Detailed information for compound 1183503

Basic information

Technical information
  • TDR Targets ID: 1183503
  • Name: 3,5-dimethoxy-8-[2-(2-methylpropylamino)ethyl ]phenanthrene-2,6-diol
  • MW: 369.454 | Formula: C22H27NO4
  • H donors: 3 H acceptors: 2 LogP: 4.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(O)cc(c2c1c1cc(OC)c(cc1cc2)O)CCNCC(C)C
  • InChi: 1S/C22H27NO4/c1-13(2)12-23-8-7-15-10-19(25)22(27-4)21-16(15)6-5-14-9-18(24)20(26-3)11-17(14)21/h5-6,9-11,13,23-25H,7-8,12H2,1-4H3
  • InChiKey: WYEBUHQQFLDPCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-[2-(isobutylamino)ethyl]-3,5-dimethoxy-phenanthrene-2,6-diol
  • 8-[2-(isobutylamino)ethyl]-3,5-dimethoxyphenanthrene-2,6-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0408 0.0385
Brugia malayi Transient-receptor-potential like protein 0.0039 0.1077 0.1088
Entamoeba histolytica hypothetical protein 0.004 0.1107 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0818 0.0816
Schistosoma mansoni hypothetical protein 0.0085 0.2771 0.274
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0408 0.0629
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0408 0.0428
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0408 0.0385
Schistosoma mansoni coup transcription factor 0.0021 0.0408 0.0367
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.2771 0.287
Loa Loa (eye worm) hypothetical protein 0.0184 0.6413 0.6714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0269 0.0227
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0408 0.0367
Loa Loa (eye worm) hypothetical protein 0.0036 0.0948 0.0992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1315 0.1278
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0408 0.0629
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0408 0.0428
Loa Loa (eye worm) hypothetical protein 0.0086 0.2784 0.2915
Echinococcus multilocularis transient receptor potential ion channel A 0.0102 0.3386 0.5214
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0408 0.0367
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0342 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.2071 0.2169
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0408 0.0629
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1835 0.2826
Echinococcus granulosus geminin 0.0187 0.6494 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0045
Brugia malayi mbt repeat family protein 0.0046 0.1339 0.1363
Loa Loa (eye worm) hypothetical protein 0.0043 0.1226 0.1283
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0342 0.139
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.056 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0408 0.0629
Echinococcus multilocularis zinc finger protein 0.0021 0.0401 0.0617
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.4353 0.4558
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0408 0.0385
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.4353 0.4558
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0408 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0408 0.0385
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0408 0.0629
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Brugia malayi Latrophilin receptor protein 2 0.0085 0.2771 0.287
Brugia malayi nuclear receptor NHR-88 0.0021 0.0408 0.0385
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.1339 0.1301
Brugia malayi ecdysteroid receptor 0.0021 0.0408 0.0385
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0582 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.027 0.9551 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.1339 0.1301
Schistosoma mansoni zinc finger protein 0.0021 0.0401 0.0359
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0408 0.0629
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0408 0.0385
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.1107 0.1705
Echinococcus multilocularis cpg binding protein 0.0036 0.0954 0.147
Loa Loa (eye worm) MBCTL1 0.0053 0.1575 0.1649
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0408 0.0367
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.1339 0.2061
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0371 0.0388
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0918 0.1414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0408 0.0428
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0243 0.0201
Schistosoma mansoni transient receptor potential channel 0.0106 0.3515 0.3487
Schistosoma mansoni hypothetical protein 0.0187 0.6494 0.6479
Schistosoma mansoni hypothetical protein 0.0085 0.2771 0.274
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.2771 0.2902
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0609
Brugia malayi Bromodomain containing protein 0.0075 0.2382 0.246
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0408 0.0367
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.6353 0.9784
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0582 0.5
Leishmania major hypothetical protein, conserved 0.0025 0.056 0.9469
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0582 1
Brugia malayi PHD-finger family protein 0.0026 0.0591 0.0577
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.2771 0.4267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1315 0.1338
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1575 0.2425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1315 0.1278
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1575 0.1649
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0408 0.0629
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0582 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0507 0.0781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0408 0.0428
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0049 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0269 0.0227
Schistosoma mansoni cpg binding protein 0.0032 0.0818 0.0779
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1575 0.1611
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.1339 0.1301
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0408 0.0367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1315 0.2026
Mycobacterium ulcerans hypothetical protein 0.0026 0.0582 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0582 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0582 1
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0064 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0408 0.0629
Schistosoma mansoni eyes absent homolog 0.0086 0.2784 0.2753
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.1077 0.1659
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0243 0.0201
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0408 0.0385
Loa Loa (eye worm) hypothetical protein 0.0019 0.0342 0.0358
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.1339 0.2061
Loa Loa (eye worm) hypothetical protein 0.004 0.109 0.1141
Loa Loa (eye worm) hypothetical protein 0.0085 0.2771 0.2902
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0408 0.0629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0609
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0818 0.0857
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0045
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.056 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0582 0.0567
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0582 1
Schistosoma mansoni cpg binding protein 0.0036 0.0954 0.0915
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.2201 0.3389
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0243 0.0374
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0408 0.0629
Schistosoma mansoni hypothetical protein 0.0085 0.2771 0.274
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0049 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0269 0.0282
Echinococcus granulosus transient receptor potential gamma protein 0.0106 0.3515 0.5413
Schistosoma mansoni hypothetical protein 0.0015 0.018 0.0138
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0043 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Loa Loa (eye worm) pigment dispersing factor receptor c 0.027 0.9551 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0582 1
