Detailed information for compound 1182765

Basic information

Technical information
  • TDR Targets ID: 1182765
  • Name: 6-amino-2-[2-[4-(2-methoxyphenyl)piperazin-1- yl]-2-oxoethyl]sulfanyl-1H-pyrimidin-4-one
  • MW: 375.445 | Formula: C17H21N5O3S
  • H donors: 2 H acceptors: 4 LogP: 1.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)C(=O)CSc1nc(N)cc(n1)O
  • InChi: 1S/C17H21N5O3S/c1-25-13-5-3-2-4-12(13)21-6-8-22(9-7-21)16(24)11-26-17-19-14(18)10-15(23)20-17/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,23)
  • InChiKey: SMDJECDTRPAQFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-amino-2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxo-ethyl]sulfanyl-1H-pyrimidin-4-one
  • 6-amino-2-[[2-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxoethyl]thio]-1H-pyrimidin-4-one
  • 6-amino-2-[[2-keto-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]thio]-1H-pyrimidin-4-one
  • STK246642
  • ZINC01060069
  • 6-amino-2-({2-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxoethyl}thio)-4(3H)-pyrimidinone
  • MLS000531520
  • SMR000136498

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0389 0.0389
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0157 0.0157
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0752 1
Echinococcus granulosus chromobox protein 1 0.0084 0.1123 0.1123
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.9581
Brugia malayi MH2 domain containing protein 0.0017 0.0109 0.031
Schistosoma mansoni smad 0.0017 0.0109 0.0109
Echinococcus granulosus geminin 0.0166 0.235 0.235
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0361 0.0823
Brugia malayi chromobox protein homolog 3 0.0047 0.0568 0.1615
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0019 0.0054
Echinococcus granulosus chromobox protein 2 0.0014 0.0067 0.0067
Brugia malayi Inositol-1 0.0036 0.0403 0.1145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0172 0.0294
Schistosoma mansoni nuclear hormone receptor 0.002 0.0157 0.0157
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0123 0.0158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0172 0.0294
Schistosoma mansoni inositol monophosphatase 0.0036 0.0403 0.0403
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0172 0.0294
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0109 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0346 0.0346
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0757 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0346 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0389 0.0389
Schistosoma mansoni coup transcription factor 0.002 0.0157 0.0157
Schistosoma mansoni chromobox protein 0.0014 0.0067 0.0067
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0157 0.043
Loa Loa (eye worm) hypothetical protein 0.0132 0.1839 0.523
Brugia malayi Protein cec-1. 0.0014 0.0067 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0157 0.0446
Loa Loa (eye worm) hypothetical protein 0.0037 0.0415 0.118
Echinococcus granulosus FTZ F1 alpha 0.002 0.0157 0.0157
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0157 0.0157
Brugia malayi hypothetical protein 0.001 0.0017 0.0048
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0017 0.0017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0017 0.0017
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0067 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0157 0.0446
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0048
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.3188 0.9063
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0093 0.0265
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0157 0.0446
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0622 0.1551
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0318 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0157 0.0446
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.1615
Onchocerca volvulus Huntingtin homolog 0.0132 0.1839 0.5045
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0752 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0346 0.0346
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0157 0.0157
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0403 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0123 0.0158
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0189
Schistosoma mansoni inositol monophosphatase 0.0036 0.0403 0.0403
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0157 0.0446
Brugia malayi Pre-SET motif family protein 0.0222 0.3188 0.9063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0346 0.0346
Echinococcus multilocularis Chromo domain 0.0014 0.0067 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0752 1
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0067 0.0067
Echinococcus granulosus cpg binding protein 0.0033 0.035 0.035
Echinococcus multilocularis cpg binding protein 0.0033 0.035 0.035
Schistosoma mansoni smad1 5 8 and 0.0017 0.0109 0.0109
Schistosoma mansoni cpg binding protein 0.0033 0.035 0.035
Echinococcus multilocularis chromobox protein 1 0.0084 0.1123 0.1123
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0109 0.0109
Brugia malayi ecdysteroid receptor 0.002 0.0157 0.0446
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0389 0.0389
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0553 0.0553
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0752 0.0752
Onchocerca volvulus 0.0031 0.0324 0.0888
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.9581
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0157 0.0446
Loa Loa (eye worm) helicase 0.0014 0.0067 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0157 0.0446
Brugia malayi hypothetical protein 0.0132 0.1839 0.523
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0403 0.5
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0067 0.0067
Brugia malayi hypothetical protein 0.001 0.0017 0.0048
Echinococcus multilocularis chromobox protein 2 0.0014 0.0067 0.0067
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0067 0.0067
Brugia malayi MH1 domain containing protein 0.0017 0.0109 0.031
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0752 0.0752
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0403 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0157 0.043
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0157 0.0157
Schistosoma mansoni cpg binding protein 0.0033 0.035 0.035
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0403 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0157 0.0446
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0189
Onchocerca volvulus 0.0252 0.3646 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0189
Brugia malayi nuclear receptor RXR 0.001 0.0017 0.0048
Echinococcus granulosus chromobox protein 1 0.0084 0.1123 0.1123
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0157 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0157 0.0446
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0109 0.031
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0093 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0157 0.0157
Plasmodium vivax SET domain protein, putative 0.0032 0.0346 1
Echinococcus granulosus Chromobox protein 3 0.0014 0.0067 0.0067
Schistosoma mansoni Smad4 0.0017 0.0109 0.0109
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0752 0.0752
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0752 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0093 0.0093
Onchocerca volvulus 0.002 0.0157 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0568 0.1401
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Schistosoma mansoni smad1 5 8 and 0.0017 0.0109 0.0109
Onchocerca volvulus 0.0014 0.0067 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0157 0.0157
