Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Echinococcus granulosus | muscleblind protein | 0.031 | 0.1489 | 0.4033 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.1369 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.1489 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0292 | 0.1382 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.031 | 0.1489 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.1489 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0689 | 0.3693 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0188 | 0.0776 | 0.2102 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 0.1439 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0689 | 0.3693 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 0.1439 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.031 | 0.1489 | 0.4033 |
Mycobacterium ulcerans | glutaminase | 0.0273 | 0.1272 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.1272 | 0.8544 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0292 | 0.1382 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.0609 | 0.3093 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0632 | 0.3361 | 1 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.1272 | 0.3446 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0302 | 0.1439 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.1272 | 0.8544 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0143 | 0.0514 | 0.2107 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.1272 | 0.8544 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0302 | 0.1439 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0188 | 0.0776 | 0.2102 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Chlamydia trachomatis | recombinase RecA | 0.0108 | 0.0311 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.0108 | 0.0311 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.1382 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.0609 | 0.01 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0689 | 0.3693 | 1 |
Brugia malayi | Muscleblind-like protein | 0.031 | 0.1489 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0143 | 0.0514 | 0.0664 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1666 | 0.9373 | 0.9339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Displacement of [3H]WIN-55212-2 from CB2 receptor in Sprague-Dawley rat spleen membrane | ChEMBL. | 17582659 | |
Inhibition (functional) | = 17 % | Agonist activity at CB1 receptor in electrically-stimulated Swiss mouse vas deferens at 1.0 uM | ChEMBL. | 17582659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.