Detailed information for compound 1181965

Basic information

Technical information
  • TDR Targets ID: 1181965
  • Name: N-(1,3-benzodioxol-5-ylmethyl)-2-[(5-chloro-2 -methoxyphenyl)sulfonyl-methylamino]acetamide
  • MW: 426.871 | Formula: C18H19ClN2O6S
  • H donors: 1 H acceptors: 3 LogP: 2.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)N(CC(=O)NCc1ccc2c(c1)OCO2)C)Cl
  • InChi: 1S/C18H19ClN2O6S/c1-21(28(23,24)17-8-13(19)4-6-15(17)25-2)10-18(22)20-9-12-3-5-14-16(7-12)27-11-26-14/h3-8H,9-11H2,1-2H3,(H,20,22)
  • InChiKey: KYTZGDRCDDPIIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(1,3-benzodioxol-5-ylmethyl)-2-[(5-chloro-2-methoxy-phenyl)sulfonyl-methyl-amino]acetamide
  • N-(1,3-benzodioxol-5-ylmethyl)-2-[(5-chloro-2-methoxy-phenyl)sulfonyl-methyl-amino]ethanamide
  • ASN 12932716
  • STK319147

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0456 0.589 0.589
Echinococcus granulosus kelch ECH associated protein 1 0.0105 0.1289 0.1289
Onchocerca volvulus 0.0047 0.0525 0.2063
Trypanosoma cruzi glyoxalase II 0.0018 0.0141 0.0563
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0158 0.1589
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0395
Brugia malayi hypothetical protein 0.0018 0.0141 0.0415
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0249 0.0478
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0148 0.0587
Trichomonas vaginalis beta lactamase domain, putative 0.0018 0.0141 0.0338
Mycobacterium ulcerans hypothetical protein 0.0018 0.0141 0.0187
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0248 0.0592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0037 0.0037
Trypanosoma brucei unspecified product 0.0028 0.0273 0.1083
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0107 0.1313 0.1313
Onchocerca volvulus Serine\/threonine kinase homolog 0.0198 0.2505 0.9834
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0249 0.0995
Mycobacterium ulcerans lipoprotein LpqF 0.0142 0.1771 0.457
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0099
Onchocerca volvulus 0.001 0.0037 0.0146
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0018 0.0141 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0148 0.0148
Brugia malayi protein M110.5 0.0008 0.0013 0.0039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0148 0.0336
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0448 0.0916
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0395 0.1551
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0072 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0395
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0099 0.039
Echinococcus granulosus pyruvate kinase 0.0019 0.0158 0.0158
Entamoeba histolytica alkyl sulfatase, putative 0.0018 0.0141 0.0338
Trypanosoma brucei unspecified product 0.0028 0.0273 0.1083
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0107 0.131 0.6304
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0148 0.0355
Trichomonas vaginalis hypothetical protein 0.0038 0.0403 0.0963
Entamoeba histolytica metallo-beta-lactamase family protein 0.0018 0.0141 0.0338
Brugia malayi pyruvate kinase 0.0008 0.001 0.003
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0296 0.3789 1
Schistosoma mansoni tensin-related 0.0008 0.0013 0.0013
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0077 0.0924 0.0924
Echinococcus granulosus raf serine:threonine protein kinase 0.0048 0.0538 0.0538
Echinococcus multilocularis ETHE1 protein 0.0018 0.0141 0.0141
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.4182 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0099 0.0703
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0142 0.1771 0.8787
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0249 0.4568
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0099 0.0237
Trichomonas vaginalis apoptosis inducing factor, putative 0.0022 0.0192 0.0459
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0437 0.0982
Echinococcus granulosus hypothetical protein 0.0008 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0141 0.0338
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0437 0.1501
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0569 0.0569
Loa Loa (eye worm) histone methyltransferase 0.001 0.0037 0.0085
Leishmania major metallo-beta-lactamase family protein-like protein 0.0018 0.0141 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0538 0.0538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0006
Brugia malayi RNA, U transporter 1 0.0091 0.1107 0.3249
Echinococcus multilocularis voltage dependent calcium channel 0.0107 0.1313 0.1313
Brugia malayi TBC domain containing protein 0.0008 0.0013 0.0039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0148 0.0206
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0437 0.1045
Trypanosoma brucei trypanothione reductase 0.0042 0.0461 0.1834
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.1169 0.29
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0099 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0864 0.0864
Echinococcus multilocularis G protein signaling modulator 2 0.0013 0.0084 0.0084
Brugia malayi glutathione reductase 0.0042 0.0461 0.1353
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0207
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0605 0.0605
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0166 0.2092 0.4745
