Detailed information for compound 1181709

Basic information

Technical information
  • TDR Targets ID: 1181709
  • Name: 2-[(2R,4aR,8R,8aR)-8,8a-dihydroxy-4a,8-dimeth yl-2,3,4,5,6,7-hexahydro-1H-naphthalen-2-yl]p rop-2-enoic acid
  • MW: 268.349 | Formula: C15H24O4
  • H donors: 3 H acceptors: 4 LogP: 1.74 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=C([C@@H]1CC[C@@]2([C@@](C1)(O)[C@](C)(O)CCC2)C)C(=O)O
  • InChi: 1S/C15H24O4/c1-10(12(16)17)11-5-8-13(2)6-4-7-14(3,18)15(13,19)9-11/h11,18-19H,1,4-9H2,2-3H3,(H,16,17)/t11-,13-,14-,15-/m1/s1
  • InChiKey: BWSMNSAZRMJSSZ-NMFUWQPSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2R,4aR,8R,8aR)-8,8a-dihydroxy-4a,8-dimethyl-decalin-2-yl]prop-2-enoic acid
  • 2-[(2R,4aR,8R,8aR)-8,8a-dihydroxy-4a,8-dimethyl-2-decalinyl]prop-2-enoic acid
  • 2-[(2R,4aR,8R,8aR)-8,8a-dihydroxy-4a,8-dimethyl-decalin-2-yl]acrylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0036 0.0157 0.0598
Echinococcus multilocularis tumor protein p63 0.0689 0.5858 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0722 0.1774
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0185 0.0708
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.0254
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0167 0.0816
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1843 0.3139
Plasmodium vivax hypothetical protein, conserved 0.003 0.0104 0.0551
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0167 0.1166
Brugia malayi glutathione reductase 0.0048 0.0256 0.0629
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0893 0.5887
Brugia malayi Pre-SET motif family protein 0.0031 0.011 0.027
Schistosoma mansoni Smad4 0.0033 0.0129 0.0487
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0554 0.1362
Brugia malayi RNA, U transporter 1 0.0082 0.0557 0.1369
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0159 0.039
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.011 0.0412
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0185 0.0735
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0167 0.1166
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0093 0.0357
Loa Loa (eye worm) Smad1 0.0033 0.0129 0.0316
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0787 0.0782
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0701 0.1189
Echinococcus granulosus lamin 0.0082 0.0554 0.0937
Mycobacterium ulcerans lipase LipD 0.0182 0.1431 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.011 0.0178
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0223 0.0548
Brugia malayi Pre-SET motif family protein 0.0215 0.1717 0.422
Onchocerca volvulus 0.0082 0.0554 0.2406
Onchocerca volvulus 0.0182 0.1431 0.709
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.142 0.2416
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0787 0.0782
Loa Loa (eye worm) inositol-1 0.0036 0.0157 0.0385
Echinococcus granulosus GPCR family 2 0.0031 0.011 0.0178
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0277 0.1113
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0787 0.0782
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0256 0.1028
Brugia malayi beta-lactamase family protein 0.0182 0.1431 0.3518
Brugia malayi Latrophilin receptor protein 2 0.0031 0.011 0.0271
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0157 0.062
Loa Loa (eye worm) hypothetical protein 0.0038 0.0172 0.0423
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0256 0.1635
Plasmodium falciparum glutathione reductase 0.0048 0.0256 1
Trichomonas vaginalis D-aminoacylase, putative 0.0182 0.1431 0.7234
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0157 0.062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1309 0.2227
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0277 0.0463
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0006 0.0014
Onchocerca volvulus 0.0182 0.1431 0.709
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0256 0.0427
Loa Loa (eye worm) MH2 domain-containing protein 0.0484 0.4068 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0256 0.0629
Schistosoma mansoni lamin 0.0082 0.0554 0.2173
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0104 0.0551
Toxoplasma gondii thioredoxin reductase 0.0048 0.0256 0.1635
Leishmania major trypanothione reductase 0.0048 0.0256 0.1028
Schistosoma mansoni smad1 5 8 and 0.0033 0.0129 0.0487
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0277 0.1374
Trypanosoma brucei trypanothione reductase 0.0048 0.0256 0.1028
Echinococcus granulosus lamin dm0 0.0082 0.0554 0.0937
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0129 0.021
Entamoeba histolytica hypothetical protein 0.0177 0.1385 1
Brugia malayi MH1 domain containing protein 0.0033 0.0129 0.0316
Echinococcus granulosus beta LACTamase domain containing family member 0.0182 0.1431 0.2435
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0177 0.1385 0.2357
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.011 0.0178
Trichomonas vaginalis D-aminoacylase, putative 0.0182 0.1431 0.7234
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0093 0.0357
Onchocerca volvulus 0.0097 0.069 0.3133
Onchocerca volvulus 0.0082 0.0554 0.2406
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0692 0.1701
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0182 0.1431 0.3518
Loa Loa (eye worm) hypothetical protein 0.0182 0.1431 0.3518
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0167 0.0275
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0787 0.0782
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0185 0.0305
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0177 0.1385 0.2357
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0104 0.0167
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.0199
Brugia malayi MH2 domain containing protein 0.0033 0.0129 0.0316
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0157 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0291 0.0716
