Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1028 | 0.1028 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0286 | 0.0974 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0099 | 0.0025 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 0.5 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0017 | 0.0286 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0608 | 0.2108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0286 | 0.0974 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0074 | 0.0074 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0286 | 0.0974 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Echinococcus multilocularis | smad | 0.0009 | 0.0099 | 0.0025 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0286 | 0.0974 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0648 | 0.0648 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0099 | 0.0316 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0099 | 0.0099 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.1351 | 0.4728 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0648 | 0.0578 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0099 | 0.0025 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1028 | 0.0961 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0099 | 0.0316 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0017 | 0.0286 | 0.0213 |
Onchocerca volvulus | 0.0031 | 0.0608 | 0.5 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0286 | 0.0974 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.2847 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0154 | 0.3424 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0063 | 0.1351 | 0.1286 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0017 | 0.0286 | 0.0213 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0017 | 0.0286 | 0.0213 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0154 | 0.3424 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0099 | 0.0316 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0648 | 0.0648 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0063 | 0.1351 | 0.1286 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0017 | 0.0286 | 0.0213 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0063 | 0.1351 | 0.1286 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0286 | 0.0974 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0286 | 0.0974 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1028 | 0.359 |
Schistosoma mansoni | protein phosphatase 2C | 0.0017 | 0.0286 | 0.0286 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.1403 | 0.1403 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0017 | 0.0286 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0017 | 0.0286 | 0.5 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0019 | 0.0326 | 0.0253 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0099 | 0.0099 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0017 | 0.0286 | 0.0213 |
Schistosoma mansoni | jumonji domain containing protein | 0.0063 | 0.1351 | 0.1351 |
Echinococcus granulosus | smad | 0.0009 | 0.0099 | 0.0025 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0065 | 0.1391 | 0.1327 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0019 | 0.0326 | 0.0253 |
Schistosoma mansoni | jumonji domain containing protein | 0.0017 | 0.0286 | 0.0286 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0648 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0286 | 0.0974 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0099 | 0.0099 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1028 | 0.1028 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1028 | 0.0961 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0154 | 0.3424 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0315 | 0.7117 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0286 | 0.0974 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0099 | 0.0025 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0017 | 0.0286 | 0.0286 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1028 | 0.1028 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0065 | 0.1391 | 0.1391 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0099 | 0.0099 |
Brugia malayi | Smad1 | 0.0009 | 0.0099 | 0.0316 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0099 | 0.0025 |
Schistosoma mansoni | phd/f-box containing protein | 0.0017 | 0.0286 | 0.0286 |
Plasmodium vivax | JmjC domain containing protein | 0.0017 | 0.0286 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0608 | 0.0608 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0315 | 0.7117 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0286 | 0.0974 |
Echinococcus multilocularis | phd:f box containing protein | 0.0017 | 0.0286 | 0.0213 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0099 | 0.0025 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1028 | 0.0961 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0099 | 0.0099 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0099 | 0.0316 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0017 | 0.0286 | 0.0213 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0315 | 0.7117 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1028 | 0.0961 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0065 | 0.1391 | 0.487 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0608 | 0.2108 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1028 | 0.359 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0017 | 0.0286 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.2847 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0065 | 0.1391 | 0.487 |
Echinococcus granulosus | phd:f box containing protein | 0.0017 | 0.0286 | 0.0213 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0017 | 0.0286 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.2847 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0099 | 0.0316 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0099 | 0.0025 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0118 | 0.0382 |
Schistosoma mansoni | smad | 0.0009 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0099 | 0.0316 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0099 | 0.0316 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0115 | 0.0372 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0017 | 0.0286 | 0.0286 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.1242 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0065 | 0.1391 | 0.1391 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 mM | Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose 1 phosphate | ChEMBL. | 18485716 |
Inhibition (binding) | = 65 % | Inhibition of rabbit glycogen phosphorylase assessed as release of phosphate from glucose 1 phosphate at 22 mM | ChEMBL. | 18485716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.