Detailed information for compound 1179920

Basic information

Technical information
  • TDR Targets ID: 1179920
  • Name: 2-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-imidaz ole
  • MW: 206.241 | Formula: C11H14N2O2
  • H donors: 1 H acceptors: 0 LogP: 0.83 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1=NCCN1
  • InChi: 1S/C11H14N2O2/c1-14-9-4-3-8(7-10(9)15-2)11-12-5-6-13-11/h3-4,7H,5-6H2,1-2H3,(H,12,13)
  • InChiKey: NXHHUAOYFMCRFK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Monoamine oxidase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein Monoamine oxidase A   526 aa 464 aa 21.6 %
Dictyostelium discoideum amine oxidase Monoamine oxidase A   526 aa 491 aa 31.0 %
Dictyostelium discoideum hypothetical protein Monoamine oxidase A   526 aa 518 aa 22.4 %
Dictyostelium discoideum hypothetical protein Monoamine oxidase A   526 aa 524 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protoporphyrinogen oxidase 0.0025 0.0377 0.0588
Onchocerca volvulus 0.0023 0.0333 0.0573
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0843 0.1314
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0377 0.133
Schistosoma mansoni Smad4 0.0017 0.0191 0.0297
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.2157 0.336
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0449 0.0913
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0449 0.0913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0181 0.0181
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0191 0.0171
Loa Loa (eye worm) hypothetical protein 0.0017 0.0202 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.141 0.193
Brugia malayi hypothetical protein 0.0025 0.0377 0.0361
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0435 0.0347
Mycobacterium ulcerans hypothetical protein 0.0156 0.3274 0.4209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.1794 0.2794
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0435 0.165
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.1516 0.1949
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0377 0.0377
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0181 0.0181
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0272 0.2211
Loa Loa (eye worm) hypothetical protein 0.0053 0.0986 0.0982
Brugia malayi Smad1 0.0017 0.0191 0.0171
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0843 0.1314
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0333 0.0181
Loa Loa (eye worm) MH2 domain-containing protein 0.0247 0.5308 0.5392
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0333 0.0181
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2157 0.4387
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0083 0.1657 0.2581
Loa Loa (eye worm) hypothetical protein 0.0025 0.0377 0.0361
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0272 0.0082
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0931 0.0931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1794 0.2794
Loa Loa (eye worm) hypothetical protein 0.0072 0.141 0.1415
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0449 0.1175
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0191 0.0297
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0272 0.0423
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0435 0.0347
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.2157 0.336
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.6381 1
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0843 0.0837
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0449 0.0913
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.7217 0.7217
Trichomonas vaginalis set domain proteins, putative 0.023 0.4917 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0986 0.1535
Mycobacterium ulcerans beta-lactamase 0.0072 0.141 0.1813
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1794 0.2794
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0333 0.0333
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0986 0.0982
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.141 0.141
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0449 0.0913
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0025 0.0377 0.1203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0181 0.0181
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0221 0.1026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.1794 0.2794
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0449 0.1875
Echinococcus multilocularis 0.0025 0.0377 0.0588
Mycobacterium leprae conserved hypothetical protein 0.0072 0.141 0.6539
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.1098 0.1424
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0318 0.0647
Loa Loa (eye worm) hypothetical protein 0.0025 0.0377 0.0361
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.141 0.2869
Toxoplasma gondii ABC1 family protein 0.0072 0.141 0.9184
Schistosoma mansoni ap endonuclease 0.0018 0.0221 0.0345
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.1516 1
Loa Loa (eye worm) Smad1 0.0017 0.0191 0.0171
Brugia malayi MH1 domain containing protein 0.0017 0.0191 0.0171
Schistosoma mansoni smad1 5 8 and 0.0017 0.0191 0.0297
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0272 0.0527
Leishmania major hypothetical protein, conserved 0.0072 0.141 0.193
Loa Loa (eye worm) hypothetical protein 0.0017 0.0202 0.0183
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.141 0.141
Loa Loa (eye worm) hypothetical protein 0.0025 0.0377 0.0361
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2157 0.4387
Loa Loa (eye worm) phosphofructokinase 0.0105 0.2157 0.2177
Loa Loa (eye worm) hypothetical protein 0.0017 0.0202 0.0183
Mycobacterium ulcerans oxidoreductase 0.0025 0.0377 0.0485
Entamoeba histolytica Ran family GTPase 0.0021 0.0272 0.026
Mycobacterium tuberculosis Conserved protein 0.0072 0.141 0.141
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.2157 0.2177
