Detailed information for compound 1180186

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.353 | Formula: C15H14FN3O4S
  • H donors: 3 H acceptors: 5 LogP: 0.45 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2c1cscc1)F
  • InChi: 1S/C15H14FN3O4S/c16-8-3-19(15-13(22)12(21)9(4-20)23-15)14-10(8)11(17-6-18-14)7-1-2-24-5-7/h1-3,5-6,9,12-13,15,20-22H,4H2/t9-,12-,13-,15-/m1/s1
  • InChiKey: SETNXZWHVIMWGW-QGMIFYJMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans putative adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus granulosus adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania infantum adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Brugia malayi Adenosine kinase-like Get druggable targets OG5_128398 All targets in OG5_128398
Neospora caninum GG10762, related Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania major adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma congolense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus multilocularis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania mexicana adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Cryptosporidium parvum adenosine kinase like ribokinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania donovani adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Toxoplasma gondii kinase, pfkB family protein Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Babesia bovis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma japonicum ko:K00856 adenosine kinase [EC2.7.1.20], putative Get druggable targets OG5_128398 All targets in OG5_128398
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128398 All targets in OG5_128398
Onchocerca volvulus Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania braziliensis adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi adenosine kinase, putative adenosine kinase 345 aa 337 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi major cysteine proteinase, putative 0.0807 0.3192 0.7283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0921 0.6561
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0027 0.0015
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0121 0.0432 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0363 0.1404 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.017 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0213 0.1517
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0067 0.0213 0.1425
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Brugia malayi mothers against decapentaplegic homolog 3 0.0025 0.0042 0.0091
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0199 0.0545
Trypanosoma cruzi cysteine peptidase, putative 0.012 0.0426 0.0972
Brugia malayi TAR-binding protein 0.0063 0.0199 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0067 0.0213 0.1517
Brugia malayi Cathepsin L-like precursor 0.0363 0.1404 0.4384
Brugia malayi Cathepsin L-like precursor 0.0363 0.1404 0.4384
Plasmodium falciparum serine repeat antigen 6 0.0067 0.0213 0.1352
Trypanosoma cruzi cysteine peptidase, putative 0.1102 0.4383 1
Entamoeba histolytica cysteine protease, putative 0.0067 0.0213 0.1517
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0067 0.0213 0.1425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Entamoeba histolytica cysteine protease, putative 0.0067 0.0213 0.1517
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0088 0.0051
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0199 0.0585
Schistosoma mansoni smad1 5 8 and 0.0055 0.0164 0.0434
Schistosoma mansoni smad 0.0055 0.0164 0.0434
Echinococcus granulosus tumor protein p63 0.2293 0.9177 1
Onchocerca volvulus Cathepsin L homolog 0.0363 0.1404 0.7295
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0121 0.0432 0.1347
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0055 0.0125
Schistosoma mansoni Smad4 0.0025 0.0042 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0921 0.6561
Onchocerca volvulus 0.0363 0.1404 0.7295
Loa Loa (eye worm) hypothetical protein 0.0067 0.0213 0.059
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0049 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0143 0.0102
Brugia malayi Cathepsin L-like precursor 0.0363 0.1404 0.4384
Brugia malayi Papain family cysteine protease containing protein 0.0187 0.0696 0.2151
Loa Loa (eye worm) hypothetical protein 0.0243 0.0921 0.2832
Brugia malayi beta-lactamase 0.0121 0.0432 0.1321
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Mycobacterium tuberculosis Probable esterase LipL 0.0121 0.0432 0.1347
Loa Loa (eye worm) hypothetical protein 0.0336 0.1295 0.4015
Loa Loa (eye worm) MH1 domain-containing protein 0.0055 0.0164 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0067 0.0213 0.1517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Mycobacterium ulcerans beta-lactamase 0.0121 0.0432 1
