Detailed information for compound 1183120

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.534 | Formula: C28H30O6
  • H donors: 3 H acceptors: 4 LogP: 7.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=CCc1c(O)cc2c(c1O)c(=O)c1c(o2)c(CC=C(C)C)c(c2c1C=CC(O2)(C)C)O)C
  • InChi: 1S/C28H30O6/c1-14(2)7-9-16-19(29)13-20-22(23(16)30)25(32)21-17-11-12-28(5,6)34-27(17)24(31)18(26(21)33-20)10-8-15(3)4/h7-8,11-13,29-31H,9-10H2,1-6H3
  • InChiKey: ADFJMFQSYNRLEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni thyroid hormone receptor 0.001 0.0071 0.0071
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0285 0.2067
Echinococcus granulosus lamin 0.0058 0.1256 0.1256
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0707 0.1219
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0273 0.0273
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0071 0.0071
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0072 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Echinococcus granulosus lamin dm0 0.0058 0.1256 0.1256
Onchocerca volvulus 0.001 0.0072 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0273 0.0289
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.3379 0.4559
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0537 0.0915
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0071 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0234 0.5621 0.5621
Loa Loa (eye worm) glutathione reductase 0.0052 0.1123 0.1962
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0462 0.0462
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0285 0.0305
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0071 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1136 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0063 0.0391
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0707 0.1219
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0063 0.0391
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0303 0.033
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0067
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.1123 0.1123
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0273 0.0441
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0707 0.0886
Loa Loa (eye worm) intermediate filament protein 0.0058 0.1256 0.22
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0285 0.0462
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0071 0.0071
Schistosoma mansoni ferritin light chain 0.0009 0.0033 0.0033
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.7337 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Brugia malayi hypothetical protein 0.015 0.3535 0.6272
Schistosoma mansoni ferritin 0.0009 0.0033 0.0033
Echinococcus multilocularis lamin 0.0058 0.1256 0.1256
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0273 0.0289
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0273 0.0289
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0067
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0072 0.0072
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.078 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0303 0.0303
Onchocerca volvulus 0.0029 0.0537 0.1366
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0071 0.0071
Brugia malayi beta-lactamase 0.0036 0.0707 0.1219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.5621 0.5621
Brugia malayi Inositol-1 0.0039 0.078 0.135
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0462 0.0549
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0072 0.051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Trypanosoma brucei unspecified product 0.0019 0.0303 0.033
Brugia malayi nuclear hormone receptor 0.001 0.0071 0.0082
Schistosoma mansoni ferritin light chain 0.0009 0.0033 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0707 0.1797
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0514 0.0514
Schistosoma mansoni ferritin 0.0009 0.0033 0.0033
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0072 0.0072
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1136 0.1475
Brugia malayi hypothetical protein 0.001 0.0063 0.0067
Toxoplasma gondii exonuclease III APE 0.0019 0.0285 0.1992
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0071 0.0082
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0273 0.0273
Echinococcus multilocularis cpg binding protein 0.003 0.0578 0.0578
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0041 0.0028
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.1123 0.1962
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0071 0.0071
Onchocerca volvulus 0.0036 0.0707 0.1856
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0462 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0025 0.0025
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0303 0.3605
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.078 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.1123 0.2003
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0067
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0707 0.9019
Echinococcus granulosus nibrin 0.001 0.0063 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0071 0.0071
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0303 0.3345
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.2789 0.8928
Schistosoma mansoni inositol monophosphatase 0.0039 0.078 0.078
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0154 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0071 0.0082
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.2789 0.5065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0707 0.1219
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0285 0.0305
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0879 0.1122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0071 0.0082
Schistosoma mansoni DNA polymerase eta 0.0019 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0337 0.8172 0.8172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0071 0.0071
Entamoeba histolytica G protein alpha subunit, putative 0.001 0.0072 0.0124
Brugia malayi hypothetical protein 0.0053 0.1136 0.1986
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0071 0.0082
Schistosoma mansoni intermediate filament proteins 0.0058 0.1256 0.1256
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0273 0.0273
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.078 0.0718
Leishmania major trypanothione reductase 0.0052 0.1123 0.1203
Plasmodium falciparum thioredoxin reductase 0.0018 0.0273 0.1961
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0273 0.064
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0072 0.0083
Schistosoma mansoni lamin 0.0058 0.1256 0.1256
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0063 0.0067
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.001 0.0072 0.051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0071 0.0071
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0273 0.1961
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.312 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0072 0.051
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0707 0.1238
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0707 0.0707
Toxoplasma gondii ABC1 family protein 0.0036 0.0707 0.5786
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.312 0.5674
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0072 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0071 0.0082
