Detailed information for compound 1181855

Basic information

Technical information
  • TDR Targets ID: 1181855
  • Name: (E)-2-(4-phenylphenyl)-3-(3,4,5-trimethoxyphe nyl)prop-2-enoic acid
  • MW: 390.428 | Formula: C24H22O5
  • H donors: 1 H acceptors: 2 LogP: 5.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C(\c2ccc(cc2)c2ccccc2)/C(=O)O)cc(c1OC)OC
  • InChi: 1S/C24H22O5/c1-27-21-14-16(15-22(28-2)23(21)29-3)13-20(24(25)26)19-11-9-18(10-12-19)17-7-5-4-6-8-17/h4-15H,1-3H3,(H,25,26)/b20-13+
  • InChiKey: BGBZINXZBCPRCI-DEDYPNTBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2-(4-phenylphenyl)-3-(3,4,5-trimethoxyphenyl)acrylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase LipL 0.0226 0.1218 0.1452
Leishmania major hypothetical protein, conserved 0.0027 0.0087 0.0516
Mycobacterium tuberculosis Probable dehydrogenase 0.0673 0.3769 0.4599
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0088 0.0522
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0167 0.0167
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0025 0.0029
Brugia malayi MH2 domain containing protein 0.0026 0.0081 0.0149
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0127 0.0655 0.1352
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0025 0.0026
Echinococcus multilocularis survival motor neuron protein 1 0.0266 0.1447 0.1447
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0286 0.0286
Treponema pallidum NADH oxidase 0.0102 0.0515 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0087 0.042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0152 0.0917
Plasmodium vivax ferrodoxin reductase, putative 0.0027 0.0087 0.0403
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.0393 0.0803
Echinococcus granulosus bloom syndrome protein 0.0023 0.0067 0.0077
Loa Loa (eye worm) hypothetical protein 0.0047 0.02 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0029
Echinococcus granulosus protein C ets 2 0.0021 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.0067 0.0314 0.0364
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0152 0.0746
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0027 0.0087 0.0101
Echinococcus granulosus ecdysone induced protein 78C 0.0127 0.0655 0.0758
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0081 0.0093
Echinococcus multilocularis translational activator gcn1 0.0027 0.0087 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0286 0.0328
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0087 0.0516
Brugia malayi TAR-binding protein 0.0062 0.0286 0.0579
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0159 0.0181
Brugia malayi kap beta 3 protein 0.0027 0.0087 0.0162
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0137 0.0137
Leishmania major DNA polymerase eta, putative 0.0025 0.0076 0.0444
Echinococcus granulosus mothers against decapentaplegic 2 0.0026 0.0081 0.0093
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0102 0.0515 0.4004
Brugia malayi Bromodomain containing protein 0.0076 0.0364 0.0743
Loa Loa (eye worm) hypothetical protein 0.0287 0.1571 0.1817
Loa Loa (eye worm) hypothetical protein 0.037 0.2041 0.236
Trypanosoma cruzi DNA polymerase eta, putative 0.0025 0.0076 0.0444
Leishmania major DNA polymerase kappa, putative 0.0025 0.0076 0.0444
Loa Loa (eye worm) CYP4Cod1 0.003 0.0102 0.0118
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0139 0.0271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0041
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0076 0.0336
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0081 0.0393 0.0455
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0673 0.3769 0.4599
Mycobacterium tuberculosis Conserved protein 0.0226 0.1218 0.1452
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0102 0.0118
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0159 0.0181
Loa Loa (eye worm) nuclear receptor NHR-67 0.006 0.0274 0.0316
Trypanosoma brucei unspecified product 0.0081 0.0393 0.2417
Brugia malayi Cytochrome P450 family protein 0.0063 0.029 0.0588
Schistosoma mansoni apoferritin-2 0.0035 0.0134 0.0152
Brugia malayi hypothetical protein 0.0039 0.0157 0.0309
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0087 0.0407
Brugia malayi nuclear receptor NHR-88 0.006 0.0274 0.0553
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0279 0.0279
Echinococcus granulosus snurportin 1 0.1528 0.8646 1
Loa Loa (eye worm) cytochrome P450 0.002 0.0046 0.0053
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.006 0.0274 0.0274
Brugia malayi steroid hormone receptor 0.0127 0.0655 0.1352
Mycobacterium leprae conserved hypothetical protein 0.0226 0.1218 0.2824
Schistosoma mansoni hypothetical protein 0.0205 0.1099 0.1269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.02 0.0228
Brugia malayi tailless protein 0.006 0.0274 0.0553
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0226 0.1218 0.1452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.025 0.1529
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0025 0.0026
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0027 0.0087 0.0353
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0025 0.0104
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0295 0.1614 0.1941
Loa Loa (eye worm) hypothetical protein 0.003 0.0101 0.0117
Loa Loa (eye worm) hypothetical protein 0.0143 0.0749 0.0866
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.013 0.0151
Onchocerca volvulus 0.0226 0.1218 0.9632
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0152 0.0903
Loa Loa (eye worm) beta-lactamase 0.0226 0.1218 0.1409
Schistosoma mansoni steroid hormone receptor ad4bp 0.0127 0.0655 0.0755
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0139 0.068
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0046 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.0127 0.0655 0.0755
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0046 0.0006
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0087 0.0516
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0046 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0226 0.1218 1
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0087 0.0516
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Brugia malayi nuclear hormone receptor family member odr-7 0.006 0.0274 0.0553
Echinococcus granulosus transportin 1 0.0027 0.0087 0.0101
Brugia malayi beta-lactamase family protein 0.0226 0.1218 0.253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0104 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0127 0.0655 0.1352
Echinococcus granulosus nuclear receptor nhr 48 0.006 0.0274 0.0316
Brugia malayi orphan nuclear receptor NR2E1 0.006 0.0274 0.0553
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0027 0.0087 0.0292
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0087 0.041
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0046 0.0259
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0102 0.0515 0.1059
Loa Loa (eye worm) RecQ helicase 0.0023 0.0067 0.0077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0133 0.0691 0.0691
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0515 0.3175
Schistosoma mansoni glutamate synthase 0.0027 0.0087 0.0098
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0076 0.0444
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0025 0.0026
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0152 0.0176
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0393 0.2417
Brugia malayi hypothetical protein 0.0266 0.1447 0.3008
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0087 0.042
Brugia malayi hypothetical protein 0.0067 0.0314 0.0638
Mycobacterium ulcerans NADH dehydrogenase 0.0027 0.0087 0.0353
Leishmania major cytochrome p450-like protein 0.002 0.0046 0.0259
Echinococcus granulosus tar DNA binding protein 0.0062 0.0286 0.0331
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0027 0.0087 0.042