Entamoeba histolytica hypothetical protein 0.0041 0.0107 0.0763
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0143 0.041
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0067 0.0213 0.059
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0067 0.0213 0.059
Echinococcus multilocularis beta LACTamase domain containing family member 0.0121 0.0432 0.0392
Loa Loa (eye worm) cysteine protease 0.0363 0.1404 0.436
Entamoeba histolytica cysteine protease, putative 0.0067 0.0213 0.1517
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0199 0.0543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Brugia malayi RNA binding protein 0.0063 0.0199 0.0585
Echinococcus multilocularis cathepsin L cysteine protease 0.0363 0.1404 0.1367
Trypanosoma cruzi cysteine peptidase, putative 0.1102 0.4383 1
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0052 0.0118
Leishmania major cathepsin L-like protease 0.0363 0.1404 0.3203
Echinococcus multilocularis Smad4 0.0055 0.0164 0.0123
Brugia malayi Papain family cysteine protease containing protein 0.0187 0.0696 0.2151
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.0367 0.2537
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0363 0.1404 1
Trypanosoma cruzi cysteine peptidase, putative 0.1102 0.4383 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0432 0.1284
Brugia malayi cathepsin L-like cysteine proteinase 0.0067 0.0213 0.0629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0143 0.0111
Brugia malayi hypothetical protein 0.0041 0.0107 0.0296
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0187 0.0696 0.2116
Schistosoma mansoni hypothetical protein 0.0078 0.0256 0.0726
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0067 0.0213 0.1517
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0213 0.0629
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0401 0.1223
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0067 0.0213 0.0588
Toxoplasma gondii cathepsin CPC2 0.0067 0.0213 0.143
Onchocerca volvulus Cathepsin L homolog 0.0067 0.0213 0.0915
Onchocerca volvulus Cathepsin F homolog 0.0363 0.1404 0.7295
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0367 0.0837
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0199 0.0543
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.1055 0.1109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Giardia lamblia Cathepsin L precursor 0.0067 0.0213 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0067 0.0213 0.1517
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Toxoplasma gondii cathepsin B 0.0067 0.0213 0.143
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0052 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.012 0.0426 0.1302
Schistosoma mansoni cathepsin F (C01 family) 0.0363 0.1404 0.4356
Loa Loa (eye worm) hypothetical protein 0.0121 0.0432 0.1284
Trypanosoma cruzi major cysteine proteinase, putative 0.0067 0.0213 0.0486
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0055 0.0391
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0052 0.0181
Schistosoma mansoni Smad4 0.0025 0.0042 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0121 0.0432 0.1321
Loa Loa (eye worm) hypothetical protein 0.0276 0.1055 0.3256
Trypanosoma cruzi cysteine protease, putative 0.0187 0.0696 0.1587
Loa Loa (eye worm) hypothetical protein 0.0105 0.0367 0.1077
Plasmodium falciparum serine repeat antigen 5 0.0067 0.0213 0.1352
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0088 0.0046
Loa Loa (eye worm) hypothetical protein 0.0121 0.0432 0.1284
Plasmodium vivax vivapain-2 0.0363 0.1404 1
Toxoplasma gondii cathepsin CPC1 0.0067 0.0213 0.143
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Onchocerca volvulus 0.0363 0.1404 0.7295
Loa Loa (eye worm) RecQ helicase 0.0026 0.0049 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0213 0.1517
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0088 0.0051
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0067 0.0213 0.1425
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0363 0.1404 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0067 0.0213 0.1425
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Giardia lamblia Cathepsin L precursor 0.0067 0.0213 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.0432 0.1282
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0432 0.308
Echinococcus granulosus cathepsin l cysteine peptidase 0.0363 0.1404 0.1491
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0213 0.0629
Echinococcus multilocularis microtubule associated protein 2 0.0805 0.3187 0.3159
Mycobacterium tuberculosis Probable lipase LipE 0.0121 0.0432 0.1347
Giardia lamblia Cysteine protease 0.0067 0.0213 0.5