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0277 0.1374
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1309 0.2227
Mycobacterium tuberculosis Probable reductase 0.0108 0.0787 0.0782
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1208 0.1203
Plasmodium falciparum phd finger protein, putative 0.003 0.0104 0.3372
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0129 0.0316
Onchocerca volvulus 0.0031 0.011 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1976 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0271
Schistosoma mansoni survival motor neuron protein 0.0047 0.0249 0.0965
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0223 0.0548
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0554 0.1362
Echinococcus multilocularis snurportin 1 0.0308 0.2529 0.4311
Loa Loa (eye worm) hypothetical protein 0.0038 0.0172 0.0423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.142 0.2416
Loa Loa (eye worm) hypothetical protein 0.0039 0.0185 0.0455
Mycobacterium tuberculosis Conserved protein 0.0182 0.1431 0.1426
Plasmodium vivax hypothetical protein, conserved 0.0182 0.1431 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0167 0.0816
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0277 0.068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.142 0.2416
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0206 0.0343
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0277 0.1113
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.2437 1
Mycobacterium leprae conserved hypothetical protein 0.0182 0.1431 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0277 0.1073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.107 0.4375
Brugia malayi hypothetical protein 0.0177 0.1385 0.3405
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.01 0.0161
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0157 0.093
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0206 0.0343
Toxoplasma gondii ABC1 family protein 0.0182 0.1431 1
Echinococcus multilocularis lamin dm0 0.0082 0.0554 0.0937
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0157 0.0258
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1309 0.2227
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.011 0.0178
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0185 0.0305
Mycobacterium leprae Probable lipase LipE 0.0182 0.1431 1
Schistosoma mansoni smad 0.0033 0.0129 0.0487
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0277 0.1113
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0159 0.0261
Mycobacterium tuberculosis Probable esterase LipL 0.0182 0.1431 0.1426
Brugia malayi Bromodomain containing protein 0.003 0.0104 0.0254
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0277 0.1113
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0256 0.0427
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0524 0.2056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.142 0.2416
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0159 0.0607
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0748
Brugia malayi PHD-finger family protein 0.003 0.0104 0.0254
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.1431 0.5861
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0692 0.1701
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0129 0.0487
Loa Loa (eye worm) hypothetical protein 0.0182 0.1431 0.3518
Echinococcus granulosus peregrin 0.003 0.0104 0.0167
Brugia malayi MH2 domain containing protein 0.0484 0.4068 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0185 0.0305
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.011 0.0596
Schistosoma mansoni hypothetical protein 0.017 0.1328 0.5241
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0167 0.041
Entamoeba histolytica hypothetical protein 0.0177 0.1385 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0157 0.062
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0157 0.0766
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1309 0.3219
Trichomonas vaginalis esterase, putative 0.0182 0.1431 0.7234
Brugia malayi beta-lactamase family protein 0.0182 0.1431 0.3518
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0182 0.1431 0.1426
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0185 0.0305
Plasmodium falciparum thioredoxin reductase 0.0048 0.0256 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.2529 0.6216
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.142 0.349
Entamoeba histolytica hypothetical protein 0.0177 0.1385 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0157 0.0598
Schistosoma mansoni importin beta-1 0.0029 0.0093 0.0344
Trypanosoma brucei protein kinase, putative 0.005 0.0277 0.1113
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0185 0.0735
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0182 0.1431 0.1426
Schistosoma mansoni ran 0.0021 0.0026 0.008
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0722 0.2837
Mycobacterium ulcerans beta-lactamase 0.0182 0.1431 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0157 0.0766
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0093 0.0148
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0185 0.6602
Echinococcus granulosus importin subunit beta 1 0.0029 0.0093 0.0148
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0277 0.1113
Schistosoma mansoni ran 0.0021 0.0026 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.0182 0.1431 0.7234
Brugia malayi Smad1 0.0033 0.0129 0.0316
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0277 0.1374
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0185 0.0735
Brugia malayi MH1 domain containing protein 0.0033 0.0129 0.0316
Echinococcus multilocularis geminin 0.017 0.1328 0.2259
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0423 0.1039
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0167 0.0816