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0025 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0152 0.0917
Loa Loa (eye worm) MH2 domain-containing protein 0.0852 0.4789 0.5539
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0286 0.0579
Trypanosoma brucei glucosidase, putative 0.0036 0.0139 0.0836
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0046 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0376 0.2078 0.2078
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0101 0.0496
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0041
Echinococcus multilocularis expressed protein 0.0016 0.0025 0.0025
Schistosoma mansoni glutamate synthase 0.0027 0.0087 0.0098
Toxoplasma gondii HEAT repeat-containing protein 0.0143 0.0749 0.4564
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0673 0.3769 0.4599
Plasmodium falciparum ferrodoxin reductase-like protein 0.0027 0.0087 0.0292
Echinococcus multilocularis smad 0.0058 0.0264 0.0264
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0076 0.0444
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0279 0.1986
Schistosoma mansoni cpg binding protein 0.0035 0.013 0.0148
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0226 0.1218 0.1409
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0046 0.0006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0046 0.0006
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0158 0.0836 0.0967
Loa Loa (eye worm) hypothetical protein 0.0266 0.1447 0.1674
Mycobacterium tuberculosis Probable oxidoreductase 0.0748 0.4197 0.5127
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0673 0.3769 0.4599
Entamoeba histolytica hypothetical protein 0.0039 0.0157 0.2591
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0127 0.0655 0.1352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0029
Brugia malayi Nuclear hormone receptor E75 0.006 0.0274 0.0553
Schistosoma mansoni hypothetical protein 0.0021 0.0054 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0029
Schistosoma mansoni hypothetical protein 0.0027 0.0087 0.0098
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0041 0.0067
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0025 0.0026
Schistosoma mansoni nuclear receptor 0.006 0.0274 0.0314
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0158 0.0836 0.5167
Plasmodium vivax hypothetical protein, conserved 0.003 0.0101 0.049
Echinococcus multilocularis FTZ F1 alpha 0.0127 0.0655 0.0655
Brugia malayi glutamate synthase 0.0027 0.0087 0.0163
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0152 0.0808
Echinococcus multilocularis 0.002 0.0046 0.0046
Leishmania major importin beta-1 subunit, putative 0.0116 0.0594 0.3666
Echinococcus granulosus dna polymerase kappa 0.0081 0.0393 0.0455
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0152 0.0746
Brugia malayi jmjC domain containing protein 0.004 0.0159 0.0312
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0009 0.0032
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0021 0.0054 0.006
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0084 0.0412 0.4427
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0087 0.0516
Echinococcus multilocularis mothers against decapentaplegic 2 0.0026 0.0081 0.0081
Echinococcus granulosus translational activator gcn1 0.0027 0.0087 0.0101
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0088 0.0522
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0009 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0087 0.0101
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0102 0.0515 0.4004
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.007 0.0081
Brugia malayi Pre-SET motif family protein 0.003 0.0104 0.0198
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0101 0.0117
Echinococcus multilocularis ecdysone induced protein 78C 0.0127 0.0655 0.0655
Brugia malayi beta-lactamase 0.0226 0.1218 0.253
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0286 0.0328
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0027 0.0087 0.01
Schistosoma mansoni ap endonuclease 0.0038 0.0152 0.0173
Echinococcus granulosus ETS transcription factor Elf 1 0.0021 0.0054 0.0063
Mycobacterium tuberculosis Probable hydrolase 0.0226 0.1218 0.1452
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0393 0.2417
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0025 0.0026
Trichomonas vaginalis hypothetical protein 0.0027 0.0087 0.0419
Brugia malayi nuclear receptor RXR 0.0067 0.0314 0.0638
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0102 0.0515 0.4004
Echinococcus granulosus mothers against decapentaplegic 5 0.0058 0.0264 0.0305
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.0393 0.1967
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.2078 0.2401
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0139 0.068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0127 0.0655 0.0758
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0046 0.0006
Schistosoma mansoni hypothetical protein 0.0133 0.0691 0.0797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0376 0.2078 0.2403
Echinococcus multilocularis zinc finger protein 0.0021 0.0054 0.0054
Mycobacterium ulcerans hypothetical protein 0.0027 0.0087 0.0353
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0084 0.0412 0.2535
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0027 0.0087 0.0353
Trichomonas vaginalis ferritin, putative 0.0035 0.0134 0.0657
Echinococcus granulosus Smad4 0.0058 0.0264 0.0305
Echinococcus multilocularis nuclear receptor nhr 48 0.006 0.0274 0.0274
Onchocerca volvulus 0.0054 0.0242 0.1849
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0127 0.0655 0.1352
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0027 0.0087 0.0101
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0158 0.0836 0.5113
Mycobacterium ulcerans hypothetical protein 0.0226 0.1218 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0075 0.0361 0.0735
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0127 0.0655 0.0758
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0087 0.042
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0076 0.033
Plasmodium falciparum transportin 0.0027 0.0087 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0139 0.0836
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0046 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0127 0.0655 0.1352
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0028 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0295 0.1614 1
Echinococcus multilocularis cpg binding protein 0.0039 0.0152 0.0152
Trypanosoma brucei DNA polymerase eta, putative 0.0081 0.0393 0.2417
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0226 0.1218 0.253
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.02 0.0231
Schistosoma mansoni hypothetical protein 0.0248 0.1344 0.1552
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.025 0.1529
Giardia lamblia NADH oxidase lateral transfer candidate 0.0102 0.0515 0.5783
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0025 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0087 0.0516
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Schistosoma mansoni terminal deoxycytidyl transferase 0.0081 0.0393 0.0452
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0041
Brugia malayi PHD-finger family protein 0.0014 0.001 0.0001
Leishmania major hypothetical protein, conserved 0.0226 0.1218 0.7541
Leishmania major cytochrome p450-like protein 0.003 0.0102 0.0608
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0025 0.0026
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0021 0.0054 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0836 0.4205
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0152 0.1002
Brugia malayi CXXC zinc finger family protein 0.0035 0.013 0.0253
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0067 0.0314 0.0364
Echinococcus granulosus mothers against decapentaplegic 6 0.0026 0.0081 0.0093
