Detailed information for compound 1182084

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.567 | Formula: C25H37NO2
  • H donors: 0 H acceptors: 2 LogP: 9.08 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCC/C=C\CCCCCCC(=O)c1nc2c(o1)c(C)ccc2
  • InChi: 1S/C25H37NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23(27)25-26-22-19-17-18-21(2)24(22)28-25/h10-11,17-19H,3-9,12-16,20H2,1-2H3/b11-10-
  • InChiKey: XCVHITKETZMTSY-KHPPLWFESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fatty acid amide hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major hypothetical protein, conserved fatty acid amide hydrolase 579 aa 471 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0056 0.0109
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0015 0.0052 0.1351
Brugia malayi hypothetical protein 0.0011 0.0011 0.0008
Brugia malayi Latrophilin receptor protein 2 0.01 0.1077 0.1815
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0341 0.0655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0444 0.0857
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0666 0.1293
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.0975 0.0975
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0444 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0056 0.017
Echinococcus granulosus Chromo domain 0.0011 0.0011 0.0022
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0385 0.1287
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0444 0.0868
Brugia malayi MH2 domain containing protein 0.0034 0.0283 0.0469
Schistosoma mansoni hypothetical protein 0.0215 0.2474 0.4838
Schistosoma mansoni chromobox protein 0.0011 0.0011 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0342 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0019
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0262 0.0514
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0283 0.0283
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0006 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0011 0.0016
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0063 0.1694
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0011 0.0011
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.01 0.1077 0.2098
Brugia malayi Heterochromatin protein 1 0.007 0.0722 0.1214
Leishmania major hypothetical protein, conserved 0.0039 0.0341 0.9956
Onchocerca volvulus 0.0044 0.0401 0.1345
Brugia malayi Smad1 0.0034 0.0283 0.0469
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.0006 0.0011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2866 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.0975 0.0975
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0063 0.0063
Mycobacterium tuberculosis Conserved protein 0.0039 0.0341 0.1027
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0341 0.1027
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0011 0.0143
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0011 0.0143
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0063 0.0112
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0011 0.0008
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0063 0.0097
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0056 0.0095
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.0006 0.0006
Onchocerca volvulus 0.0039 0.0341 0.1136
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0063 0.0587
Brugia malayi Pre-SET motif family protein 0.0032 0.0262 0.0434
Brugia malayi beta-lactamase family protein 0.0039 0.0341 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0019
Brugia malayi CXXC zinc finger family protein 0.003 0.024 0.0396
Schistosoma mansoni hypothetical protein 0.0179 0.2041 0.3989
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0011 0.0143
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0011 0.0022
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0011 0.0143
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0032 0.005
Schistosoma mansoni hypothetical protein 0.01 0.1077 0.2098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0311 0.0311
Trichomonas vaginalis esterase, putative 0.0039 0.0341 0.1151
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.0063
Schistosoma mansoni cpg binding protein 0.0032 0.0261 0.0498
Echinococcus granulosus Chromobox protein 3 0.0011 0.0011 0.0022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0342 1
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0011 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0006 0.0006
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.008 0.0841 0.0841
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0341 0.1027
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0063 0.1694
Onchocerca volvulus 0.0011 0.0011 0.00000005517
Schistosoma mansoni Smad4 0.0015 0.0056 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.005 0.0149
Loa Loa (eye worm) MH2 domain-containing protein 0.0498 0.5901 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Schistosoma mansoni ap endonuclease 0.0039 0.0342 0.0658
Echinococcus multilocularis geminin 0.0179 0.2041 0.2041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0311 0.0609
Brugia malayi isocitrate dehydrogenase 0.0016 0.0063 0.0097
Brugia malayi MH1 domain containing protein 0.0034 0.0283 0.0469
Brugia malayi Amidase family protein 0.0015 0.0052 0.0077
Echinococcus granulosus chromobox protein 1 0.007 0.0722 0.1413
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0262 0.2641
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0348 0.1162
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0341 0.1151
Brugia malayi MH2 domain containing protein 0.0015 0.0056 0.0084
Onchocerca volvulus 0.0031 0.0246 0.0808
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0341 0.1151
Trichomonas vaginalis hypothetical protein 0.0011 0.0011 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0341 0.9956
Schistosoma mansoni hypothetical protein 0.01 0.1077 0.2098
Schistosoma mansoni smad1 5 8 and 0.0034 0.0283 0.0542
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0011 0.0143
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0011 0.0009
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.1362 0.1362
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0283 0.048
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.008 0.0841 0.1647
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0095 0.0303
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0063 0.0107
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0019
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0011 0.0049
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.0975 0.191
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0032 0.0055
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0063 0.1694
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0348 0.1177
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0311 0.0597
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0032 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0063 0.0063
Echinococcus multilocularis chromobox protein 1 0.007 0.0722 0.0722
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0011 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0444 0.0857
