Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0013 | 0.0004 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0232 | 0.0223 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0509 | 0.0552 |
Wolbachia endosymbiont of Brugia malayi | Kef-type K+ transport system, membrane component | 0.0021 | 0.0259 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.001 | 0.0011 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0021 | 0.0259 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0099 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0099 | 0.0089 |
Mycobacterium ulcerans | TRK system potassium uptake protein CeoB | 0.0021 | 0.0259 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0317 | 0.0308 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0432 | 0.0468 |
Brugia malayi | Pre-SET motif family protein | 0.022 | 0.4613 | 0.4608 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0464 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0464 | 0.9036 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0432 | 0.0468 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.011 | 0.012 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.001 | 0.0011 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0432 | 0.0468 |
Onchocerca volvulus | 0.0032 | 0.0512 | 0.0084 | |
Echinococcus granulosus | calcium activated potassium channel | 0.0035 | 0.0573 | 0.0622 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.001 | 0.0011 |
Echinococcus granulosus | geminin | 0.0379 | 0.8099 | 0.8784 |
Onchocerca volvulus | 0.025 | 0.5274 | 0.5061 | |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.8099 | 0.8784 |
Schistosoma mansoni | smad | 0.0009 | 0.001 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.8099 | 0.8784 |
Trichomonas vaginalis | set domain proteins, putative | 0.025 | 0.5274 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0464 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.004 | 0.0044 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0432 | 0.0468 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0512 | 0.0555 |
Echinococcus multilocularis | potassium large conductance calcium activated | 0.0035 | 0.0573 | 0.0622 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0013 | 0.0104 | 0.0112 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.004 | 0.0031 |
Mycobacterium ulcerans | TRK system potassium uptake protein CeoC1 | 0.0021 | 0.0259 | 0.5 |
Echinococcus granulosus | smad | 0.0009 | 0.001 | 0.0011 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.001 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.011 | 0.0101 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0143 | 0.0134 |
Trypanosoma brucei | TrkA-N domain containing protein, putative | 0.0021 | 0.0259 | 0.5463 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.001 | 0.0011 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0432 | 0.0468 |
Echinococcus granulosus | potassium large conductance calcium activated | 0.0035 | 0.0573 | 0.0622 |
Echinococcus multilocularis | Protein lozenge | 0.0058 | 0.1089 | 0.1181 |
Schistosoma mansoni | lamin | 0.0028 | 0.0432 | 0.0468 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0432 | 0.0468 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.001 | 0.0011 |
Loa Loa (eye worm) | runx1 | 0.0058 | 0.1089 | 0.108 |
Mycobacterium tuberculosis | TRK system potassium uptake protein CeoC | 0.0021 | 0.0259 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.0432 | 0.0468 |
Schistosoma mansoni | hypothetical protein | 0.043 | 0.922 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0035 | 0.0573 | 0.0622 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0512 | 0.464 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0472 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0512 | 0.0503 |
Mycobacterium tuberculosis | TRK system potassium uptake protein CeoB | 0.0021 | 0.0259 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0432 | 0.0423 |
Schistosoma mansoni | lozenge | 0.0058 | 0.1089 | 0.1181 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.2733 | 0.2726 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0512 | 0.0555 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.2733 | 0.2726 |
Echinococcus multilocularis | smad | 0.0009 | 0.001 | 0.0011 |
Loa Loa (eye worm) | MaxiK calcium-activated potassium channel | 0.0023 | 0.0317 | 0.0308 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.022 | 0.4613 | 0.4608 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0013 | 0.0104 | 0.0112 |
Echinococcus granulosus | dnaJ subfamily B | 0.043 | 0.922 | 1 |
Treponema pallidum | hypothetical protein | 0.0021 | 0.0259 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0512 | 0.0555 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0512 | 1 |
Treponema pallidum | hypothetical protein | 0.0021 | 0.0259 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0512 | 0.0503 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.004 | 0.0044 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0512 | 0.0555 |
Brugia malayi | hypothetical protein | 0.003 | 0.0464 | 0.0454 |
Mycobacterium ulcerans | TRK system potassium uptake protein CeoC | 0.0021 | 0.0259 | 0.5 |
Echinococcus multilocularis | geminin | 0.0379 | 0.8099 | 0.8784 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0432 | 0.0423 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.001 | 0.0011 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0464 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0512 | 0.0555 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.001 | 0.0011 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0509 | 0.0552 |
Schistosoma mansoni | calcium-activated potassium channel | 0.003 | 0.0462 | 0.0501 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0104 | 0.0112 |
Echinococcus multilocularis | dnaJ subfamily B | 0.043 | 0.922 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0464 | 0.0454 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0432 | 0.0423 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0038 | 0.0028 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0464 | 0.4192 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0432 | 0.0423 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0032 | 0.052 | 0.0511 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0143 | 0.0134 |
Onchocerca volvulus | 0.003 | 0.0471 | 0.0041 | |
Schistosoma mansoni | calcium-activated potassium channel | 0.0032 | 0.052 | 0.0564 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0032 | 0.052 | 0.0564 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.2733 | 0.2726 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0035 | 0.0573 | 0.0622 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0471 | 0.0462 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0512 | 0.0555 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0464 | 1 |
Brugia malayi | Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog | 0.0023 | 0.0317 | 0.0308 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.1088 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0464 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0509 | 0.0552 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.001 | 0.0011 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0464 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.0432 | 0.0468 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0471 | 0.0462 |
Treponema pallidum | potassium transporter peripheral membrane component | 0.0021 | 0.0259 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0509 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.042 | 0.0411 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.011 | 0.012 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.001 | 0.0011 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0432 | 0.0423 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.1237 | 0.1342 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.001 | 0.0011 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0021 | 0.0259 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0512 | 0.0555 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0032 | 0.052 | 0.0564 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0471 | 0.0511 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 150 ug ml-1 | Inhibition of HIV1 RT | ChEMBL. | 1710653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.