Trypanosoma brucei trypanothione reductase 0.0052 0.1123 0.1458
Plasmodium falciparum thioredoxin reductase 0.0052 0.1123 0.9879
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0273 0.0289
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.1136 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0273 0.321
Loa Loa (eye worm) hypothetical protein 0.0036 0.0707 0.1219
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0072 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0273 0.0289
Plasmodium falciparum glutathione reductase 0.0052 0.1123 0.9879
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0071 0.0082
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0071 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0303 0.0718
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0285 1
Onchocerca volvulus 0.0036 0.0707 0.1856
Mycobacterium tuberculosis Probable reductase 0.012 0.2789 0.5065
Mycobacterium tuberculosis Conserved protein 0.0036 0.0707 0.1238
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2793 0.4947
Echinococcus granulosus geminin 0.0337 0.8172 0.8172
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0707 0.2182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0488 0.0828
Echinococcus granulosus smad 0.0008 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0071 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0514 0.0875
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0025 0.0025
Echinococcus granulosus Smad4 0.0008 0.0025 0.0025
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0462 0.5568
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.1136 0.1475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0071 0.0082
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.078 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.001 0.0072 0.051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0071 0.0071
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0462 0.0782
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0072 0.0072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0273 0.0289
Echinococcus granulosus cpg binding protein 0.003 0.0578 0.0578
Echinococcus granulosus flap endonuclease 1 0.0026 0.0462 0.0462
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0412 0.0412
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Onchocerca volvulus 0.0058 0.1256 0.3437
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0707 0.0707
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0285 0.0464
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.7337 1
Toxoplasma gondii thioredoxin reductase 0.0052 0.1123 0.9521
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0303 0.0495
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.001 0.0072 0.051
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0072 0.0083
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0412 0.0412
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0072 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.5621 0.5621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0234 0.5621 0.5621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0071 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.312 0.5674
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0303 0.0303
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.1123 0.9879
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.059 0.1011
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0063 0.0391
Schistosoma mansoni apoferritin-2 0.0009 0.0033 0.0033
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0072 0.0072
Schistosoma mansoni ap endonuclease 0.0019 0.0285 0.0285
Onchocerca volvulus 0.015 0.3535 1
Brugia malayi hypothetical protein 0.0034 0.067 0.1154
Schistosoma mansoni Smad4 0.0008 0.0025 0.0025
Treponema pallidum NADH oxidase 0.0018 0.0273 0.9547
Schistosoma mansoni topbp1 0.001 0.0063 0.0063
Mycobacterium ulcerans beta-lactamase 0.0036 0.0707 0.1797
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0273 0.0289
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0063 0.0391
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0071 0.0071
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0072 0.0083
Schistosoma mansoni inositol monophosphatase 0.0039 0.078 0.078
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0707 0.1238
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.078 0.1993
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0071 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0273 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0285 0.0285
Mycobacterium ulcerans hypothetical protein 0.016 0.3781 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0285 0.5552
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0154 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0071 0.0082
Echinococcus granulosus FTZ F1 alpha 0.001 0.0071 0.0071
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0072 0.0072
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Schistosoma mansoni ferritin 0.0009 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0083
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0707 0.1238
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.2789 0.5065
Echinococcus multilocularis smad 0.0008 0.0025 0.0025
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0707 0.1238
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0707 0.0886
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0071 0.0082
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0303 0.033
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.3781 0.6888
Brugia malayi nuclear receptor NHR-88 0.001 0.0071 0.0082
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0063 0.0391
Echinococcus multilocularis geminin 0.0337 0.8172 0.8172
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0285 0.3362
Mycobacterium tuberculosis Conserved protein 0.0036 0.0707 0.1238
Leishmania major DNA polymerase kappa, putative 0.0019 0.0303 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0303 0.033
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0072 0.0083
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0071 0.0071
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0303 0.3605
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0273 0.0444
Schistosoma mansoni smad 0.0008 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.0036 0.0707 0.0614
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0273 0.189
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0063 0.0391
Mycobacterium tuberculosis Conserved protein 0.0036 0.0707 0.1238
Plasmodium falciparum flap endonuclease 1 0.0026 0.0462 0.3723
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.078 1
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0072 0.0083
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0462 0.5742
Echinococcus granulosus expressed protein 0.0009 0.0033 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2793 0.4947
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0707 0.0707
Schistosoma mansoni DNA ligase IV 0.001 0.0063 0.0063
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0273 0.064
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.312 0.5674
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0462 0.0549
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Schistosoma mansoni ferritin 0.0009 0.0033 0.0033
