TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 253.299 | Formula: C15H15N3O
H donors: 0 H acceptors: 2 LogP: 1.98 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1=C(C)C(=C)N(C1=O)c1ccc(cc1)N(C)C
InChi: 1S/C15H15N3O/c1-10-11(2)18(15(19)14(10)9-16)13-7-5-12(6-8-13)17(3)4/h5-8H,2H2,1,3-4H3
InChiKey: SVKFLPGSJLJPCL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.0901	0.0457
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0106	0.1492	0.1492
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0901	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0762	0.0503
Toxoplasma gondii	ABC1 family protein	0.0074	0.0901	0.1505
Brugia malayi	beta-lactamase family protein	0.0074	0.0901	0.0901
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0901	0.0901
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.015	0.2309	0.2309
Onchocerca volvulus		0.0053	0.0509	0.1938
Brugia malayi	thymidylate synthase	0.0106	0.1492	0.1492
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0405	0.0405
Entamoeba histolytica	hypothetical protein	0.004	0.0273	1
Schistosoma mansoni	hypothetical protein	0.004	0.0273	0.0273
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0273	0.0273
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0901	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0349	0.5987	1
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0268	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0223	0.0223
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.0762	0.0312
Brugia malayi	bHLH-PAS transcription factor	0.004	0.0273	0.0273
Onchocerca volvulus		0.0074	0.0901	0.515
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0509	0.0509
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0268	0.9808
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0901	0.0852
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0089	0.1183	0.1183
Mycobacterium ulcerans	hydrolase	0.0051	0.0484	0.0217
Loa Loa (eye worm)	carbonic anhydrase 3	0.019	0.3044	0.3007
Echinococcus granulosus	carbonic anhydrase II	0.019	0.3044	0.3044
Echinococcus multilocularis	zinc finger protein	0.0027	0.0029	0.0029
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0106	0.1492	0.1077
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.015	0.2309	0.2309
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0349	0.5987	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0901	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0901	0.0852
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.019	0.3044	0.5085
Echinococcus granulosus	carbonic anhydrase	0.0089	0.1183	0.1183
Leishmania major	hypothetical protein, conserved	0.0074	0.0901	0.0701
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0259	0.432	0.4289
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0901	0.0457
Onchocerca volvulus	Matrilysin homolog	0.0094	0.1265	0.8138
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1183	0.1135
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0762	0.0762
Schistosoma mansoni	bromodomain containing protein	0.0079	0.0988	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0484	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0375	0.0323
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0517	0.0864
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0168	0.2629	0.2589
Brugia malayi	Hemopexin family protein	0.006	0.064	0.064
Echinococcus granulosus	survival motor neuron protein 1	0.0259	0.432	0.432
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0901	0.0438
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0154	0.2372	0.2372
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0321	0.0321
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0349	0.5987	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0542	0.0542
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0901	0.0901
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0901	0.0852
Trypanosoma brucei	PAB1-binding protein , putative	0.0053	0.0517	0.0864
Brugia malayi	Bromodomain containing protein	0.0093	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1183	0.1135
Brugia malayi	PHD-finger family protein	0.0033	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0542	0.0491
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0106	0.1492	0.1059
Echinococcus granulosus	thymidylate synthase	0.0106	0.1492	0.1492
Brugia malayi	Matrixin family protein	0.0042	0.0314	0.0314
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0517	0.0781
Echinococcus granulosus	carbonic anhydrase	0.0089	0.1183	0.1183
Echinococcus multilocularis	carbonic anhydrase	0.0089	0.1183	0.1183
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0089	0.1183	0.1183
Brugia malayi	hypothetical protein	0.0053	0.0517	0.0517
Echinococcus multilocularis	geminin	0.0541	0.9527	0.9527
Schistosoma mansoni	single-minded	0.0054	0.0533	0.0533
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0386	0.0386
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0054	0.0054
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0509	0.0509
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0386	0.0645
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0405	0.0405
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0349	0.5987	1
Schistosoma mansoni	carbonic anhydrase-related	0.0089	0.1183	0.1183
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0386	0.0645
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0154	0.2372	0.2372
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.019	0.3044	0.3007
Onchocerca volvulus		0.0074	0.0901	0.515
Schistosoma mansoni	carbonic anhydrase	0.0089	0.1183	0.1183
Brugia malayi	hypothetical protein	0.0182	0.2888	0.2888
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.005	0.0465	0.0777
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0542	0.0491
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.0901	0.0457
Onchocerca volvulus		0.0106	0.1492	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.0762	0.0448
Brugia malayi	Matrixin family protein	0.0042	0.0314	0.0314
Entamoeba histolytica	hypothetical protein	0.004	0.0273	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.509	0.5064
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0762	0.0503
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0901	0.0645
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0075	0.0909	0.0909
Loa Loa (eye worm)	acetyltransferase	0.015	0.2309	0.2268
Schistosoma mansoni	hypothetical protein	0.0037	0.0223	0.0223
Mycobacterium ulcerans	thymidylate synthase	0.0106	0.1492	0.1253
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.0901	0.0457
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.019	0.3044	0.3044
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0901	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0535	0.0484
Brugia malayi	RNA, U transporter 1	0.008	0.1013	0.1013
Toxoplasma gondii	hypothetical protein	0.0089	0.1183	0.1975
Onchocerca volvulus		0.0074	0.0901	0.515
Echinococcus multilocularis	carbonic anhydrase II	0.019	0.3044	0.3044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0901	0.0852
Echinococcus granulosus	carbonic anhydrase	0.0089	0.1183	0.1183
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0405	0.0405
Brugia malayi	Matrixin family protein	0.0102	0.1421	0.1421
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.0901	0.0457
Brugia malayi	acetyltransferase, GNAT family protein	0.015	0.2309	0.2309
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0901	0.1505
Echinococcus granulosus	snurportin 1	0.0301	0.509	0.509
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0349	0.5987	1