Onchocerca volvulus 0.0245 0.1976 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0256 0.1635
Schistosoma mansoni alpha-glucosidase 0.0145 0.1105 0.4356
Echinococcus multilocularis lamin 0.0082 0.0554 0.0937
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.0185 0.0454
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0383 0.0942
Trichomonas vaginalis penicillin-binding protein, putative 0.0182 0.1431 0.7234
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0129 0.0316
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0277 0.0463
Schistosoma mansoni smad1 5 8 and 0.0033 0.0129 0.0487
Mycobacterium tuberculosis Conserved protein 0.0182 0.1431 0.1426
Echinococcus granulosus snurportin 1 0.0308 0.2529 0.4311
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1717 0.422
Loa Loa (eye worm) hypothetical protein 0.0097 0.0692 0.1701
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0413
Leishmania major importin beta-1 subunit, putative 0.0023 0.0045 0.0161
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0167 0.0661
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0182 0.1431 0.3518
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0167 0.0661
Loa Loa (eye worm) hypothetical protein 0.0182 0.1431 0.3518
Brugia malayi jmjC domain containing protein 0.0099 0.0701 0.1724
Echinococcus multilocularis peregrin 0.003 0.0104 0.0167
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0787 0.5079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0412
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0159 0.0261
Echinococcus multilocularis GPCR, family 2 0.0031 0.011 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0167 0.0816
Brugia malayi Thioredoxin reductase 0.0048 0.0256 0.0629
Loa Loa (eye worm) hypothetical protein 0.0182 0.1431 0.3518
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0277 0.1783
Echinococcus granulosus intermediate filament protein 0.0082 0.0554 0.0937
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0167 0.0816
Echinococcus multilocularis musashi 0.0082 0.0554 0.0937
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0185 0.0454
Mycobacterium tuberculosis Probable lipase LipE 0.0182 0.1431 0.1426
Plasmodium vivax SET domain protein, putative 0.0031 0.011 0.0596
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0167 0.041
Entamoeba histolytica Ran family GTPase 0.0021 0.0026 0.0147
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0206 0.0823
Loa Loa (eye worm) hypothetical protein 0.0067 0.0423 0.1039
Onchocerca volvulus 0.0101 0.0722 0.3301
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.011 0.0178
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0083
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0093 0.0473
Plasmodium vivax importin-beta 2, putative 0.0029 0.0093 0.0473
Schistosoma mansoni hypothetical protein 0.017 0.1328 0.5241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.142 0.5605
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.011 0.0271
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0167 0.0816
Schistosoma mansoni alpha-glucosidase 0.0145 0.1105 0.4356
Echinococcus granulosus smad 0.0033 0.0129 0.021
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0026 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.0182 0.1431 0.5861
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0893 0.0888
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.011 0.0178
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0167 0.0816
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0277 0.1113
Echinococcus multilocularis beta LACTamase domain containing family member 0.0182 0.1431 0.2435
Loa Loa (eye worm) hypothetical protein 0.0182 0.1431 0.3518
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0129 0.021
Echinococcus multilocularis Smad4 0.0033 0.0129 0.021
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0277 1
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1843 0.3139
Mycobacterium tuberculosis Conserved protein 0.0182 0.1431 0.1426
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0159 0.0607
Brugia malayi intermediate filament protein 0.0082 0.0554 0.1362
Schistosoma mansoni hypothetical protein 0.0067 0.0423 0.1652
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0206 0.0823
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.2437 1
Mycobacterium ulcerans esterase/lipase LipP 0.0182 0.1431 1
Brugia malayi MAP kinase sur-1 0.005 0.0277 0.068
Loa Loa (eye worm) hypothetical protein 0.0229 0.1843 0.4531
Loa Loa (eye worm) transcription factor SMAD2 0.0484 0.4068 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0185 0.1296
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.0199
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0413
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0185 0.0305
Trichomonas vaginalis ran, putative 0.0021 0.0026 0.0103
Schistosoma mansoni hypothetical protein 0.0047 0.0249 0.0965
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0249 0.0612
Loa Loa (eye worm) beta-lactamase 0.0182 0.1431 0.3518
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0157 0.1094
Plasmodium falciparum importin beta, putative 0.0029 0.0093 0.2893
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0277 0.1374
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0157 0.0258
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0157 0.0766
Entamoeba histolytica hypothetical protein 0.0023 0.0045 0.0284
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0286 0.1151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.011 0.0178
Schistosoma mansoni transcription factor LCR-F1 0.0177 0.1385 0.5467
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0064
Brugia malayi Inositol-1 0.0036 0.0157 0.0385
Leishmania major hypothetical protein, conserved 0.0182 0.1431 0.5861
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0185 0.0708