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0141 0.0338
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0107 0.1313 0.1313
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0437 0.0982
Mycobacterium ulcerans hydrolase 0.0018 0.0141 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0864 0.0864
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0018 0.0141 0.0338
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0395 0.1578
Echinococcus multilocularis pyruvate kinase 0.0029 0.0292 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0437 0.0437
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0018 0.0141 0.0141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0037 0.0037
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0107 0.1313 0.3855
Entamoeba histolytica hypothetical protein 0.0013 0.0077 0.0185
Brugia malayi CED-6 protein 0.0008 0.0013 0.0039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0448 0.1789
Loa Loa (eye worm) hypothetical protein 0.0037 0.0395 0.0896
Entamoeba histolytica metallo-beta-lactamase family protein 0.0018 0.0141 0.0338
Plasmodium falciparum thioredoxin reductase 0.0015 0.0099 0.0703
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0249 0.0596
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0003 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0434 0.0434
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0434 0.0434
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0795 0.1947
Plasmodium vivax unspecified product 0.0018 0.0141 0.1786
Schistosoma mansoni hypothetical protein 0.0047 0.0525 0.0525
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 0.4182 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0099 0.0815
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.032
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0329 0.1308
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.1169 0.29
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0077 0.0309
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.032
Trichomonas vaginalis beta lactamase domain, putative 0.0018 0.0141 0.0338
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0142 0.1771 0.453
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0702 0.0702
Entamoeba histolytica hypothetical protein 0.0013 0.0077 0.0185
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0448 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.2505 0.2505
Echinococcus multilocularis regulator of G protein signaling 7 0.0015 0.0107 0.0107
Echinococcus granulosus pyruvate kinase 0.0019 0.0158 0.0158
Treponema pallidum fructose-bisphosphate aldolase 0.0325 0.4182 1
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0605 0.0605
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0048 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0273 0.1083
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0018 0.0141 0.0563
Echinococcus multilocularis pyruvate kinase 0.0037 0.0395 0.0395
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0107 0.1313 0.1313
Brugia malayi ethe1-prov protein 0.0018 0.0141 0.0415
Loa Loa (eye worm) hypothetical protein 0.0107 0.1313 0.2977
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0329 0.3849
Mycobacterium tuberculosis Conserved protein 0.0018 0.0141 0.0114
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0018 0.0141 0.0558
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0249 0.0596
Loa Loa (eye worm) hypothetical protein 0.0041 0.0448 0.1016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0099 0.0074
Echinococcus granulosus geminin 0.0165 0.2079 0.2079
Echinococcus multilocularis sodium channel protein 0.0045 0.0504 0.0504
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0099 0.039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0012 0.0012
Entamoeba histolytica hypothetical protein, conserved 0.0018 0.0141 0.0338
Echinococcus multilocularis amyloid beta A4 protein 0.0078 0.0927 0.0927
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0795 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0569 0.136
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0395 0.8319
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0018 0.0141 0.0169
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0018 0.0141 0.0141
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0569 0.0569
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2505 0.5991
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0448 0.1072
Loa Loa (eye worm) DIX domain-containing protein 0.0014 0.0091 0.0207
Echinococcus multilocularis pyruvate kinase 0.0037 0.0395 0.0395
Brugia malayi serine/threonine-protein kinase plk-2 0.0198 0.2505 0.7357
Brugia malayi metallo-beta-lactamase superfamily protein 0.0018 0.0141 0.0415
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0248 0.0562
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0329 0.1308
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0077 0.0924 0.0924
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0099 0.0112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0006
Echinococcus granulosus voltage dependent calcium channel 0.0022 0.0202 0.0202
Schistosoma mansoni cpg binding protein 0.0034 0.0351 0.0351
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0525 0.1543