Plasmodium vivax SET domain protein, putative 0.0029 0.0459 0.1955
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0931 0.145
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0221 0.146
Schistosoma mansoni amine oxidase 0.0025 0.0377 0.0588
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0221 0.0345
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0333 0.0428
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0449 0.0913
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.1098 0.1098
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0459 0.0715
Loa Loa (eye worm) hypothetical protein 0.0087 0.1741 0.1752
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.2157 0.2157
Loa Loa (eye worm) hypothetical protein 0.0077 0.1516 0.1523
Schistosoma mansoni smad1 5 8 and 0.0017 0.0191 0.0297
Trichomonas vaginalis ran, putative 0.0021 0.0272 0.0553
Loa Loa (eye worm) transcription factor SMAD2 0.0247 0.5308 0.5392
Loa Loa (eye worm) hypothetical protein 0.0025 0.0377 0.0361
Loa Loa (eye worm) hypothetical protein 0.0072 0.141 0.1415
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0449 0.1875
Toxoplasma gondii hypothetical protein 0.0026 0.0402 0.1395
Brugia malayi follicle stimulating hormone receptor 0.0451 0.9824 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.1794 0.1806
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1098 0.1711
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0449 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.6381 1
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.141 0.141
Loa Loa (eye worm) hypothetical protein 0.0023 0.0333 0.0316
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.141 0.141
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.3945 0.6146
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0272 0.0253
Leishmania major GTP-binding protein, putative 0.0021 0.0272 0.0082
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0221 0.0202
Brugia malayi RNA, U transporter 1 0.0079 0.1575 0.1583
Brugia malayi 6-phosphofructokinase 0.0105 0.2157 0.2177
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.3274 0.3274
Mycobacterium ulcerans monoamine oxidase 0.0025 0.0377 0.0485
Schistosoma mansoni smad 0.0017 0.0191 0.0297
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0191 0.0171
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0272 0.0527
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0449 0.2081
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0191 0.0297
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0025 0.0377 0.0588
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0377 0.0253
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0333 0.0428
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0931 0.4314
Schistosoma mansoni ap endonuclease 0.0018 0.0221 0.0345
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0436 0.0679
Echinococcus multilocularis smad 0.0017 0.0191 0.0297
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0931 0.0931
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0941 0.1169
Echinococcus multilocularis Smad4 0.0017 0.0191 0.0297
Echinococcus multilocularis snurportin 1 0.0297 0.6419 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.141 0.1415
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0318 0.0157
Loa Loa (eye worm) hypothetical protein 0.0028 0.0435 0.042
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.1012 0.1009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0333 0.0316
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0272 0.0253
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0459 0.0715
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0025 0.0377 0.0485
Toxoplasma gondii histone lysine-specific demethylase 0.0025 0.0377 0.1203
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0087 0.1741 0.1752
Mycobacterium ulcerans dehydrogenase 0.0025 0.0377 0.0485
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2157 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.1516 0.2362
Loa Loa (eye worm) beta-lactamase 0.0072 0.141 0.1415
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2157 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.6381 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0333 0.0316
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0333 0.0428
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0318 0.0647
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.1516 0.1949
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.141 0.1415
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0739 0.0841
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.1794 0.1806
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1794 0.2794
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.141 0.2869
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0402 0.1864
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0221 0.0145
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1098 0.1412
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.141 0.2197
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0449 0.1875
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.141 0.141
Loa Loa (eye worm) hypothetical protein 0.0072 0.141 0.1415
Leishmania major importin beta-1 subunit, putative 0.0023 0.0318 0.0157
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0377 0.0377
Brugia malayi beta-lactamase 0.0072 0.141 0.1415
Entamoeba histolytica hypothetical protein 0.0023 0.0318 0.0499
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0072 0.141 0.1415
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.141 0.193
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.141 0.2869
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0377 0.133
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0843 0.1314
Loa Loa (eye worm) MBCTL1 0.0053 0.0986 0.0982
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.6381 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2923 0.4386