Loa Loa (eye worm) ctsf protein 0.0363 0.1404 0.436
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.1055 0.1017
Plasmodium vivax hypothetical protein, conserved 0.0121 0.0432 0.3005
Schistosoma mansoni hypothetical protein 0.0036 0.0088 0.0194
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0055 0.0695
Entamoeba histolytica hypothetical protein 0.0067 0.0213 0.1517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0088 0.0195
Leishmania major cathepsin L-like protease 0.1102 0.4383 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0187 0.0696 0.1587
Leishmania major hypothetical protein, conserved 0.0121 0.0432 0.0986
Schistosoma mansoni survival motor neuron protein 0.0056 0.017 0.0453
Onchocerca volvulus 0.0363 0.1404 0.7295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0143 0.0368
Giardia lamblia Cathepsin L-like protease 0.0067 0.0213 0.5
Giardia lamblia Encystation-specific protease 0.0067 0.0213 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Brugia malayi Smad1 0.0055 0.0164 0.0476
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0121 0.0432 0.1347
Brugia malayi Cathepsin L-like precursor 0.0363 0.1404 0.4384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0696 0.4956
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Loa Loa (eye worm) cathepsin B 0.0067 0.0213 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0055 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0213 0.1517
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0052 0.0118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0121 0.0432 0.1347
Schistosoma mansoni hypothetical protein 0.0056 0.017 0.0453
Trypanosoma cruzi cysteine proteinase, putative 0.0187 0.0696 0.1587
Entamoeba histolytica cysteine proteinase, putative 0.0363 0.1404 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.0432 0.308
Plasmodium falciparum serine repeat antigen 2 0.0067 0.0213 0.1352
Trypanosoma cruzi cysteine peptidase, putative 0.0363 0.1404 0.3203
Loa Loa (eye worm) hypothetical protein 0.0067 0.0213 0.059
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0067 0.0213 0.0486
Echinococcus multilocularis cysteine protease 0.0363 0.1404 0.1367
Leishmania major hypothetical protein, conserved 0.0027 0.0052 0.0118
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0067 0.0213 0.1352
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Schistosoma mansoni cathepsin F (C01 family) 0.0243 0.0921 0.2829
Echinococcus granulosus tar DNA binding protein 0.0063 0.0199 0.0171
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Schistosoma mansoni smad 0.0025 0.0042 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0143 0.0368
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0067 0.0213 0.5
Giardia lamblia Cathepsin L precursor 0.0067 0.0213 0.5
Onchocerca volvulus 0.0363 0.1404 0.7295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Giardia lamblia Cathepsin L precursor 0.0067 0.0213 0.5
Brugia malayi Cathepsin L-like precursor 0.0363 0.1404 0.4384
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0067 0.0213 0.1517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Brugia malayi MH1 domain containing protein 0.0055 0.0164 0.0476
Echinococcus multilocularis smad 0.0055 0.0164 0.0123
Onchocerca volvulus 0.0121 0.0432 0.2091
Loa Loa (eye worm) hypothetical protein 0.012 0.0426 0.1265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0213 0.1517
Mycobacterium tuberculosis Probable hydrolase 0.0121 0.0432 0.1347
Loa Loa (eye worm) hypothetical protein 0.0067 0.0213 0.059
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0199 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0199 0.0543
Echinococcus granulosus cathepsin l1 0.0363 0.1404 0.1491
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0055 0.0695
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0055 0.0695
Plasmodium falciparum cysteine proteinase falcipain 1 0.0187 0.0696 0.4858
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0089
Trypanosoma brucei cysteine peptidase C (CPC) 0.0067 0.0213 0.0486
Leishmania major cathepsin L-like protease 0.1102 0.4383 1
Plasmodium vivax vivapain-1 0.0187 0.0696 0.4901
Trichomonas vaginalis esterase, putative 0.0121 0.0432 0.308
Echinococcus granulosus TGF beta signal transducer SmadC 0.0055 0.0164 0.0134
Brugia malayi Cathepsin L-like precursor 0.0243 0.0921 0.2862
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0363 0.1404 0.436
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0067 0.0213 0.5
Onchocerca volvulus Cathepsin L homolog 0.0363 0.1404 0.7295
Entamoeba histolytica cysteine protease, putative 0.0363 0.1404 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Brugia malayi MH2 domain containing protein 0.0055 0.0164 0.0476