Brugia malayi Steroid receptor seven-up type 2 0.0127 0.0655 0.1352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0133 0.0691 0.0799
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0152 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0159 0.0183
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1265 0.637
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Leishmania major hypothetical protein, conserved 0.0027 0.0088 0.0522
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0025 0.0026
Brugia malayi Fli-1 protein 0.0446 0.2475 0.5159
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0094 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0087 0.0516
Leishmania major cytochrome p450-like protein 0.002 0.0046 0.0259
Schistosoma mansoni Smad4 0.0026 0.0081 0.009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0127 0.0655 0.0755
Brugia malayi isocitrate dehydrogenase 0.0019 0.0041 0.0067
Schistosoma mansoni alpha glucosidase 0.0036 0.0139 0.0158
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0025 0.0026
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0027 0.0087 0.0087
Mycobacterium tuberculosis Probable lipase LipD 0.0226 0.1218 0.1452
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.037 0.2041 0.425
Loa Loa (eye worm) hypothetical protein 0.0126 0.0649 0.075
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0127 0.0655 0.1352
Onchocerca volvulus 0.006 0.0274 0.2105
Echinococcus multilocularis dna polymerase eta 0.0081 0.0393 0.0393
Trichomonas vaginalis D-aminoacylase, putative 0.0226 0.1218 0.6137
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0748 0.4197 0.5127
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0862 0.0862
Brugia malayi PHD-finger family protein 0.003 0.0101 0.0192
Plasmodium falciparum phd finger protein, putative 0.003 0.0101 0.038
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0076 0.0444
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0025 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0127 0.0655 0.1352
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0102 0.0515 0.3175
Brugia malayi hypothetical protein 0.006 0.0274 0.0553
Mycobacterium leprae Probable lipase LipE 0.0226 0.1218 0.2824
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0041 0.0231
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0286 0.0331
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0025 0.0029
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0102 0.0515 0.3013
Echinococcus multilocularis peregrin 0.0032 0.0114 0.0114
Mycobacterium ulcerans dehydrogenase 0.0027 0.0087 0.0353
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0134
Echinococcus multilocularis microtubule associated protein 2 0.1476 0.8349 0.8349
Brugia malayi nuclear hormone receptor family member nhr-6 0.006 0.0274 0.0553
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0009 0.0032
Schistosoma mansoni hypothetical protein 0.003 0.0101 0.0114
Brugia malayi Nuclear hormone receptor-like 1 0.0127 0.0655 0.1352
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.0836 0.0965
Echinococcus granulosus thioredoxin glutathione reductase 0.0298 0.1629 0.1884
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Echinococcus granulosus GA binding protein alpha chain 0.0147 0.077 0.0891
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0025 0.0026
Brugia malayi MH1 domain containing protein 0.0032 0.0116 0.0222
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.0054 0.0054
Echinococcus granulosus TGF beta signal transducer SmadC 0.0058 0.0264 0.0305
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0226 0.1218 0.1407
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0102 0.0515 0.0593
Schistosoma mansoni coup transcription factor 0.0127 0.0655 0.0755
Entamoeba histolytica disulphide oxidoreductase, putative 0.0027 0.0087 0.1409
Loa Loa (eye worm) RNA binding protein 0.0062 0.0286 0.0331
Echinococcus multilocularis mothers against decapentaplegic 5 0.0058 0.0264 0.0264
Giardia lamblia Kinase, CMGC MAPK 0.0158 0.0836 1
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.1218 0.7541
Brugia malayi nuclear receptor NHR-88 0.0127 0.0655 0.1352
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0087 0.0057
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0327 0.1913
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0152 0.0702
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0046 0.0006
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0025 0.0029
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0226 0.1218 0.1452
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0041 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Loa Loa (eye worm) thioredoxin reductase 0.0295 0.1614 0.1867
Echinococcus granulosus GTP binding nuclear protein Ran 0.0084 0.0412 0.0477
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0046 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0058 0.0264 0.0305
Trichomonas vaginalis ran, putative 0.0084 0.0412 0.2063
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Brugia malayi Pre-SET motif family protein 0.0205 0.1104 0.2289
Echinococcus granulosus expressed protein 0.0035 0.0134 0.0155
Brugia malayi MH1 domain containing protein 0.0032 0.0116 0.0222
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0286 0.0328
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0084 0.0412 0.2446
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0025 0.0104
Loa Loa (eye worm) hypothetical protein 0.0051 0.0222 0.0256
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0139 0.068
Onchocerca volvulus Protein ultraspiracle homolog 0.0127 0.0655 0.5146
Brugia malayi hypothetical protein 0.006 0.0274 0.0553
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0087 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.1218 0.7541
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0027 0.0087 0.1409
Onchocerca volvulus Bile acid receptor homolog 0.0127 0.0655 0.5146
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.007 0.007
Leishmania major hypothetical protein, conserved 0.0027 0.0087 0.0516
Schistosoma mansoni hypothetical protein 0.002 0.0046 0.005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0116 0.0594 0.3666
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0063
Echinococcus granulosus beta LACTamase domain containing family member 0.0226 0.1218 0.1409
Schistosoma mansoni hypothetical protein 0.0287 0.1571 0.1815
Schistosoma mansoni thyroid hormone receptor 0.0374 0.2067 0.2389
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0371 0.0426
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0027 0.0087 0.0087
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0281 0.0325
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0279 0.1706
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0041 0.0121
Loa Loa (eye worm) programmed cell death 8 0.0027 0.0087 0.0101
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0127 0.0655 0.0755
Brugia malayi beta-lactamase family protein 0.0226 0.1218 0.253
Brugia malayi jmjC domain containing protein 0.0097 0.0485 0.0994
Echinococcus multilocularis expressed protein 0.0035 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0011
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0025 0.0032
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.0186
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0133 0.0691 0.1426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0067 0.0314 0.0314
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0025 0.0104
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.029 0.0336
Treponema pallidum bacterioferrin (TpF1) 0.0035 0.0134 0.1095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0226 0.1218 0.1407
Plasmodium vivax importin-beta 2, putative 0.0143 0.0749 0.456
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0025 0.0032
Brugia malayi MH2 domain containing protein 0.0058 0.0264 0.0532
Brugia malayi Smad1 0.0058 0.0264 0.0532