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0037 0.011
Onchocerca volvulus 0.0053 0.0605 0.2375
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0437 0.1739
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2505 0.5991
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0795 0.1947
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0072 0.0281
Brugia malayi polk-prov protein 0.0013 0.0072 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Echinococcus granulosus snurportin 1 0.0343 0.4409 0.4409
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0141 0.0338
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0468 0.0468
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0141 0.0114
Echinococcus multilocularis kelch ECH associated protein 1 0.0105 0.1289 0.1289
Trichomonas vaginalis beta lactamase domain, putative 0.0018 0.0141 0.0338
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0437 0.0437
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0018 0.0141 0.137
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0249 0.5074
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0048 0.0142
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0072 0.0454
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.007 0.0821 0.241
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0148 0.0592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1196 0.2861
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0461 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0014 0.0091 0.0268
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.0504 0.0504
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0018 0.0141 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0437 0.1744
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2505 0.5991
Schistosoma mansoni amyloid beta A4 protein related 0.0078 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Brugia malayi CXXC zinc finger family protein 0.0032 0.0327 0.0961
Echinococcus multilocularis carboxyl terminal PDZ ligand of neuronal nitric 0.0008 0.0013 0.0013
Schistosoma mansoni numb 0.0008 0.0013 0.0013
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2938 0.2938
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0468 0.0468
Brugia malayi GoLoco motif family protein 0.0013 0.0084 0.0246
Loa Loa (eye worm) hypothetical protein 0.002 0.0166 0.0377
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0107 0.1313 0.1313
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0099 0.0395
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0099 0.0291
Brugia malayi MAP kinase sur-1 0.005 0.0569 0.167
Echinococcus granulosus importin subunit beta 1 0.0032 0.0329 0.0329
Loa Loa (eye worm) GoLoco domain-containing protein family protein 0.0013 0.0084 0.019
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0107 0.1313 0.1313
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0112
Loa Loa (eye worm) MBCTL1 0.006 0.0702 0.1591
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0018 0.0141 0.0141
Mycobacterium ulcerans beta lactamase-like protein 0.0018 0.0141 0.0187
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0448 0.0448
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0072 0.0454
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0107 0.1313 0.1313
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0395 0.4721
Brugia malayi Thioredoxin reductase 0.0042 0.0461 0.1353
Loa Loa (eye worm) pyruvate kinase 0.0008 0.001 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0437 0.1744
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0107 0.131 0.3282
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2505 0.5991
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0249 0.0596
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.1995 0.5175
Echinococcus multilocularis kelch ECH associated protein 1 0.0105 0.1289 0.1289
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0437 0.1045
Trichomonas vaginalis beta lactamase domain, putative 0.0018 0.0141 0.0338
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0437 0.0437
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0014 0.0091 0.0359
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0018 0.0141 0.0558
Brugia malayi TAR-binding protein 0.0073 0.0864 0.2537
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0185
Trypanosoma cruzi DNA polymerase eta, putative 0.0013 0.0072 0.0286
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0395 0.1578
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0249 0.0407
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0395 0.0896
Onchocerca volvulus 0.0018 0.0141 0.0554
Entamoeba histolytica hypothetical protein 0.004 0.0434 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0141 0.0338
Leishmania major pyruvate kinase 0.0037 0.0395 0.1329
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.1995 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0107 0.131 0.3282
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0233 0.0929
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0099 0.0074
Brugia malayi Mammalian fe65 homolog protein 1 0.0008 0.0013 0.0039
Schistosoma mansoni voltage-gated cation channel 0.0107 0.1313 0.1313
Schistosoma mansoni tsg101-related 0.0064 0.0754 0.0754
Loa Loa (eye worm) raf kinase 0.0048 0.0538 0.122
Entamoeba histolytica hypothetical protein 0.0013 0.0077 0.0185