Entamoeba histolytica cysteine proteinase 1, putative 0.0187 0.0696 0.4956
Entamoeba histolytica hypothetical protein 0.0041 0.0107 0.0763
Brugia malayi MH2 domain containing protein 0.0805 0.3185 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0055 0.0695
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0187 0.0696 0.2116
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0055 0.0125
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0363 0.1404 1
Entamoeba histolytica hypothetical protein 0.0041 0.0107 0.0763
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Onchocerca volvulus 0.0121 0.0432 0.2091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.0432 0.308
Schistosoma mansoni cathepsin F (C01 family) 0.0363 0.1404 0.4356
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0432 0.0986
Loa Loa (eye worm) hypothetical protein 0.0067 0.0213 0.059
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.0696 0.4956
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0213 0.1517
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0367 0.0837
Leishmania major adenosine kinase, putative 0.0105 0.0367 0.0837
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0067 0.0213 0.1352
Brugia malayi hypothetical protein 0.0276 0.1055 0.3284
Echinococcus multilocularis tumor protein p63 0.2293 0.9177 0.9173
Trypanosoma brucei hypothetical protein, conserved 0.0121 0.0432 0.0986
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0199 0.0543
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0067 0.0213 0.0588
Schistosoma mansoni adenosine kinase 0.0105 0.0367 0.1075
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.0921 0.6561
Leishmania major cathepsin L-like protease 0.0363 0.1404 0.3203
Echinococcus granulosus geminin 0.0536 0.2102 0.2255
Schistosoma mansoni Smad4 0.0055 0.0164 0.0434
Loa Loa (eye worm) nuclear factor I 0.003 0.0066 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0213 0.1517
Loa Loa (eye worm) hypothetical protein 0.0114 0.0401 0.1186
Brugia malayi cathepsin Z-like cysteine proteinase 0.0067 0.0213 0.0629
Entamoeba histolytica cysteine proteinase, putative 0.0363 0.1404 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0143 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0696 0.4956
Echinococcus granulosus cathepsin L 0.0067 0.0213 0.0187
Giardia lamblia Hypothetical protein 0.0067 0.0213 0.5
Onchocerca volvulus 0.0363 0.1404 0.7295
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.0432 0.1282
Plasmodium falciparum serine repeat antigen 8 0.0067 0.0213 0.1352
Mycobacterium leprae Probable lipase LipE 0.0121 0.0432 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0055 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0055 0.0131
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Giardia lamblia Cathepsin L precursor 0.0067 0.0213 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0805 0.3185 1
Onchocerca volvulus 0.0336 0.1295 0.6712
Echinococcus granulosus GPCR family 2 0.0036 0.0088 0.0051
Onchocerca volvulus 0.0488 0.1909 1
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Entamoeba histolytica hypothetical protein 0.0041 0.0107 0.0763
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0055 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0067 0.0213 0.1517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Echinococcus multilocularis mothers against decapentaplegic 5 0.0055 0.0164 0.0123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0088 0.0236
Toxoplasma gondii cathepsin CPL 0.0363 0.1404 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0213 0.1517
Brugia malayi fibroinase precursor 0.0067 0.0213 0.0629
Plasmodium vivax unspecified product 0.0067 0.0213 0.1425
Brugia malayi cathepsin F-like cysteine proteinase 0.012 0.0426 0.1302
Schistosoma mansoni microtubule-associated protein tau 0.0805 0.3187 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0052 0.0181
Giardia lamblia Cysteine protease 0.0067 0.0213 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.0696 0.4956
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0067 0.0213 0.0588
Brugia malayi beta-lactamase family protein 0.0121 0.0432 0.1321
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0199 0.0543
Onchocerca volvulus 0.0121 0.0432 0.2091
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0055 0.0391
Loa Loa (eye worm) beta-lactamase 0.0121 0.0432 0.1284
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0401 0.1186
Echinococcus multilocularis cathepsin b 0.0067 0.0213 0.0172
Schistosoma mansoni hypothetical protein 0.0036 0.0088 0.0194
Plasmodium falciparum serine repeat antigen 3 0.0067 0.0213 0.1352
Echinococcus multilocularis cysteine protease 0.0363 0.1404 0.1367
Mycobacterium ulcerans lipase LipD 0.0121 0.0432 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0055 0.0164 0.0434