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0449 0.1875
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.1516 0.2362
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0843 0.1623
Toxoplasma gondii hypothetical protein 0.0048 0.0875 0.505
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.3945 0.6146
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0025 0.0377 0.0588
Schistosoma mansoni importin beta-1 0.0028 0.0435 0.0678
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.2157 0.3142
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.1098 0.1711
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0435 0.0678
Schistosoma mansoni hypothetical protein 0.0297 0.6419 1
Brugia malayi Probable ClpP-like protease 0.0077 0.1516 0.1523
Schistosoma mansoni amine oxidase 0.0025 0.0377 0.0588
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0221 0.045
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0449 0.0913
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0221 0.0345
Schistosoma mansoni hypothetical protein 0.0285 0.6142 0.9568
Onchocerca volvulus 0.0029 0.0459 0.0833
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0333 0.0576
Loa Loa (eye worm) hypothetical protein 0.0029 0.0459 0.0445
Onchocerca volvulus 0.0046 0.0843 0.1623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0459 0.0715
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0739 0.0841
Mycobacterium ulcerans lipase LipD 0.0072 0.141 0.1813
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.7778 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0202 0.0202
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0843 0.1314
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.1741 0.2712
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0459 0.1837
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.141 0.2197
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0191 0.0297
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0333 0.0181
Brugia malayi MH2 domain containing protein 0.0017 0.0191 0.0171
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.1516 0.7029
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0025 0.0377 0.133
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0402 0.152
Mycobacterium tuberculosis Conserved protein 0.0072 0.141 0.141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.141 0.1415
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.2157 0.336
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.2157 0.336
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.141 0.141
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.141 0.1813
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.2157 0.2773
Schistosoma mansoni ran 0.0021 0.0272 0.0423
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0202 0.026
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.1516 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0087 0.1741 0.2712
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.1516 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0333 0.0428
Mycobacterium leprae Probable lipase LipE 0.0072 0.141 0.6539
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0333 0.0428
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0272 0.0082
Brugia malayi mbt repeat family protein 0.0046 0.0843 0.0837
Onchocerca volvulus 0.0025 0.0377 0.0664
Onchocerca volvulus 0.0072 0.141 0.2789
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.1516 0.7029
Echinococcus granulosus potassium voltage gated channel protein 0.0087 0.1741 0.2712
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0333 0.0576
Mycobacterium ulcerans hypothetical protein 0.0072 0.141 0.1813
Loa Loa (eye worm) hypothetical protein 0.0025 0.0377 0.0361
Brugia malayi Pre-SET motif family protein 0.0029 0.0459 0.0445
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.2923 0.4386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0459 0.0715
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0333 0.0316
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0402 0.1864
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0272 0.0388
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0739 0.0841
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.2157 0.3142
Mycobacterium tuberculosis Conserved protein 0.0072 0.141 0.141
Leishmania major UDP-galactopyranose mutase 0.0025 0.0377 0.0253
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0318 0.0647
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1098 0.1097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0333 0.0316
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.141 0.1813
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0459 0.0715
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.141 0.193
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0221 0.0145
Chlamydia trachomatis protoporphyrinogen oxidase 0.0025 0.0377 0.133
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0221 0.0285
Onchocerca volvulus 0.023 0.4917 1
Onchocerca volvulus 0.0072 0.141 0.2789
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0377 0.0588
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0449 0.1756
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0451 0.9824 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0377 0.0361
Echinococcus granulosus smad 0.0017 0.0191 0.0297
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0449 0.1875
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.4298 0.4361
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0272 0.0082
Brugia malayi beta-lactamase family protein 0.0072 0.141 0.1415
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.2157 0.2177
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.141 0.2197
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.141 0.141
Brugia malayi MH2 domain containing protein 0.0017 0.0191 0.0171
