Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0961 | 0.0742 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0044 | 0.1979 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1979 | 0.1979 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0961 | 0.4087 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0.1745 | 1 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0257 | 0.0021 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0236 | 0.0316 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0246 | 0.001 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1979 | 0.1979 |
Brugia malayi | Inositol-1 | 0.0044 | 0.1979 | 0.2823 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0141 | 0.697 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0236 | 0.0236 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0257 | 0.0021 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0236 | 0.0236 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0567 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0961 | 0.0742 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0961 | 0.1359 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0236 | 0.0316 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0557 | 0.2815 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.1979 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.0331 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0246 | 0.001 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0961 | 0.1359 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0236 | 0.0236 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.0331 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0246 | 0.0246 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0044 | 0.1979 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.1244 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0.1745 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.0246 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0246 | 0.001 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.1979 | 0.1785 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0141 | 0.697 | 1 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0236 | 0.0236 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0246 | 0.0331 |
Schistosoma mansoni | smad | 0.001 | 0.0236 | 0.0236 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0257 | 0.0021 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0961 | 0.4087 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0246 | 0.0331 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0.0257 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0394 | 0.0796 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Brugia malayi | Smad1 | 0.001 | 0.0236 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.587 | 0.8419 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0813 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.1979 | 0.2823 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0257 | 0.0257 |
Echinococcus granulosus | ferritin | 0.001 | 0.0257 | 0.0021 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0257 | 0.0257 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.1979 | 0.1785 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0705 | 0.0705 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0257 | 0.0257 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0394 | 0.1991 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0246 | 0.001 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.1244 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0236 | 0.0316 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0236 | 0.0236 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0141 | 0.697 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.