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0042 0.0049
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0055 0.0107
Echinococcus granulosus cathepsin L cysteine proteinase 0.0363 0.1404 0.1491
Echinococcus granulosus smad 0.0055 0.0164 0.0134
Giardia lamblia Hypothetical protein 0.0067 0.0213 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0187 0.0696 0.1587
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0067 0.0213 0.1425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Schistosoma mansoni adenosine kinase 0.0105 0.0367 0.1075
Brugia malayi MH2 domain containing protein 0.0055 0.0164 0.0476
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0067 0.0213 0.1425
Onchocerca volvulus 0.0363 0.1404 0.7295
Brugia malayi cathepsin Z-like cysteine proteinase 0.0067 0.0213 0.0629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.0696 0.4956
Plasmodium vivax unspecified product 0.0187 0.0696 0.4901
Schistosoma mansoni cathepsin B (C01 family) 0.0067 0.0213 0.0588
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0049 0.0351
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0067 0.0213 0.0588
Brugia malayi MH1 domain containing protein 0.003 0.0066 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0213 0.1517
Mycobacterium tuberculosis Conserved protein 0.0121 0.0432 0.1347
Brugia malayi MH1 domain containing protein 0.0055 0.0164 0.0476
Echinococcus granulosus cathepsin L 0.0187 0.0696 0.0715
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0363 0.1404 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Plasmodium vivax unspecified product 0.012 0.0426 0.2961
Loa Loa (eye worm) hypothetical protein 0.0363 0.1404 0.436
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0067 0.0213 0.5
Brugia malayi Adenosine kinase-like 0.0105 0.0367 0.1114
Loa Loa (eye worm) hypothetical protein 0.012 0.0426 0.1265
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Echinococcus multilocularis cathepsin L 0.0067 0.0213 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0067 0.0213 0.1517
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0067 0.0213 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0213 0.1517
Leishmania major cathepsin L-like protease 0.1102 0.4383 1
Mycobacterium ulcerans esterase/lipase LipP 0.0121 0.0432 1
Echinococcus multilocularis cathepsin L 0.0187 0.0696 0.0656
Brugia malayi Cathepsin L-like precursor 0.0363 0.1404 0.4384
Echinococcus granulosus bloom syndrome protein 0.0026 0.0049 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0213 0.1517
Echinococcus granulosus cathepsin b 0.0067 0.0213 0.0187
Loa Loa (eye worm) hypothetical protein 0.0121 0.0432 0.1284
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0055 0.0391
Onchocerca volvulus 0.0243 0.0921 0.4709
Brugia malayi cathepsin L precursor 0.0067 0.0213 0.0629
Schistosoma mansoni hypothetical protein 0.0036 0.0088 0.0194
Entamoeba histolytica cysteine proteinase 2 0.0187 0.0696 0.4956
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0067 0.0213 0.1352
Mycobacterium tuberculosis Conserved protein 0.0121 0.0432 0.1347
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0121 0.0432 0.1284
Echinococcus multilocularis geminin 0.0536 0.2102 0.2069
Mycobacterium tuberculosis Probable lipase LipD 0.0121 0.0432 0.1347
Loa Loa (eye worm) transcription factor SMAD2 0.0805 0.3185 1
Loa Loa (eye worm) Smad1 0.0055 0.0164 0.0436
Leishmania major cathepsin L-like protease 0.0363 0.1404 0.3203
Plasmodium vivax serine-repeat antigen (SERA) 0.0067 0.0213 0.1425
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0187 0.0696 0.2116
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0067 0.0213 0.1425
Toxoplasma gondii ABC1 family protein 0.0121 0.0432 0.3009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0363 0.1404 0.1367
Loa Loa (eye worm) fibroinase 0.0363 0.1404 0.436
Loa Loa (eye worm) hypothetical protein 0.012 0.0426 0.1265
Schistosoma mansoni smad1 5 8 and 0.0055 0.0164 0.0434
Schistosoma mansoni cellular tumor antigen P53 0.0336 0.1295 0.4012
Echinococcus granulosus cathepsin l1 0.0243 0.0921 0.0962
Schistosoma mansoni cathepsin s 0.012 0.0426 0.1263
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0067 0.0213 0.0588
Echinococcus granulosus cysteine protease 0.0187 0.0696 0.0715
Giardia lamblia Cathepsin L-like protease 0.0067 0.0213 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0067 0.0213 0.0486
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0067 0.0213 0.1425
Giardia lamblia Cathepsin L precursor 0.0067 0.0213 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.012 0.0426 0.1265
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0912 0.2802
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0143 0.0111