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0148 0.1971
Onchocerca volvulus Putative hydrolase PNKD 0.0018 0.0141 0.0554
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0461 0.098
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Schistosoma mansoni hypothetical protein 0.0105 0.1293 0.1293
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0148 0.0134
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0569 0.227
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0198 0.2505 0.5991
Echinococcus multilocularis snurportin 1 0.0343 0.4409 0.4409
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0107 0.131 0.3282
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0569 0.0569
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0018 0.0141 0.0563
Mycobacterium tuberculosis Conserved protein 0.0018 0.0141 0.0114
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0702 0.206
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.3406 0.7723
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0148 0.0315
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.4182 1
Schistosoma mansoni shc transforming protein 0.0008 0.0013 0.0013
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0702 0.0702
Echinococcus granulosus voltage dependent calcium channel 0.0107 0.1313 0.1313
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.006 0.0702 0.1591
Leishmania major hypothetical protein, conserved 0.0018 0.0141 0.0285
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0055 0.0161
Schistosoma mansoni kinase 0.0101 0.1231 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0018 0.0141 0.0554
Echinococcus multilocularis geminin 0.0165 0.2079 0.2079
Echinococcus multilocularis voltage dependent calcium channel 0.0107 0.1313 0.1313
Entamoeba histolytica hypothetical protein 0.004 0.0434 0.1037
Loa Loa (eye worm) calcium channel 0.0107 0.1313 0.2977
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Brugia malayi RNA binding protein 0.0073 0.0864 0.2537
Plasmodium falciparum thioredoxin reductase 0.0042 0.0461 1
Chlamydia trachomatis ribonuclease Z 0.0018 0.0141 0.1421
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0099 0.0703
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0304
Echinococcus granulosus kelch ECH associated protein 1 like 0.0105 0.1289 0.1289
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0072 0.0281
Schistosoma mansoni pyruvate kinase 0.0019 0.0158 0.0158
Leishmania major pyruvate kinase 0.0037 0.0395 0.1329
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0018 0.0141 0.0558
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0605 0.0605
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.589 0.589
Schistosoma mansoni ap endonuclease 0.0018 0.0148 0.0148
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0018 0.0141 0.0563
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0605 0.0605
Echinococcus multilocularis pyruvate kinase 0.0019 0.0158 0.0158
Schistosoma mansoni DNA polymerase eta 0.004 0.0437 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0569 0.0569
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0395
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0112
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0012 0.0012
Loa Loa (eye worm) X11 protein 0.0078 0.0927 0.2102
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0018 0.0141 0.137
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.2505 1
Brugia malayi mbt repeat family protein 0.0053 0.0605 0.1776
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0461 0.1839
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0018 0.0141 0.0563
Schistosoma mansoni hypothetical protein 0.0018 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0231 0.2938 0.6663
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0202 0.2168
Schistosoma mansoni hypothetical protein 0.004 0.0434 0.0434
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0569 0.7011
Brugia malayi hypothetical protein 0.0073 0.0873 0.2562
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.002 0.0166 0.17
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0107 0.1313 0.1313
Leishmania major importin beta-1 subunit, putative 0.0026 0.0249 0.073
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0072 0.0281
Onchocerca volvulus 0.0093 0.1123 0.4409
Mycobacterium ulcerans glyoxalase II, GloB 0.0018 0.0141 0.0187
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0448 0.1784
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0163
Schistosoma mansoni cpg binding protein 0.0032 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0201 0.2548 0.5778
Mycobacterium ulcerans hypothetical protein 0.0018 0.0141 0.0187
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0018 0.0141 0.0563
Loa Loa (eye worm) hypothetical protein 0.0077 0.0924 0.2096
Loa Loa (eye worm) hypothetical protein 0.0093 0.1123 0.2548
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0072 0.0072
Brugia malayi RasGEF domain containing protein 0.0011 0.0054 0.0159
Entamoeba histolytica hypothetical protein 0.004 0.0434 0.1037
Trichomonas vaginalis A-type flavoprotein 0.0018 0.0141 0.0338
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0448 0.0448
Schistosoma mansoni z-protein (S1r protein) 0.0015 0.0107 0.0107
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0395 0.0945