Onchocerca volvulus 0.0026 0.0582 0.186
Echinococcus multilocularis transient receptor potential gamma protein 0.0106 0.3515 0.5413
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0582 0.0567
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.2771 0.4267
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.2771 0.4267
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0408 0.0385
Loa Loa (eye worm) hypothetical protein 0.0019 0.0342 0.0358
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0582 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0918 0.1414
Brugia malayi hypothetical protein 0.0016 0.0232 0.0199
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0408 0.0629
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.056 1
Brugia malayi MH2 domain containing protein 0.0128 0.4353 0.4533
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0408 0.0629
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.1077 0.1659
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0408 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0408 0.0428
Schistosoma mansoni zinc finger protein 0.0015 0.018 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.056 1
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.2201 0.3389
Onchocerca volvulus 0.0046 0.1339 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0507 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1315 0.1278
Entamoeba histolytica hypothetical protein 0.004 0.1107 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0408 0.0629
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0408 0.0367
Schistosoma mansoni transient receptor potential channel 4 0.0106 0.3515 0.3487
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0265 0.0277
Loa Loa (eye worm) hypothetical protein 0.0106 0.3515 0.3681
Echinococcus multilocularis geminin 0.0187 0.6494 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1835 0.2826
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0408 0.0367
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0408 0.0428
Loa Loa (eye worm) hypothetical protein 0.0069 0.2162 0.2263
Entamoeba histolytica hypothetical protein 0.004 0.1107 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0507 0.0781
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0408 0.0367
Schistosoma mansoni hypothetical protein 0.002 0.0371 0.033
Loa Loa (eye worm) hypothetical protein 0.027 0.9551 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1575 0.2425
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0408 0.0629
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.6353 0.9784
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0582 1
Schistosoma mansoni cpg binding protein 0.0036 0.0954 0.0915
Schistosoma mansoni hypothetical protein 0.0011 0.0049 0.0006
Echinococcus granulosus transient receptor potential ion channel A 0.0102 0.3386 0.5214
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0582 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1315 0.2026
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.1339 0.2061
Brugia malayi latrophilin 2 splice variant baaae 0.0184 0.6413 0.67
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0408 0.0385
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1315 0.2026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0408 0.0629
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.2771 0.4267
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1575 0.1538
Brugia malayi hypothetical protein 0.0086 0.2784 0.2883
Loa Loa (eye worm) hypothetical protein 0.0086 0.2784 0.2915
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0243 0.0374
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0408 0.0367
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0408 0.0367
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0428
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.2201 0.3389
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0582 1
Brugia malayi steroid hormone receptor 0.0021 0.0408 0.0385
Loa Loa (eye worm) hypothetical protein 0.0019 0.0342 0.0358
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0408 0.0367
Schistosoma mansoni bromodomain containing protein 0.0063 0.1963 0.1929
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.2147 0.2113
Echinococcus granulosus zinc finger protein 0.0021 0.0401 0.0617
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0408 0.0385
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0408 0.0385
Schistosoma mansoni hypothetical protein 0.0085 0.2771 0.274
Schistosoma mansoni transcription factor LCR-F1 0.004 0.1107 0.1069
Schistosoma mansoni hypothetical protein 0.0187 0.6494 0.6479
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.056 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0408 0.0428
Brugia malayi nuclear hormone receptor 0.0021 0.0408 0.0385
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.2201 0.3389
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0269 0.0414
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.1339 0.2061
Schistosoma mansoni hypothetical protein 0.004 0.1107 0.1069
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0043 0.0066
Schistosoma mansoni transient receptor potential channel 0.007 0.2201 0.2167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0342 0.0358
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.1339 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.1077 0.1128
Loa Loa (eye worm) hypothetical protein 0.0046 0.1339 0.1402
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.1339 0.1402
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0269 0.0414
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.1107 0.1705
Schistosoma mansoni hypothetical protein 0.0184 0.6413 0.6397
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0408 0.0629
Schistosoma mansoni transient receptor potential channel 0.007 0.2201 0.2167
Brugia malayi Calcitonin receptor-like protein seb-1 0.027 0.9551 1
Echinococcus granulosus GPCR family 2 0.0085 0.2771 0.4267
Loa Loa (eye worm) hypothetical protein 0.0019 0.0342 0.0358
Brugia malayi hypothetical protein 0.004 0.1107 0.1119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1315 0.2026
Echinococcus multilocularis GPCR, family 2 0.0085 0.2771 0.4267
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0582 1
Brugia malayi hypothetical protein 0.0025 0.056 0.0544
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0043 0.0066
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1575 0.2425
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0408 0.0629
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0408 0.0428
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1963 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1315 0.1377
Loa Loa (eye worm) hypothetical protein 0.0037 0.1005 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0408 0.0385
Brugia malayi mbt repeat family protein 0.0046 0.1339 0.1363
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0408 0.0629
Brugia malayi Bromodomain containing protein 0.0037 0.1003 0.1009
Loa Loa (eye worm) hypothetical protein 0.0025 0.056 0.0587
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.056 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0408 0.0367
Echinococcus granulosus cpg binding protein 0.0036 0.0954 0.147
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0408 0.0385
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0582 0.0567
Entamoeba histolytica hypothetical protein 0.004 0.1107 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0408 0.0385
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1575 0.2425
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0045
Onchocerca volvulus 0.0032 0.0818 0.4407
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0408 0.0385

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 61.99 uM Inhibition of electric eel AChE by colorimetric method ChEMBL. 9461651

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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