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0006 0.0013
Schistosoma mansoni Smad4 0.0034 0.0283 0.0542
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0444 0.0868
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0283 0.0554
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.1077 0.2108
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.0006 0.0013
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.1362 0.2666
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0444 0.0741
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0262 0.0262
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0315 0.3679 0.6234
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0341 0.9956
Brugia malayi Pre-SET motif family protein 0.0221 0.2544 0.4305
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0015 0.0052 0.0102
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0341 0.0578
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0091 0.0975 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0341 0.1027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0011 0.0016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0095 0.0303
Leishmania major hypothetical protein, conserved 0.0015 0.0052 0.1351
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0342 1
Brugia malayi putative amidase 0.0015 0.0052 0.0077
Brugia malayi MH1 domain containing protein 0.0034 0.0283 0.0469
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0056 0.0084
Echinococcus multilocularis Smad4 0.0034 0.0283 0.0283
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0342 0.067
Echinococcus multilocularis chromobox protein 1 0.007 0.0722 0.0722
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0095 0.0303
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0341 0.0567
Mycobacterium ulcerans lipase LipD 0.0039 0.0341 0.9949
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0011 0.0049
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.1362 0.2656
Trichomonas vaginalis chromobox protein, putative 0.007 0.0722 0.2462
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0342 0.1032
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0385 0.1301
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0056 0.0154
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0019
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0341 0.1027
Schistosoma mansoni cpg binding protein 0.003 0.024 0.0457
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0341 0.1027
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0341 0.9949
Echinococcus multilocularis GPCR, family 2 0.01 0.1077 0.1077
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0011 0.0049
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0015 0.0052 0.1351
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0095
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.0006 0.0013
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0056 0.0109
Brugia malayi hypothetical protein 0.0036 0.0311 0.0517
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0006 0.0013
Schistosoma mansoni hypothetical protein 0.0433 0.5107 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0209 0.0698
Schistosoma mansoni Smad4 0.0015 0.0056 0.0097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0341 0.0655
Loa Loa (eye worm) PDE1B protein 0.0011 0.0006 0.0011
Schistosoma mansoni smad 0.0015 0.0056 0.0097
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0722 0.1223
Loa Loa (eye worm) hypothetical protein 0.0039 0.0341 0.0578
Schistosoma mansoni amidase 0.0123 0.1362 0.2656
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0168
Loa Loa (eye worm) hypothetical protein 0.0315 0.3679 0.6234
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.0591
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0063 0.0587
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.2474 0.4187
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.1077 0.1824
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0063 0.1694
Brugia malayi SET domain containing protein 0.0013 0.0033 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0385 0.1301
Loa Loa (eye worm) Smad1 0.0034 0.0283 0.048
Loa Loa (eye worm) helicase 0.0011 0.0011 0.0019
Trypanosoma cruzi amidase, putative 0.0015 0.0052 0.1351
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.008 0.0841 0.1425
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0283 0.0542
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0019
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0011 0.0008
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0315 0.3679 0.623
Brugia malayi MH1 domain containing protein 0.0019 0.0099 0.0158
Schistosoma mansoni fatty-acid amide hydrolase 0.0015 0.0052 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0095 0.0303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0444 0.0444
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.024 0.047
Schistosoma mansoni smad1 5 8 and 0.0034 0.0283 0.0542
Echinococcus multilocularis Chromo domain 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0215 0.2474 0.4193
Loa Loa (eye worm) hypothetical protein 0.0039 0.0341 0.0578
Schistosoma mansoni cpg binding protein 0.0032 0.0261 0.0498
Brugia malayi beta-lactamase family protein 0.0039 0.0341 0.0567
Entamoeba histolytica hypothetical protein 0.0036 0.0311 0.9054
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0342 1
Mycobacterium leprae Probable lipase LipE 0.0039 0.0341 1
Schistosoma mansoni chromobox protein 0.007 0.0722 0.1402
Entamoeba histolytica hypothetical protein 0.0036 0.0311 0.9054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0011
Onchocerca volvulus 0.0039 0.0341 0.1136
Brugia malayi CHD4 protein 0.0013 0.0032 0.0044
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0011 0.0016
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0063 0.1694
Mycobacterium ulcerans beta-lactamase 0.0039 0.0341 0.9949
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0341 0.1151
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.1077 0.2108
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0262 0.0262
Echinococcus multilocularis chromobox protein 2 0.0011 0.0011 0.0011
Echinococcus granulosus fatty acid amide hydrolase 1 0.0015 0.0052 0.0102
Schistosoma mansoni ap endonuclease 0.0039 0.0342 0.0658
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0011 0.0016
Trypanosoma cruzi amidase, putative 0.0015 0.0052 0.1351
Brugia malayi MH2 domain containing protein 0.0034 0.0283 0.0469
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0019
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0063 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.0124
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0341 0.0578
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0063 0.1694
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.0975 0.191
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0056 0.017
Echinococcus granulosus dnaJ subfamily B 0.0433 0.5107 1
Echinococcus granulosus Smad4 0.0034 0.0283 0.0554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0342 0.0342
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0283 0.0554
Onchocerca volvulus 0.003 0.024 0.0788