Brugia malayi Flap endonuclease-1 0.0026 0.0462 0.0782
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0072 0.0072
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0273 0.5268
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0285 0.3092
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0072 0.0083
Brugia malayi glutathione reductase 0.0052 0.1123 0.1962
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0063 0.0391
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0072 0.0083
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1136 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0154 0.023
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0707 0.1797
Brugia malayi DKFZp564C0469 protein 0.001 0.0063 0.0067
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0514 0.0514
Schistosoma mansoni nuclear hormone receptor 0.001 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0067
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0072 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0285 0.0305
Onchocerca volvulus 0.0036 0.0707 0.1856
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0072 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0303 0.033
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0072 0.0072
Echinococcus multilocularis dna polymerase eta 0.0019 0.0303 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0071 0.0082
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0285 0.3362
Schistosoma mansoni thyroid hormone receptor 0.001 0.0071 0.0071
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0273 0.0289
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0707 0.1238
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0063 0.0391
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.3379 0.4397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0303 0.0496
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0071 0.0023
Brugia malayi topoisomerase 0.001 0.0063 0.0067
Brugia malayi hypothetical protein 0.001 0.0063 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0154 0.0125
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0154 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0083
Brugia malayi Thioredoxin reductase 0.0052 0.1123 0.1962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0071 0.0082
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.2789 0.5065
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0072 0.0072
Mycobacterium ulcerans lipase LipD 0.0036 0.0707 0.1797
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0234 0.5621 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0303 0.033
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.078 0.078
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0273 0.0289
Brugia malayi beta-lactamase family protein 0.0036 0.0707 0.1219
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0071 0.0082
Echinococcus multilocularis expressed protein 0.0009 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.015 0.3535 0.6272
Schistosoma mansoni apoferritin-2 0.0009 0.0033 0.0033
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0879 0.1122
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0303 0.033
Loa Loa (eye worm) hypothetical protein 0.0057 0.123 0.2153
Schistosoma mansoni ap endonuclease 0.0019 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0337 0.8172 0.8172
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0071 0.0071
Echinococcus granulosus replication factor c subunit 1 0.001 0.0063 0.0063
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0063 0.0391
Echinococcus multilocularis nibrin 0.001 0.0063 0.0063
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0072 0.0072
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0063 0.0063
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0072 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.1123 0.1458
Onchocerca volvulus 0.001 0.0072 0.0026
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0072 0.0083
Brugia malayi G-protein alpha subunit 0.001 0.0072 0.0083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0234 0.5621 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0303 0.0496
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0285 0.3362
Brugia malayi beta-lactamase family protein 0.0036 0.0707 0.1219
Echinococcus multilocularis Smad4 0.0008 0.0025 0.0025
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0462 0.3723
Loa Loa (eye worm) hypothetical protein 0.0053 0.1136 0.1986
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0071 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0071 0.0071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.1256 0.22
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0071 0.0082
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0879 0.1122
Echinococcus granulosus expressed protein 0.001 0.0072 0.0072
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0273 0.1961
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0071 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0303 0.033
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0707 0.1238
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0285 0.0285
Loa Loa (eye worm) inositol-1 0.0039 0.078 0.135
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0707 0.9019
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0072 0.0072
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.078 0.6444
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0303 0.0303
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0707 0.9019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0488 0.0828
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Onchocerca volvulus 0.0058 0.1256 0.3437
Echinococcus granulosus intermediate filament protein 0.0058 0.1256 0.1256
Echinococcus granulosus ferritin 0.0009 0.0033 0.0033
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0071 0.0082
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0273 0.189
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.1123 0.1123
Treponema pallidum DNA ligase (lig) 0.001 0.0063 0.1163
Loa Loa (eye worm) hypothetical protein 0.0036 0.0707 0.1219
Echinococcus multilocularis lamin dm0 0.0058 0.1256 0.1256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.5621 0.5621
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0273 0.0289
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0273 0.321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0072 0.051
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0303 0.0303
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0303 0.0495
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0071 0.0082
Schistosoma mansoni lamin 0.0058 0.1256 0.1256
Leishmania major hypothetical protein, conserved 0.0053 0.1136 0.1221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0303 0.033
Plasmodium vivax glutathione reductase, putative 0.0052 0.1123 0.9879
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.078 0.078
Schistosoma mansoni hypothetical protein 0.0024 0.0412 0.0412
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0273 0.0289
Loa Loa (eye worm) beta-lactamase 0.0036 0.0707 0.1219
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0273 0.1961
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0083
Schistosoma mansoni coup transcription factor 0.001 0.0071 0.0071
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0462 0.0268
