Detailed information for compound 1182698

Basic information

Technical information
  • TDR Targets ID: 1182698
  • Name: 2-(6-chloro-2-oxo-1,3-benzoxazol-3-yl)-N-[3-( trifluoromethyl)phenyl]acetamide
  • MW: 370.71 | Formula: C16H10ClF3N2O3
  • H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c(=O)oc2c1ccc(c2)Cl)Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C16H10ClF3N2O3/c17-10-4-5-12-13(7-10)25-15(24)22(12)8-14(23)21-11-3-1-2-9(6-11)16(18,19)20/h1-7H,8H2,(H,21,23)
  • InChiKey: VPMFJJAMPILMCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(6-chloro-2-keto-1,3-benzoxazol-3-yl)-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-(6-chloro-2-oxo-1,3-benzoxazol-3-yl)-N-[3-(trifluoromethyl)phenyl]ethanamide
  • K904-0311
  • NCGC00140788-01
  • ZINC02927619

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0051 0.5
Brugia malayi TAR-binding protein 0.0063 0.0707 0.1263
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0051 0.5
Brugia malayi Cytochrome P450 family protein 0.0011 0.0051 0.0076
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0051 0.5
Brugia malayi Cytochrome P450 family protein 0.0011 0.0051 0.0076
Loa Loa (eye worm) fli-1 protein 0.0224 0.2734 0.4935
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0525 0.0935
Onchocerca volvulus 0.0026 0.0252 0.4805
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.012 0.0113
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0354 0.0625
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0051 0.5
Brugia malayi transcription factor E74 isoform 0.0011 0.0054 0.0081
Echinococcus multilocularis muscleblind protein 1 0.0447 0.553 0.5526
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0051 0.5
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0054 0.0046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0354 0.0627
Loa Loa (eye worm) RNA binding protein 0.0063 0.0707 0.1263
Loa Loa (eye worm) hypothetical protein 0.0232 0.2834 0.5117
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0051 0.5
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0051 0.5
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0846 0.0839
Loa Loa (eye worm) hypothetical protein 0.0013 0.008 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1681 0.303
Echinococcus granulosus muscleblind protein 0.0447 0.553 1
Schistosoma mansoni gabp alpha 0.0074 0.0846 0.3076
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0054 0.0083
Schistosoma mansoni Smad4 0.0007 0.0009 0.0005
Schistosoma mansoni cytochrome P450 0.0011 0.0051 0.0159
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.012 0.0204
Onchocerca volvulus 0.0028 0.0276 0.5292
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0073 0.0117
Onchocerca volvulus 0.0047 0.0514 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0276 0.0484
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0276 0.0484
Schistosoma mansoni hypothetical protein 0.0035 0.0354 0.1271
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.1294 0.2328
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0051 0.5
Brugia malayi MH1 domain containing protein 0.0016 0.012 0.0202
Loa Loa (eye worm) hypothetical protein 0.0012 0.0073 0.0117
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0054 0.0046
Schistosoma mansoni lamin 0.0026 0.0252 0.0894
Schistosoma mansoni smad1 5 8 and 0.0016 0.012 0.0413
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0252 0.0439
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0051 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0051 0.5
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0051 0.5
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0051 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0051 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0859 0.154
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1681 0.3029
Echinococcus multilocularis ets variant gene 4 0.0011 0.0054 0.0046
Loa Loa (eye worm) nuclear factor I 0.0009 0.003 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1681 0.1675
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0051 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0051 0.5
Echinococcus multilocularis cpg binding protein 0.003 0.0296 0.0289
Echinococcus granulosus Smad4 0.0016 0.012 0.0204
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0009 0.0001
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0051 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2834 0.2828
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1294 0.2328
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0051 0.5
Brugia malayi Fli-1 protein 0.0224 0.2734 0.4935
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0051 0.5
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0051 0.5
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0054 0.0046
Brugia malayi Muscleblind-like protein 0.0447 0.553 1
Echinococcus multilocularis musashi 0.0026 0.0252 0.0244
Echinococcus multilocularis GPCR, family 2 0.0035 0.0354 0.0347
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0168
Schistosoma mansoni ets-related 0.0011 0.0054 0.0168
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0596 1
Brugia malayi RNA binding protein 0.0063 0.0707 0.1263
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0054 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0051 0.5
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0707 0.0699
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.012 0.0204
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0051 0.5
Brugia malayi Smad1 0.0016 0.012 0.0202
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0051 0.5
Brugia malayi MH2 domain containing protein 0.0016 0.012 0.0202
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0097 0.016
Schistosoma mansoni smad1 5 8 and 0.0016 0.012 0.0413
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0447 0.553 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1681 0.303
Brugia malayi MH1 domain containing protein 0.0009 0.003 0.0039
Brugia malayi Ets-domain containing protein 0.0074 0.0846 0.1516
Echinococcus granulosus smad 0.0016 0.012 0.0204
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.0037
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.012 0.0413
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0707 0.2564
Mycobacterium leprae putative cytochrome p450 0.0011 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.0859 0.154
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0051 0.5
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0051 0.5
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0051 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1681 0.6138
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0051 0.0076
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0009 0.0002
Brugia malayi MH2 domain containing protein 0.0016 0.012 0.0202
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0022
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0051 0.5
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0051 0.5
Schistosoma mansoni smad1 5 8 and 0.0016 0.012 0.0413
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0051 0.5
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0054 0.0046
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0051 0.0076
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0051 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0354 0.0627
Loa Loa (eye worm) cytochrome P450 0.0011 0.0051 0.0076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0354 0.0347
