Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1741 | 0.3265 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.3121 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1741 | 0.3265 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.1143 | 0.1327 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.5774 | 0.8982 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0159 | 0.6428 | 0.7465 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.3121 | 0.3121 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.5774 | 0.6705 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3121 | 0.2905 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.5332 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0304 | 0.0353 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0768 | 0.144 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.3121 | 0.4855 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.8611 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1741 | 0.3265 |
Schistosoma mansoni | kinase | 0.0047 | 0.0877 | 0.1645 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.1329 | 0.2068 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.1741 | 0.2022 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0056 | 0.1329 | 0.3638 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.1329 | 0.2493 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.1741 | 0.2022 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0768 | 0.1194 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0159 | 0.6428 | 0.7465 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.3121 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.1329 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.3121 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.3121 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.5774 | 0.8982 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0304 | 0.0353 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.1741 | 0.2022 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0056 | 0.1329 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3121 | 0.2905 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.1741 | 0.2708 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.1225 | 0.2297 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0768 | 0.1194 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.5332 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0768 | 0.144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1741 | 0.3265 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0768 | 0.0891 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.3121 | 0.4855 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.1225 | 0.1905 |
Onchocerca volvulus | 0.0092 | 0.311 | 0.311 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3121 | 0.2905 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.1329 | 0.5 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0304 | 0.0474 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.3121 | 0.5853 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.1225 | 0.1905 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.5774 | 0.8982 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1741 | 0.3265 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1329 | 0.1543 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0817 | 0.0528 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0304 | 0.0571 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0768 | 0.1194 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.3121 | 0.3624 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.1329 | 0.2068 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.6428 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.6428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.5774 | 0.6705 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0159 | 0.6428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.5774 | 0.6705 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.1741 | 0.2022 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3121 | 0.2905 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0304 | 0.0474 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.3121 | 0.3624 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.3121 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0768 | 0.144 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3121 | 0.2905 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.1741 | 0.2708 |
Brugia malayi | RNA binding protein | 0.0064 | 0.1741 | 0.2022 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.1741 | 0.2022 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0304 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.8611 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0768 | 0.0891 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0817 | 0.0528 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3121 | 0.2905 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0768 | 0.1194 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3121 | 0.2905 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.3121 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.