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0333 0.1544
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0449 0.1875
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0025 0.0377 0.133
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1098 0.1711
Loa Loa (eye worm) hypothetical protein 0.0072 0.141 0.1415
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0459 0.0715
Brugia malayi MH2 domain containing protein 0.0247 0.5308 0.5392
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0377 0.133
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0986 0.1535
Mycobacterium ulcerans hypothetical protein 0.0023 0.0333 0.0428
Plasmodium vivax hypothetical protein, conserved 0.0072 0.141 0.9195
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0843 0.1314
Brugia malayi Importin beta-1 subunit 0.0028 0.0435 0.042
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.6419 0.6526
Brugia malayi Pre-SET motif family protein 0.0202 0.4298 0.4361
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.1794 0.2794
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0333 0.0316
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0333 0.0576
Loa Loa (eye worm) hypothetical protein 0.0046 0.0843 0.0837
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0986 0.1535
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2157 0.4387
Echinococcus granulosus importin subunit beta 1 0.0028 0.0435 0.0678
Loa Loa (eye worm) hypothetical protein 0.0017 0.0202 0.0183
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0931 0.145
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0377 0.0588
Brugia malayi MH1 domain containing protein 0.0017 0.0191 0.0171
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.1516 0.2362
Echinococcus granulosus snurportin 1 0.0297 0.6419 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.1516 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0459 0.0715
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0449 0.1756
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.1794 0.2794
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0191 0.0297
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2923 0.4386
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0333 0.0428
Brugia malayi mbt repeat family protein 0.0046 0.0843 0.0837
Schistosoma mansoni smad1 5 8 and 0.0017 0.0191 0.0297
Plasmodium vivax importin-beta 2, putative 0.0028 0.0435 0.177
Onchocerca volvulus 0.0072 0.141 0.2789
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2157 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0202 0.0183
Brugia malayi SWIRM domain containing protein 0.0025 0.0377 0.0361
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0181 0.0181
Plasmodium falciparum importin beta, putative 0.0028 0.0435 0.177
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.2157 0.3142
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2157 0.4387
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0221 0.0202
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0333 0.0428
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.2157 1
Brugia malayi beta-lactamase family protein 0.0072 0.141 0.1415
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0191 0.0297
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0025 0.0377 0.0588
Echinococcus multilocularis potassium voltage gated channel protein 0.0087 0.1741 0.2712
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.2157 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0333 0.0333
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.141 0.2197
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.1516 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0377 0.0253
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0272 0.0423
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.141 0.2869
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0025 0.0377 0.1749
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.7778 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0449 0.1756
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0402 0.152
Brugia malayi 6-phosphofructokinase 0.0105 0.2157 0.2177
Schistosoma mansoni ran 0.0021 0.0272 0.0423
Trichomonas vaginalis esterase, putative 0.0072 0.141 0.2869
Loa Loa (eye worm) hypothetical protein 0.0025 0.0377 0.0361
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1098 0.1412
Brugia malayi phosphofructokinase 0.0105 0.2157 0.2177
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0025 0.0377 0.133
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0449 0.0913
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.141 0.2869
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.1516 1
Echinococcus granulosus Smad4 0.0017 0.0191 0.0297
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0986 0.1535
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.1516 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0986 0.1535
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0739 0.0841
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0843 0.1314
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.1741 0.2712
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0221 0.045
Plasmodium falciparum protoporphyrinogen oxidase 0.0025 0.0377 0.133
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0333 0.1544
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0843 0.1314

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 13.57 uM Binding affinity to MAOA imidazoline binding site in rat brain mitochondrial homogenate assessed as 4-hydroxyquinoline production by spectrophotometry ChEMBL. 19064321
Ki (binding) = 1000 uM Binding affinity to MAOB imidazoline binding site in rat brain mitochondrial homogenate assessed as 4-hydroxyquinoline production by spectrophotometry ChEMBL. 19064321

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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