Schistosoma mansoni chromobox protein 0.007 0.0722 0.1402
Brugia malayi Protein cec-1. 0.0011 0.0011 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0341 0.1151
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0011 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.2544 0.4311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0315 0.3679 0.623
Schistosoma mansoni chromobox protein 0.0011 0.0011 0.0009
Brugia malayi Amidase family protein 0.0015 0.0052 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0348 0.1177
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0009
Echinococcus granulosus chromobox protein 1 0.007 0.0722 0.1413
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0341 0.0341
Brugia malayi chromobox protein homolog 3 0.0039 0.0348 0.058
Loa Loa (eye worm) hypothetical protein 0.0032 0.0262 0.0445
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0342 0.1156
Loa Loa (eye worm) transcription factor SMAD2 0.0498 0.5901 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0342 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0342 0.3466
Schistosoma mansoni smad 0.0034 0.0283 0.0542
Brugia malayi MH1 domain containing protein 0.0019 0.0099 0.0158
Mycobacterium tuberculosis Conserved protein 0.0039 0.0341 0.1027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.0063
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0342 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0209 0.0698
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0341 0.0667
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.0006 0.0013
Brugia malayi MH2 domain containing protein 0.0498 0.5901 1
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0342 0.1156
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0342 1
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0052 0.1351
Schistosoma mansoni hypothetical protein 0.0179 0.2041 0.3989
Echinococcus multilocularis smad 0.0034 0.0283 0.0283
Echinococcus multilocularis cpg binding protein 0.0032 0.0261 0.0261
Trichomonas vaginalis set domain proteins, putative 0.0251 0.2912 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.1362 0.1362
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0341 0.1027
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.024 0.0406
Loa Loa (eye worm) nuclear factor I 0.0019 0.0099 0.0168
Loa Loa (eye worm) hypothetical protein 0.0031 0.0246 0.0416
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0091 0.0975 1
Echinococcus granulosus cpg binding protein 0.0032 0.0261 0.0511
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0583 0.5947
Loa Loa (eye worm) amidase 0.0015 0.0052 0.0088
Entamoeba histolytica hypothetical protein 0.0036 0.0311 0.9054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0342 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.1077 0.1815
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0262 0.0502
Onchocerca volvulus 0.0251 0.2912 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0342 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0342 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0011
Trichomonas vaginalis chromobox protein, putative 0.007 0.0722 0.2462
Echinococcus granulosus chromobox protein 2 0.0011 0.0011 0.0022
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0011 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.1077 0.1077
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.0006 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0341 1
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.5107 0.5107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0444 0.0752
Entamoeba histolytica hypothetical protein 0.0036 0.0311 0.9054
Schistosoma mansoni smad1 5 8 and 0.0034 0.0283 0.0542
Plasmodium vivax SET domain protein, putative 0.0032 0.0262 0.7619
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0063 0.1694
Onchocerca volvulus 0.0039 0.0341 0.1136
Loa Loa (eye worm) amidase 0.0015 0.0052 0.0088
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0011 0.0143
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0052 0.5
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0015 0.0052 0.0052
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.0006 0.0006
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0032 0.0063
Mycobacterium ulcerans hypothetical protein 0.0039 0.0341 0.9949
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0262 0.0502
Brugia malayi amidase 0.0123 0.1362 0.2299
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0011 0.0016
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.008 0.0841 0.1416
Toxoplasma gondii ABC1 family protein 0.0039 0.0341 0.3451
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0091 0.0975 0.1899
Loa Loa (eye worm) beta-lactamase 0.0039 0.0341 0.0578
Schistosoma mansoni hypothetical protein 0.01 0.1077 0.2098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0011 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0341 0.9956
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0342 0.058
Echinococcus granulosus smad 0.0034 0.0283 0.0554
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0283 0.048
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0056 0.0095
Loa Loa (eye worm) hypothetical protein 0.01 0.1077 0.1824
Loa Loa (eye worm) hypothetical protein 0.0039 0.0341 0.0578
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0095 0.0303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0095 0.0303
Loa Loa (eye worm) hypothetical protein 0.0039 0.0341 0.0578
Brugia malayi beta-lactamase 0.0039 0.0341 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0341 0.1151
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0341 0.9949
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0095 0.0303
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0011 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0095 0.0303
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0015 0.0052 0.0052
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0052 0.0089
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.1362 0.2666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0444 0.0857
Toxoplasma gondii exonuclease III APE 0.0039 0.0342 0.3466
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0123 0.1362 0.2307
Loa Loa (eye worm) hypothetical protein 0.0091 0.0975 0.1653
Echinococcus granulosus GPCR family 2 0.01 0.1077 0.2108
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0342 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0262 0.0502
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0341 0.9956
Schistosoma mansoni hypothetical protein 0.0036 0.0311 0.0597
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0056 0.0056
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0341 0.1027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0341 0.0578
Echinococcus granulosus geminin 0.0179 0.2041 0.3996
Mycobacterium tuberculosis Conserved protein 0.0039 0.0341 0.1027
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0401 0.0774

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 13 uM Inhibition of FAAH ChEMBL. 18983142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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