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0101
Trypanosoma brucei importin beta-1 subunit, putative 0.0143 0.0749 0.4624
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1528 0.8646 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0084 0.0412 0.0412
Schistosoma mansoni smad1 5 8 and 0.0058 0.0264 0.0302
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0152 0.0917
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0279 0.1612
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0127 0.0655 0.0755
Echinococcus granulosus ETS domain containing protein Elk 1 0.0021 0.0054 0.0063
Schistosoma mansoni ferritin 0.0035 0.0134 0.0152
Echinococcus granulosus geminin 0.0205 0.1099 0.1272
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0087 0.0516
Brugia malayi transcription factor E74 isoform 0.0021 0.0054 0.0093
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0048
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0041 0.0231
Trypanosoma brucei hypothetical protein, conserved 0.0226 0.1218 0.7541
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0102 0.0515 0.0585
Mycobacterium tuberculosis Conserved protein 0.0226 0.1218 0.1452
Loa Loa (eye worm) glutathione reductase 0.0295 0.1614 0.1867
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0076 0.0444
Brugia malayi Ets-domain containing protein 0.0021 0.0054 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0226 0.1218 0.6137
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0087 0.042
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0046 0.0006
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0027 0.0087 0.0101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0104 0.0516
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0009 0.001
Brugia malayi ecdysone receptor 0.006 0.0274 0.0553
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0087 0.01
Schistosoma mansoni gabp alpha 0.0147 0.077 0.0888
Schistosoma mansoni nuclear hormone receptor 0.006 0.0274 0.0314
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0104 0.0118
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0087 0.0101
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0058 0.0264 0.0302
Schistosoma mansoni hypothetical protein 0.0494 0.2749 0.3177
Echinococcus multilocularis mitogen activated protein kinase 0.0158 0.0836 0.0836
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0274 0.2105
Onchocerca volvulus 0.0234 0.1265 1
Brugia malayi Ets-domain containing protein 0.0147 0.077 0.1591
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0088 0.0409
Leishmania major hypothetical protein, conserved 0.0027 0.0087 0.0514
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0041 0.0231
Loa Loa (eye worm) transcription factor SMAD2 0.0852 0.4789 0.5539
Schistosoma mansoni zinc finger protein 0.006 0.0274 0.0314
Brugia malayi mothers against decapentaplegic homolog 3 0.0026 0.0081 0.0149
Leishmania major DNA damage repair protein, putative 0.0025 0.0076 0.0444
Plasmodium vivax transportin, putative 0.0027 0.0087 0.0401
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0748 0.4197 0.5127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0133 0.0691 0.0691
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0087 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0127 0.0655 0.1352
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0027 0.0087 0.042
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0248 0.1344 0.1344
Echinococcus granulosus microtubule associated protein 2 0.1476 0.8349 0.9657
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0027 0.0087 0.0087
Plasmodium falciparum glutathione reductase 0.0295 0.1614 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0027 0.0087 0.1409
Echinococcus granulosus GPCR family 2 0.0133 0.0691 0.0799
Onchocerca volvulus 0.0094 0.047 0.3669
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0515 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0087 0.041
Trypanosoma brucei protein kinase, putative 0.0158 0.0836 0.5167
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0088 0.0416
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Toxoplasma gondii NADPH-glutathione reductase 0.0102 0.0515 0.3098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0127 0.0655 0.1352
Schistosoma mansoni hypothetical protein 0.1528 0.8646 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0226 0.1218 0.1218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0127 0.0655 0.0758
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0084 0.0412 0.0477
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0152 0.1506
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0286 0.0328
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0139 0.228
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0087 0.042
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0025 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0011
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0084 0.0412 0.2451
Loa Loa (eye worm) hypothetical protein 0.0226 0.1218 0.1409
Loa Loa (eye worm) kap beta 3 protein 0.0027 0.0087 0.0101
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0102 0.0608
Mycobacterium tuberculosis Conserved protein 0.0226 0.1218 0.1452
Schistosoma mansoni smad 0.0026 0.0081 0.009
Brugia malayi nuclear hormone receptor 0.006 0.0274 0.0553
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.042 0.2329 0.2694
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0102 0.0515 0.3093
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0101 0.0496
Brugia malayi Cytochrome P450 family protein 0.003 0.0102 0.0194
Schistosoma mansoni Smad4 0.0026 0.0081 0.009
Echinococcus multilocularis protein C ets 2 0.0021 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0127 0.0655 0.0758
Brugia malayi hypothetical protein 0.0016 0.0025 0.0032
Mycobacterium ulcerans hypothetical protein 0.0025 0.0076 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0226 0.1218 0.1409
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0139 0.068
Schistosoma mansoni nuclear receptor nhr-48 0.006 0.0274 0.0314
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0025 0.0104
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0025 0.0025
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0102 0.0479
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0862 0.0997
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0393 0.2963
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0248 0.1344 0.1555
Loa Loa (eye worm) hypothetical protein 0.0067 0.0314 0.0364
Trichomonas vaginalis importin beta-1, putative 0.0116 0.0594 0.2983
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0127 0.0655 0.0758
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0046 0.0259
Schistosoma mansoni hypothetical protein 0.0133 0.0691 0.0797
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0314 0.0361
Schistosoma mansoni ets-related 0.0446 0.2475 0.286
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0127 0.0655 0.5146
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0274 0.0274
Onchocerca volvulus 0.006 0.0274 0.2105
Mycobacterium ulcerans beta-lactamase 0.0226 0.1218 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0029 0.0095 0.0565
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0157 0.0157
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0027 0.0087 0.1409
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.0026
Echinococcus multilocularis importin subunit beta 1 0.0143 0.0749 0.0749
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0376 0.2078 0.4328
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0102 0.0515 0.3098
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0152 0.0152
Schistosoma mansoni ferritin light chain 0.0035 0.0134 0.0152
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0274 0.0274
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0274 0.0316