Giardia lamblia Cathepsin B precursor 0.0067 0.0213 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Brugia malayi Cathepsin L-like precursor 0.012 0.0426 0.1302
Loa Loa (eye worm) hypothetical protein 0.0067 0.0213 0.059
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0067 0.0213 0.1425
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0367 0.0837
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0199 0.0545
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Echinococcus granulosus Smad4 0.0055 0.0164 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0027 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0036 0.0071
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.0696 0.4956
Giardia lamblia Cysteine protease 0.0067 0.0213 0.5
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0067 0.0213 0.1425
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0363 0.1404 0.1367
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0067 0.0213 0.1425
Brugia malayi cathepsin B-like cysteine proteinase 0.0067 0.0213 0.0629
Trypanosoma cruzi cysteine peptidase, putative 0.0187 0.0696 0.1587
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0367 0.0837
Entamoeba histolytica cysteine protease, putative 0.0067 0.0213 0.1517
Mycobacterium tuberculosis Conserved protein 0.0121 0.0432 0.1347
Entamoeba histolytica cysteine protease, putative 0.0067 0.0213 0.1517
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0042 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0055 0.0695
Echinococcus multilocularis cathepsin L cysteine protease 0.0363 0.1404 0.1367
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0049 0.0351
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0055 0.0107
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0983 0.39 0.8899
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0089
Plasmodium falciparum serine repeat antigen 9 0.0067 0.0213 0.1352
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Echinococcus granulosus adenosine kinase 0.0105 0.0367 0.0355
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0187 0.0696 0.1587
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0363 0.1404 0.436
Entamoeba histolytica cysteine protease, putative 0.0067 0.0213 0.1517
Loa Loa (eye worm) hypothetical protein 0.0488 0.1909 0.5958
Schistosoma mansoni smad1 5 8 and 0.0055 0.0164 0.0434
Schistosoma mansoni cathepsin S (C01 family) 0.0067 0.0213 0.0588
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0052 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0055 0.0164 0.0123
Onchocerca volvulus 0.0093 0.0318 0.148
Mycobacterium ulcerans hypothetical protein 0.0028 0.0055 0.0695
Loa Loa (eye worm) hypothetical protein 0.0132 0.0477 0.1425
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0052 0.0269
Plasmodium vivax vivapain-3 0.0187 0.0696 0.4901
Onchocerca volvulus 0.0028 0.0055 0.0068
Toxoplasma gondii preprocathepsin c precursor, putative 0.0067 0.0213 0.143
Loa Loa (eye worm) hypothetical protein 0.0078 0.0256 0.0727
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0107 0.0253
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0123
Echinococcus granulosus cathepsin L cysteine protease 0.0187 0.0696 0.0715
Echinococcus granulosus cathepsin b 0.0067 0.0213 0.0187
Schistosoma mansoni hypothetical protein 0.0536 0.2102 0.6567
Echinococcus multilocularis cathepsin b 0.0067 0.0213 0.0172
Schistosoma mansoni hypothetical protein 0.0036 0.0088 0.0194
Brugia malayi Papain family cysteine protease containing protein 0.0363 0.1404 0.4384
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0027 0.0084
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0049 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Plasmodium falciparum serine repeat antigen 4 0.0067 0.0213 0.1352
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0432 0.0986
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Mycobacterium leprae conserved hypothetical protein 0.0121 0.0432 1
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0088 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0143 0.0368
Brugia malayi beta-lactamase family protein 0.0121 0.0432 0.1321
Plasmodium vivax vivapain-2 0.0363 0.1404 1
Plasmodium falciparum serine repeat antigen 7 0.0067 0.0213 0.1352
Brugia malayi cathepsin L-like precursor 0.0243 0.0921 0.2862
Brugia malayi hypothetical protein 0.0488 0.1909 0.5976
Schistosoma mansoni hypothetical protein 0.0536 0.2102 0.6567
Brugia malayi Cathepsin L-like precursor 0.0243 0.0921 0.2862
Leishmania major cathepsin L-like protease 0.0363 0.1404 0.3203
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0401 0.1223
Onchocerca volvulus 0.0363 0.1404 0.7295
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0067 0.0213 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0067 0.0213 0.1517