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0045	0.0357	0.0357
Brugia malayi	beta-lactamase	0.0074	0.0901	0.0901
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0054	0.009
Echinococcus multilocularis	carbonic anhydrase	0.0089	0.1183	0.1183
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0517	0.0781
Trichomonas vaginalis	esterase, putative	0.0074	0.0901	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0901	0.0901
Onchocerca volvulus		0.0042	0.0314	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0314	0.0262
Schistosoma mansoni	hypothetical protein	0.0089	0.1183	0.1183
Schistosoma mansoni	hypothetical protein	0.006	0.064	0.064
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0901	0.1428
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.019	0.3044	0.3044
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0901	0.0457
Mycobacterium ulcerans	lipase LipD	0.0074	0.0901	0.0645
Schistosoma mansoni	zinc finger protein	0.0027	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0541	0.9527	0.9527
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0465	0.5161
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0901	0.1505
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0054	0.009
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0762	0.0762
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.0901	0.0645
Echinococcus granulosus	geminin	0.0541	0.9527	0.9527
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0094	0.1265	0.8138
Brugia malayi	Matrixin family protein	0.0042	0.0314	0.0314
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0901	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0089	0.1183	0.1183
Schistosoma mansoni	hypothetical protein	0.0541	0.9527	0.9527
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0321	0.0321
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0901	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0901	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0901	0.0852
Onchocerca volvulus		0.006	0.064	0.3012
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.019	0.3044	0.3044
Brugia malayi	hypothetical protein	0.005	0.0465	0.0465
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.0762	0.0762
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.019	0.3044	0.3044
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0273	0.0273
Brugia malayi	hypothetical protein	0.0034	0.0168	0.0168
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.0901	0.0457
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0762	0.0503
Entamoeba histolytica	hypothetical protein	0.004	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0901	0.0852
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0405	0.0354
Plasmodium vivax	ataxin-2 like protein, putative	0.0053	0.0517	0.0781
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0027	0.0027
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0054	0.0054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0542	0.0542
Loa Loa (eye worm)	matrixin family protein	0.0094	0.1265	0.1218
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0051	0.0484	0.002
Echinococcus granulosus	single minded 2	0.004	0.0273	0.0273
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0268	0.036
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0042	0.0314	0.0314
Brugia malayi	hypothetical protein	0.004	0.0273	0.0273
Schistosoma mansoni	aryl hydrocarbon receptor	0.0054	0.0533	0.0533
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0143	0.2181	0.2181
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0386	0.056
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0314	0.0262
Echinococcus multilocularis	snurportin 1	0.0301	0.509	0.509
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0314	0.0262
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.0901	0.0645
Leishmania major	carbonic anhydrase-like protein	0.019	0.3044	0.462
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.019	0.3044	0.5085
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.0901	0.0457
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.0901	0.0457
Echinococcus multilocularis	carbonic anhydrase	0.0089	0.1183	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0182	0.2888	0.285
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0901	0.0852
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0386	0.4287
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0517	0.0864
Plasmodium falciparum	carbonic anhydrase	0.0089	0.1183	0.1903
Echinococcus multilocularis	thymidylate synthase	0.0106	0.1492	0.1492
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0273	0.0273
Entamoeba histolytica	hypothetical protein	0.004	0.0273	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0349	0.5987	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0259	0.432	0.432
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0386	0.4287
Schistosoma mansoni	carbonic anhydrase-related	0.0089	0.1183	0.1183
Echinococcus multilocularis	transfer RNA-Lys	0.004	0.0273	0.0273
Brugia malayi	PAS domain containing protein	0.0054	0.0533	0.0533
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.0762	0.0762
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0089	0.1183	0.1183
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0089	0.1183	0.1183
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0405	0.0405
Brugia malayi	hypothetical protein	0.0259	0.432	0.432
Toxoplasma gondii	LsmAD domain-containing protein	0.0053	0.0517	0.0864
Echinococcus granulosus	zinc finger protein	0.0027	0.0029	0.0029
Brugia malayi	Matrixin family protein	0.0042	0.0314	0.0314
Mycobacterium ulcerans	beta-lactamase	0.0074	0.0901	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1183	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1084	0.1036
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0901	0.0457
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0517	0.0466
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.0762	0.1273
Schistosoma mansoni	carbonic anhydrase-related	0.0089	0.1183	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0493	0.0442
Brugia malayi	hypoxia-induced factor 1	0.0168	0.2629	0.2629
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0089	0.1183	0.1135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0405	0.0405
Schistosoma mansoni	hypothetical protein	0.0053	0.0509	0.0509
Trypanosoma brucei	carbonic anhydrase-like protein	0.019	0.3044	0.5085
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0901	0.0852
Schistosoma mansoni	importin beta-1	0.0028	0.0054	0.0054
Loa Loa (eye worm)	matrix metalloproteinase	0.0042	0.0314	0.0262
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0473	0.8272	0.8187
Brugia malayi	Bromodomain containing protein	0.0049	0.044	0.044
Onchocerca volvulus	Matrilysin homolog	0.0042	0.0314	0.0334
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0901	0.0901
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0051	0.0484	0.0484
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0301	0.509	0.509
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0075	0.0909	0.0909
Loa Loa (eye worm)	matrixin family protein	0.0102	0.1421	0.1375
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0054	0.009
Brugia malayi	Importin beta-1 subunit	0.0028	0.0054	0.0054
Loa Loa (eye worm)	thymidylate synthase	0.0106	0.1492	0.1446
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0223	0.017
Brugia malayi	beta-lactamase family protein	0.0074	0.0901	0.0901
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0901	0.0438

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1253695

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1180891