Loa Loa (eye worm) hypothetical protein 0.0226 0.1218 0.1409
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0279 0.0322
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0862 0.0997
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0748 0.4197 1
Onchocerca volvulus 0.0016 0.0025 0.0122
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0087 0.0292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0029
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0027 0.0087 0.0514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0376 0.2078 0.2403
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Entamoeba histolytica Ran family GTPase 0.0084 0.0412 0.6915
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0088 0.0298
Echinococcus granulosus ETS transcription factor Elf 5 0.0021 0.0054 0.0063
Plasmodium falciparum glutathione reductase 0.0102 0.0515 0.3013
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0139 0.068
Entamoeba histolytica thioredoxin reductase, putative 0.0027 0.0087 0.1409
Brugia malayi hypothetical protein 0.0067 0.0314 0.0638
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0127 0.0655 0.0758
Echinococcus granulosus smad 0.0058 0.0264 0.0305
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2749 0.3179
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0393 0.2417
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0102 0.0515 0.3175
Onchocerca volvulus 0.0127 0.0655 0.5146
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0836 0.4205
Echinococcus multilocularis transportin 1 0.0027 0.0087 0.0087
Schistosoma mansoni nuclear hormone receptor 0.0127 0.0655 0.0755
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0067 0.0315
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0286 0.0328
Brugia malayi hypothetical protein 0.0018 0.0033 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0127 0.0655 0.1352
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.0836 0.5167
Schistosoma mansoni Smad4 0.0058 0.0264 0.0302
Loa Loa (eye worm) latrophilin receptor protein 2 0.0133 0.0691 0.0799
Toxoplasma gondii exonuclease III APE 0.0038 0.0152 0.0815
Leishmania major hypothetical protein, conserved 0.0027 0.0087 0.0516
Schistosoma mansoni ets 0.0021 0.0054 0.006
Brugia malayi polk-prov protein 0.0025 0.0076 0.0139
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0025 0.0104
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0028 0.0028
Loa Loa (eye worm) steroid hormone receptor 0.0127 0.0655 0.0758
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0088 0.0298
Giardia lamblia Glutamate synthase 0.0027 0.0087 0.0154
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0009 0.0026
Schistosoma mansoni zinc finger protein 0.0021 0.0054 0.0059
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0102 0.0515 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Loa Loa (eye worm) hypothetical protein 0.0081 0.0393 0.0455
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0032 0.0037
Brugia malayi Thioredoxin reductase 0.0295 0.1614 0.3358
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0127 0.0655 0.0755
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0088
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0046 0.0006
Echinococcus multilocularis mothers against decapentaplegic 6 0.0026 0.0081 0.0081
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0139 0.0161
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0279 0.1986
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0025 0.0025
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0046 0.015
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0027 0.0087 0.0516
Loa Loa (eye worm) ets-domain-containing protein 0.0021 0.0054 0.0063
Schistosoma mansoni cpg binding protein 0.0039 0.0152 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0054 0.0242 0.0277
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0081 0.0093
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0025 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0046 0.0006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0279 0.0279
Brugia malayi glutathione reductase 0.0295 0.1614 0.3358
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0025 0.0032
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0041 0.0045
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0027 0.0087 0.0353
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0358 0.0412
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0171
Brugia malayi PHD-finger family protein 0.0026 0.0084 0.0155
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0158 0.0836 0.5167
Brugia malayi Cytochrome P450 family protein 0.003 0.0102 0.0194
Trichomonas vaginalis D-aminoacylase, putative 0.0226 0.1218 0.6137
Schistosoma mansoni ran 0.0084 0.0412 0.0474
Brugia malayi G-protein alpha subunit 0.0016 0.0025 0.0032
Trypanosoma cruzi ISWI complex protein 0.0015 0.0018 0.0088
Brugia malayi Nuclear hormone receptor E75 0.006 0.0274 0.0553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.0655 0.0655
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0002 0.0003
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0063
Entamoeba histolytica deoxycytidyl transferase, putative 0.0081 0.0393 0.6594
Schistosoma mansoni ferritin 0.0035 0.0134 0.0152
Leishmania major DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Schistosoma mansoni hypothetical protein 0.0039 0.0157 0.0179
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1441 0.8147 1
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0101 0.0117
Plasmodium vivax hypothetical protein, conserved 0.0226 0.1218 0.7511
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0081 0.0393 0.0434
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0836 0.4205
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0836 0.4205
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0242 0.0486
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Mycobacterium ulcerans glutamate synthase subunit beta 0.0027 0.0087 0.0353
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0084 0.0412 0.2535
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0279 0.0323
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0102 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0133 0.0691 0.0797
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0087 0.042
Echinococcus multilocularis importin 5 0.0027 0.0087 0.0087
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0025 0.0032
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0158 0.0836 0.5167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0226 0.1218 0.1452
Trichomonas vaginalis D-aminoacylase, putative 0.0226 0.1218 0.6137
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0025 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.0393 0.1967
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0076 0.0218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.0655 0.0758
Schistosoma mansoni thyroid hormone receptor 0.0374 0.2067 0.2389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0127 0.0655 0.0758
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0046 0.0006
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0021 0.0054 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0127 0.0655 0.0758
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0116 0.0594 0.2983
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0025 0.0025
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.005 0.0056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0515 0.3175
Echinococcus multilocularis thyroid hormone receptor alpha 0.0374 0.2067 0.2067
Onchocerca volvulus 0.003 0.0104 0.0756
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0028 0.0033
Onchocerca volvulus 0.0016 0.0025 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0076 0.0444
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0139 0.0836
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0087 0.0516
