 0.0041 | 0.0298 | 0.0298 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.006 | 0.0573 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.006 | 0.0573 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0218 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.006 | 0.0573 | 1 |
Echinococcus granulosus | RUN | 0.0041 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.6315 | 1 |
Schistosoma mansoni | loxhd1 | 0.0041 | 0.0298 | 0.0298 |
Onchocerca volvulus | 0.046 | 0.6315 | 1 | |
Plasmodium falciparum | LCCL domain-containing protein | 0.0041 | 0.0298 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.006 | 0.0573 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.006 | 0.0573 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.