Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.0413 | 0.0939 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.227 | 0.6204 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.016 | 0.0224 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.227 | 0.6108 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.227 | 0.6108 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.227 | 0.6204 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1207 | 0.3189 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0698 | 0.1721 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0106 | 0.361 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0106 | 0.361 | 0.9845 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0776 | 0.197 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0616 | 0.1516 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.361 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.1032 | 0.286 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0776 | 0.2151 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.361 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0107 | 0.3665 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0081 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0085 | 0.2605 | 0.7152 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.0081 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0698 | 0.1721 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0107 | 0.3665 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0776 | 0.2151 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0106 | 0.361 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.361 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0616 | 0.1493 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0616 | 0.1707 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.004 | 0.0413 | 0.0925 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.227 | 0.629 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.1032 | 0.286 |
Onchocerca volvulus | 0.0034 | 0.016 | 0.0224 | |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0081 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.004 | 0.0413 | 0.0925 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0106 | 0.361 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0106 | 0.361 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.361 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.0413 | 0.0939 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.361 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0107 | 0.3665 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0616 | 0.1707 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.227 | 0.6108 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.227 | 0.6204 |
Giardia lamblia | Kinase, PLK | 0.0106 | 0.361 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.227 | 0.6108 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0106 | 0.361 | 0.9845 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.227 | 0.6108 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0.0081 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0616 | 0.1516 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.227 | 0.629 |
Schistosoma mansoni | kinase | 0.0054 | 0.11 | 0.2887 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0106 | 0.361 | 0.9845 |
Brugia malayi | jmjC domain containing protein | 0.004 | 0.0413 | 0.0925 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.361 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.1758 | 0.4754 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.004 | 0.0413 | 0.0939 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.361 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.