Echinococcus granulosus cpg binding protein 0.0039 0.0152 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0139 0.228
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0134 0.0155
Schistosoma mansoni zinc finger protein 0.0015 0.0018 0.0018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Brugia malayi Bromodomain containing protein 0.0038 0.0147 0.0289
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0087 0.0407
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0087 0.0516
Giardia lamblia DINP protein human, muc B family 0.0081 0.0393 0.4178
Trypanosoma cruzi trypanothione reductase, putative 0.0295 0.1614 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0102 0.0515 0.0596
Entamoeba histolytica HEAT repeat domain containing protein 0.0027 0.0087 0.1403
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0101 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0376 0.2078 0.2078
Brugia malayi Ets-domain containing protein 0.0147 0.077 0.1591
Brugia malayi nuclear hormone receptor 0.0127 0.0655 0.1352
Brugia malayi Bromodomain containing protein 0.0032 0.0114 0.022
Schistosoma mansoni microtubule-associated protein tau 0.1476 0.8349 0.9657
Trypanosoma brucei unspecified product 0.0056 0.025 0.1529
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0152 0.0298
Trichomonas vaginalis mercuric reductase, putative 0.0102 0.0515 0.2584
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0127 0.0655 0.0755
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0067 0.0315
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0314 0.0638
Toxoplasma gondii thioredoxin reductase 0.0295 0.1614 1
Entamoeba histolytica hypothetical protein 0.0116 0.0594 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0025 0.0026
Toxoplasma gondii selenide, water dikinase 0.0027 0.0087 0.041
Echinococcus multilocularis ets variant gene 4 0.0021 0.0054 0.0054
Schistosoma mansoni smad1 5 8 and 0.0058 0.0264 0.0302
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0139 0.0161
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1104 0.1276
Echinococcus multilocularis glutamate synthase 0.0027 0.0087 0.0087
Echinococcus multilocularis ETS transcription factor Elf 5 0.0021 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.0026
Brugia malayi Importin beta-1 subunit 0.0143 0.0749 0.1547
Loa Loa (eye worm) nuclear hormone receptor 0.006 0.0274 0.0316
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0116 0.0594 0.2983
Brugia malayi ecdysteroid receptor 0.0127 0.0655 0.1352
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0102 0.0608
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0041 0.0231
Echinococcus multilocularis GPCR, family 2 0.0133 0.0691 0.0691
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0076 0.0444
Mycobacterium ulcerans monoxygenase 0.0027 0.0087 0.0353
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0076 0.0336
Schistosoma mansoni ferritin 0.0035 0.0134 0.0152
Loa Loa (eye worm) hypothetical protein 0.042 0.2329 0.2694
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0026 0.0081 0.0566
Trypanosoma brucei ISWI complex protein 0.0015 0.0018 0.0088
Schistosoma mansoni elf1 0.0021 0.0054 0.006
Brugia malayi conserved hypotetical protein 0.006 0.0274 0.0553
Brugia malayi photoreceptor-specific nuclear receptor 0.0127 0.0655 0.1352
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2749 0.2749
Loa Loa (eye worm) hypothetical protein 0.0226 0.1218 0.1409
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0152 0.0917
Schistosoma mansoni DNA polymerase eta 0.0081 0.0393 0.0452
Echinococcus granulosus mitogen activated protein kinase 3 0.0158 0.0836 0.0967
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0102 0.0118
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0081 0.0393 0.0452
Trypanosoma brucei trypanothione reductase 0.0295 0.1614 1
Leishmania major NADH dehydrogenase, putative 0.0027 0.0087 0.0516
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0046 0.0006
Schistosoma mansoni ap endonuclease 0.0038 0.0152 0.0173
Schistosoma mansoni RAR-like nuclear receptor 0.0127 0.0655 0.0755
Entamoeba histolytica hypothetical protein 0.0039 0.0157 0.2591
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0127 0.0655 0.0758
Trichomonas vaginalis conserved hypothetical protein 0.036 0.1983 1
Schistosoma mansoni ferritin 0.0035 0.0134 0.0152
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0279 0.0293
Brugia malayi cytochrome P450 0.002 0.0046 0.0076
Mycobacterium ulcerans lipase LipD 0.0226 0.1218 1
Onchocerca volvulus 0.0226 0.1218 0.9632
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0093
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0076 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.0655 0.0758
Loa Loa (eye worm) importin-beta domain-containing protein 0.0027 0.0087 0.0101
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0102
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0084 0.0412 0.0843
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0027 0.0087 0.0163
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0027 0.0087 0.041
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.0026
Schistosoma mansoni ferritin light chain 0.0035 0.0134 0.0152
Echinococcus multilocularis mitogen activated protein kinase 3 0.0158 0.0836 0.0836
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0139 0.068
Schistosoma mansoni disulfide oxidoreductase 0.0027 0.0087 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0139 0.068
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0076 0.0336
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0102 0.0515 0.3013
Entamoeba histolytica hypothetical protein 0.0039 0.0157 0.2591
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0084 0.0412 0.2535
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0087 0.0353
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0139 0.068
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.007 0.0078
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Loa Loa (eye worm) hypothetical protein 0.007 0.0329 0.0381
Echinococcus granulosus dna polymerase eta 0.0081 0.0393 0.0455
Loa Loa (eye worm) D-ets-2 protein 0.0021 0.0054 0.0063
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0101 0.0101
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0025 0.0104
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0862 0.1783
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.006 0.0274 0.0553
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0862 0.0862
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.0134 0.0753
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0009 0.0009
Trypanosoma cruzi ISWI complex protein 0.0015 0.0018 0.0088
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0041 0.0231
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0485 0.0485
Schistosoma mansoni ets-related 0.0021 0.0054 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0127 0.0655 0.0758
Trichomonas vaginalis penicillin-binding protein, putative 0.0226 0.1218 0.6137
Plasmodium vivax SET domain protein, putative 0.003 0.0104 0.051
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0027 0.0087 0.01
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0515 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.0054 0.0063
Brugia malayi DNA-binding protein D-ETS-3 0.0021 0.0054 0.0093
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0025 0.0349
Brugia malayi hypothetical protein 0.0027 0.0088 0.0165
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0027 0.0087 0.0101
Brugia malayi RNA binding protein 0.0062 0.0286 0.0579
Schistosoma mansoni smad1 5 8 and 0.0058 0.0264 0.0302
Plasmodium vivax glutathione reductase, putative 0.0295 0.1614 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0279 0.032
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0087 0.0516
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0046 0.0006
Brugia malayi MH2 domain containing protein 0.0852 0.4789 1
