Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0108 | 0.0398 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0664 | 0.1267 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0108 | 0.0118 |
Schistosoma mansoni | jumonji domain containing protein | 0.0061 | 0.1897 | 0.6899 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0664 | 0.2437 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0664 | 0.2291 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0053 | 0.1574 | 0.5772 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.1042 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0061 | 0.1897 | 0.6957 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0081 | 0.2727 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0108 | 0.0213 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0016 | 0.0051 | 0.0189 |
Onchocerca volvulus | 0.004 | 0.1042 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.0553 | 0.113 |
Schistosoma mansoni | lamin | 0.0031 | 0.0664 | 0.2291 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0028 | 0.0533 | 0.1801 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0108 | 0.0213 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0664 | 0.2437 |
Schistosoma mansoni | lamin | 0.0031 | 0.0664 | 0.2291 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0108 | 0.0213 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0664 | 0.2437 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.1042 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.1042 | 0.2321 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2727 | 0.5574 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.1042 | 0.3704 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.0051 | 0.0105 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0954 | 0.1864 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.4892 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0053 | 0.1574 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0051 | 0.0105 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.1897 | 0.6899 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.1042 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.1042 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0016 | 0.0051 | 0.0189 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.1979 | 0.1045 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0.0533 | 0.1801 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1682 | 0.3368 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0053 | 0.1574 | 0.0593 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0028 | 0.0533 | 0.1801 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.1042 | 0.3704 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0954 | 0.1949 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0108 | 0.0398 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.4892 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0664 | 0.1358 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0016 | 0.0051 | 0.0189 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0108 | 0.0398 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0053 | 0.1574 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1042 | 0.2131 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.1042 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0061 | 0.1897 | 0.6957 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0061 | 0.1897 | 0.6957 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0051 | 0.0105 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.1979 | 0.7257 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1042 | 0.2131 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.1897 | 0.6899 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.1042 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0068 | 0.0139 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0664 | 0.2437 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1979 | 0.7204 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0016 | 0.0051 | 0.0189 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0641 | 0.131 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.0051 | 0.0105 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0108 | 0.0213 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.1042 | 0.3823 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0664 | 0.1358 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.1042 | 0.3704 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.0553 | 0.1035 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.1042 | 1 |
Onchocerca volvulus | 0.004 | 0.1042 | 1 | |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0081 | 0.2727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1042 | 0.2131 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0664 | 0.2437 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.1042 | 0.2047 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0108 | 0.0398 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0108 | 0.0118 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.1979 | 0.7204 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0016 | 0.0051 | 0.0189 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.0051 | 0.0105 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0081 | 0.2727 | 0.5527 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.2727 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.1042 | 0.2321 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.1897 | 0.3878 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.1979 | 0.7257 |
Echinococcus multilocularis | phd:f box containing protein | 0.0016 | 0.0051 | 0.0189 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.1042 | 0.3704 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0108 | 0.0398 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1979 | 0.5559 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0108 | 0.0222 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.1042 | 0.2131 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1979 | 0.7204 |
Brugia malayi | jmjC domain containing protein | 0.0061 | 0.1897 | 0.3813 |
Echinococcus granulosus | phd:f box containing protein | 0.0016 | 0.0051 | 0.0189 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0016 | 0.0051 | 0.0189 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.1042 | 0.2047 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0016 | 0.0051 | 0.0189 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0081 | 0.2727 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0108 | 0.0398 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0016 | 0.0051 | 0.0189 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.2727 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1979 | 0.5559 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0664 | 0.1267 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.4892 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.0664 | 0.2437 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1042 | 0.2131 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0061 | 0.1897 | 0.6957 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.1042 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0068 | 0.0035 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1682 | 0.3438 |
Brugia malayi | jmjC domain containing protein | 0.0061 | 0.1897 | 0.3813 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.1042 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1042 | 0.2131 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0051 | 0.0105 |
Brugia malayi | beta-lactamase | 0.004 | 0.1042 | 0.2047 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0664 | 0.1358 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1682 | 0.3368 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 1 |
Onchocerca volvulus | 0.004 | 0.1042 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1979 | 0.5559 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1042 | 0.2131 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.2727 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0108 | 0.0222 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.1042 | 0.5142 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0053 | 0.1574 | 0.5772 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.1042 | 0.2047 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.1042 | 0.3823 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0954 | 0.3372 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.1042 | 0.2131 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1682 | 0.3438 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.1979 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.