Brugia malayi Raf kinase 0.0048 0.0538 0.158
Echinococcus granulosus dnaJ subfamily B 0.0456 0.589 0.589
Echinococcus granulosus amyloid beta A4 protein 0.0078 0.0927 0.0927
Schistosoma mansoni pyruvate kinase 0.0037 0.0395 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Echinococcus multilocularis segment polarity protein dishevelled 0.0014 0.0091 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Schistosoma mansoni pyruvate kinase 0.0037 0.0395 0.0395
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0569 0.129
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0434 0.0434
Brugia malayi hypothetical protein 0.004 0.0434 0.1273
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0795 0.1887
Echinococcus multilocularis muscleblind protein 1 0.0166 0.2092 0.2092
Toxoplasma gondii thioredoxin reductase 0.0042 0.0461 0.5584
Echinococcus granulosus segment polarity protein dishevelled 0.0014 0.0091 0.0091
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0249 0.073
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0148 0.0436
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0448 0.0448
Echinococcus granulosus pyruvate kinase 0.0037 0.0395 0.0395
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0015 0.0107 0.0244
Schistosoma mansoni hypothetical protein 0.0008 0.0013 0.0013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0569 0.227
Trypanosoma cruzi glyoxalase II 0.0018 0.0141 0.0563
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0795 0.0795
Schistosoma mansoni survival motor neuron protein 0.0047 0.0525 0.0525
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0018 0.0141 0.032
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0437 0.1739
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0703 0.8783
Echinococcus multilocularis dna polymerase kappa 0.004 0.0437 0.0437
Schistosoma mansoni cpg binding protein 0.0034 0.0351 0.0351
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0461 0.1045
Plasmodium vivax importin-beta 2, putative 0.0032 0.0329 0.6618
Loa Loa (eye worm) voltage-dependent calcium channel 0.0022 0.0202 0.0457
Brugia malayi follicle stimulating hormone receptor 0.0266 0.3406 1
Trichomonas vaginalis beta lactamase domain, putative 0.0018 0.0141 0.0338
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0448 0.1789
Echinococcus granulosus protein numb 0.0008 0.0013 0.0013
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0395 0.0896
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0018 0.0141 0.0415
Trypanosoma brucei polo-like protein kinase 0.0198 0.2505 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0072 0.0286
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0395 0.1573
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.1169 0.29
Echinococcus granulosus ETHE1 protein 0.0018 0.0141 0.0141
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0018 0.0141 0.1786
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0437 0.1283
Plasmodium falciparum glutathione reductase 0.0015 0.0099 0.0703
Echinococcus multilocularis tensin 0.0008 0.0013 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0864 0.196
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0437 0.1744
Echinococcus granulosus SHC transforming protein 3 0.0008 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2505 0.5991
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0198 0.2505 0.2505
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0448 0.1072
Entamoeba histolytica hypothetical protein 0.0026 0.0249 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1196 0.2861
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0107 0.1313 0.1313
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0448 0.0448
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0437 0.1744
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0569 0.0569
Chlamydia trachomatis pyruvate kinase 0.0037 0.0395 1
Onchocerca volvulus 0.0018 0.0141 0.0554
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0795 0.2974
Schistosoma mansoni tsg101-related 0.0064 0.0754 0.0754
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0702 0.0702
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0395 0.137
Echinococcus granulosus kelch ECH associated protein 1 like 0.0105 0.1289 0.1289
Schistosoma mansoni dep domain containing protein 0.001 0.0037 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0099 0.0395
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0327 0.4197 0.4197
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0395 0.0803
Schistosoma mansoni zinc phosphodiesterase 0.0018 0.0141 0.0141
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0018 0.0141 0.2801
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0437 0.1744
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0141 0.0338
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0249 0.099
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0099 0.0067
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0233 0.0923
Plasmodium falciparum pyruvate kinase 0.0037 0.0395 0.8319
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.1169 0.29
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0795 0.0795
Loa Loa (eye worm) RasGEF domain-containing protein 0.0011 0.0054 0.0123
Entamoeba histolytica type A flavoprotein, putative 0.0018 0.0141 0.0338
