Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3408 | 0.6295 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3408 | 0.6295 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1073 | 0.1952 | 0.1952 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3408 | 0.6295 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.0096 | 0.0096 |
Brugia malayi | thymidylate synthase | 0.1073 | 0.1952 | 0.1151 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1073 | 0.1952 | 0.1151 |
Onchocerca volvulus | 0.1073 | 0.1952 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3408 | 0.6295 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1073 | 0.1952 | 0.1952 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3408 | 0.6295 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3408 | 0.6295 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.0096 | 0.0096 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0511 | 0.0905 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0076 | 0.0096 | 0.0096 |
Echinococcus multilocularis | thymidylate synthase | 0.1073 | 0.1952 | 0.1952 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | < 30 % | Antiexploratory activity (EXPL) of mice determined by an antimex activity meter, 100 mg/kg of dose was administered perorally; No inhibition | ChEMBL. | 2891853 |
Inhibition (functional) | < 30 % | Antireserpine activity (RES) of mice after peroral administration of 100 mg/kg of compound; No inhibition | ChEMBL. | 2891853 |
Inhibition (functional) | = 31 % | Antitremorine activity(TRM) of mice after peroral administration of 100 mg/kg of compound; Slight inhibition (31-50%) | ChEMBL. | 2891853 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.