Echinococcus granulosus GPCR family 2 0.0035 0.0354 0.0627
Echinococcus multilocularis lamin 0.0026 0.0252 0.0244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0354 0.0625
Schistosoma mansoni elf1 0.0011 0.0054 0.0168
Schistosoma mansoni smad 0.0007 0.0009 0.0005
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0054 0.0081
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.012 0.0113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1294 0.2328
Leishmania major cytochrome p450-like protein 0.0011 0.0051 0.5
Brugia malayi MH1 domain containing protein 0.0016 0.012 0.0202
Brugia malayi Ets-domain containing protein 0.0011 0.0054 0.0081
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0846 0.1516
Echinococcus multilocularis Smad4 0.0016 0.012 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0428
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1681 0.3029
Loa Loa (eye worm) Smad1 0.0016 0.012 0.0202
Echinococcus multilocularis 0.0011 0.0051 0.0043
Brugia malayi hypothetical protein 0.0232 0.2834 0.5117
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0168
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0051 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0514 0.0914
Brugia malayi Ets-domain containing protein 0.0074 0.0846 0.1516
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0051 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0354 0.1271
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0051 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.2875 0.5191
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0354 0.0347
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0051 0.5
Brugia malayi MH1 domain containing protein 0.0009 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.011 0.1294 0.2328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1681 0.6138
Schistosoma mansoni hypothetical protein 0.0011 0.0051 0.0159
Loa Loa (eye worm) hypothetical protein 0.0009 0.003 0.0039
Echinococcus granulosus tar DNA binding protein 0.0063 0.0707 0.1265
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0051 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0707 0.1263
Schistosoma mansoni smad 0.0016 0.012 0.0413
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0054 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0081
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0051 0.5
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0354 0.0625
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0707 0.2564
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0051 0.5
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0051 0.0078
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0009 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0051 0.5
Schistosoma mansoni ets-related 0.0224 0.2734 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0252 0.0894
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0051 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0051 0.5
Schistosoma mansoni Smad4 0.0007 0.0009 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1681 0.1675
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0051 0.5
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0054 0.0081
Schistosoma mansoni lamin 0.0026 0.0252 0.0894
Schistosoma mansoni cpg binding protein 0.0028 0.0276 0.0984
Brugia malayi Cytochrome P450 family protein 0.0048 0.0525 0.0935
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.2875 0.5191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1681 0.6138
Schistosoma mansoni survival motor neuron protein 0.0047 0.0514 0.1856
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0054 0.0168
Loa Loa (eye worm) hypothetical protein 0.0447 0.553 1
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0054 0.0083
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0051 0.5
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0054 0.0083
Onchocerca volvulus 0.0026 0.0252 0.4805
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0707 0.2564
Echinococcus multilocularis protein C ets 2 0.0011 0.0054 0.0046
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.008 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0707 0.2564
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0054 0.0046
Echinococcus granulosus cpg binding protein 0.003 0.0296 0.0523
Brugia malayi intermediate filament protein 0.0026 0.0252 0.0439
Echinococcus granulosus protein C ets 2 0.0011 0.0054 0.0083
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0846 0.1518
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0051 0.5
Echinococcus multilocularis smad 0.0016 0.012 0.0113
Echinococcus granulosus lamin 0.0026 0.0252 0.0441
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0676 0.2453
Leishmania major cytochrome p450-like protein 0.0011 0.0051 0.5
Brugia malayi Cytochrome P450 family protein 0.0011 0.0051 0.0076
Schistosoma mansoni hypothetical protein 0.0047 0.0514 0.1856
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0097 0.016
Brugia malayi cytochrome P450 0.0011 0.0051 0.0076
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.012 0.0202
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0054 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0051 0.5
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0051 0.5
Schistosoma mansoni ets 0.0011 0.0054 0.0168
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.012 0.0202
Schistosoma mansoni cpg binding protein 0.003 0.0296 0.1059
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0051 0.5
Schistosoma mansoni Smad4 0.0016 0.012 0.0413
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0354 0.0625
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0051 0.5
Echinococcus granulosus lamin dm0 0.0026 0.0252 0.0441
Brugia malayi MH2 domain containing protein 0.0236 0.2875 0.5191
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0252 0.0439
Schistosoma mansoni hypothetical protein 0.0075 0.0859 0.3123
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.008 0.013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0051 0.5
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0051 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0051 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0707 0.2564
Leishmania major cytochrome p450-like protein 0.0011 0.0051 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0051 0.5
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0054 0.0046
Echinococcus multilocularis lamin dm0 0.0026 0.0252 0.0244
Schistosoma mansoni cpg binding protein 0.003 0.0296 0.1059
Echinococcus granulosus intermediate filament protein 0.0026 0.0252 0.0441
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0054 0.0083
Schistosoma mansoni hypothetical protein 0.0035 0.0354 0.1271
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0707 0.1263
Loa Loa (eye worm) hypothetical protein 0.0026 0.0252 0.0439
Schistosoma mansoni hypothetical protein 0.0035 0.0354 0.1271
Loa Loa (eye worm) hypothetical protein 0.0063 0.0712 0.1273
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0034
Echinococcus multilocularis muscleblind protein 0.0447 0.553 0.5526
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0707 0.1263
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2834 0.5118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0081
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0252 0.0439
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0009 0.0001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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