Plasmodium falciparum importin beta, putative 0.0143 0.0749 0.4497
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.02 0.02
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0167 0.0193
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.0393 0.0803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0515 0.3175
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0025 0.0032
Trypanosoma brucei NADH dehydrogenase 0.0027 0.0087 0.0516
Plasmodium falciparum thioredoxin reductase 0.0295 0.1614 1
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0018
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0087 0.0098
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.0134 0.0114
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0081 0.0393 0.0455
Echinococcus multilocularis ETS transcription factor Elf 1 0.0021 0.0054 0.0054
Echinococcus granulosus ewsr:fli fusion protein type 0.0021 0.0054 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0139 0.068
Leishmania major DNA polymerase eta, putative 0.0081 0.0393 0.2417
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0087 0.0163
Brugia malayi MAP kinase sur-1 0.0158 0.0836 0.173
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0046 0.0006
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0021 0.0054 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0127 0.0655 0.0758
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0076 0.0444
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0393 0.0434
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0087 0.1409
Schistosoma mansoni apoferritin-2 0.0035 0.0134 0.0152
Schistosoma mansoni hypothetical protein 0.0133 0.0691 0.0797
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.0134 0.0753
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0087 0.0516
Onchocerca volvulus 0.0027 0.0087 0.0621
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0104 0.0104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0043 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0139 0.0836
Trypanosoma brucei importin beta-1 subunit, putative 0.0143 0.0749 0.4624
Brugia malayi Cytochrome P450 family protein 0.002 0.0046 0.0076
Loa Loa (eye worm) hypothetical protein 0.0067 0.0314 0.0364
Schistosoma mansoni survival motor neuron protein 0.0054 0.0242 0.0277
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0157 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.025 0.1529
Loa Loa (eye worm) DR-78 0.006 0.0274 0.0316
Leishmania major trypanothione reductase 0.0295 0.1614 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0152 0.0176
Brugia malayi MH2 domain containing protein 0.0058 0.0264 0.0532
Echinococcus granulosus zinc finger protein 0.0021 0.0054 0.0062
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0274 0.2105
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0673 0.3769 0.8969
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0157 0.0179
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0067 0.0314 0.0361
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0025 0.0032
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0041 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0025 0.0025
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0158 0.0836 0.5167
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0376 0.2078 0.2403
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0127 0.0655 0.0655
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0081 0.0393 0.0393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.2078 0.2401
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0279 0.032
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0046 0.0006
Trichomonas vaginalis esterase, putative 0.0226 0.1218 0.6137
Loa Loa (eye worm) Smad1 0.0058 0.0264 0.0305
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0027 0.0087 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0087 0.042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.0655 0.0655
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0067 0.012
Brugia malayi nuclear receptor NHR-67 0.006 0.0274 0.0553
Brugia malayi MH1 domain containing protein 0.0058 0.0264 0.0532
Schistosoma mansoni alpha-glucosidase 0.014 0.0732 0.0844
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.0836 0.5167
Giardia lamblia PHD finger protein 15 0.003 0.0101 0.0335
Loa Loa (eye worm) MH1 domain-containing protein 0.0058 0.0264 0.0305
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0087 0.0098
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0046 0.0006
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0027 0.0087 0.0057
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0027 0.0087 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0314 0.0638
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0147 0.077 0.0891
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.006 0.0274 0.0274
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0076 0.0444
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0127 0.0655 0.0655
Echinococcus granulosus importin subunit beta 1 0.0143 0.0749 0.0866
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.006 0.0274 0.0316
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0027 0.0087 0.041
Brugia malayi Calcitonin receptor-like protein seb-1 0.042 0.2329 0.4854
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0067 0.0314 0.0364
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0027 0.0087 0.0101
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0515 0.3175
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0087 0.041
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0041 0.0048
Echinococcus multilocularis thioredoxin glutathione reductase 0.0298 0.1629 0.1629
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0027 0.0087 0.0516
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0025 0.0029
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0027 0.0087 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.0026
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0009 0.0026
Trypanosoma brucei cytochrome P450, putative 0.003 0.0102 0.0608
Loa Loa (eye worm) hypothetical protein 0.0044 0.0183 0.0212
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0046 0.0006
Trypanosoma brucei unspecified product 0.0056 0.025 0.1529
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0009 0.0032
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0035 0.0134 0.0213
Echinococcus granulosus expressed protein 0.0016 0.0025 0.0029
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0027 0.0087 0.01
Echinococcus multilocularis ferritin 0.0035 0.0134 0.0134
Echinococcus multilocularis snurportin 1 0.1528 0.8646 0.8646
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0075 0.0361 0.0735
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0159 0.0183
Loa Loa (eye worm) hypothetical protein 0.0133 0.0691 0.0799
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0046 0.0053
Echinococcus multilocularis GA binding protein alpha chain 0.0147 0.077 0.077
Brugia malayi Latrophilin receptor protein 2 0.0133 0.0691 0.1426
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0025 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0088 0.0522
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0038 0.0042
Schistosoma mansoni nuclear hormone receptor 0.006 0.0274 0.0314
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0393 0.2963
Schistosoma mansoni alpha-glucosidase 0.014 0.0732 0.0844
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0027 0.0087 0.0403
Echinococcus granulosus survival motor neuron protein 1 0.0266 0.1447 0.1674
Brugia malayi hypothetical protein 0.0182 0.0973 0.2016
Brugia malayi RNA, U transporter 1 0.0407 0.2254 0.4696
Schistosoma mansoni hypothetical protein 0.0205 0.1099 0.1269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.2078 0.2401
Loa Loa (eye worm) hypothetical protein 0.0127 0.0655 0.0758