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0403 0.0939
Echinococcus granulosus Chromo domain 0.0014 0.0067 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0014 0.0067 0.0067
Echinococcus multilocularis Smad4 0.0017 0.0109 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0172 0.0294
Brugia malayi Heterochromatin protein 1 0.0084 0.1123 0.3193
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0346 0.0346
Schistosoma mansoni thyroid hormone receptor 0.002 0.0157 0.0157
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0017 0.0048
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0403 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0115 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0157 0.0446
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0752 0.9936
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0189
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0109 0.0109
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0157 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.3517 1
Brugia malayi hypothetical protein 0.0035 0.0389 0.1105
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0157 0.0157
Loa Loa (eye worm) Smad1 0.0017 0.0109 0.031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Onchocerca volvulus 0.0037 0.0415 0.1138
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0403 0.487
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0752 0.0752
Schistosoma mansoni hypothetical protein 0.0166 0.235 0.235
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0157 0.0157
Brugia malayi MH1 domain containing protein 0.0017 0.0109 0.031
Loa Loa (eye worm) inositol-1 0.0036 0.0403 0.1145
Schistosoma mansoni chromobox protein 0.0084 0.1123 0.1123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0157 0.0446
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0172 0.0294
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0346 0.0346
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0622 0.1705
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0157 0.0446
Onchocerca volvulus 0.0046 0.0553 0.1516
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0157 0.0446
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0109 0.031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0346 0.0983
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0189
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0067 0.0189
Schistosoma mansoni cpg binding protein 0.0031 0.0324 0.0324
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0067 0.0189
Plasmodium falciparum heterochromatin protein 1 0.0014 0.0067 0.5
Brugia malayi MH2 domain containing protein 0.0017 0.0109 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0021
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0568 0.1558
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0157 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0157 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0157 0.0446
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0157 0.0157
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0157 0.0446
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0048
Echinococcus multilocularis smad 0.0017 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0157 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0361 0.0823
Schistosoma mansoni chromobox protein 0.0084 0.1123 0.1123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0172 0.0294
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0048
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1123 0.2952
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0048
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0403 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0622 0.1551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0157 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0157 0.0446
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0157 0.0157
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.9581
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0862 0.0862
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0157 0.0157
Brugia malayi nuclear receptor NHR-88 0.002 0.0157 0.0446
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0067 0.0067
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0403 0.0403
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0157 0.0157
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0189
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.9581
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1123 0.3193
Echinococcus multilocularis geminin 0.0166 0.235 0.235
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0067 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0048
Onchocerca volvulus 0.0014 0.0067 0.0183
Schistosoma mansoni smad1 5 8 and 0.0017 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0157 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0568 0.1401
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0067 0.0067
Schistosoma mansoni chromobox protein 0.0014 0.0067 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0346 0.0346
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0157 0.0446
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0157 0.0157
Brugia malayi CHD4 protein 0.0016 0.0093 0.0265
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.3517 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0157 0.0157
Echinococcus granulosus smad 0.0017 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0752 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0157 0.0157
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0324 0.0921
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0021 0.006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0157 0.0157
Echinococcus granulosus Smad4 0.0017 0.0109 0.0109
Brugia malayi CXXC zinc finger family protein 0.0031 0.0324 0.0921
Brugia malayi Smad1 0.0017 0.0109 0.031
Brugia malayi MH2 domain containing protein 0.0244 0.3517 1
Brugia malayi steroid hormone receptor 0.002 0.0157 0.0446
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0157 0.0446
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0172 0.0294
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0157 0.043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0403 0.0939
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0403 0.0939
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0446
Onchocerca volvulus Huntingtin homolog 0.0132 0.1839 0.5045
Schistosoma mansoni hypothetical protein 0.0166 0.235 0.235
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0346 0.4048
Echinococcus multilocularis chromobox protein 1 0.0084 0.1123 0.1123
Brugia malayi SET domain containing protein 0.0016 0.0094 0.0268
Loa Loa (eye worm) hypothetical protein 0.0132 0.1839 0.523
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0067 0.5
Brugia malayi hypothetical protein 0.0014 0.0067 0.0189
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0093 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0157 0.0157
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0172 0.0294
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0189
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0067 0.0067
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0157 0.0446
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0067 0.5
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1123 0.2952
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0157 0.0157
Trichomonas vaginalis set domain proteins, putative 0.0252 0.3646 1
Brugia malayi nuclear hormone receptor 0.002 0.0157 0.0446
Brugia malayi Pre-SET motif family protein 0.0032 0.0346 0.0983

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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