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0213 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0067 0.0213 0.1517
Brugia malayi cathepsin F-like cysteine proteinase 0.0067 0.0213 0.0629
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0776 0.3067 1
Onchocerca volvulus 0.0067 0.0213 0.0915
Loa Loa (eye worm) hypothetical protein 0.0243 0.0921 0.2832
Loa Loa (eye worm) hypothetical protein 0.0243 0.0921 0.2832
Leishmania major cathepsin L-like protease 0.0363 0.1404 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0363 0.1404 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Echinococcus multilocularis GPCR, family 2 0.0036 0.0088 0.0046
Loa Loa (eye worm) hypothetical protein 0.0067 0.0213 0.059
Loa Loa (eye worm) MH2 domain-containing protein 0.0055 0.0164 0.0436
Trypanosoma cruzi cysteine proteinase, putative 0.0187 0.0696 0.1587
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0067 0.0213 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.012 0.0426 0.0972
Echinococcus granulosus mothers against decapentaplegic 5 0.0055 0.0164 0.0134
Loa Loa (eye worm) RNA binding protein 0.0063 0.0199 0.0545
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0432 0.308
Echinococcus granulosus microtubule associated protein 2 0.0805 0.3187 0.3443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0213 0.0588
Schistosoma mansoni cathepsin C 0.0067 0.0213 0.0588
Plasmodium falciparum serine repeat antigen 1 0.0067 0.0213 0.1352
Mycobacterium ulcerans hypothetical protein 0.0121 0.0432 1
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Loa Loa (eye worm) hypothetical protein 0.0121 0.0432 0.1284
Leishmania major cysteine peptidase A (CPA) 0.0363 0.1404 0.3203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0195
Brugia malayi follicle stimulating hormone receptor 0.024 0.0912 0.2833
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0055 0.0695
Schistosoma mansoni hypothetical protein 0.0041 0.0107 0.0253
Echinococcus multilocularis adenosine kinase 0.0105 0.0367 0.0326
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0067 0.0213 0.1517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1102 0.4383 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0055 0.0131
Brugia malayi Cathepsin L-like cysteine proteinase 0.0243 0.0921 0.2862
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0107 0.0065
Brugia malayi MH1 domain containing protein 0.003 0.0066 0.0165
Onchocerca volvulus 0.0056 0.017 0.0686
Giardia lamblia Cysteine protease 0.0067 0.0213 0.5
Loa Loa (eye worm) hypothetical protein 0.0121 0.0432 0.1284
Trypanosoma cruzi cruzipain precursor, putative 0.1102 0.4383 1
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0432 0.308
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0067 0.0213 0.059
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0256 0.0766
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0143 0.0102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0107 0.0071
Entamoeba histolytica cysteine protease, putative 0.0187 0.0696 0.4956
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0213 0.1517
Brugia malayi hypothetical protein 0.0027 0.0052 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0067 0.0213 0.1517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0363 0.1404 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0213 0.059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0079
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0088 0.0046
Echinococcus granulosus beta LACTamase domain containing family member 0.0121 0.0432 0.0427

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 51 % Activity of human ADK assessed as compound conversion to 5'-phosphate form incubated at 37 degC for 20 mins by HPLC method ChEMBL. No reference
CC50 (ADMET) = 50 uM Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay ChEMBL. No reference
GI50 (functional) = 0.066 uM Cytostatic activity against human DU145 cells after 5 days by SRB assay ChEMBL. 19929004
GI50 (functional) = 0.14 uM Cytostatic activity against human HCT116 cells after 5 days by SRB assay ChEMBL. 19929004
GI50 (functional) = 0.38 uM Cytostatic activity against human A549 cells after 5 days by SRB assay ChEMBL. 19929004
IC50 (functional) = 0.56 uM Cytotoxicity against human CCRF-CEM cells after 3 days by XTT assay ChEMBL. 19929004
IC50 (functional) = 4.9 uM Cytotoxicity against human HL60 cells after 3 days by XTT assay ChEMBL. 19929004
IC50 (binding) > 10 uM Inhibition of human ADK using [3H]-adenosine by scintillation counting method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19929004

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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