Loa Loa (eye worm) hypothetical protein 0.0226 0.1218 0.1409
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0393 0.2417
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0226 0.1218 0.1452
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.0393 0.2417
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0102 0.0515 0.3175
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0102 0.0515 0.3175
Giardia lamblia Thioredoxin reductase 0.0027 0.0087 0.0154
Plasmodium falciparum thioredoxin reductase 0.0102 0.0515 0.3013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.042 0.2329 0.4854
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0046 0.0006
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0025 0.0029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0081 0.0393 0.2417
Onchocerca volvulus Alhambra homolog 0.003 0.0101 0.0731
Onchocerca volvulus 0.0226 0.1218 0.9632
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0139 0.0733
Echinococcus multilocularis geminin 0.0205 0.1099 0.1099
Mycobacterium ulcerans esterase/lipase LipP 0.0226 0.1218 1
Toxoplasma gondii ABC1 family protein 0.0226 0.1218 0.7513
Schistosoma mansoni ran 0.0084 0.0412 0.0474
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0087 0.042
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0274 0.0316
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0041 0.0115
Echinococcus granulosus ferritin 0.0035 0.0134 0.0155
Brugia malayi nuclear receptor RXR 0.006 0.0274 0.0553
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.0515 0.3175
Loa Loa (eye worm) hypothetical protein 0.0118 0.0607 0.0702
Echinococcus granulosus mitogen activated protein kinase 0.0158 0.0836 0.0967
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0009 0.0026
Echinococcus granulosus glutamate synthase 0.0027 0.0087 0.0101
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0027 0.0087 0.0353
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0046 0.0006
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0046 0.0259
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0279 0.1986
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0087 0.042
Echinococcus granulosus FTZ F1 alpha 0.0127 0.0655 0.0758
Schistosoma mansoni cytochrome P450 0.002 0.0046 0.005
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0048 0.0056
Schistosoma mansoni bromodomain containing protein 0.0064 0.0299 0.0343
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0087 0.0403
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0127 0.0655 0.1352
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.0134 0.0114
Onchocerca volvulus 0.0035 0.013 0.0964
Loa Loa (eye worm) fli-1 protein 0.0446 0.2475 0.2862
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0139 0.0139
Leishmania major GTP-binding protein, putative 0.0084 0.0412 0.2535
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.0067 0.0314 0.0364
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0084 0.0412 0.2358
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0002 0.0002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0158 0.0836 0.5167
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0076 0.0444
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0127 0.0655 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0127 0.0655 0.1352
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0087 0.1409
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0025 0.0032
Loa Loa (eye worm) hypothetical protein 0.0226 0.1218 0.1409
Loa Loa (eye worm) hypothetical protein 0.006 0.0274 0.0316
Onchocerca volvulus 0.0182 0.0973 0.7677
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0065 0.0116
Brugia malayi MH1 domain containing protein 0.0058 0.0264 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0076 0.0444
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0274 0.0316
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0152 0.2501
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0127 0.0655 0.0655
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0027 0.0087 0.0353
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0087 0.042
Echinococcus multilocularis dna polymerase kappa 0.0081 0.0393 0.0393
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0087 0.0516
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0025 0.0104
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0673 0.3769 0.4599
Loa Loa (eye worm) nuclear factor I 0.0032 0.0116 0.0134
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0087 0.0163
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0009 0.0032
Schistosoma mansoni smad 0.0058 0.0264 0.0302
Schistosoma mansoni importin-beta 2 0.0027 0.0087 0.0098
Entamoeba histolytica hypothetical protein 0.0039 0.0157 0.2591
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0152 0.1506
Loa Loa (eye worm) hypothetical protein 0.0182 0.0973 0.1125
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0035 0.0134 0.1095
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0286 0.0331
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.006 0.0274 0.0314
Loa Loa (eye worm) hypothetical protein 0.0067 0.0314 0.0364
Loa Loa (eye worm) nuclear receptor nhr-7B 0.006 0.0274 0.0316
Mycobacterium tuberculosis Probable reductase 0.0673 0.3769 0.4599
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0127 0.0655 0.1352
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0027 0.0087 0.0057
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0025 0.0029
Echinococcus granulosus peregrin 0.0032 0.0114 0.0132
Echinococcus multilocularis ewsr:fli fusion protein type 0.0021 0.0054 0.0054
Schistosoma mansoni glutamate synthase 0.0027 0.0087 0.0098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0127 0.0655 0.0755
Mycobacterium ulcerans ferredoxin reductase 0.0027 0.0087 0.0353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0515 0.3175
Echinococcus granulosus importin 5 0.0027 0.0087 0.0101
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0025 0.0026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0127 0.0655 0.0655
Schistosoma mansoni nuclear receptor 0.006 0.0274 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0076 0.0444
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0027 0.0087 0.0087
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.006 0.0274 0.0314
Trichomonas vaginalis glutathione reductase, putative 0.0102 0.0515 0.2584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.02 0.0228
Schistosoma mansoni importin beta-1 0.0143 0.0749 0.0864
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0087 0.0516
Schistosoma mansoni cpg binding protein 0.0039 0.0152 0.0173
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0058 0.0264 0.0264
Schistosoma mansoni hypothetical protein 0.0021 0.0054 0.006
Brugia malayi latrophilin 2 splice variant baaae 0.0287 0.1571 0.3267
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0102 0.0515 0.3093
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0027 0.0087 0.0516
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0027 0.0087 0.0154
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0025 0.0029
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0028 0.003
Echinococcus multilocularis Smad4 0.0058 0.0264 0.0264
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0485 0.056
Onchocerca volvulus 0.0016 0.0025 0.0122
Echinococcus granulosus thyroid hormone receptor alpha 0.006 0.0274 0.0316
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0133 0.0691 0.0799
Leishmania major hypothetical protein, conserved 0.0015 0.0018 0.0088
Trichomonas vaginalis apoptosis inducing factor, putative 0.0027 0.0087 0.042

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.4 uM Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 20810285
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20810285

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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