Schistosoma mansoni hypothetical protein 0.0018 0.0141 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0395
Brugia malayi Muscleblind-like protein 0.0166 0.2092 0.6143
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0018 0.0141 0.032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.032
Echinococcus multilocularis protein numb 0.0008 0.0013 0.0013
Brugia malayi hypothetical protein 0.001 0.0037 0.011
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0065 0.0762 0.3039
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0074
Echinococcus granulosus regulator of G protein signaling 7 0.0015 0.0107 0.0107
Loa Loa (eye worm) glutathione reductase 0.0042 0.0461 0.1045
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.0166 0.2092 0.4745
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0249 0.4568
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0569 0.2043
Brugia malayi hypothetical protein 0.0231 0.2938 0.8626
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0018 0.0141 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0273 0.1083
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0099 0.0395
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.1169 0.5545
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0569 0.227
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0569 0.136
Schistosoma mansoni hypothetical protein 0.0013 0.0084 0.0084
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0201 0.2548 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Schistosoma mansoni importin beta-1 0.0032 0.0329 0.0329
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0437 0.1739
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0605 0.0605
Echinococcus granulosus zinc phosphodiesterase 0.0018 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0165 0.2079 0.2079
Leishmania major DNA polymerase kappa, putative 0.004 0.0437 0.1501
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0864 0.0864
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0077 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0141 0.0338
Mycobacterium tuberculosis Beta lactamase like protein 0.0018 0.0141 0.0114
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.4409 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0569 0.2043
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0702 0.0702
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0198 0.2505 0.5682
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0072 0.0454
Loa Loa (eye worm) hypothetical protein 0.0022 0.0202 0.0457
Plasmodium vivax glutathione reductase, putative 0.0042 0.0461 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0395 0.1573
Brugia malayi regulator of G-protein signaling egl-10 0.0015 0.0107 0.0315
Echinococcus granulosus muscleblind protein 0.0166 0.2092 0.2092
Entamoeba histolytica hypothetical protein 0.0026 0.0249 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0037 0.0037
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0437 0.1283
Schistosoma mansoni tensin-related 0.0008 0.0013 0.0013
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0099 0.039
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0107 0.0107
Trypanosoma brucei unspecified product 0.004 0.0437 0.1739
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Brugia malayi DIX domain containing protein 0.0014 0.0091 0.0268
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0099 0.0703
Loa Loa (eye worm) hypothetical protein 0.004 0.0437 0.0991
Plasmodium falciparum importin beta, putative 0.0032 0.0329 0.6618
Giardia lamblia Pyruvate kinase 0.0037 0.0395 0.0787
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0437 0.1739
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0006
Brugia malayi hypothetical protein 0.001 0.0037 0.011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.1169 0.29
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0448 0.0448
Brugia malayi GoLoco motif family protein 0.0013 0.0084 0.0246
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0864 0.196
Mycobacterium ulcerans hydrolase 0.0018 0.0141 0.0187
Loa Loa (eye worm) RNA binding protein 0.0073 0.0864 0.196
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0249 0.2797
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0448 0.0448
Leishmania major hypothetical protein, conserved 0.0025 0.0233 0.0661
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0395 0.1161
Schistosoma mansoni dishevelled 0.0014 0.0091 0.0091
Onchocerca volvulus 0.0008 0.0013 0.0053
Echinococcus multilocularis regulator of G protein signaling 7 0.0015 0.0107 0.0107
Echinococcus granulosus dna polymerase kappa 0.004 0.0437 0.0437
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0702 0.0702
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0395 0.087
Schistosoma mansoni dishevelled 0.0014 0.0091 0.0091
Echinococcus multilocularis segment polarity protein dishevelled 0.0014 0.0091 0.0091
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0864 0.0864
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0448 0.1072
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.2505 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0448 0.1072
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.1123 0.1123
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0141 0.0114
Echinococcus multilocularis cpg binding protein 0.0034 0.0351 0.0351