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0206 0.0823
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0182 0.1431 0.5649
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0104 0.0551
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0167 0.0661
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0893 0.0888
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0026 0.0035
Mycobacterium tuberculosis Probable lipase LipD 0.0182 0.1431 0.1426
Loa Loa (eye worm) glutathione reductase 0.0048 0.0256 0.0629
Mycobacterium tuberculosis Probable hydrolase 0.0182 0.1431 0.1426
Schistosoma mansoni intermediate filament proteins 0.0082 0.0554 0.2173
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0129 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.142 0.5605
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0787 0.0782
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0157 0.062
Echinococcus multilocularis smad 0.0033 0.0129 0.021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0083
Schistosoma mansoni hypothetical protein 0.0177 0.1385 0.5467
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0692 0.1701
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.107 0.4375
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0185 0.0306
Schistosoma mansoni lamin 0.0082 0.0554 0.2173
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.107 0.4375
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0185 0.0305
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0104 0.0387
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0256 0.025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.011 0.0271
Schistosoma mansoni smad1 5 8 and 0.0033 0.0129 0.0487
Onchocerca volvulus 0.0047 0.0249 0.0778
Echinococcus granulosus Smad4 0.0033 0.0129 0.021
Loa Loa (eye worm) hypothetical protein 0.008 0.0541 0.133
Brugia malayi Importin beta-1 subunit 0.0029 0.0093 0.0227
Schistosoma mansoni hypothetical protein 0.0308 0.2529 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1309 0.3219
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0104 0.0254
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0277 0.0463
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0277 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0185 0.0907
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.027
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0157 0.1058
Brugia malayi MH2 domain containing protein 0.0033 0.0129 0.0316
Brugia malayi beta-lactamase 0.0182 0.1431 0.3518
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2437 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.142 0.5605
Mycobacterium ulcerans hypothetical protein 0.0157 0.1208 0.8439
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0083
Leishmania major GTP-binding protein, putative 0.0021 0.0026 0.0083
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0182 0.1431 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0167 0.0816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0182 0.1431 0.5649
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0167 0.0275
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0167 0.0816
Loa Loa (eye worm) hypothetical protein 0.0182 0.1431 0.3518
Giardia lamblia PHD finger protein 15 0.003 0.0104 0.361
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.142 0.349
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.011 0.0178
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0413
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0701 0.1189
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0124 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.1431 0.5861
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0893 0.0888
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0554 0.1362
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0206 0.0823
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2437 1
Trypanosoma brucei glucosidase, putative 0.0037 0.0167 0.0661
Schistosoma mansoni hypothetical protein 0.003 0.0104 0.0387
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0277 0.1113
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0129 0.021
Brugia malayi jmjC domain containing protein 0.0036 0.0159 0.039
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0185 0.0735
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0413
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0227
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0167 0.1001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0045 0.0161
Trichomonas vaginalis D-aminoacylase, putative 0.0182 0.1431 0.7234
Schistosoma mansoni alpha glucosidase 0.0037 0.0167 0.0637
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0014
Brugia malayi hypothetical protein 0.0229 0.1843 0.4531
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0412
Entamoeba histolytica hypothetical protein 0.0177 0.1385 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0045 0.0199
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0182 0.1431 0.1426
Mycobacterium ulcerans hypothetical protein 0.0182 0.1431 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0554 0.1362
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0185 0.0907
Toxoplasma gondii hypothetical protein 0.0048 0.026 0.1662
Onchocerca volvulus 0.0182 0.1431 0.709
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0185 0.0306
Echinococcus granulosus tumor protein p63 0.0689 0.5858 1
Echinococcus granulosus geminin 0.017 0.1328 0.2259
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0185 0.0907
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0014
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0014

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 0.0001 mol/L Cytotoxicity against human KB cells after 72 hrs ChEMBL. 12932128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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