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0063 0.0095
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0071 0.0071
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0071 0.0082
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0285 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0067
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0707 0.9019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0707 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0071 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.7337 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.078 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0707 0.2182
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0707 0.9019
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0072 0.0072
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1176 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0273 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0072 0.0072
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0072 0.0072
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0072 0.0083
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0303 0.0042
Echinococcus multilocularis musashi 0.0058 0.1256 0.1256
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.059 0.1011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0234 0.5621 0.5621
Giardia lamblia DINP protein human, muc B family 0.0019 0.0303 0.6007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.7337 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.5474 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1136 0.1475
Trypanosoma brucei unspecified product 0.0013 0.0154 0.0125
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0303 0.033
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.068 0.2094
Brugia malayi intermediate filament protein 0.0058 0.1256 0.22
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0072 0.0072
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0063 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.078 0.0987
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0273 0.321
Schistosoma mansoni cpg binding protein 0.0029 0.0537 0.0537
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0234 0.5621 0.5621
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0273 0.1961
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1338 0.1338
Schistosoma mansoni topbp1 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0058 0.1256 0.22
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0072 0.0072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0285 0.2067
Onchocerca volvulus 0.001 0.0072 0.0026
Toxoplasma gondii hypothetical protein 0.0049 0.1035 0.8727
Brugia malayi steroid hormone receptor 0.001 0.0071 0.0082
Trichomonas vaginalis esterase, putative 0.0036 0.0707 0.9019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0071 0.0071
Onchocerca volvulus 0.001 0.0071 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0071 0.0082
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.078 0.0987
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0303 0.0718
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.3379 0.4559
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Brugia malayi MH2 domain containing protein 0.012 0.2793 0.4947
Schistosoma mansoni flap endonuclease-1 0.0023 0.0401 0.0401
Leishmania major DNA polymerase eta, putative 0.0019 0.0303 0.0042
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0063 0.0391
Plasmodium falciparum glutathione reductase 0.0018 0.0273 0.1961
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0273 0.064
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.001 0.0072 0.051
Brugia malayi CXXC zinc finger family protein 0.0029 0.0537 0.0915
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0285 0.067
Echinococcus multilocularis expressed protein 0.001 0.0072 0.0072
Echinococcus multilocularis ferritin 0.0009 0.0033 0.0033
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0025 0.0025
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0273 0.321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0071 0.0082
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0462 0.3588
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.2789 0.5065
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.068 0.1188
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0303 0.0303
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.2789 0.5065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0071 0.0082
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0025 0.0025
Brugia malayi hypothetical protein 0.001 0.0072 0.0083
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0285 0.0464
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0063 0.0078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0707 0.1219
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0707 0.1219
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0072 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0083
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0072 0.0072
Mycobacterium ulcerans hypothetical protein 0.0036 0.0707 0.1797
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0303 0.0303
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.1256 0.22
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0063 0.0391
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0071 0.0023
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0071 0.0023
Trypanosoma brucei unspecified product 0.0013 0.0154 0.0125
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0273 0.0289
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0303 0.0496
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.078 0.0987
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0879 0.1122
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0063 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.111 0.144
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0072 0.0072
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.1136 0.9638
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0072 0.0072
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0707 0.0886
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0707 0.1238
Loa Loa (eye worm) hypothetical protein 0.0036 0.0707 0.1219
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0707 0.6003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0303 0.033
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0071 0.0082
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0303 0.0496
Brugia malayi ecdysteroid receptor 0.001 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0083

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 74.7 % Inhibition of aromatase in human placental microsomes at 20 ug/ml relative to control ChEMBL. 18558747
IC50 (functional) = 2.6 ug ml-1 Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs ChEMBL. 19296616
IC50 (functional) = 2.6 ug ml-1 Cytotoxicity against human MCF7 cells ChEMBL. 24113365
IC50 (functional) = 2.8 ug ml-1 Antiplasmodial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcB1 by [3H]hypoxanthine uptake ChEMBL. 19296616

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19296616
Plasmodium falciparum 19296616

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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