Echinococcus granulosus regulator of G protein signaling 7 0.0015 0.0107 0.0107
Schistosoma mansoni zinc phosphodiesterase 0.0018 0.0141 0.0141
Echinococcus multilocularis muscleblind protein 0.0166 0.2092 0.2092
Schistosoma mansoni hypothetical protein 0.0018 0.0141 0.0141
Plasmodium falciparum cytosolic glyoxalase II 0.0018 0.0141 0.1786
Loa Loa (eye worm) hypothetical protein 0.0015 0.0107 0.0244
Loa Loa (eye worm) hypothetical protein 0.002 0.0166 0.0377
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0296 0.3789 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0148 0.1465
Giardia lamblia Pyruvate kinase 0.0019 0.0158 0.0209
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0605 0.0605
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0099 0.0703
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0395
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0018 0.0141 0.0338
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0249 0.0583
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0448 0.1547
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0795 0.1947
Onchocerca volvulus 0.0008 0.0013 0.0053
Brugia malayi hypothetical protein 0.0008 0.0013 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0072 0.0281
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0072 0.0281
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0569 0.227
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0072 0.0286
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0249 0.0368
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2505 0.5991
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Onchocerca volvulus 0.0032 0.0327 0.1285
Echinococcus granulosus segment polarity protein dishevelled 0.0014 0.0091 0.0091
Entamoeba histolytica metallo-beta-lactamase family protein 0.0018 0.0141 0.0338
Trypanosoma brucei glyoxalase II 0.0018 0.0141 0.0558
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0605 0.0605
Echinococcus multilocularis SHC transforming protein 3 0.0008 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0273 0.1083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0141 0.0114
Schistosoma mansoni hypothetical protein 0.0165 0.2079 0.2079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0012 0.0012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0437 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0006
Mycobacterium tuberculosis Conserved protein 0.0018 0.0141 0.0114
Echinococcus granulosus pyruvate kinase 0.0019 0.0158 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0185
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0003 0.0006
Entamoeba histolytica alkyl sulfatase, putative 0.0018 0.0141 0.0338
Loa Loa (eye worm) hypothetical protein 0.0026 0.0248 0.0562
Schistosoma mansoni hypothetical protein 0.0343 0.4409 0.4409
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0072 0.0286
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0141 0.0114
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0072 0.0281
Loa Loa (eye worm) AIDA-1b 0.0008 0.0013 0.003
Entamoeba histolytica type A flavoprotein, putative 0.0018 0.0141 0.0338
Echinococcus multilocularis pyruvate kinase 0.0019 0.0158 0.0158
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0213 0.2705 0.2705
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0018 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0198 0.2505 0.2505
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0437 0.0437
Giardia lamblia DINP protein human, muc B family 0.004 0.0437 0.0889
Brugia malayi AIDA-1b 0.0008 0.0013 0.0039
Trypanosoma cruzi glyoxalase II 0.0018 0.0141 0.0563
Brugia malayi mbt repeat family protein 0.0053 0.0605 0.1776
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0192 0.0459
Echinococcus granulosus carboxyl terminal PDZ ligand of neuronal nitric 0.0008 0.0013 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0148 0.0148
Schistosoma mansoni ap endonuclease 0.0018 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0605 0.1372
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0053 0.0599 0.1433
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0148 0.0186
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0036 0.0105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0798 0.0798
Echinococcus granulosus cpg binding protein 0.0034 0.0351 0.0351
Mycobacterium tuberculosis Probable reductase 0.0096 0.1169 0.29
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0018 0.0141 0.0169
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0012 0.0012
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0018 0.0141 0.0141
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0018 0.0141 0.0563
Trichomonas vaginalis beta lactamase domain, putative 0.0018 0.0141 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0249 0.2797
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0795 0.0795
Giardia lamblia Kinase, PLK 0.0198 0.2505 0.5921
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0198 0.2505 1
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0395 0.1551
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0158 0.2213
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0072 0.0281
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0395 0.0945
Echinococcus multilocularis raf serine:threonine protein kinase 0.0048 0.0538 0.0538
Plasmodium falciparum glutathione reductase 0.0042 0.0461 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0795 0.0795
Echinococcus multilocularis pyruvate kinase 0.0019 0.0158 0.0158
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0448 0.0448
Mycobacterium ulcerans hypothetical protein 0.0018 0.0141 0.0187
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2938 0.2938
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Entamoeba histolytica hypothetical protein 0.0013 0.0077 0.0185
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0569 0.1209
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0065 0.0762 0.3043
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0437 0.1739
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0395 0.0896
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.1123 0.1123
Echinococcus multilocularis Kelch repeat type 1 0.0105 0.1293 0.1293
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0437 0.0916
Mycobacterium ulcerans hypothetical protein 0.0018 0.0141 0.0187
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Leishmania major metallo-beta-lactamase family-like protein 0.0018 0.0141 0.0285
Entamoeba histolytica hypothetical protein 0.004 0.0434 0.1037
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0864 0.2537
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0099 0.039
Brugia malayi hypothetical protein 0.0077 0.0924 0.2714
Loa Loa (eye worm) hypothetical protein 0.0032 0.0329 0.0746
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0213 0.2705 0.2705
Echinococcus granulosus pyruvate kinase 0.0037 0.0395 0.0395
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.1123 0.3299
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0448 0.1316
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2505 0.5991
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0864 0.0864
Brugia malayi N-terminal motif family protein 0.0201 0.2548 0.7481
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0437 0.1045
Brugia malayi Importin beta-1 subunit 0.0032 0.0329 0.0966
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0327 0.0742
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0107 0.1313 0.1313
Mycobacterium ulcerans hydrolase 0.0018 0.0141 0.0187
Trichomonas vaginalis helicase, putative 0.0007 0.0003 0.0006
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0148 0.0121
Loa Loa (eye worm) hypothetical protein 0.0073 0.0873 0.1979
Trypanosoma brucei beta lactamase 0.0142 0.1771 0.7066
Schistosoma mansoni tsg101-related 0.0053 0.0599 0.0599
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0249 0.0478
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0569 0.136
Trypanosoma brucei protein kinase, putative 0.005 0.0569 0.2266
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0605 0.1372
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0395 0.1161
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0148 0.328
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0569 0.2266
Echinococcus multilocularis zinc phosphodiesterase 0.0018 0.0141 0.0141
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0148 0.0355
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0006
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.001 0.003
Echinococcus granulosus dna polymerase eta 0.004 0.0437 0.0437
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.1995 0.5139
Treponema pallidum ribonuclease Z 0.0018 0.0141 0.0103
Echinococcus multilocularis dna polymerase eta 0.004 0.0437 0.0437
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0605 0.2375
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0148 0.0355
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0395 0.1551
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0018 0.0141 0.0141
Leishmania major trypanothione reductase 0.0042 0.0461 0.1598
Leishmania major DNA polymerase eta, putative 0.004 0.0437 0.1501
Echinococcus granulosus tar DNA binding protein 0.0073 0.0864 0.0864
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0099 0.0112
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0099 0.0815
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0006
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0141 0.0114
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0569 0.136
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0158 0.2213
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0077 0.0309
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0148 0.0592
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0018 0.0141 0.0285
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0018 0.0141 0.0187
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0249 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0437 0.0916
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0395
Echinococcus granulosus G protein signaling modulator 2 0.0013 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.4182 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0864 0.0864
Brugia malayi metallo-beta-lactamase superfamily protein 0.0018 0.0141 0.0415
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.1123 0.1123
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0018 0.0141 0.0141
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0148 0.1971

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.